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Panama City

$205+ Cheap flights from Myrtle Beach (MYR) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama City

Best flights from Myrtle Beach to Panama City
Discover carefully curated flight deals from Myrtle Beach to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 23, 2025.

This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/45:44 pmMYR - PTY
2 stops21h 54mAmerican Airlines
Wed 3/42:50 pmPTY - MYR
2 stops20h 59mAmerican Airlines
Deal found 12/21$460
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/26:54 pmMYR - PTY
1 stop19h 01mDelta
Wed 3/43:15 pmPTY - MYR
1 stop18h 30mDelta
Deal found 12/21$490
This Kiwi.com deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/159:09 amMYR - PTY
1 stop11h 10mMultiple Airlines
Thu 2/192:55 amPTY - MYR
2 stops29h 18mMultiple Airlines
Deal found 12/21$598
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:44 pmMYR - PTY
2 stops19h 43mAmerican Airlines
Tue 3/32:50 pmPTY - MYR
2 stops19h 54mAmerican Airlines
Deal found 12/21$480
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:54 pmMYR - PTY
1 stop19h 01mDelta
Wed 3/43:15 pmPTY - MYR
1 stop18h 30mDelta
Deal found 12/21$490
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:38 pmMYR - PTY
2 stops19h 12mAmerican Airlines
Mon 2/232:39 pmPTY - MYR
2 stops18h 56mAmerican Airlines
Deal found 12/22$560
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:00 amMYR - PTY
1 stop7h 55mDelta
Wed 3/43:15 pmPTY - MYR
1 stop26h 43mDelta
Deal found 12/21$605
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:25 pmMYR - PTY
2 stops18h 57mAmerican Airlines
Fri 2/202:39 pmPTY - MYR
2 stops20h 05mAmerican Airlines
Deal found 12/21$560
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/77:19 pmMYR - PTY
2 stops18h 08mAmerican Airlines
Sat 1/175:00 pmPTY - MYR
2 stops18h 44mAmerican Airlines
Deal found 12/22$570
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:56 pmMYR - PTY
2 stops19h 19mAmerican Airlines
Sun 3/83:13 pmPTY - MYR
2 stops22h 08mAmerican Airlines
Deal found 12/21$591
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:56 pmMYR - PTY
2 stops17h 26mAmerican Airlines
Thu 2/194:05 pmPTY - MYR
2 stops19h 44mAmerican Airlines
Deal found 12/21$600
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:00 amMYR - PTY
2 stops8h 50mAmerican Airlines
Thu 3/121:44 pmPTY - MYR
2 stops20h 55mAmerican Airlines
Deal found 12/21$600

Find flight deals from Myrtle Beach to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$440
(American Airlines)

One-way from

$205
(American Airlines)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From Myrtle Beach Intl to Panama City Tocumen Intl
Search Deals
One-way flight from Myrtle Beach Intl to Panama City Tocumen Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Fly from

Myrtle Beach

Fly to

Panama City

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 2/4

5:44 pm-3:38 pm

2 stops21h 54m

Panama City Tocumen Intl

Wed 3/4

2:50 pm-11:49 am

2 stops20h 59m

$460

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/3

5:44 pm-1:27 pm

2 stops19h 43m

Panama City Tocumen Intl

Tue 3/3

2:50 pm-10:44 am

2 stops19h 54m

$480

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 2/2

6:54 pm-1:55 pm

1 stop19h 01m

Panama City Tocumen Intl

Wed 3/4

3:15 pm-9:45 am

1 stop18h 30m

$490

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 2/1

6:54 pm-1:55 pm

1 stop19h 01m

Panama City Tocumen Intl

Wed 3/4

3:15 pm-9:45 am

1 stop18h 30m

$490

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 2/16

6:38 pm-1:50 pm

2 stops19h 12m

Panama City Tocumen Intl

Mon 2/23

2:39 pm-9:35 am

2 stops18h 56m

$560

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 2/15

6:25 pm-1:22 pm

2 stops18h 57m

Panama City Tocumen Intl

Fri 2/20

2:39 pm-10:44 am

2 stops20h 05m

$560

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 1/7

7:19 pm-1:27 pm

2 stops18h 08m

Panama City Tocumen Intl

Sat 1/17

5:00 pm-11:44 am

2 stops18h 44m

$570

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/5

7:56 pm-3:15 pm

2 stops19h 19m

Panama City Tocumen Intl

Sun 3/8

3:13 pm-2:21 pm

2 stops22h 08m

$591

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 2/15

9:09 am-8:19 pm

1 stop11h 10m

Panama City Tocumen Intl

Thu 2/19

2:55 am-8:13 am

2 stops29h 18m

$598

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/12

7:56 pm-1:22 pm

2 stops17h 26m

Panama City Tocumen Intl

Thu 2/19

4:05 pm-11:49 am

2 stops19h 44m

$600

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 23 results
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Compare providers for flights from Myrtle Beach to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 23, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama City, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,054 reviews

Crew

8.0

Food

6.4

Boarding

7.5

Entertainment

6.9

Overall

7.2

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,054 reviews
American Airlines
7.2
Good
11,054 reviews

Crew

8.0

Food

6.4

Boarding

7.5

Entertainment

6.9

Overall

7.2

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Panama City?

    There are many flights that can get you from Myrtle Beach to Panama City in 19h 01m. Fly via American Airlines or Delta to get the fastest option. The distance between Myrtle Beach and Panama City is about 1700 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Myrtle Beach to Panama City round-trip?

    Cheapflights users have booked flights from Myrtle Beach to Panama City round-trip from $486.

  • Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.

  • Can I find deals for business class flights from Myrtle Beach to Panama City?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Myrtle Beach to Panama City

Discover the top airline that operate flights from Myrtle Beach to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$486Average$572FlexibilityNo cancel feeOn-time71%

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