HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Panama City

$205+ Cheap flights from Myrtle Beach (MYR) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to Panama City

Best flights from Myrtle Beach to Panama City
Discover carefully curated flight deals from Myrtle Beach to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 28, 2025.

This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:07 pmMYR - PTY
2 stops19h 15mAmerican Airlines
Thu 3/261:44 pmPTY - MYR
2 stops17h 47mAmerican Airlines
Deal found 12/26$510
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/159:09 amMYR - PTY
1 stop11h 10mMultiple Airlines
Thu 2/192:55 amPTY - MYR
2 stops29h 18mMultiple Airlines
Deal found 12/26$594
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 amMYR - PTY
1 stop8h 03mDelta
Thu 3/262:28 pmPTY - MYR
1 stop8h 38mDelta
Deal found 12/26$868
This American Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/105:44 pmMYR - PTY
2 stops19h 43mAmerican Airlines
Tue 2/172:50 pmPTY - MYR
2 stops19h 54mAmerican Airlines
Deal found 12/27$550
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/206:38 pmMYR - PTY
2 stops20h 37mAmerican Airlines
Mon 3/24:05 pmPTY - MYR
2 stops18h 39mAmerican Airlines
Deal found 12/26$550
This Kiwi.com deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/108:15 pmMYR - PTY
1 stop24h 04mMultiple Airlines
Mon 2/162:55 amPTY - MYR
2 stops29h 18mMultiple Airlines
Deal found 12/27$681
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/29:54 amMYR - PTY
1 stop10h 25mMultiple Airlines
Fri 1/911:25 amPTY - MYR
2 stops31h 55mMultiple Airlines
Deal found 12/26$802

Find flight deals from Myrtle Beach to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$460
(American Airlines)

One-way from

$205
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
Search Deals
From Myrtle Beach Intl to Panama City Tocumen Intl
Search Deals
One-way flight from Myrtle Beach Intl to Panama City Tocumen Intl
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Fly from

Myrtle Beach

Fly to

Panama City

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

8:07 pm-2:22 pm

2 stops19h 15m

Panama City Tocumen Intl

Thu 3/26

1:44 pm-8:31 am

2 stops17h 47m

$510

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/10

5:44 pm-1:27 pm

2 stops19h 43m

Panama City Tocumen Intl

Tue 2/17

2:50 pm-10:44 am

2 stops19h 54m

$550

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 2/20

6:38 pm-3:15 pm

2 stops20h 37m

Panama City Tocumen Intl

Mon 3/2

4:05 pm-10:44 am

2 stops18h 39m

$550

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 2/15

9:09 am-8:19 pm

1 stop11h 10m

Panama City Tocumen Intl

Thu 2/19

2:55 am-8:13 am

2 stops29h 18m

$594

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/10

8:15 pm-8:19 pm

1 stop24h 04m

Panama City Tocumen Intl

Mon 2/16

2:55 am-8:13 am

2 stops29h 18m

$681

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Fri 1/2

9:54 am-8:19 pm

1 stop10h 25m

Panama City Tocumen Intl

Fri 1/9

11:25 am-7:20 pm

2 stops31h 55m

$802

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Thu 3/26

2:28 pm-12:06 am

1 stop8h 38m

$868

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

5:44 pm-3:38 pm

2 stops21h 54m

$205

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

6:00 am-1:55 pm

1 stop7h 55m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Compare providers for flights from Myrtle Beach to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 28, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama City, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,072 reviews

Crew

8.0

Food

6.5

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,072 reviews
American Airlines
7.2
Good
11,072 reviews

Crew

8.0

Food

6.5

Comfort

7.2

Overall

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Panama City?

    There are many flights that can get you from Myrtle Beach to Panama City in 19h 15m. Fly via American Airlines to get the fastest option. The distance between Myrtle Beach and Panama City is about 1700 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Panama City round-trip?

    Cheapflights users have booked flights from Myrtle Beach to Panama City round-trip from $486.

  • Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.

  • Can I find deals for business class flights from Myrtle Beach to Panama City?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Panama City flights
Charleston to Panama City flights
Columbia to Panama City flights
Greenville to Panama City flights
Savannah to Panama City flights
Augusta to Panama City flights

Top airline flying from Myrtle Beach to Panama City

Discover the top airline that operate flights from Myrtle Beach to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$486Average$572FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.