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$71+ Cheap flights from South Carolina to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAN
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from South Carolina to San Diego

Cheapest flights from South Carolina to San Diego
Explore the most affordable flight options available from South Carolina to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Frontier deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:37 pmCLT - SAN
1 stop9h 10mFrontier
Wed 12/316:25 amSAN - CLT
1 stop6h 54mFrontier
Deal found 12/21$383
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amCLT - SAN
1 stop7h 55mSouthwest
Sat 12/271:25 pmSAN - CLT
1 stop7h 50mSouthwest
Deal found 12/21$398
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:48 pmCLT - SAN
Nonstop5h 14mAmerican Airlines
Thu 1/16:15 amSAN - CLT
Nonstop4h 45mAmerican Airlines
Deal found 12/22$403
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:05 amCLT - SAN
1 stop7h 58mDelta
Wed 12/318:00 amSAN - CLT
1 stop8h 10mDelta
Deal found 12/21$408
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2510:00 amCLT - SAN
1 stop8h 55mUnited Airlines
Sat 12/2711:12 amSAN - CLT
2 stops9h 47mUnited Airlines
Deal found 12/21$421
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:54 pmCLT - SAN
1 stop8h 58mUnited Airlines
Thu 1/19:30 pmSAN - CLT
1 stop9h 33mUnited Airlines
Deal found 12/22$423
This American Airlines deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:48 pmCLT - SAN
Nonstop5h 14mAmerican Airlines
Tue 1/612:40 pmSAN - CLT
Nonstop4h 42mAmerican Airlines
Deal found 12/23$425
This Booking.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:32 pmCLT - SAN
1 stop7h 27mFrontier
Sun 1/46:25 amSAN - CLT
1 stop8h 39mFrontier
Deal found 12/22$431
This Frontier deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2312:17 pmCLT - SAN
1 stop9h 58mFrontier
Sun 12/286:25 amSAN - CLT
1 stop6h 58mFrontier
Deal found 12/21$432
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/232:52 pmCLT - SAN
1 stop8h 16mAmerican Airlines
Sat 12/2711:55 amSAN - CLT
Nonstop4h 50mAmerican Airlines
Deal found 12/22$433
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:48 pmCLT - SAN
Nonstop5h 14mAmerican Airlines
Thu 1/111:55 amSAN - CLT
Nonstop4h 50mAmerican Airlines
Deal found 12/21$438
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/233:00 pmCAE - SAN
1 stop9h 00mDelta
Mon 1/510:30 pmSAN - CAE
1 stop7h 58mDelta
Deal found 12/22$481

Find flight deals from South Carolina to San Diego

Keep the following information in mind while searching for South Carolina to San Diego flight deals. Data was last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(JetBlue)

One-way from

$71
(WAYA)

Popular in

December

Cheapest in

September

Average price

$642
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From South Carolina to San Diego
Search Deals
One-way flight from South Carolina to San Diego
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($44 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from South Carolina to San Diego that are best for you.

Fly from

South Carolina

Fly to

San Diego

Route

Depart

Return

Price

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Sat 1/17

12:09 pm-8:20 pm

1 stop11h 11m

San Diego

Tue 1/20

9:30 pm-11:13 am

1 stop10h 43m

$269

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Fri 3/13

6:32 pm-10:04 am

1 stop18h 32m

San Diego

Mon 3/16

6:15 am-5:32 pm

1 stop32h 17m

$315

SavannahSan Diego

SAV - SAN

SAVSAN

Savannah/Hilton Head

Sat 1/17

7:00 am-11:33 am

1 stop7h 33m

San Diego

Mon 1/19

10:45 pm-9:55 am

1 stop8h 10m

$325

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Thu 2/26

6:32 pm-10:04 am

1 stop18h 32m

San Diego

Mon 3/2

8:26 pm-5:32 pm

1 stop18h 06m

$325

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Sat 2/14

3:45 pm-10:26 pm

1 stop9h 41m

San Diego

Thu 2/19

12:52 pm-10:25 pm

1 stop6h 33m

$328

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Wed 2/25

5:35 am-10:01 am

1 stop7h 26m

San Diego

Sun 3/1

10:20 pm-9:28 am

1 stop8h 08m

$329

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Sun 2/1

5:35 am-9:58 am

1 stop7h 23m

San Diego

Sun 2/8

10:30 pm-9:32 am

1 stop8h 02m

$329

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Wed 1/14

6:18 am-11:33 am

1 stop8h 15m

San Diego

Mon 1/19

10:45 pm-9:42 am

1 stop7h 57m

$329

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Fri 1/23

10:10 am-4:54 pm

1 stop9h 44m

San Diego

Sun 1/25

12:32 pm-10:58 pm

1 stop7h 26m

$329

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Sun 2/1

1:09 pm-8:41 pm

1 stop10h 32m

San Diego

Sun 2/8

10:45 pm-9:42 am

1 stop7h 57m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Diego

What is the cheapest month to book a flight from South Carolina to San Diego?

Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $141). Flying from South Carolina to San Diego in June is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SAN?

Find hourly flight availability from South Carolina to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

One of the essential ways to save on airfare from South Carolina to San Diego is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the morning could potentially save you up to 8% on airfare.

What is the cheapest day to fly from South Carolina to San Diego?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to San Diego flight should consider departing on Saturday afternoons when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from South Carolina?

    San Diego (SAN) is the airport you will fly into if you book a flight from South Carolina to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How long is the flight from South Carolina to San Diego?

    A quick flight from South Carolina to San Diego can take about 7h 33m. JetBlue provides one of the quickest options available for as low as $325. South Carolina and San Diego are separated by a distance of 2088 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to San Diego one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $153. Alaska Airlines flights start at $160 while deals on Delta start at $169 one-way.

  • What are the most popular routes from South Carolina to San Diego?

    The most popular flight routes from South Carolina to San Diego are Charlotte Douglas - San Diego, Charleston - San Diego and Columbia Metropolitan - San Diego.

  • Can I find deals for flights from South Carolina to San Diego that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Diego.

  • Can I find deals for business class flights from South Carolina to San Diego?

    Yes. Cheapflights offers flight deals from South Carolina to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Diego?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $141). Flying from South Carolina to San Diego in June is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for South Carolina to San Diego

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Top 5 airlines flying from South Carolina to San Diego

Discover the top 5 airlines that operate flights from South Carolina to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$170Average$252FlexibilityNo cancel feeOn-time62%
DeltaCheapest$220Average$447FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$426FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$294Average$454FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$318Average$477FlexibilityNo cancel feeOn-time63%

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