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$65+ Cheap flights from South Carolina to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAN
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Find flight deals from South Carolina to San Diego

Cheapest flights from South Carolina to San Diego
Explore the most affordable flight options available from South Carolina to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Alaska Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:24 pmCHS - SAN
1 stop17h 49mAlaska Airlines
Wed 12/104:25 pmSAN - CHS
1 stop22h 59mAlaska Airlines
Deal found 11/3$306
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:05 amCAE - SAN
1 stop6h 49mDelta
Tue 12/162:19 pmSAN - CAE
1 stop6h 12mDelta
Deal found 11/3$309
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:11 pmCHS - SAN
1 stop9h 19mUnited Airlines
Wed 12/108:40 pmSAN - CHS
2 stops11h 06mUnited Airlines
Deal found 11/3$312
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:43 pmCHS - SAN
1 stop23h 44mMultiple Airlines
Tue 11/181:37 pmSAN - CHS
2 stops38h 49mMultiple Airlines
Deal found 11/3$327
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/911:42 amGSP - SAN
1 stop12h 03mAmerican Airlines
Sun 12/146:15 amSAN - GSP
1 stop10h 29mAmerican Airlines
Deal found 11/4$338
This Kiwi.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:43 pmCHS - SAN
1 stop23h 44mMultiple Airlines
Wed 11/191:37 pmSAN - CHS
2 stops38h 49mMultiple Airlines
Deal found 11/3$340
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2212:17 pmCLT - SAN
1 stop14h 42mFrontier
Sat 12/274:47 pmSAN - CLT
1 stop15h 35mFrontier
Deal found 11/4$340
This CheapOair deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/78:34 pmSAV - SAN
1 stop25h 47mJetBlue
Fri 12/128:31 pmSAN - SAV
1 stop11h 24mJetBlue
Deal found 11/5$340
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2512:17 pmCLT - SAN
1 stop9h 58mFrontier
Thu 1/16:25 amSAN - CLT
1 stop25h 57mFrontier
Deal found 11/4$341
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1911:38 amCLT - SAN
2 stops14h 22mFrontier
Sat 1/36:44 amSAN - CLT
1 stop30h 39mFrontier
Deal found 11/4$342
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:14 pmCLT - SAN
2 stops22h 24mMultiple Airlines
Mon 1/54:47 pmSAN - CLT
1 stop21h 05mMultiple Airlines
Deal found 11/4$343
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amGSP - SAN
1 stop9h 41mAmerican Airlines
Wed 12/106:15 amSAN - GSP
1 stop12h 30mAmerican Airlines
Deal found 11/4$344

Cheap flight deals from South Carolina to San Diego

Keep the following information in mind while searching for South Carolina to San Diego flight deals. Data was last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$275
(Expedia)

One-way from

$65
(Frontier)

Popular in

June

Cheapest in

September

Average price

$564
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From South Carolina to San Diego
Search Deals
One-way flight from South Carolina to San Diego
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from South Carolina to San Diego that are best for you.

Fly from

South Carolina

Fly to

San Diego

Route

Depart

Return

Price

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 12/3

7:24 pm-10:13 am

1 stop17h 49m

San Diego

Wed 12/10

4:25 pm-6:24 pm

1 stop22h 59m

$306

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Tue 1/13

12:45 pm-5:41 pm

1 stop7h 56m

San Diego

Sat 1/17

10:30 pm-9:30 am

1 stop8h 00m

$309

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Fri 1/23

4:57 pm-10:50 pm

1 stop8h 53m

San Diego

Sun 1/25

6:20 am-4:23 pm

1 stop7h 03m

$309

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Sat 12/13

6:05 am-9:54 am

1 stop6h 49m

San Diego

Mon 12/15

10:30 pm-10:12 am

1 stop8h 42m

$309

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Fri 1/9

12:45 pm-7:41 pm

1 stop9h 56m

San Diego

Sat 1/17

10:30 pm-9:30 am

1 stop8h 00m

$309

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Sat 2/28

8:45 am-1:05 pm

1 stop7h 20m

San Diego

Wed 3/4

11:05 am-8:29 pm

1 stop6h 24m

$309

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Fri 1/9

12:45 pm-7:41 pm

1 stop9h 56m

San Diego

Wed 1/14

8:00 am-7:27 pm

1 stop8h 27m

$309

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 12/3

4:11 pm-10:30 pm

1 stop9h 19m

San Diego

Wed 12/10

8:40 pm-10:46 am

2 stops11h 06m

$312

SavannahSan Diego

SAV - SAN

SAVSAN

Savannah/Hilton Head

Sun 12/7

8:34 pm-7:21 pm

1 stop25h 47m

San Diego

Fri 12/12

8:31 pm-10:55 am

1 stop11h 24m

$340

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 12/3

6:00 am-12:41 pm

1 stop9h 41m

San Diego

Wed 12/10

6:15 am-9:45 pm

1 stop12h 30m

$344

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/4

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Diego

What is the cheapest month to book a flight from South Carolina to San Diego?

Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $141). Flying from South Carolina to San Diego in February is currently the most expensive (average of $262). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAN?

Find hourly flight availability from South Carolina to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

One of the essential ways to save on airfare from South Carolina to San Diego is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the morning could potentially save you up to 8% on airfare.

What is the cheapest day to fly from South Carolina to San Diego?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to San Diego flight should consider departing on Saturday afternoons when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from South Carolina?

    San Diego (SAN) is the airport you will fly into if you book a flight from South Carolina to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How long is the flight from South Carolina to San Diego?

    A quick flight from South Carolina to San Diego can take about 7h 56m. Alaska Airlines provides one of the quickest options available for as low as $309. South Carolina and San Diego are separated by a distance of 2072 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to San Diego one-way?

    To fly one-way, consider booking your trip with JetBlue, which is currently one of the cheapest options available, starting at $149. Southwest flights start at $166 while deals on American Airlines start at $184 one-way.

  • What are the most popular routes from South Carolina to San Diego?

    The most popular flight routes from South Carolina to San Diego are Charlotte Douglas - San Diego, Columbia Metropolitan - San Diego and Greenville - San Diego.

  • Can I find deals for flights from South Carolina to San Diego that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Diego.

  • Can I find deals for business class flights from South Carolina to San Diego?

    Yes. Cheapflights offers flight deals from South Carolina to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Diego?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $141). Flying from South Carolina to San Diego in February is currently the most expensive (average of $262). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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Alternative routes for South Carolina to San Diego

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Top 5 airlines flying from South Carolina to San Diego

Discover the top 5 airlines that operate flights from South Carolina to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$170Average$265FlexibilityNo cancel feeOn-time62%
DeltaCheapest$257Average$450FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$261Average$428FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$294Average$468FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$348Average$468FlexibilityNo cancel feeOn-time63%

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