HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Diego

$59+ Cheap flights from South Carolina to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAN
Apr 1 — Apr 81
Wed 4/1
Wed 4/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to San Diego

Cheapest flights from South Carolina to San Diego
Explore the most affordable flight options available from South Carolina to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 2, 2026.

This Expedia deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:04 am
CHS
-
SAN
1 stop12h 13m
JetBlue
Tue 5/199:15 pm
SAN
-
CHS
1 stop10h 00m
JetBlue
Deal found 3/1$279
This JetBlue deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:45 am
SAV
-
SAN
1 stop12h 19m
JetBlue
Mon 4/279:15 pm
SAN
-
SAV
1 stop9h 40m
JetBlue
Deal found 2/27$283
This CheapOair deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:55 pm
CHS
-
SAN
1 stop23h 29m
JetBlue
Mon 4/279:15 pm
SAN
-
CHS
1 stop10h 13m
JetBlue
Deal found 2/28$322
This Kiwi.com deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/278:44 pm
CHS
-
SAN
2 stops18h 36m
Breeze Airways
Mon 8/311:05 pm
SAN
-
CHS
1 stop23h 17m
Breeze Airways
Deal found 2/27$325
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:04 am
MYR
-
SAN
1 stop8h 09m
American Airlines
Wed 4/159:45 pm
SAN
-
MYR
1 stop7h 39m
American Airlines
Deal found 2/26$327
This Delta deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:34 am
CAE
-
SAN
1 stop7h 18m
Delta
Thu 4/1610:30 pm
SAN
-
CAE
1 stop7h 44m
Delta
Deal found 2/27$329
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:48 pm
CHS
-
SAN
1 stop7h 49m
American Airlines
Tue 4/71:03 pm
SAN
-
CHS
1 stop6h 33m
American Airlines
Deal found 3/2$331
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:19 pm
CHS
-
SAN
2 stops9h 55m
United Airlines
Tue 5/198:54 am
SAN
-
CHS
1 stop7h 38m
United Airlines
Deal found 3/1$332
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:12 pm
CHS
-
SAN
1 stop7h 14m
United Airlines
Wed 4/1511:01 am
SAN
-
CHS
2 stops9h 58m
United Airlines
Deal found 2/26$336
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:45 pm
CHS
-
SAN
1 stop7h 14m
American Airlines
Mon 3/301:37 pm
SAN
-
CHS
1 stop7h 18m
American Airlines
Deal found 2/28$337
This CheapOair deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:23 am
SAV
-
SAN
1 stop27h 25m
Multiple Airlines
Mon 4/208:35 pm
SAN
-
SAV
1 stop11h 30m
Multiple Airlines
Deal found 3/1$337
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:15 pm
CHS
-
SAN
2 stops9h 10m
Southwest
Tue 5/196:45 am
SAN
-
CHS
2 stops10h 15m
Southwest
Deal found 3/1$341

Find flight deals from South Carolina to San Diego

Keep the following information in mind while searching for South Carolina to San Diego flight deals. Data was last updated March 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Expedia)

One-way from

$59
(Trip.com)

Popular in

December

Cheapest in

September

Average price

$515
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From South Carolina to San Diego
Search Deals
One-way flight from South Carolina to San Diego
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($84 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
Use the filters below to find and compare flights from South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SavannahSan Diego

SAV - SAN

SAVSAN

Savannah/Hilton Head

Thu 4/23

10:45 am-8:04 pm

1 stop12h 19m

San Diego

Mon 4/27

9:15 pm-9:55 am

1 stop9h 40m

$330

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Thu 4/9

5:12 pm-9:26 pm

1 stop7h 14m

San Diego

Wed 4/15

11:01 am-11:59 pm

2 stops9h 58m

$336

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Thu 4/9

3:00 pm-9:05 pm

1 stop9h 05m

San Diego

Wed 4/15

6:20 am-8:25 pm

1 stop11h 05m

$337

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 4/1

6:15 am-10:15 am

1 stop7h 00m

San Diego

Wed 4/8

6:45 am-8:00 pm

2 stops10h 15m

$344

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Tue 5/19

5:08 pm-10:00 pm

1 stop7h 52m

San Diego

Sat 5/23

9:25 pm-8:29 am

1 stop8h 04m

$352

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Mon 5/11

7:50 pm-11:27 pm

1 stop6h 37m

San Diego

Sat 5/16

10:30 pm-9:18 am

1 stop7h 48m

$352

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 3/25

5:32 pm-10:40 pm

1 stop8h 08m

San Diego

Tue 3/31

10:30 pm-9:56 am

1 stop8h 26m

$367

CharlotteSan Diego

CLT - SAN

CLTSAN

Charlotte Douglas

Sat 5/9

6:10 am-12:55 pm

2 stops9h 45m

San Diego

Tue 5/12

10:05 am-9:40 pm

2 stops8h 35m

$369

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Thu 4/2

5:42 am-9:52 am

1 stop7h 10m

San Diego

Tue 4/7

10:30 pm-9:16 am

1 stop7h 46m

$375

CharlotteSan Diego

CLT - SAN

CLTSAN

Charlotte Douglas

Wed 4/1

12:50 pm-7:30 pm

1 stop9h 40m

San Diego

Wed 4/8

6:20 am-5:45 pm

1 stop8h 25m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/28

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from South Carolina to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Diego

What is the cheapest month to book a flight from South Carolina to San Diego?

Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $143). Flying from South Carolina to San Diego in April is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAN?

Find hourly flight availability from South Carolina to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 2, 2026.

One of the essential ways to save on airfare from South Carolina to San Diego is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 20% on airfare.

What is the cheapest day to fly from South Carolina to San Diego?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to San Diego. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their South Carolina to San Diego flight should consider departing on Saturday afternoons when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from South Carolina?

    San Diego (SAN) is the airport you will fly into if you book a flight from South Carolina to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How long is the flight from South Carolina to San Diego?

    A quick flight from South Carolina to San Diego can take about 7h 14m. JetBlue provides one of the quickest options available for as low as $336. South Carolina and San Diego are separated by a distance of 2145 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to San Diego one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $153. Alaska Airlines flights start at $160 while deals on Southwest start at $169 one-way.

  • What are the most popular routes from South Carolina to San Diego?

    The most popular flight routes from South Carolina to San Diego are Charlotte Douglas - San Diego, Charleston - San Diego and Savannah/Hilton Head - San Diego.

  • Can I find deals for flights from South Carolina to San Diego that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Diego.

  • Can I find deals for business class flights from South Carolina to San Diego?

    Yes. Cheapflights offers flight deals from South Carolina to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Diego?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $143). Flying from South Carolina to San Diego in April is currently the most expensive (average of $267). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to San Francisco flights
John F Kennedy Intl to Los Angeles flights
John F Kennedy Intl to Las Vegas flights
Newark to San Francisco flights
Newark to Los Angeles flights
Seattle to Las Vegas flights
Newark to Las Vegas flights
Dallas/Fort Worth to Las Vegas flights
O'Hare Intl to Las Vegas flights
LaGuardia to San Francisco flights
Seattle to Los Angeles flights
San Francisco to Las Vegas flights
Dallas/Fort Worth to Los Angeles flights
Dulles Intl to Las Vegas flights
San Francisco to Los Angeles flights
LaGuardia to Los Angeles flights
Seattle to Ontario flights
Denver to Las Vegas flights
O'Hare Intl to Los Angeles flights
LaGuardia to Las Vegas flights
Boston to Las Vegas flights
Dallas/Fort Worth to San Francisco flights
Atlanta to Las Vegas flights
Minneapolis to Las Vegas flights
Baltimore to Los Angeles flights
Dulles Intl to Los Angeles flights
Los Angeles to San Francisco flights
Los Angeles to Las Vegas flights
Reagan-National to Los Angeles flights
Boston to Los Angeles flights
Baltimore to Las Vegas flights
Detroit to Las Vegas flights
O'Hare Intl to San Francisco flights
Reagan-National to Las Vegas flights
San Francisco to Santa Ana flights
Boston to San Francisco flights
Austin to Las Vegas flights
Philadelphia to Las Vegas flights
Portland to Las Vegas flights
Seattle to San Diego flights
Dallas/Fort Worth to Ontario flights
Orlando to Las Vegas flights
Cleveland to Las Vegas flights
Los Angeles to San Jose flights
Hobby to Las Vegas flights
Atlanta to Los Angeles flights
Dulles Intl to San Francisco flights
Burbank to Las Vegas flights
Hobby to Los Angeles flights
Midway to Las Vegas flights

Top 5 airlines flying from South Carolina to San Diego

Discover the top 5 airlines that operate flights from South Carolina to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$137Average$252FlexibilityNo cancel feeOn-time62%
DeltaCheapest$148Average$462FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$228Average$448FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$266Average$441FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$318Average$479FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights