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San Diego

$54+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Jan 28 — Feb 41
Wed 1/28
Wed 2/4
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMCI - SAN
1 stop9h 05mDelta
Wed 1/710:30 pmSAN - MCI
1 stop9h 46mDelta
Deal found 12/26$384
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:07 pmMCI - SAN
1 stop5h 40mUnited Airlines
Wed 1/76:15 amSAN - MCI
2 stops7h 53mUnited Airlines
Deal found 12/26$389
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:45 amMCI - SAN
1 stop5h 54mUnited Airlines
Mon 1/54:10 pmSAN - MCI
1 stop5h 05mUnited Airlines
Deal found 12/26$397
This CheapOair deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:10 pmSTL - SAN
1 stop16h 01mFrontier
Tue 1/63:29 pmSAN - STL
1 stop16h 33mFrontier
Deal found 12/25$408
This Frontier deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:45 pmMCI - SAN
1 stop5h 14mFrontier
Mon 1/56:25 amSAN - MCI
1 stop11h 25mFrontier
Deal found 12/26$423
This United Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:00 amMCI - SAN
1 stop7h 30mUnited Airlines
Wed 1/76:15 amSAN - MCI
2 stops12h 18mUnited Airlines
Deal found 12/27$432
This Southwest deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:35 pmMCI - SAN
1 stop6h 20mSouthwest
Mon 1/53:15 pmSAN - MCI
1 stop6h 00mSouthwest
Deal found 12/28$438
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/272:42 pmSTL - SAN
1 stop5h 55mAmerican Airlines
Tue 12/306:15 amSAN - STL
1 stop8h 55mAmerican Airlines
Deal found 12/26$451
This Frontier deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:45 pmMCI - SAN
1 stop5h 14mFrontier
Fri 1/26:25 amSAN - MCI
1 stop11h 25mFrontier
Deal found 12/26$452
This Frontier deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/288:45 pmMCI - SAN
1 stop5h 14mFrontier
Mon 1/56:25 amSAN - MCI
1 stop11h 25mFrontier
Deal found 12/26$453
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:02 pmMCI - SAN
1 stop5h 57mAmerican Airlines
Tue 12/302:23 pmSAN - MCI
1 stop6h 31mAmerican Airlines
Deal found 12/26$464
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/319:00 amMCI - SAN
1 stop8h 01mUnited Airlines
Mon 1/511:12 amSAN - MCI
2 stops10h 03mUnited Airlines
Deal found 12/26$469

Find flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated December 29, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$109
(WAYA)

One-way from

$54
(WAYA)

Popular in

December

Cheapest in

October

Average price

$476

Good round-trip deal

$426 or less

Good one-way deal

$174 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($32 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 29, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 1/23

8:41 pm-11:31 pm

1 stop28h 50m

San Diego

Sun 1/25

6:30 am-7:51 pm

1 stop11h 21m

$163

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 2/17

7:00 am-8:24 pm

2 stops15h 24m

San Diego

Sat 2/21

12:23 pm-12:59 pm

1 stop22h 36m

$225

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 1/15

11:26 am-8:21 am

2 stops22h 55m

San Diego

Sun 1/18

9:12 pm-6:18 pm

1 stop19h 06m

$262

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 3/3

5:35 am-1:04 pm

1 stop9h 29m

San Diego

Sun 3/8

6:20 am-2:54 pm

1 stop6h 34m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 1/29

2:45 pm-11:09 pm

1 stop10h 24m

San Diego

Mon 2/2

8:42 pm-1:50 pm

1 stop15h 08m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Sat 1/17

4:01 pm-10:45 pm

1 stop8h 44m

San Diego

Tue 1/20

6:15 am-5:00 pm

1 stop8h 45m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 3/3

2:49 pm-11:03 pm

1 stop10h 14m

San Diego

Sun 3/8

7:00 am-4:22 pm

1 stop7h 22m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 2/12

7:55 pm-11:46 pm

1 stop5h 51m

San Diego

Mon 2/16

3:20 pm-11:29 pm

1 stop6h 09m

$269

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Thu 2/19

7:55 pm-11:46 pm

1 stop5h 51m

San Diego

Sun 2/22

3:20 pm-11:29 pm

1 stop6h 09m

$269

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 2/27

2:22 pm-10:20 pm

2 stops9h 58m

San Diego

Mon 3/2

10:59 am-11:23 pm

2 stops10h 24m

$276

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/28

Showing 1-10 of 55 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $180). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 29, 2025.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 36% versus a flight at noon.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on December 27, 2025.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Saturday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 3 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    Frontier, Delta, and Alaska Airlines can get you from Missouri to San Diego in just under 9h 29m. Your travel time can differ by up to 19h 21m. The distance from Missouri to San Diego is about 1330 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $55 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $83 and JetBlue from $112 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Kansas City - San Diego or Springfield-Branson - San Diego, Lambert-St Louis - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $344, our data indicates the cheapest price to be $149. The most popular route (Lambert-St Louis - San Diego), is priced around $215.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $180). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$88Average$204FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$125Average$203FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$182Average$350FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$219Average$389FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$228Average$284FlexibilityNo cancel feeOn-time75%
DeltaCheapest$243Average$287FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$266Average$459FlexibilityNo cancel feeOn-time63%

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