How popular is this Missouri to San Diego flight route?

Within the past month, 1 users have taken a look at flights from Missouri to San Diego.

How long is the flight from Missouri to San Diego?

Frontier, Delta, and American Airlines can get you from Missouri to San Diego in just under 7h 11m. Your travel time can differ by up to 10h 03m. The distance from Missouri to San Diego is about 1378 mi. This flight may include one or multiple stops.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

What are the most popular routes from Missouri to San Diego?

While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

What are the cheapest flights from Missouri to San Diego?

Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $326, our data indicates the cheapest price to be $138. The most popular route (Kansas City - San Diego), is priced around $189.

What are the most popular airlines that fly from Missouri to San Diego?

Before booking your flight from Missouri to San Diego check out the most popular airlines for this route: American Airlines, Delta or Frontier.

What airport do you fly into for flights to San Diego from Missouri?

For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

Can I find deals for flights from Missouri to San Diego that include hotel bookings?

Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to San Diego?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

Can I find deals for business class flights from Missouri to San Diego?

Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$72+ Flights from Missouri to San Diego

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Diego

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$144 (Frontier)
One-way from	$72 (Frontier)
Popular in	March
Cheapest in	January
Average price	$290
Good round-trip deal	$373 or less
Good one-way deal	$174 or less

Provider with most accurate pricing for Kansas City-San Diego flight deals.

Search Deals

Provider most trusted by Cheapflights users for Kansas City-San Diego flights.

Search Deals

From Missouri to San Diego

Search Deals

One-way flight from Missouri to San Diego

Search Deals

Highest demand for flights based on searches. 5% potential increase in price ($18 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in September 2025

Search Deals

Price to beat on a round-trip flight from Missouri to San Diego.

Search Deals

Price to beat on a one-way flight from Missouri to San Diego.

Search Deals

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.

Wed 10/157:52 pmSTL - SAN

1 stop5h 58mFrontier

Fri 10/179:03 pmSAN - STL

1 stop10h 04mFrontier

Deal found 9/23

$144

Wed 10/227:52 pmSTL - SAN

1 stop5h 58mFrontier

Tue 11/41:37 pmSAN - STL

1 stop17h 30mFrontier

Deal found 9/24

$145

Fri 10/37:55 pmSTL - SAN

1 stop28h 29mFrontier

Sun 10/59:03 pmSAN - STL

1 stop10h 03mFrontier

Deal found 9/23

$146

Fri 10/109:59 pmSTL - SAN

1 stop24h 52mFrontier

Tue 10/146:41 amSAN - STL

1 stop24h 26mFrontier

Deal found 9/22

$157

Fri 10/179:59 pmSTL - SAN

1 stop24h 52mFrontier

Sun 10/194:06 pmSAN - STL

1 stop26h 58mFrontier

Deal found 9/23

$159

Sat 10/184:51 pmSTL - SAN

1 stop6h 00mFrontier

Mon 10/206:25 amSAN - STL

1 stop12h 39mFrontier

Deal found 9/23

$177

Sat 10/184:51 pmSTL - SAN

1 stop6h 00mFrontier

Mon 10/279:03 pmSAN - STL

1 stop10h 04mFrontier

Deal found 9/23

$178

Wed 11/57:45 pmSTL - SAN

1 stop17h 32mFrontier

Fri 11/76:41 amSAN - STL

1 stop24h 26mFrontier

Deal found 9/24

$179

Wed 12/37:43 pmSTL - SAN

1 stop14h 22mFrontier

Fri 12/52:28 pmSAN - STL

1 stop17h 34mFrontier

Deal found 9/23

$184

Thu 11/67:45 pmSTL - SAN

1 stop6h 05mFrontier

Sat 11/87:30 pmSAN - STL

1 stop11h 37mFrontier

Deal found 9/23

$190

Sat 10/47:55 pmSTL - SAN

1 stop17h 14mFrontier

Mon 10/66:35 amSAN - STL

1 stop24h 32mFrontier

Deal found 9/24

$192

Sun 11/212:31 pmMCI - SAN

1 stop6h 09mFrontier

Tue 11/46:58 amSAN - MCI

1 stop8h 21mFrontier

Deal found 9/24

$210

Best flights from Missouri to San Diego
Discover carefully curated flight deals from Missouri to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2025.

Sat 10/47:55 pmSTL - SAN

1 stop17h 14mFrontier

Mon 10/66:35 amSAN - STL

1 stop24h 32mFrontier

Deal found 9/24

$192

Wed 10/2212:44 pmSGF - SAN

1 stop10h 36mMultiple Airlines

Wed 10/299:00 amSAN - SGF

1 stop23h 31mMultiple Airlines

Deal found 9/24

$218

Tue 11/114:02 pmSGF - SAN

1 stop7h 11mDelta

Sat 11/156:24 amSAN - SGF

1 stop6h 53mDelta

Deal found 9/23

$269

Thu 2/198:25 amSGF - SAN

1 stop7h 12mAmerican Airlines

Wed 2/258:49 amSAN - SGF

1 stop5h 10mAmerican Airlines

Deal found 9/22

$269

Tue 11/47:00 amMCI - SAN

1 stop7h 56mAlaska Airlines

Tue 11/117:00 amSAN - MCI

1 stop6h 54mAlaska Airlines

Deal found 9/24

$270

Tue 1/271:28 pmSGF - SAN

2 stops8h 26mUnited Airlines

Sat 2/141:55 pmSAN - SGF

1 stop6h 20mUnited Airlines

Deal found 9/23

$274

Sun 11/165:40 amMCI - SAN

1 stop6h 30mSouthwest

Wed 11/192:55 pmSAN - MCI

Nonstop3h 10mSouthwest

Deal found 9/24

$313

Tue 10/288:40 pmSTL - SAN

1 stop29h 10mFrontier

Fri 10/3112:34 pmSAN - STL

2 stops18h 33mFrontier

Deal found 9/23

$216

Fri 10/108:38 pmMCI - SAN

2 stops26h 13mMultiple Airlines

Mon 10/133:23 pmSAN - MCI

1 stop20h 37mMultiple Airlines

Deal found 9/23

$262

Thu 11/206:40 amMCI - SAN

1 stop8h 26mDelta

Mon 11/245:15 pmSAN - MCI

1 stop5h 09mDelta

Deal found 9/24

$269

Wed 12/101:34 pmMCI - SAN

2 stops11h 56mAlaska Airlines

Sun 12/149:06 pmSAN - MCI

1 stop13h 34mAlaska Airlines

Deal found 9/23

$280

Thu 10/96:36 pmMCI - SAN

1 stop19h 41mMultiple Airlines

Sat 10/111:01 pmSAN - MCI

2 stops19h 41mMultiple Airlines

Deal found 9/23

$268

Thu 11/134:49 pmMCI - SAN

1 stop9h 10mAlaska Airlines

Mon 11/1710:09 pmSAN - MCI

2 stops15h 45mAlaska Airlines

Deal found 9/24

$293

Fri 10/176:00 amMCI - SAN

1 stop5h 12mUnited Airlines

Mon 10/2010:30 pmSAN - MCI

1 stop8h 39mUnited Airlines

Deal found 9/23

$323

Tue 1/277:09 amSGF - SAN

1 stop8h 27mAmerican Airlines

Sat 2/142:30 pmSAN - SGF

1 stop7h 19mAmerican Airlines

Deal found 9/23

$341

Tue 2/310:55 amSTL - SAN

Nonstop4h 15mSouthwest

Tue 2/108:35 amSAN - STL

1 stop6h 55mSouthwest

Deal found 9/22

$343

Wed 12/101:35 pmSGF - SAN

2 stops8h 17mUnited Airlines

Sat 12/138:01 amSAN - SGF

1 stop6h 13mUnited Airlines

Deal found 9/23

$329

Tue 11/187:00 amMCI - SAN

2 stops16h 19mAlaska Airlines

Sat 11/228:23 pmSAN - MCI

1 stop16h 13mAlaska Airlines

Deal found 9/23

$300

Tue 11/43:15 pmSTL - SAN

Nonstop4h 00mSouthwest

Sat 11/87:00 amSAN - STL

1 stop6h 50mSouthwest

Deal found 9/24

$343

Wed 2/1812:41 pmSGF - SAN

1 stop8h 22mAmerican Airlines

Sat 2/2110:00 amSAN - SGF

1 stop5h 54mAmerican Airlines

Deal found 9/22

$349

Fri 11/74:45 pmSGF - SAN

1 stop7h 08mUnited Airlines

Sat 11/1511:02 amSAN - SGF

2 stops8h 44mUnited Airlines

Deal found 9/24

$335

Tue 12/234:56 pmMCI - SAN

1 stop26h 21mAlaska Airlines

Mon 1/59:15 pmSAN - MCI

1 stop16h 47mAlaska Airlines

Deal found 9/23

$320

Sat 2/288:54 amJLN - SAN

1 stop8h 49mUnited Airlines

Wed 3/44:10 pmSAN - JLN

1 stop5h 31mUnited Airlines

Deal found 9/21

$344

Tue 11/47:00 amSTL - SAN

1 stop9h 47mAlaska Airlines

Thu 11/139:28 amSAN - STL

1 stop12h 31mAlaska Airlines

Deal found 9/23

$329

Mon 11/35:07 pmSGF - SAN

1 stop7h 22mUnited Airlines

Sat 11/86:45 amSAN - SGF

1 stop7h 37mUnited Airlines

Deal found 9/23

$344

Tue 10/215:25 pmCOU - SAN

1 stop7h 03mAmerican Airlines

Sat 11/156:30 amSAN - COU

2 stops9h 17mAmerican Airlines

Deal found 9/24

$435

Mon 11/177:00 amSTL - SAN

1 stop9h 47mAlaska Airlines

Mon 11/175:25 pmSAN - STL

1 stop19h 53mAlaska Airlines

Deal found 9/23

$342

Tue 3/32:55 pmSTL - SAN

1 stop11h 12mAlaska Airlines

Wed 3/411:30 amSAN - STL

1 stop10h 26mAlaska Airlines

Deal found 9/22

$342

Tue 2/32:55 pmSTL - SAN

1 stop11h 12mAlaska Airlines

Tue 2/102:40 pmSAN - STL

1 stop21h 12mAlaska Airlines

Deal found 9/22

$342

Mon 10/139:01 amCOU - SAN

1 stop26h 11mUnited Airlines

Wed 11/129:00 amSAN - COU

1 stop9h 51mUnited Airlines

Deal found 9/23

$455

Last-minute flights from Missouri to San Diego
Discover last-minute flight deals from Missouri to San Diego. Data last updated September 24, 2025 and is based on user searches.

Fri 9/267:55 pmSTL - SAN

1 stop28h 29mFrontier

Tue 10/76:41 amSAN - STL

1 stop24h 26mFrontier

Deal found 9/24

$205

Fri 10/37:55 pmSTL - SAN

1 stop28h 29mFrontier

Sun 10/59:03 pmSAN - STL

1 stop10h 03mFrontier

Deal found 9/23

$146

Sat 10/47:55 pmSTL - SAN

1 stop17h 14mFrontier

Mon 10/66:35 amSAN - STL

1 stop24h 32mFrontier

Deal found 9/24

$192

Thu 10/910:17 amSTL - SAN

1 stop10h 11mFrontier

Mon 10/138:11 amSAN - STL

1 stop9h 15mFrontier

Deal found 9/24

$190

Fri 10/109:59 pmSTL - SAN

1 stop24h 52mFrontier

Tue 10/146:41 amSAN - STL

1 stop24h 26mFrontier

Deal found 9/22

$157

Wed 10/157:52 pmSTL - SAN

1 stop5h 58mFrontier

Fri 10/179:03 pmSAN - STL

1 stop10h 04mFrontier

Deal found 9/23

$144

Fri 10/179:59 pmSTL - SAN

1 stop24h 52mFrontier

Sun 10/194:06 pmSAN - STL

1 stop26h 58mFrontier

Deal found 9/23

$159

Sat 10/184:51 pmSTL - SAN

1 stop6h 00mFrontier

Mon 10/206:25 amSAN - STL

1 stop12h 39mFrontier

Deal found 9/23

$177

Sat 10/184:51 pmSTL - SAN

1 stop6h 00mFrontier

Mon 10/279:03 pmSAN - STL

1 stop10h 04mFrontier

Deal found 9/23

$178

Sat 10/184:51 pmSTL - SAN

1 stop6h 00mFrontier

Tue 10/216:41 amSAN - STL

1 stop24h 26mFrontier

Deal found 9/23

$179

Wed 10/227:52 pmSTL - SAN

1 stop5h 58mFrontier

Tue 11/41:37 pmSAN - STL

1 stop17h 30mFrontier

Deal found 9/24

$145

Thu 10/3011:29 amMCI - SAN

2 stops14h 21mFrontier

Sat 11/16:41 amSAN - MCI

1 stop10h 57mFrontier

Deal found 9/24

$214

One-way flights from Missouri to San Diego
Search for one-way flight options from Missouri to San Diego. Find affordable one-way fares based on user searches. Data last updated September 24, 2025.

Sat 10/254:51 pmSTL - SAN

1 stop6h 00mFrontier

Deal found 9/23

$72

Fri 11/77:45 pmSTL - SAN

1 stop6h 05mFrontier

Deal found 9/23

$73

Sun 10/2610:17 amSTL - SAN

1 stop10h 11mFrontier

Deal found 9/23

$78

Mon 10/278:38 pmMCI - SAN

1 stop18h 50mFrontier

Deal found 9/23

$80

Mon 11/38:28 pmMCI - SAN

1 stop27h 11mFrontier

Deal found 9/24

$82

Thu 10/238:38 pmMCI - SAN

1 stop15h 19mFrontier

Deal found 9/23

$84

Sun 11/912:10 pmSTL - SAN

1 stop9h 04mFrontier

Deal found 9/24

$85

Wed 10/227:02 pmMCI - SAN

1 stop6h 48mFrontier

Deal found 9/23

$86

Sun 12/78:33 pmMCI - SAN

1 stop18h 57mFrontier

Deal found 9/24

$88

Wed 12/37:43 pmSTL - SAN

1 stop14h 22mFrontier

Deal found 9/24

$88

Sat 11/18:28 pmMCI - SAN

1 stop17h 49mFrontier

Deal found 9/23

$89

Sat 12/67:43 pmSTL - SAN

1 stop14h 22mFrontier

Deal found 9/24

$89

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 10/4

7:55 pm-11:09 am

1 stop17h 14m

San Diego

Mon 10/6

6:35 am-9:07 am

1 stop24h 32m

$192

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 10/28

8:40 pm-11:50 pm

1 stop29h 10m

San Diego

Fri 10/31

12:34 pm-9:07 am

2 stops18h 33m

$216

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Wed 10/22

12:44 pm-9:20 pm

1 stop10h 36m

San Diego

Wed 10/29

9:00 am-10:31 am

1 stop23h 31m

$218

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 10/10

8:38 pm-8:51 pm

2 stops26h 13m

San Diego

Mon 10/13

3:23 pm-2:00 pm

1 stop20h 37m

$262

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 10/9

6:36 pm-12:17 pm

1 stop19h 41m

San Diego

Sat 10/11

1:01 pm-10:42 am

2 stops19h 41m

$268

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 11/11

4:02 pm-9:13 pm

1 stop7h 11m

San Diego

Sat 11/15

6:24 am-3:17 pm

1 stop6h 53m

$269

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Thu 2/19

8:25 am-1:37 pm

1 stop7h 12m

San Diego

Wed 2/25

8:49 am-3:59 pm

1 stop5h 10m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 11/20

6:40 am-1:06 pm

1 stop8h 26m

San Diego

Mon 11/24

5:15 pm-12:24 am

1 stop5h 09m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 11/4

7:00 am-12:56 pm

1 stop7h 56m

San Diego

Tue 11/11

7:00 am-3:54 pm

1 stop6h 54m

$270

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Tue 1/27

1:28 pm-7:54 pm

2 stops8h 26m

San Diego

Sat 2/14

1:55 pm-10:15 pm

1 stop6h 20m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 60 results

...

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Related info for your journey

What airport do you fly into for flights to San Diego from Missouri?
For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.
How popular is this Missouri to San Diego flight route?
Within the past month, 1 users have taken a look at flights from Missouri to San Diego.
How long is the flight from Missouri to San Diego?
Frontier, Delta, and American Airlines can get you from Missouri to San Diego in just under 7h 11m. Your travel time can differ by up to 10h 03m. The distance from Missouri to San Diego is about 1378 mi. This flight may include one or multiple stops.
What are the most popular routes from Missouri to San Diego?
While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.
What are the cheapest flights from Missouri to San Diego?
Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $326, our data indicates the cheapest price to be $138. The most popular route (Kansas City - San Diego), is priced around $189.
Can I find deals for flights from Missouri to San Diego that include hotel bookings?
Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to San Diego?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.
Can I find deals for business class flights from Missouri to San Diego?
Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to San Diego?
Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

El Cajon

Chula Vista

Coronado

La Mesa

Poway

Lemon Grove

Imperial Beach

National City

Browse thousands of different options on Cheapflights for your next trip

Top 7 airlines flying from Missouri to San Diego

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$82	Average$204	FlexibilityNo cancel fee	On-time65%
Frontier	Cheapest$108	Average$219	FlexibilityNo cancel fee	On-time62%
Alaska Airlines	Cheapest$228	Average$284	FlexibilityNo cancel fee	On-time75%
American Airlines	Cheapest$229	Average$391	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$235	Average$287	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$239	Average$364	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$261	Average$474	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$72+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to San Diego with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated September 24, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San DiegoExplore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.

Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 24, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to San Diego from Missouri?

How popular is this Missouri to San Diego flight route?

How long is the flight from Missouri to San Diego?

What are the most popular routes from Missouri to San Diego?

What are the cheapest flights from Missouri to San Diego?

Can I find deals for flights from Missouri to San Diego that include hotel bookings?

How can I find direct flights from Missouri to San Diego?

Can I find deals for business class flights from Missouri to San Diego?

What is the cheapest month to book a flight from Missouri to San Diego?

Traveling to a place near San Diego?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.

Top 7 airlines flying from Missouri to San Diego

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.