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$221+ Cheap flights from Myrtle Beach (MYR) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Feb 11 — Feb 181
Wed 2/11
Wed 2/18
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 12, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$481
(American Airlines)

One-way from

$221
(Kiwi.com)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From Myrtle Beach Intl to Panama City Tocumen Intl
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One-way flight from Myrtle Beach Intl to Panama City Tocumen Intl
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Find flight deals from Myrtle Beach to Panama City

Cheapest flights from Myrtle Beach to Panama City
Explore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 12, 2026.

This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:11 pm
MYR
-
PTY
2 stops20h 09m
American Airlines
Wed 9/93:40 pm
PTY
-
MYR
2 stops20h 21m
American Airlines
Deal found 1/12$441
This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:22 pm
MYR
-
PTY
2 stops20h 58m
American Airlines
Thu 3/261:40 pm
PTY
-
MYR
2 stops17h 51m
American Airlines
Deal found 1/10$481
This Delta deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
MYR
-
PTY
1 stop8h 13m
Delta
Wed 9/92:28 pm
PTY
-
MYR
1 stop8h 11m
Delta
Deal found 1/12$489
This Kiwi.com deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/249:09 am
MYR
-
PTY
1 stop11h 10m
Multiple Airlines
Mon 3/22:55 am
PTY
-
MYR
2 stops29h 18m
Multiple Airlines
Deal found 1/10$507
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/239:09 am
MYR
-
PTY
1 stop11h 10m
Multiple Airlines
Sat 2/285:50 pm
PTY
-
MYR
2 stops38h 23m
Multiple Airlines
Deal found 1/12$515
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/194:58 pm
MYR
-
PTY
2 stops20h 38m
American Airlines
Sat 4/251:49 pm
PTY
-
MYR
2 stops21h 14m
American Airlines
Deal found 1/12$521
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1111:28 am
MYR
-
PTY
1 stop8h 51m
Multiple Airlines
Wed 2/185:50 pm
PTY
-
MYR
2 stops38h 23m
Multiple Airlines
Deal found 1/12$541
This American Airlines deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:10 pm
MYR
-
PTY
2 stops18h 30m
American Airlines
Tue 3/32:40 pm
PTY
-
MYR
2 stops20h 59m
American Airlines
Deal found 1/10$551
This Delta deal was found by Cheapflights users on 1/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
MYR
-
PTY
1 stop7h 50m
Delta
Tue 3/33:15 pm
PTY
-
MYR
1 stop8h 42m
Delta
Deal found 1/10$561
This Kiwi.com deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/99:58 am
MYR
-
PTY
1 stop10h 21m
Multiple Airlines
Mon 2/165:50 pm
PTY
-
MYR
2 stops38h 23m
Multiple Airlines
Deal found 1/12$570
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/117:19 pm
MYR
-
PTY
2 stops19h 56m
American Airlines
Wed 2/182:40 pm
PTY
-
MYR
2 stops20h 59m
American Airlines
Deal found 1/12$571
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/57:19 pm
MYR
-
PTY
2 stops20h 19m
American Airlines
Tue 2/102:27 pm
PTY
-
MYR
2 stops19h 21m
American Airlines
Deal found 1/12$591

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 12, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Fly from

Myrtle Beach

Fly to

Panama City

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 3/19

6:22 pm-2:20 pm

2 stops20h 58m

Panama City Tocumen Intl

Thu 3/26

1:40 pm-8:31 am

2 stops17h 51m

$481

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/24

9:09 am-8:19 pm

1 stop11h 10m

Panama City Tocumen Intl

Mon 3/2

2:55 am-8:13 am

2 stops29h 18m

$507

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 4/19

4:58 pm-12:36 pm

2 stops20h 38m

Panama City Tocumen Intl

Sat 4/25

1:49 pm-12:03 pm

2 stops21h 14m

$521

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 2/11

11:28 am-8:19 pm

1 stop8h 51m

Panama City Tocumen Intl

Wed 2/18

5:50 pm-8:13 am

2 stops38h 23m

$541

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/24

7:10 pm-1:40 pm

2 stops18h 30m

Panama City Tocumen Intl

Tue 3/3

2:40 pm-11:39 am

2 stops20h 59m

$551

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 2/24

6:00 am-1:50 pm

1 stop7h 50m

Panama City Tocumen Intl

Tue 3/3

3:15 pm-11:57 pm

1 stop8h 42m

$561

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 2/9

9:58 am-8:19 pm

1 stop10h 21m

Panama City Tocumen Intl

Mon 2/16

5:50 pm-8:13 am

2 stops38h 23m

$570

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 2/11

7:19 pm-3:15 pm

2 stops19h 56m

Panama City Tocumen Intl

Wed 2/18

2:40 pm-11:39 am

2 stops20h 59m

$571

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Thu 2/5

7:19 pm-3:38 pm

2 stops20h 19m

Panama City Tocumen Intl

Tue 2/10

2:27 pm-9:48 am

2 stops19h 21m

$591

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 2/9

5:44 pm-1:27 pm

2 stops19h 43m

Panama City Tocumen Intl

Mon 2/16

4:05 pm-11:39 am

2 stops19h 34m

$611

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Showing 1-10 of 14 results
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Compare providers for flights from Myrtle Beach to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Panama City in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Panama City?

    There are many flights that can get you from Myrtle Beach to Panama City in 20h 58m. Fly via American Airlines to get the fastest option. The distance between Myrtle Beach and Panama City is about 1700 mi.

  • Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.

  • Can I find deals for business class flights from Myrtle Beach to Panama City?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $549). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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