$350+ Cheap flights from Des Moines (DSM) to Italy
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — NAP
Jun 5 — Jun 121
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to ItalyExplore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
Explore the most affordable flight options available from Des Moines to Italy. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:15 am
DSM
- MXP
2 stops18h 15m
United Airlines
Tue 11/171:05 pm
MXP
- DSM
2 stops32h 06m
United Airlines
Deal found 5/5![United Airlines logo]()
$723
This Air Canada deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:15 pm
DSM
- MXP
2 stops30h 40m
Air Canada
Fri 12/111:05 pm
MXP
- DSM
2 stops35h 28m
Air Canada
Deal found 5/6![Air Canada logo]()
$727
This Air Canada deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:00 am
DSM
- MXP
2 stops21h 55m
Air Canada
Tue 11/171:05 pm
MXP
- DSM
3 stops30h 25m
Air Canada
Deal found 5/4![Air Canada logo]()
$731
This Air Canada deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/283:15 pm
DSM
- MXP
3 stops35h 40m
Air Canada
Tue 12/81:05 pm
MXP
- DSM
3 stops32h 06m
Air Canada
Deal found 5/6![Air Canada logo]()
$736
This KLM deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1511:04 am
DSM
- MXP
1 stop17h 06m
KLM
Tue 11/171:05 pm
MXP
- DSM
1 stop16h 24m
KLM
Deal found 5/5![KLM logo]()
$743
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2911:30 am
DSM
- MXP
1 stop18h 35m
United Airlines
Fri 12/119:10 am
MXP
- DSM
2 stops22h 30m
United Airlines
Deal found 5/6![United Airlines logo]()
$746
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am
DSM
- MXP
2 stops18h 15m
United Airlines
Wed 10/2112:20 pm
MXP
- DSM
2 stops29h 00m
United Airlines
Deal found 5/5![United Airlines logo]()
$747
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:55 am
DSM
- MXP
2 stops17h 45m
Delta
Tue 12/81:05 pm
MXP
- DSM
1 stop16h 24m
Delta
Deal found 5/6![Delta logo]()
$748
This Air France deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air France is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:30 pm
DSM
- MXP
1 stop33h 40m
Multiple Airlines
Tue 12/81:05 pm
MXP
- DSM
1 stop16h 24m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$749
This Air Canada deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/308:15 pm
DSM
- MXP
2 stops30h 40m
Air Canada
Wed 12/91:05 pm
MXP
- DSM
2 stops18h 35m
Air Canada
Deal found 5/6![Air Canada logo]()
$750
This Air Canada deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1311:30 am
DSM
- MXP
3 stops15h 50m
Multiple Airlines
Wed 10/2112:20 pm
MXP
- DSM
2 stops29h 00m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$751
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/286:30 pm
DSM
- MXP
1 stop33h 40m
Delta
Thu 12/101:05 pm
MXP
- DSM
2 stops27h 19m
Delta
Deal found 5/6![Delta logo]()
$753
Best flights from Des Moines to ItalyDiscover carefully curated flight deals from Des Moines to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
Discover carefully curated flight deals from Des Moines to Italy that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am
DSM
- MXP
2 stops18h 15m
United Airlines
Wed 10/2112:20 pm
MXP
- DSM
2 stops29h 00m
United Airlines
Deal found 5/1![United Airlines logo]()
$747
This KLM deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/112:45 pm
DSM
- FCO
1 stop14h 55m
KLM
Thu 8/209:45 am
FCO
- DSM
1 stop19h 52m
KLM
Deal found 5/4![KLM logo]()
$791
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:45 pm
DSM
- LIN
2 stops16h 10m
Delta
Tue 9/2211:00 am
LIN
- DSM
2 stops16h 45m
Delta
Deal found 5/4![Delta logo]()
$803
This FlightHub deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:45 pm
DSM
- LIN
2 stops16h 00m
Lufthansa
Tue 10/279:45 am
LIN
- DSM
2 stops19h 16m
Lufthansa
Deal found 5/1![Lufthansa logo]()
$842
This Mytrip deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:03 pm
DSM
- TRN
2 stops21h 32m
Air France
Wed 6/246:00 am
TRN
- DSM
2 stops21h 41m
Air France
Deal found 5/3![Air France logo]()
$1,139
This British Airways deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/161:51 pm
DSM
- VCE
2 stops14h 49m
British Airways
Tue 6/2312:45 pm
VCE
- DSM
2 stops18h 50m
British Airways
Deal found 5/1![British Airways logo]()
$1,299
This Mytrip deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:17 pm
DSM
- VCE
2 stops32h 53m
Multiple Airlines
Mon 6/221:25 pm
VCE
- DSM
2 stops16h 26m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$1,347
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/151:33 pm
DSM
- VCE
1 stop13h 22m
American Airlines
Mon 6/221:40 pm
VCE
- DSM
1 stop15h 18m
American Airlines
Deal found 5/1![American Airlines logo]()
$1,402
This Gotogate deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:00 am
DSM
- TRN
3 stops24h 30m
Air Canada
Thu 6/259:55 am
TRN
- DSM
3 stops19h 56m
Air Canada
Deal found 5/4![Air Canada logo]()
$1,528
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:23 am
DSM
- FCO
1 stop13h 32m
United Airlines
Thu 8/2011:30 am
FCO
- DSM
2 stops33h 35m
United Airlines
Deal found 5/3![United Airlines logo]()
$771
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:35 pm
DSM
- LIN
2 stops16h 20m
Delta
Sun 9/206:40 am
LIN
- DSM
2 stops21h 05m
Delta
Deal found 5/4![Delta logo]()
$863
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:15 pm
DSM
- LIN
2 stops16h 40m
Delta
Fri 9/186:40 am
LIN
- DSM
2 stops21h 37m
Delta
Deal found 5/4![Delta logo]()
$863
This KLM deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/224:11 pm
DSM
- MXP
1 stop34h 14m
KLM
Sat 9/511:40 am
MXP
- DSM
1 stop17h 46m
KLM
Deal found 5/5![KLM logo]()
$954
This Cheapflightsfares deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:45 pm
DSM
- FLR
2 stops14h 50m
Lufthansa
Tue 10/201:40 pm
FLR
- DSM
2 stops16h 21m
Lufthansa
Deal found 5/1![Lufthansa logo]()
$956
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:15 am
DSM
- FCO
2 stops20h 45m
United Airlines
Sat 11/712:15 pm
FCO
- DSM
2 stops39h 17m
United Airlines
Deal found 5/4![United Airlines logo]()
$896
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
DSM
- MXP
2 stops17h 45m
Delta
Wed 8/129:00 am
MXP
- DSM
2 stops18h 45m
Delta
Deal found 5/1![Delta logo]()
$894
This KLM deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:45 am
DSM
- FCO
1 stop22h 05m
KLM
Mon 9/282:45 pm
FCO
- DSM
1 stop33h 57m
KLM
Deal found 5/1![KLM logo]()
$993
This Lufthansa deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Lufthansa is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:50 pm
DSM
- LIN
2 stops15h 40m
Lufthansa
Sun 9/206:50 am
LIN
- DSM
2 stops17h 12m
Lufthansa
Deal found 5/4![Lufthansa logo]()
$1,031
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:00 am
DSM
- FLR
3 stops25h 35m
United Airlines
Fri 10/301:15 pm
FLR
- DSM
2 stops17h 25m
United Airlines
Deal found 5/5![United Airlines logo]()
$956
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:52 pm
DSM
- LIN
2 stops18h 53m
Delta
Wed 8/126:25 am
LIN
- DSM
2 stops21h 20m
Delta
Deal found 5/1![Delta logo]()
$908
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:15 am
DSM
- FLR
3 stops21h 45m
United Airlines
Tue 10/201:40 pm
FLR
- DSM
2 stops16h 21m
United Airlines
Deal found 5/1![United Airlines logo]()
$976
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:52 pm
DSM
- MXP
2 stops16h 43m
Delta
Fri 7/3111:25 am
MXP
- DSM
2 stops29h 48m
Delta
Deal found 5/3![Delta logo]()
$916
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:15 am
DSM
- FLR
3 stops24h 55m
United Airlines
Tue 10/131:40 pm
FLR
- DSM
2 stops16h 21m
United Airlines
Deal found 5/2![United Airlines logo]()
$977
This KLM deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:34 pm
DSM
- LIN
2 stops15h 21m
KLM
Wed 6/246:40 am
LIN
- DSM
2 stops14h 25m
KLM
Deal found 5/3![KLM logo]()
$1,229
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:50 pm
DSM
- TRN
2 stops16h 20m
Lufthansa
Tue 6/236:00 am
TRN
- DSM
2 stops23h 51m
Lufthansa
Deal found 5/4![Lufthansa logo]()
$1,292
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:04 am
DSM
- FCO
1 stop16h 46m
Delta
Mon 9/286:30 am
FCO
- DSM
2 stops21h 15m
Delta
Deal found 5/1![Delta logo]()
$985
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/111:34 am
DSM
- FLR
2 stops22h 01m
United Airlines
Wed 7/159:50 am
FLR
- DSM
2 stops19h 45m
United Airlines
Deal found 5/3![United Airlines logo]()
$992
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:50 pm
DSM
- MXP
1 stop11h 30m
United Airlines
Mon 7/209:00 am
MXP
- DSM
2 stops40h 12m
United Airlines
Deal found 5/2![United Airlines logo]()
$999
This lastminute.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1911:26 am
DSM
- TRN
2 stops23h 59m
Lufthansa
Fri 6/266:15 am
TRN
- DSM
2 stops18h 56m
Lufthansa
Deal found 5/5![Lufthansa logo]()
$1,375
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:52 pm
DSM
- FCO
2 stops16h 38m
Delta
Sat 7/259:00 am
FCO
- DSM
1 stop15h 10m
Delta
Deal found 5/6![Delta logo]()
$1,035
Last-minute flights from Des Moines to ItalyDiscover last-minute flight deals from Des Moines to Italy. Data last updated May 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Italy. Data last updated May 6, 2026 and is based on user searches.
This Justfly.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:05 pm
DSM
- FCO
2 stops55h 10m
Air Canada
Mon 5/1812:25 pm
FCO
- DSM
2 stops32h 59m
Air Canada
Deal found 5/6![Air Canada logo]()
$1,139
This FlightHub deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:40 am
DSM
- FCO
2 stops15h 20m
Lufthansa
Mon 5/187:05 pm
FCO
- DSM
2 stops33h 18m
Lufthansa
Deal found 5/3![Lufthansa logo]()
$1,150
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:18 pm
DSM
- MXP
2 stops16h 07m
American Airlines
Fri 5/222:20 pm
MXP
- DSM
1 stop14h 38m
American Airlines
Deal found 5/5![American Airlines logo]()
$1,066
This KLM deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:57 am
DSM
- MXP
1 stop14h 28m
KLM
Fri 5/2211:40 am
MXP
- DSM
1 stop17h 52m
KLM
Deal found 5/6![KLM logo]()
$1,069
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:38 pm
DSM
- LIN
2 stops15h 52m
American Airlines
Fri 5/227:50 am
LIN
- DSM
2 stops17h 46m
American Airlines
Deal found 5/5![American Airlines logo]()
$1,077
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
DSM
- MXP
3 stops19h 20m
United Airlines
Fri 5/229:00 am
MXP
- DSM
2 stops16h 14m
United Airlines
Deal found 5/6![United Airlines logo]()
$1,140
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:02 pm
DSM
- MXP
2 stops16h 48m
American Airlines
Wed 5/2011:00 am
MXP
- DSM
2 stops17h 53m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,130
This KLM deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:28 pm
DSM
- MXP
2 stops14h 17m
Multiple Airlines
Wed 5/2011:40 am
MXP
- DSM
1 stop17h 52m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$1,133
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/148:03 pm
DSM
- LIN
2 stops15h 52m
American Airlines
Wed 5/207:50 am
LIN
- DSM
2 stops18h 43m
American Airlines
Deal found 5/4![American Airlines logo]()
$1,137
This Mytrip deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:03 pm
DSM
- LIN
2 stops17h 17m
Multiple Airlines
Wed 6/247:30 am
LIN
- DSM
3 stops20h 11m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$1,102
This Flightnetwork deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:03 pm
DSM
- VCE
2 stops16h 57m
Air France
Wed 6/245:55 am
VCE
- DSM
2 stops21h 46m
Air France
Deal found 5/3![Air France logo]()
$1,103
This Mytrip deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:03 pm
DSM
- TRN
2 stops21h 32m
Air France
Wed 6/246:00 am
TRN
- DSM
2 stops21h 41m
Air France
Deal found 5/3![Air France logo]()
$1,139
One-way flights from Des Moines to ItalySearch for one-way flight options from Des Moines to Italy. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
Search for one-way flight options from Des Moines to Italy. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
This oojo deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:33 pm
DSM
- FCO
2 stops17h 47m
British Airways
Deal found 5/5![British Airways logo]()
$350
This KLM deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/154:11 pm
DSM
- FCO
1 stop35h 39m
KLM
Deal found 5/4![KLM logo]()
$363
This Booking.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:50 pm
DSM
- FCO
2 stops32h 10m
Lufthansa
Deal found 5/4![Lufthansa logo]()
$392
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:53 pm
DSM
- VCE
3 stops38h 07m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/277:35 am
DSM
- FCO
3 stops32h 30m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$465
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:19 pm
DSM
- FCO
3 stops27h 11m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$468
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/42:36 pm
DSM
- VCE
2 stops15h 49m
American Airlines
Deal found 5/3![American Airlines logo]()
$468
This British Airways deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:43 pm
DSM
- VCE
2 stops18h 22m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$469
This Justfly.com deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/38:53 am
DSM
- FCO
2 stops46h 42m
Aer Lingus
Deal found 5/6![Aer Lingus logo]()
$470
This American Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:43 pm
DSM
- VCE
1 stop13h 12m
American Airlines
Deal found 5/6![American Airlines logo]()
$471
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
DSM
- VCE
3 stops20h 15m
United Airlines
Deal found 5/6![United Airlines logo]()
$479
This Justfly.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:00 am
DSM
- FCO
2 stops46h 25m
Aer Lingus
Deal found 5/3![Aer Lingus logo]()
$482
Find flight deals from Des Moines to Italy
Keep the following information in mind while searching for Des Moines to Italy flight deals. Data was last updated May 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $747 (United Airlines) |
One-way from | $350 (oojo) |
Popular in | June |
Cheapest in | November |
Average price | $1,117 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Italy that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Des Moines to Italy that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Tue 10/13
6:15 am-7:30 am
2 stops18h 15m
Milan Malpensa
Wed 10/21
12:20 pm-10:20 am
2 stops29h 00m
$747
Des MoinesRome
DSM - FCO
DSMFCO
Des Moines
Tue 8/11
11:23 am-7:55 am
1 stop13h 32m
Rome Fiumicino
Thu 8/20
11:30 am-2:05 pm
2 stops33h 35m
$771
Des MoinesRome
DSM - FCO
DSMFCO
Des Moines
Tue 8/11
2:45 pm-12:40 pm
1 stop14h 55m
Rome Fiumicino
Thu 8/20
9:45 am-10:37 pm
1 stop19h 52m
$791
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Sun 8/30
2:45 pm-1:55 pm
2 stops16h 10m
Milan Linate
Tue 9/22
11:00 am-8:45 pm
2 stops16h 45m
$803
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Tue 10/13
6:45 pm-5:45 pm
2 stops16h 00m
Milan Linate
Tue 10/27
9:45 am-11:01 pm
2 stops19h 16m
$842
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Mon 8/31
2:35 pm-1:55 pm
2 stops16h 20m
Milan Linate
Sun 9/20
6:40 am-8:45 pm
2 stops21h 05m
$863
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Fri 9/4
2:15 pm-1:55 pm
2 stops16h 40m
Milan Linate
Fri 9/18
6:40 am-9:17 pm
2 stops21h 37m
$863
Des MoinesMilan
DSM - MXP
DSMMXP
Des Moines
Sat 8/8
6:00 am-6:45 am
2 stops17h 45m
Milan Malpensa
Wed 8/12
9:00 am-8:45 pm
2 stops18h 45m
$894
Des MoinesRome
DSM - FCO
DSMFCO
Des Moines
Sun 11/1
6:15 am-10:00 am
2 stops20h 45m
Rome Fiumicino
Sat 11/7
12:15 pm-8:32 pm
2 stops39h 17m
$896
Des MoinesMilan
DSM - LIN
DSMLIN
Des Moines
Sat 8/8
5:52 pm-7:45 pm
2 stops18h 53m
Milan Linate
Wed 8/12
6:25 am-8:45 pm
2 stops21h 20m
$908
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Italy
Have a flexible travel schedule? Discover the best time to fly to Italy from Des Moines with our price prediction graph.
DSM-MXP
DSM-FCO
DSM-LIN
DSM-TRN
DSM-VCE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Italy
DSM-IT0
DSM-MXP
DSM-FCO
DSM-LIN
DSM-TRN
What is the cheapest month to book a flight from Des Moines to Italy?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Italy (average of $457). Flying from Des Moines to Italy in June is currently the most expensive (average of $675). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Italy
Get insights into the airlines that provide service to Italy. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Italy. Reviews last updated May 6, 2026.
Peruse reviews from past customers who have flown with Delta,KLM, andUnited Airlines from Des Moines to Italy to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Comfort
7.9
Overall
7.9
Crew
8.5
Food
7.2
Boarding
8.1
Entertainment
7.8
Reviews
1 / 20
4.0
OkayJoel,May 2026
ATL - JAX
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Italy. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Italy
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Italy by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Italy by cabin class
Find flights from Des Moines to Italy, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Italy flights
Browse other Des Moines and Italy flight options. Last updated on May 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to Italy regions
Consider these flights traveling to Italy regions.
Top 3 airlines flying from Des Moines to Italy
Discover the top 3 airlines that operate flights from Des Moines to Italy. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$457 | Average$968 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$491 | Average$636 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$655 | Average$1,063 | FlexibilityNo cancel fee | On-timeN/A |