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$76+ Cheap flights from Missouri to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAN
Jun 22 — Jun 291
Sun 6/22
Sun 6/29
1 adult, Economy
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Cheap flight deals from Missouri to San Diego

Keep the following information in mind while searching for Missouri to San Diego flight deals. Data was last updated June 17, 2025.

Round-trip from

$222
(Mytrip)

One-way from

$76
(FlightHub)

Popular in

March

Cheapest in

August

Average price

$331

Good round-trip deal

$379 or less

Good one-way deal

$198 or less
From Missouri to San Diego
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One-way flight from Missouri to San Diego
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Highest demand for flights based on searches. 7% potential increase in price ($23 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Missouri to San Diego.
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Price to beat on a one-way flight from Missouri to San Diego.
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Find flight deals from Missouri to San Diego

Cheapest flights from Missouri to San Diego
Explore the most affordable flight options available from Missouri to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 17, 2025.

This Mytrip deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/296:00 amMCI - SAN
2 stops19h 06mSpirit Airlines
Sat 8/26:15 amSAN - MCI
1 stop10h 10mSpirit Airlines
Deal found 6/14$222
This Mytrip deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/212:16 pmSGF - SAN
1 stop13h 13mMultiple Airlines
Wed 7/96:15 amSAN - SGF
1 stop12h 12mMultiple Airlines
Deal found 6/16$228
This Mytrip deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/41:49 pmMCI - SAN
2 stops35h 40mMultiple Airlines
Mon 7/76:15 amSAN - MCI
1 stop10h 40mMultiple Airlines
Deal found 6/14$238
This Frontier deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/208:01 pmMCI - SAN
1 stop5h 54mFrontier
Mon 6/236:25 amSAN - MCI
1 stop10h 41mFrontier
Deal found 6/15$239
This FlightHub deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/128:44 amSTL - SAN
1 stop7h 31mSpirit Airlines
Thu 9/183:10 pmSAN - STL
1 stop14h 39mSpirit Airlines
Deal found 6/15$247
This Alaska Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/167:00 amMCI - SAN
1 stop7h 52mAlaska Airlines
Tue 9/237:00 amSAN - MCI
1 stop7h 01mAlaska Airlines
Deal found 6/16$248
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:04 pmMCI - SAN
1 stop7h 38mDelta
Tue 7/155:00 pmSAN - MCI
1 stop5h 21mDelta
Deal found 6/15$249
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/116:05 pmMCI - SAN
1 stop6h 37mUnited Airlines
Tue 7/151:50 pmSAN - MCI
2 stops7h 41mUnited Airlines
Deal found 6/15$254
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:01 pmSGF - SAN
1 stop7h 22mAmerican Airlines
Thu 8/212:25 pmSAN - SGF
1 stop7h 28mAmerican Airlines
Deal found 6/14$269
This FlightHub deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/148:44 amSTL - SAN
1 stop7h 31mMultiple Airlines
Fri 9/1910:20 amSAN - STL
1 stop20h 47mMultiple Airlines
Deal found 6/15$298
This CheapOair deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/167:29 pmSTL - SAN
1 stop6h 26mFrontier
Wed 6/186:51 pmSAN - STL
1 stop16h 51mFrontier
Deal found 6/14$308
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/25:45 amMCI - SAN
1 stop5h 05mAmerican Airlines
Sun 7/66:30 amSAN - MCI
1 stop5h 08mAmerican Airlines
Deal found 6/14$313

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2025.
Use the filters below to find and compare flights from Missouri to San Diego that are best for you.

Fly from

Missouri

Fly to

San Diego

Route

Depart

Return

Price

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 7/29

6:00 am-11:06 pm

2 stops19h 06m

San Diego

Sat 8/2

6:15 am-6:25 pm

1 stop10h 10m

$222

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Wed 7/2

12:16 pm-11:29 pm

1 stop13h 13m

San Diego

Wed 7/9

6:15 am-8:27 pm

1 stop12h 12m

$228

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 7/4

1:49 pm-11:29 pm

2 stops35h 40m

San Diego

Mon 7/7

6:15 am-6:55 pm

1 stop10h 40m

$238

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 6/20

8:01 pm-11:55 pm

1 stop5h 54m

San Diego

Mon 6/23

6:25 am-7:06 pm

1 stop10h 41m

$239

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Fri 9/12

8:44 am-2:15 pm

1 stop7h 31m

San Diego

Thu 9/18

3:10 pm-7:49 am

1 stop14h 39m

$247

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 9/5

3:37 pm-11:53 pm

1 stop10h 16m

San Diego

Tue 9/9

7:00 am-4:01 pm

1 stop7h 01m

$248

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Tue 7/8

6:04 pm-11:42 pm

1 stop7h 38m

San Diego

Tue 7/15

5:00 pm-12:21 am

1 stop5h 21m

$249

Kansas CitySan Diego

MCI - SAN

MCISAN

Kansas City

Fri 7/11

6:05 pm-10:42 pm

1 stop6h 37m

San Diego

Tue 7/15

1:50 pm-11:31 pm

2 stops7h 41m

$254

SpringfieldSan Diego

SGF - SAN

SGFSAN

Springfield-Branson

Fri 8/15

6:01 pm-11:23 pm

1 stop7h 22m

San Diego

Thu 8/21

2:25 pm-11:53 pm

1 stop7h 28m

$269

St. LouisSan Diego

STL - SAN

STLSAN

Lambert-St Louis

Sun 9/14

8:44 am-2:15 pm

1 stop7h 31m

San Diego

Fri 9/19

10:20 am-9:07 am

1 stop20h 47m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/16

Showing 1-10 of 46 results
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Best time to book a flight from Missouri to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Diego

What is the cheapest month to book a flight from Missouri to San Diego?

Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SAN?

Find hourly flight availability from Missouri to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to San Diego as you normally would.

Weekly flight availability from Missouri to San Diego

Explore weekly flight availability from Missouri to San Diego. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 17, 2025.

The most flights from USMO to SAN are scheduled on a Sunday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Rainfall in San Diego by month

Plan your trip to San Diego by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in San Diego ranges from 0.0 - 2.3 inches per month. February is typically the wettest month, when rainfall can reach 2.3 in. July is typically the driest time to visit San Diego when rainfall is around 0.0 in.

Temperature in San Diego by month

Plan your trip to San Diego by taking into account the average temperature totals by month.

If weather is an important factor for your trip to San Diego, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 71.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 57.2 F).

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated June 17, 2025.
See what other customers who have flown with Alaska Airlines, Southwest and Delta from Missouri to San Diego have to say. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,278 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,963 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Hawaiian Airlines
7.8
Good
2,501 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,801 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Boarding

8.1

Overall

8.0

Crew

8.5

Comfort

7.8

Entertainment

7.1

Food

7.1

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Missouri?

    For a flight from Missouri to San Diego, you will be flying into San Diego. San Diego (SAN) is just 2.6 mi from the center of the city.

  • What are the cheapest airlines to fly from Missouri to San Diego one-way?

    One-way options have recently been found by users for as low as $76 on Spirit Airlines. Other airlines that offer cheap prices include Frontier from $100 and Hawaiian Airlines from $124 one-way.

  • What are the most popular routes from Missouri to San Diego?

    While some choose either Lambert-St Louis - San Diego or Springfield-Branson - San Diego, Kansas City - San Diego is the most popular route from Missouri to San Diego.

  • What are the most reliable airlines from Missouri to San Diego?

    Consider Southwest (63%), Sun Country Air (0%) or United Airlines (0%) when booking your flight. These represent the most reliable airlines when flying from Missouri to San Diego.

  • What are the cheapest flights from Missouri to San Diego?

    Looking for the cheapest flight from Missouri to San Diego? While on average our users pay $392, our data indicates the cheapest price to be $184. The most popular route (Kansas City - San Diego), is priced around $158.

  • Can I find deals for flights from Missouri to San Diego that include hotel bookings?

    Yes. In addition to deals on Missouri to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Diego.

  • Can I find deals for business class flights from Missouri to San Diego?

    Yes. Cheapflights offers flight deals from Missouri to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Missouri to San Diego (average of $286). Flying from Missouri to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Imperial Beach
La Mesa
Alpine
Lemon Grove
Poway
Santee
Coronado

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Alternative routes for Missouri to San Diego

See prices for flight routes from nearby airports that may be better suited for you.
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Top 7 airlines flying from Missouri to San Diego

Discover the top 7 airlines that operate flights from Missouri to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$97Average$218FlexibilityNo cancel feeOn-time65%
FrontierCheapest$108Average$197FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$216Average$391FlexibilityNo cancel feeOn-time71%
DeltaCheapest$218Average$281FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$228Average$284FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$238Average$368FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$266Average$475FlexibilityNo cancel feeOn-time63%

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