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$60+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Mrz 13 — Mrz 201
Fr 3/13
Fr 3/20
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Februar 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 3/78:40 pm
MCI
-
SAN
1 stop28h 28m
Frontier
Do 3/126:25 am
SAN
-
MCI
1 stop11h 30m
Frontier
Deal found 2/8$145
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 3/44:39 pm
MCI
-
SAN
2 stops26h 52m
Frontier
Sa 3/76:25 am
SAN
-
MCI
1 stop11h 30m
Frontier
Deal found 2/8$156
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 5/142:15 pm
MCI
-
SAN
1 stop11h 46m
Frontier
So 5/176:25 am
SAN
-
MCI
1 stop29h 05m
Frontier
Deal found 2/8$162
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 3/98:38 pm
MCI
-
SAN
1 stop26h 36m
Frontier
Do 3/126:25 am
SAN
-
MCI
1 stop11h 30m
Frontier
Deal found 2/8$165
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/82:15 pm
MCI
-
SAN
1 stop11h 46m
Multiple Airlines
Fr 5/159:07 pm
SAN
-
MCI
1 stop24h 26m
Multiple Airlines
Deal found 2/8$167
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 2/2711:00 am
MCI
-
SAN
2 stops39h 08m
Frontier
Fr 3/69:18 pm
SAN
-
MCI
1 stop20h 37m
Frontier
Deal found 2/8$170
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 3/44:39 pm
MCI
-
SAN
2 stops26h 52m
Frontier
Do 3/126:25 am
SAN
-
MCI
1 stop11h 30m
Frontier
Deal found 2/8$176
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 3/57:00 am
MCI
-
SAN
1 stop10h 17m
Multiple Airlines
Sa 3/76:25 am
SAN
-
MCI
1 stop11h 30m
Multiple Airlines
Deal found 2/8$179
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 3/62:09 pm
MCI
-
SAN
1 stop26h 21m
Frontier
Do 3/126:25 am
SAN
-
MCI
1 stop11h 30m
Frontier
Deal found 2/8$180
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 3/78:40 pm
MCI
-
SAN
1 stop28h 28m
Multiple Airlines
Di 3/102:08 pm
SAN
-
MCI
1 stop7h 25m
Multiple Airlines
Deal found 2/8$185
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mo 2/165:12 am
STL
-
SAN
1 stop6h 48m
American Airlines
Mo 2/234:45 pm
SAN
-
STL
1 stop5h 14m
American Airlines
Deal found 2/7$257
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 3/86:19 pm
STL
-
SAN
1 stop23h 54m
Frontier
Fr 3/139:00 am
SAN
-
STL
1 stop22h 49m
Frontier
Deal found 2/8$258

Find flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated Februar 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$145
(Kiwi.com)

One-way from

$60
(Trip.com)

Popular in

December

Cheapest in

October

Average price

$394

Good round-trip deal

$307 or less

Good one-way deal

$179 or less
Provider with most accurate pricing for Lambert-St Louis-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Diego flights.
Search Deals
From Missouri to San Diego
Search Deals
One-way flight from Missouri to San Diego
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($48 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a round-trip flight from Missouri to San Diego.
Search Deals
Price to beat on a one-way flight from Missouri to San Diego.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Februar 11, 2026.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fr 2/27

1:50 pm-5:40 pm

1 stop5h 50m

San Diego

Fr 3/6

4:12 pm-11:15 pm

1 stop5h 03m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mi 3/4

2:12 pm-11:02 pm

1 stop10h 50m

San Diego

Di 3/10

2:47 pm-11:03 pm

1 stop6h 16m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mi 4/29

1:54 pm-5:16 pm

1 stop5h 22m

San Diego

Mi 5/6

6:32 am-4:15 pm

1 stop7h 43m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mi 4/8

3:45 pm-8:45 pm

1 stop7h 00m

San Diego

Mo 4/13

10:10 pm-9:49 am

1 stop9h 39m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fr 3/6

7:55 pm-11:46 pm

1 stop5h 51m

San Diego

Mi 3/11

10:10 pm-9:51 am

1 stop9h 41m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Mo 4/6

5:40 pm-11:40 pm

1 stop8h 00m

San Diego

Mo 4/13

10:30 pm-9:43 am

1 stop9h 13m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Di 3/3

1:23 pm-8:37 pm

1 stop9h 14m

San Diego

Mo 3/9

3:45 pm-11:56 pm

1 stop6h 11m

$217

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Di 4/28

6:00 am-10:43 am

1 stop6h 43m

San Diego

So 5/3

6:20 am-2:59 pm

1 stop6h 39m

$227

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Do 6/11

5:40 am-11:35 am

1 stop7h 55m

San Diego

Di 6/16

10:30 pm-9:38 am

1 stop9h 08m

$227

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fr 3/6

7:46 pm-11:59 pm

1 stop6h 13m

San Diego

Mi 3/11

6:24 am-1:33 pm

1 stop5h 09m

$247

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 58 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $182). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Februar 11, 2026.

When flying from Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the morning, which can drop the price by up to 12% versus a flight in the evening.

What is the cheapest day to fly from Missouri to San Diego?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Diego. Price data was last updated on February 7, 2026.

Travelers seeking maximum savings on their Missouri to San Diego flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • How popular is this Missouri to San Diego flight route?

    Within the past month, 3 users have taken a look at flights from Missouri to San Diego.

  • How long is the flight from Missouri to San Diego?

    United Airlines, Delta, and American Airlines can get you from Missouri to San Diego in just under 5h 50m. Your travel time can differ by up to 5h. The distance from Missouri to San Diego is about 1330 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $64 on Frontier. Other airlines that offer cheap prices include Spirit Airlines from $83 and JetBlue from $112 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Kansas City - San Diego or Springfield-Branson - San Diego, Lambert-St Louis - San Diego is the most popular route from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $326, our data indicates the cheapest price to be $132. The most popular route (Lambert-St Louis - San Diego), is priced around $195.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, November is the cheapest month in which you can book a flight from Missouri to San Diego (average of $67). Flying from Missouri to San Diego in June is currently the most expensive (average of $182). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Missouri to San Diego

Discover the top 6 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Februar 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$88Average$208FlexibilityNo cancel feeOn-time62%
Spirit AirlinesCheapest$100Average$203FlexibilityNo cancel feeOn-time65%
DeltaCheapest$138Average$278FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$182Average$341FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$227Average$391FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$268Average$451FlexibilityNo cancel feeOn-time63%

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