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San Diego

$68+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Apr 25 — May 21
Sat 4/25
Sat 5/2
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.

This Trip.com deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:43 pm
MCI
-
SAN
1 stop5h 19m
Frontier
Sat 4/116:25 am
SAN
-
MCI
1 stop11h 33m
Frontier
Deal found 3/22$217
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:53 am
MCI
-
SAN
2 stops21h 53m
Frontier
Fri 5/86:25 am
SAN
-
MCI
1 stop29h 24m
Frontier
Deal found 3/26$218
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:34 pm
MCI
-
SAN
1 stop11h 16m
Frontier
Sun 5/101:38 pm
SAN
-
MCI
2 stops22h 11m
Frontier
Deal found 3/24$219
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:50 pm
MCI
-
SAN
2 stops8h 48m
United Airlines
Wed 5/68:54 am
SAN
-
MCI
1 stop5h 21m
United Airlines
Deal found 3/25$222
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:17 pm
MCI
-
SAN
1 stop6h 15m
United Airlines
Wed 4/226:20 am
SAN
-
MCI
2 stops7h 56m
United Airlines
Deal found 3/23$223
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:57 pm
MCI
-
SAN
1 stop5h 48m
Delta
Wed 6/33:30 pm
SAN
-
MCI
1 stop5h 46m
Delta
Deal found 3/24$225
This Expedia deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:46 pm
MCI
-
SAN
1 stop5h 19m
Frontier
Fri 4/109:28 pm
SAN
-
MCI
1 stop20h 30m
Frontier
Deal found 3/25$226
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/179:31 am
MCI
-
SAN
1 stop6h 04m
Delta
Mon 4/209:45 pm
SAN
-
MCI
1 stop9h 58m
Delta
Deal found 3/26$230
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:12 pm
MCI
-
SAN
1 stop7h 21m
American Airlines
Tue 4/143:09 pm
SAN
-
MCI
1 stop6h 50m
American Airlines
Deal found 3/24$231
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:10 pm
MCI
-
SAN
1 stop6h 25m
Southwest
Wed 4/2911:30 am
SAN
-
MCI
1 stop5h 30m
Southwest
Deal found 3/23$232
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:20 pm
MCI
-
SAN
1 stop6h 25m
Southwest
Mon 5/112:25 pm
SAN
-
MCI
1 stop6h 25m
Southwest
Deal found 3/23$233
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/212:34 pm
MCI
-
SAN
1 stop11h 16m
Frontier
Tue 5/266:25 am
SAN
-
MCI
1 stop29h 24m
Frontier
Deal found 3/25$234

Find flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated March 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$217
(Trip.com)

One-way from

$68
(Kiwi.com)

Popular in

June

Cheapest in

October

Average price

$414

Good round-trip deal

$427 or less

Good one-way deal

$198 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($3 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 5/5

8:25 am-10:25 am

Nonstop4h 00m

San Diego

Mon 5/11

10:40 pm-7:45 am

1 stop7h 05m

$241

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Wed 4/8

2:16 pm-10:59 pm

1 stop10h 43m

San Diego

Mon 4/13

10:10 pm-9:49 am

1 stop9h 39m

$243

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Mon 5/4

7:20 pm-11:25 pm

1 stop6h 05m

San Diego

Sat 5/9

2:50 pm-8:20 pm

Nonstop3h 30m

$290

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 4/10

5:25 pm-11:40 pm

1 stop8h 15m

San Diego

Tue 4/14

2:45 pm-11:14 pm

1 stop6h 29m

$297

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 5/1

6:45 pm-11:42 pm

1 stop6h 57m

San Diego

Sun 5/3

2:45 pm-11:13 pm

1 stop6h 28m

$300

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 5/5

5:35 am-11:20 am

2 stops7h 45m

San Diego

Wed 5/13

2:50 pm-11:10 pm

1 stop6h 20m

$302

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 5/7

6:00 am-9:15 am

1 stop5h 15m

San Diego

Mon 5/11

7:40 pm-8:41 am

2 stops11h 01m

$312

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 6/1

3:55 pm-8:15 pm

1 stop6h 20m

San Diego

Fri 6/5

2:20 pm-7:35 pm

Nonstop3h 15m

$319

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mon 4/6

2:40 pm-6:35 pm

1 stop5h 55m

San Diego

Mon 4/13

10:10 pm-9:49 am

1 stop9h 39m

$324

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 6/10

4:48 pm-8:46 pm

1 stop5h 58m

San Diego

Tue 6/30

6:20 am-4:33 pm

2 stops8h 13m

$331

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $186). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 11% versus a flight at noon.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on March 23, 2026.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Missouri to San Diego?

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 4 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    Southwest, Delta, and United Airlines can get you from Missouri to San Diego in just under 4h. Your travel time can differ by up to 6h 43m. The distance from Missouri to San Diego is about 1553 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $73 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $93 and United Airlines from $108 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $500, our data indicates the cheapest price to be $214. The most popular route (Kansas City - San Diego), is priced around $184.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $186). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$88Average$220FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$100Average$203FlexibilityNo cancel feeOn-time65%
Alaska AirlinesCheapest$124Average$341FlexibilityNo cancel feeOn-time75%
DeltaCheapest$138Average$292FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$182Average$336FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$210Average$397FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$261Average$441FlexibilityNo cancel feeOn-time63%

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