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$59+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/137:43 pmSTL - SAN
1 stop25h 32mFrontier
Tue 12/166:34 amSAN - STL
1 stop25h 40mFrontier
Deal found 11/12$133
This CheapOair deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:43 pmSTL - SAN
1 stop25h 32mFrontier
Sun 12/76:34 amSAN - STL
1 stop25h 40mFrontier
Deal found 11/12$134
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/137:43 pmSTL - SAN
1 stop25h 32mFrontier
Thu 12/184:47 pmSAN - STL
1 stop15h 15mFrontier
Deal found 11/12$142
This CheapOair deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/207:43 pmSTL - SAN
1 stop25h 32mFrontier
Sun 1/46:25 amSAN - STL
1 stop25h 37mFrontier
Deal found 11/12$144
This Mytrip deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:16 pmSTL - SAN
1 stop25h 22mFrontier
Thu 12/186:25 amSAN - STL
1 stop25h 37mFrontier
Deal found 11/12$149
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:43 pmSTL - SAN
1 stop22h 09mFrontier
Tue 12/166:34 amSAN - STL
1 stop25h 40mFrontier
Deal found 11/12$152
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:43 pmSTL - SAN
1 stop22h 09mFrontier
Thu 12/184:47 pmSAN - STL
1 stop15h 15mFrontier
Deal found 11/12$164
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1410:44 pmSTL - SAN
1 stop15h 54mFrontier
Tue 12/166:34 amSAN - STL
1 stop25h 40mFrontier
Deal found 11/12$166
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:43 pmSTL - SAN
2 stops19h 24mFrontier
Fri 12/124:47 pmSAN - STL
1 stop15h 27mFrontier
Deal found 11/12$170
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:45 pmMCI - SAN
1 stop24h 30mFrontier
Sat 1/37:21 pmSAN - MCI
2 stops22h 30mFrontier
Deal found 11/11$229
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:45 pmMCI - SAN
2 stops15h 12mFrontier
Thu 1/86:25 amSAN - MCI
1 stop11h 01mFrontier
Deal found 11/11$232
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:45 pmMCI - SAN
2 stops15h 12mFrontier
Fri 1/96:36 amSAN - MCI
1 stop10h 50mFrontier
Deal found 11/11$236

Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated November 13, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$133
(Kiwi.com)

One-way from

$59
(Trip.com)

Popular in

March

Cheapest in

October

Average price

$396

Good round-trip deal

$362 or less

Good one-way deal

$166 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($8 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 12/23

10:10 pm-12:11 pm

1 stop16h 01m

San Diego

Wed 1/14

7:10 am-2:48 pm

1 stop5h 38m

$231

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 12/30

8:45 pm-9:57 am

2 stops15h 12m

San Diego

Thu 1/8

6:25 am-7:26 pm

1 stop11h 01m

$232

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 1/16

11:12 am-12:01 am

2 stops14h 49m

San Diego

Sun 1/18

4:47 pm-10:04 am

1 stop15h 17m

$251

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 12/24

7:43 pm-11:59 pm

1 stop6h 16m

San Diego

Wed 1/7

9:43 am-12:12 pm

1 stop24h 29m

$256

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Tue 12/9

5:34 pm-11:44 pm

1 stop8h 10m

San Diego

Sat 12/13

7:20 am-5:19 pm

1 stop7h 59m

$259

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 12/3

9:00 am-1:04 pm

1 stop6h 04m

San Diego

Sat 12/6

8:01 am-4:04 pm

1 stop6h 03m

$259

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 12/12

6:00 am-11:14 am

1 stop7h 14m

San Diego

Wed 12/17

2:12 pm-11:29 pm

1 stop7h 17m

$259

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 12/12

1:35 pm-5:35 pm

1 stop6h 00m

San Diego

Mon 12/15

7:00 am-3:40 pm

1 stop6h 40m

$259

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sat 1/31

3:31 pm-8:50 pm

1 stop7h 19m

San Diego

Wed 2/11

3:00 pm-11:25 pm

1 stop6h 25m

$259

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Wed 2/4

6:10 am-10:48 am

1 stop6h 38m

San Diego

Sat 2/14

10:05 pm-9:38 am

1 stop9h 33m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $179). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 37% versus a flight at noon.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 2 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    Frontier, Delta, and American Airlines can get you from Missouri to San Diego in just under 8h 10m. Your travel time can differ by up to 7h 51m. The distance from Missouri to San Diego is about 1553 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $97 on Frontier. Other airlines that offer cheap prices include Southwest from $130 and Delta from $135 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Kansas City - San Diego or Springfield-Branson - San Diego, Lambert-St Louis - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $320, our data indicates the cheapest price to be $166. The most popular route (Lambert-St Louis - San Diego), is priced around $190.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $179). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$82Average$205FlexibilityNo cancel feeOn-time65%
FrontierCheapest$88Average$224FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$182Average$354FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$226Average$384FlexibilityNo cancel feeOn-time71%
Alaska AirlinesCheapest$228Average$284FlexibilityNo cancel feeOn-time75%
DeltaCheapest$248Average$286FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$266Average$469FlexibilityNo cancel feeOn-time63%

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