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San Diego

$66+ Cheap flights from Iowa to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
May 4 — May 111
Mon 5/4
Mon 5/11
1 adult, Economy
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Cheap flight deals from Iowa to San Diego

Cheapest flights from Iowa to San Diego
Explore the most affordable flight options available from Iowa to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/279:55 pm
MLI
-
SAN
1 stop17h 34m
Multiple Airlines
Mon 5/48:38 am
SAN
-
MLI
1 stop10h 27m
Multiple Airlines
Deal found 4/2$184
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:36 pm
CID
-
SAN
1 stop11h 23m
Frontier
Mon 5/46:25 am
SAN
-
CID
1 stop5h 26m
Frontier
Deal found 3/30$185
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
-
SAN
1 stop20h 26m
Frontier
Tue 5/129:37 am
SAN
-
DSM
1 stop25h 54m
Frontier
Deal found 3/31$196
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:23 pm
CID
-
SAN
1 stop14h 19m
Frontier
Sat 5/306:25 am
SAN
-
CID
1 stop11h 03m
Frontier
Deal found 3/31$196
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:16 pm
DSM
-
SAN
1 stop11h 34m
Frontier
Wed 5/136:25 am
SAN
-
DSM
1 stop5h 06m
Frontier
Deal found 3/31$205
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
-
SAN
1 stop11h 34m
Multiple Airlines
Tue 5/199:59 pm
SAN
-
DSM
1 stop13h 00m
Multiple Airlines
Deal found 4/2$208
This Frontier deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
SAN
1 stop11h 34m
Frontier
Wed 6/36:25 am
SAN
-
DSM
1 stop5h 06m
Frontier
Deal found 4/1$210
This Booking.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
-
SAN
1 stop5h 36m
Frontier
Thu 5/79:37 am
SAN
-
DSM
1 stop25h 54m
Frontier
Deal found 4/1$211
This Booking.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
-
SAN
1 stop5h 36m
Frontier
Sun 5/109:37 am
SAN
-
DSM
1 stop25h 54m
Frontier
Deal found 4/1$212
This Kiwi.com deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/279:55 pm
MLI
-
SAN
1 stop17h 34m
Multiple Airlines
Sun 5/36:56 pm
SAN
-
MLI
1 stop24h 09m
Multiple Airlines
Deal found 4/2$212
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
-
SAN
1 stop11h 55m
Frontier
Tue 5/59:37 am
SAN
-
DSM
1 stop25h 54m
Frontier
Deal found 4/1$216
This Kiwi.com deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:16 pm
DSM
-
SAN
1 stop20h 26m
Multiple Airlines
Tue 6/210:07 pm
SAN
-
DSM
1 stop12h 48m
Multiple Airlines
Deal found 4/1$220

Find flight deals from Iowa to San Diego

Keep the following information in mind while searching for Iowa to San Diego flight deals. Data was last updated April 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$184
(Kiwi.com)

One-way from

$66
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$372
Provider with most accurate pricing for Des Moines-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-San Diego flights.
Search Deals
From Iowa to San Diego
Search Deals
One-way flight from Iowa to San Diego
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($70 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Iowa to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 8/27

6:15 pm-11:42 pm

1 stop7h 27m

San Diego

Mon 8/31

2:00 pm-11:59 pm

1 stop7h 59m

$277

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 8/27

6:00 am-9:05 am

1 stop5h 05m

San Diego

Mon 8/31

2:24 pm-11:36 pm

2 stops7h 12m

$282

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Thu 8/27

6:00 am-9:05 am

1 stop5h 05m

San Diego

Sun 8/30

2:24 pm-11:36 pm

2 stops7h 12m

$282

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 9/30

1:45 pm-5:10 pm

1 stop5h 25m

San Diego

Sat 10/3

2:24 pm-11:30 pm

2 stops7h 06m

$282

MolineSan Diego

MLI - SAN

MLISAN

Moline Quad-City

Tue 5/5

10:39 am-3:33 pm

1 stop6h 54m

San Diego

Sat 5/9

11:00 am-9:02 pm

2 stops8h 02m

$296

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Sun 6/7

6:15 am-10:40 am

2 stops6h 25m

San Diego

Tue 6/9

3:05 pm-11:40 pm

2 stops6h 35m

$306

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Tue 8/4

11:25 am-8:45 pm

2 stops11h 20m

San Diego

Tue 8/11

7:25 am-4:45 pm

2 stops7h 20m

$306

Cedar RapidsSan Diego

CID - SAN

CIDSAN

Cedar Rapids

Wed 7/29

6:05 pm-10:25 pm

1 stop6h 20m

San Diego

Wed 8/5

6:35 am-2:10 pm

1 stop5h 35m

$328

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Wed 7/15

12:34 pm-3:56 pm

1 stop5h 22m

San Diego

Wed 7/29

12:59 pm-11:49 pm

1 stop8h 50m

$332
Quickest round-trip

OmahaSan Diego

OMA - SAN

OMASAN

Omaha Eppley Airfield

Sun 8/16

2:15 pm-3:25 pm

Nonstop3h 10m

San Diego

Wed 8/19

6:55 am-4:05 pm

1 stop7h 10m

$332

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Iowa to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to San Diego

What is the cheapest month to book a flight from Iowa to San Diego?

Currently, May is the cheapest month in which you can book a flight from Iowa to San Diego (average of $95). Flying from Iowa to San Diego in March is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to San Diego?

Related info for your journey

Find useful and relevant information for your journey from Iowa to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from Iowa?

    San Diego (SAN) is the airport you will fly into if you book a flight from Iowa to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How popular is this Iowa to San Diego flight route?

    Within the past month, 1 users have taken a look at flights from Iowa to San Diego.

  • How long is the flight from Iowa to San Diego?

    A quick flight from Iowa to San Diego can take about 5h 05m. Delta provides one of the quickest options available for as low as $282. The distance from Iowa to San Diego is about 1310 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to San Diego one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $60. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Iowa to San Diego for a low price.

  • What are the most popular routes from Iowa to San Diego?

    The most popular route from Iowa to San Diego is Omaha Eppley Airfield - San Diego. You may also consider Des Moines - San Diego or Cedar Rapids - San Diego.

  • Can I find deals for flights from Iowa to San Diego that include hotel bookings?

    Yes. In addition to deals on Iowa to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to San Diego.

  • Can I find deals for business class flights from Iowa to San Diego?

    Yes. Cheapflights offers flight deals from Iowa to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to San Diego?

    Currently, May is the cheapest month in which you can book a flight from Iowa to San Diego (average of $95). Flying from Iowa to San Diego in March is currently the most expensive (average of $157). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 7 airlines flying from Iowa to San Diego

Discover the top 7 airlines that operate flights from Iowa to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$100Average$268FlexibilityNo cancel feeOn-time62%
Allegiant AirCheapest$101Average$166FlexibilityNo cancel feeOn-time88%
DeltaCheapest$118Average$347FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$253Average$406FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$258Average$385FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$303Average$473FlexibilityNo cancel feeOn-time63%
Alaska AirlinesCheapest$458Average$458FlexibilityNo cancel feeOn-time75%

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