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$314+ Cheap flights from Des Moines (DSM) to Rome (ROM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ROM
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Rome

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Rome (ROM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$515
(FlightHub)

One-way from

$314
(Kiwi.com)

Popular in

June

Cheapest in

November

Average price

$1,198
From Des Moines to Rome (ROM)
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One-way flight from Des Moines to Rome (ROM)
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Highest demand for flights based on searches. 18% potential increase in price ($246 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($52 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Rome

Cheapest flights from Des Moines to Rome
Explore the most affordable flight options available from Des Moines to Rome. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/72:13 pmDSM - FCO
2 stops37h 42mScandinavian Airlines
Wed 11/1911:55 amFCO - DSM
2 stops41h 38mScandinavian Airlines
Deal found 9/15$515
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/175:34 amDSM - FCO
1 stop21h 56mDelta
Thu 12/410:05 amFCO - DSM
1 stop17h 41mDelta
Deal found 9/15$575
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/232:15 pmDSM - FCO
2 stops17h 15mAmerican Airlines
Fri 12/51:10 pmFCO - DSM
1 stop16h 49mAmerican Airlines
Deal found 9/15$579
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:33 pmDSM - FCO
1 stop32h 57mDelta
Thu 12/410:05 amFCO - DSM
1 stop17h 41mDelta
Deal found 9/15$581
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:02 amDSM - FCO
2 stops20h 03mAir Canada
Wed 12/312:45 pmFCO - DSM
2 stops39h 52mAir Canada
Deal found 9/15$589
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:14 pmDSM - FCO
2 stops58h 51mAir Canada
Wed 12/312:45 pmFCO - DSM
2 stops39h 52mAir Canada
Deal found 9/15$594
This Air Canada deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:02 amDSM - FCO
2 stops20h 03mAir Canada
Thu 12/410:55 amFCO - DSM
2 stops41h 42mAir Canada
Deal found 9/15$595
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1910:21 amDSM - FCO
2 stops15h 19mDelta
Thu 12/46:00 amFCO - DSM
2 stops18h 03mDelta
Deal found 9/15$601
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1711:28 amDSM - FCO
1 stop16h 02mDelta
Tue 12/212:45 pmFCO - DSM
2 stops27h 55mDelta
Deal found 9/15$602

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Rome that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Rome that are best for you.

Fly from

Des Moines

Fly to

Rome

Route

Depart

Return

Price

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Fri 11/7

2:13 pm-10:55 am

2 stops37h 42m

Rome Fiumicino

Wed 11/19

11:55 am-10:33 pm

2 stops41h 38m

$516

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/17

5:34 am-10:30 am

1 stop21h 56m

Rome Fiumicino

Thu 12/4

10:05 am-8:46 pm

1 stop17h 41m

$575

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/17

2:17 pm-11:05 am

2 stops37h 48m

Rome Fiumicino

Thu 12/4

11:55 am-10:33 pm

2 stops41h 38m

$580

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Wed 11/19

10:21 am-8:40 am

2 stops15h 19m

Rome Fiumicino

Thu 12/4

12:40 pm-10:33 pm

1 stop16h 53m

$580

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

6:33 pm-10:30 am

1 stop32h 57m

Rome Fiumicino

Fri 12/5

10:05 am-10:33 pm

1 stop19h 28m

$581

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

6:33 pm-10:30 am

1 stop32h 57m

Rome Fiumicino

Thu 12/4

10:05 am-8:46 pm

1 stop17h 41m

$581

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

2:15 pm-2:30 pm

2 stops17h 15m

Rome Fiumicino

Fri 12/5

11:00 am-11:45 pm

2 stops19h 45m

$584

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Sun 11/23

5:14 pm-11:05 am

2 stops58h 51m

Rome Fiumicino

Wed 12/3

12:45 pm-9:37 pm

2 stops39h 52m

$594

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/17

7:46 am-8:40 am

2 stops17h 54m

Rome Fiumicino

Tue 12/2

12:45 pm-9:40 am

2 stops27h 55m

$607

Des MoinesRome

DSM - FCO

DSMFCO

Des Moines

Mon 11/17

1:05 pm-7:45 am

1 stop11h 40m

Rome Fiumicino

Wed 12/3

9:45 am-9:37 pm

2 stops18h 52m

$609

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 18 results
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Best time to book a flight from Des Moines to Rome

Have a flexible travel schedule? Discover the best time to fly to Rome from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Rome

What is the cheapest month to book a flight from Des Moines to Rome?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Rome (average of $644). Flying from Des Moines to Rome in June is currently the most expensive (average of $1,130). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Rome?

Reviews of airlines servicing Rome

Get insights into the airlines that provide service to Rome. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Rome. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, KLM, and United Airlines from Des Moines to Rome have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
KLM
7.8
Good
1,386 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
British Airways
6.7
Okay
7,367 reviews
Delta
8.0
Very good
7,961 reviews

Comfort

7.9

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Rome. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Rome?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Rome from Des Moines. Booking flights from Des Moines (DSM) to Rome should be relatively easy as there are 0 daily outbound flights to Rome from 3 different airlines.

  • How long is the flight from Des Moines to Rome?

    A quick flight from Des Moines to Rome can take about 21h 56m. Scandinavian Airlines provides one of the quickest options available for as low as $575. The distance from Des Moines to Rome is about 5054 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Rome round-trip?

    Currently priced at $647, Delta will fly you from Des Moines to Rome and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from KLM and United Airlines - these airlines can fly you to your destination from $680 and $703, respectively. These flights start at 39% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Rome one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $453. Users have also found prices from $464 and $496 on KLM and Air France, respectively.

  • Can I find deals for flights from Des Moines to Rome that include hotel bookings?

    Yes. In addition to deals on Des Moines to Rome flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Rome?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Rome.

  • Can I find deals for business class flights from Des Moines to Rome?

    Yes. Cheapflights offers flight deals from Des Moines to Rome by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Rome?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Rome (average of $644). Flying from Des Moines to Rome in June is currently the most expensive (average of $1,130). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Rome?

Book flights to Rome if you plan to visit one of these locations
Fiumicino
Gaeta
Montepulciano
Santa Marinella

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Top 3 airlines flying from Des Moines to Rome

Discover the top 3 airlines that operate flights from Des Moines to Rome. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$647Average$1,042FlexibilityNo cancel feeOn-timeN/A
KLMCheapest$680Average$1,090FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$703Average$1,150FlexibilityNo cancel feeOn-time69%

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