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San Diego

$74+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated July 31, 2025.

Round-trip from

$207
(Cheapflightsfares)

One-way from

$76
(CheapOair)

Popular in

March

Cheapest in

August

Average price

$309

Good round-trip deal

$317 or less

Good one-way deal

$148 or less
From Missouri to San Diego
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One-way flight from Missouri to San Diego
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Highest demand for flights based on searches. 7% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Missouri to San Diego.
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Price to beat on a one-way flight from Missouri to San Diego.
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Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/123:01 pmMCI - SAN
1 stop10h 52mMultiple Airlines
Thu 9/186:15 amSAN - MCI
1 stop5h 45mMultiple Airlines
Deal found 7/29$206
This Cheapflightsfares deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/42:55 pmMCI - SAN
1 stop5h 47mSpirit Airlines
Sun 9/76:15 amSAN - MCI
1 stop5h 45mSpirit Airlines
Deal found 7/31$207
This Cheapflightsfares deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/57:55 pmSTL - SAN
1 stop5h 58mFrontier
Mon 9/812:33 pmSAN - STL
1 stop6h 11mFrontier
Deal found 7/29$215
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/231:45 pmMCI - SAN
1 stop5h 44mUnited Airlines
Wed 8/2710:30 pmSAN - MCI
1 stop8h 39mUnited Airlines
Deal found 7/30$223
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/88:01 pmMCI - SAN
1 stop5h 51mFrontier
Wed 8/136:25 amSAN - MCI
1 stop9h 58mFrontier
Deal found 7/30$228
This Hawaiian Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Hawaiian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/277:00 amMCI - SAN
1 stop7h 56mHawaiian Airlines
Wed 10/111:46 amSAN - MCI
1 stop7h 26mHawaiian Airlines
Deal found 7/31$232
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:12 amMCI - SAN
1 stop8h 51mAmerican Airlines
Tue 9/237:13 amSAN - MCI
1 stop8h 12mAmerican Airlines
Deal found 7/31$233
This Alaska Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/123:37 pmMCI - SAN
1 stop9h 21mAlaska Airlines
Tue 9/2311:46 amSAN - MCI
1 stop7h 26mAlaska Airlines
Deal found 7/30$240
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/213:42 pmMCI - SAN
1 stop5h 26mDelta
Sat 10/259:46 amSAN - MCI
1 stop5h 18mDelta
Deal found 7/31$249
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/111:21 pmSGF - SAN
1 stop6h 34mMultiple Airlines
Thu 8/211:17 pmSAN - SGF
2 stops21h 02mMultiple Airlines
Deal found 7/29$255
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:50 amMCI - SAN
1 stop5h 25mSouthwest
Sat 11/89:20 amSAN - MCI
Nonstop3h 10mSouthwest
Deal found 7/31$263
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/286:29 pmSGF - SAN
1 stop7h 42mAmerican Airlines
Wed 11/1910:48 amSAN - SGF
1 stop6h 05mAmerican Airlines
Deal found 7/30$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 9/12

3:01 pm-11:53 pm

1 stop10h 52m

San Diego

Thu 9/18

6:15 am-2:00 pm

1 stop5h 45m

$206

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 9/4

2:55 pm-6:42 pm

1 stop5h 47m

San Diego

Sun 9/7

6:15 am-2:00 pm

1 stop5h 45m

$207

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 9/5

7:55 pm-11:53 pm

1 stop5h 58m

San Diego

Mon 9/8

12:33 pm-8:44 pm

1 stop6h 11m

$215

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 8/23

1:45 pm-5:29 pm

1 stop5h 44m

San Diego

Wed 8/27

10:30 pm-9:09 am

1 stop8h 39m

$223

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 8/8

8:01 pm-11:52 pm

1 stop5h 51m

San Diego

Wed 8/13

6:25 am-6:23 pm

1 stop9h 58m

$228

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 9/27

7:00 am-2:16 pm

1 stop9h 16m

San Diego

Wed 10/1

9:30 am-9:12 pm

1 stop9h 42m

$232

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 9/16

7:12 am-2:03 pm

1 stop8h 51m

San Diego

Tue 9/23

7:13 am-5:25 pm

1 stop8h 12m

$233

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 10/21

3:42 pm-7:08 pm

1 stop5h 26m

San Diego

Sat 10/25

9:46 am-5:04 pm

1 stop5h 18m

$249

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Mon 8/11

1:21 pm-5:55 pm

1 stop6h 34m

San Diego

Thu 8/21

1:17 pm-12:19 pm

2 stops21h 02m

$255

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 8/23

2:50 pm-7:55 pm

1 stop7h 05m

San Diego

Sat 8/30

1:25 pm-6:35 pm

Nonstop3h 10m

$263

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 40 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest, and Delta from Missouri to San Diego. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,246 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,981 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Hawaiian Airlines
7.8
Good
2,611 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,900 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Comfort

7.8

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Entertainment

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $76 on Spirit Airlines. Other airlines that offer cheap prices include Southwest from $107 and Hawaiian Airlines from $108 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $330, our data indicates the cheapest price to be $169. The most popular route (Kansas City - San Diego), is priced around $150.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
Poway
National City
Lemon Grove
Imperial Beach
La Mesa
Alpine

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$97Average$205FlexibilityNo cancel feeOn-time65%
FrontierCheapest$108Average$210FlexibilityNo cancel feeOn-time62%
Alaska AirlinesCheapest$228Average$248FlexibilityNo cancel feeOn-time75%
American AirlinesCheapest$232Average$396FlexibilityNo cancel feeOn-time71%
DeltaCheapest$238Average$289FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$239Average$363FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$265Average$473FlexibilityNo cancel feeOn-time63%

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