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Panama City

$225+ Cheap flights from Myrtle Beach (MYR) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — PTY
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Panama City

Cheapest flights from Myrtle Beach to Panama City
Explore the most affordable flight options available from Myrtle Beach to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/104:03 pmMYR - PTY
2 stops21h 44mAmerican Airlines
Tue 12/162:50 pmPTY - MYR
2 stops19h 14mAmerican Airlines
Deal found 12/3$580
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:34 pmMYR - PTY
2 stops23h 19mAmerican Airlines
Tue 12/304:55 pmPTY - MYR
2 stops18h 43mAmerican Airlines
Deal found 12/3$639
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amMYR - PTY
1 stop8h 21mDelta
Tue 12/163:46 pmPTY - MYR
1 stop7h 57mDelta
Deal found 12/3$788
This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:54 amMYR - PTY
3 stops24h 36mMultiple Airlines
Mon 12/152:55 amPTY - MYR
3 stops42h 57mMultiple Airlines
Deal found 12/3$802
This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:54 amMYR - PTY
3 stops22h 56mMultiple Airlines
Mon 12/292:55 amPTY - MYR
2 stops15h 13mMultiple Airlines
Deal found 12/3$816
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amMYR - PTY
1 stop14h 00mDelta
Tue 12/308:00 amPTY - MYR
1 stop14h 50mDelta
Deal found 12/3$868

Find flight deals from Myrtle Beach to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$436
(Delta)

One-way from

$225
(Delta)
Provider with most accurate pricing for Myrtle Beach Intl-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Panama City Tocumen Intl flights.
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From Myrtle Beach Intl to Panama City Tocumen Intl
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One-way flight from Myrtle Beach Intl to Panama City Tocumen Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Panama City that are best for you.

Fly from

Myrtle Beach

Fly to

Panama City

Route

Depart

Return

Price

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 5/4

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:38 pm

1 stop8h 18m

$436

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 5/4

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-11:38 pm

1 stop8h 18m

$436

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 4/28

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Mon 5/4

2:20 pm-10:09 am

1 stop18h 49m

$443

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 4/29

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Mon 5/4

2:20 pm-1:36 pm

1 stop22h 16m

$443

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sun 5/3

6:45 pm-12:55 pm

1 stop19h 10m

Panama City Tocumen Intl

Thu 5/7

2:20 pm-11:38 pm

1 stop8h 18m

$443

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 4/7

10:23 am-12:55 pm

1 stop27h 32m

Panama City Tocumen Intl

Thu 4/16

2:20 pm-5:58 pm

1 stop26h 38m

$450

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 5/2

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Tue 5/5

2:20 pm-11:38 pm

1 stop8h 18m

$456

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Wed 4/29

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Sun 5/10

2:20 pm-11:38 pm

1 stop8h 18m

$456

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Tue 4/28

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Sun 5/10

2:20 pm-11:38 pm

1 stop8h 18m

$456

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Sat 5/2

6:00 am-12:55 pm

1 stop7h 55m

Panama City Tocumen Intl

Wed 5/6

2:20 pm-11:38 pm

1 stop8h 18m

$456

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/4

Showing 1-10 of 15 results
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Compare providers for flights from Myrtle Beach to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Panama City

What is the cheapest month to book a flight from Myrtle Beach to Panama City?

Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 4, 2025.
Read through reviews of airlines operating flights from Myrtle Beach to Panama City, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,047 reviews

Boarding

7.5

Entertainment

6.9

Food

6.5

Comfort

7.2

Crew

8.0

Overall

7.2

Reviews

1 / 20
4.0
Okay

Cameron,Nov 2025

PDX - LHR

The plane was very old...had no WiFi available. The crew were not friendly nor helpful.
American Airlines
7.2
Good
11,047 reviews
American Airlines
7.2
Good
11,047 reviews

Boarding

7.5

Entertainment

6.9

Food

6.5

Comfort

7.2

Crew

8.0

Overall

7.2

Reviews

1 / 20
4.0
Okay

Cameron,Nov 2025

PDX - LHR

The plane was very old...had no WiFi available. The crew were not friendly nor helpful.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Panama City?

    There are many flights that can get you from Myrtle Beach to Panama City in 7h 55m. Fly via Delta to get the fastest option. The distance between Myrtle Beach and Panama City is about 1700 mi.

  • What is the cheapest airline to fly from Myrtle Beach to Panama City round-trip?

    Cheapflights users have booked flights from Myrtle Beach to Panama City round-trip from $437.

  • Can I find deals for flights from Myrtle Beach to Panama City that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Panama City.

  • Can I find deals for business class flights from Myrtle Beach to Panama City?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Panama City?

    Currently, July is the cheapest month in which you can book a flight from Myrtle Beach to Panama City (average of $230). Flying from Myrtle Beach to Panama City in April is currently the most expensive (average of $548). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Myrtle Beach to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Myrtle Beach to Panama City

Discover the top airline that operate flights from Myrtle Beach to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$437Average$572FlexibilityNo cancel feeOn-time71%

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