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$209+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$493
(Trip.com)

One-way from

$209
(Kiwi.com)

Popular in

December

Cheapest in

November

Average price

$547
From Knoxville McGhee Tyson to Panama City Tocumen Intl
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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
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Highest demand for flights based on searches. 18% potential increase in price ($140 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($47 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/108:26 pmTYS - PTY
2 stops18h 59mAmerican Airlines
mié. 12/174:15 pmPTY - TYS
2 stops18h 01mAmerican Airlines
Deal found 6/12$472
This Trip.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/287:00 amTYS - PTY
1 stop8h 14mUnited Airlines
jue. 7/3110:00 amPTY - TYS
1 stop12h 27mUnited Airlines
Deal found 6/12$493
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/237:10 amTYS - PTY
3 stops18h 35mMultiple Airlines
mié. 7/3011:05 amPTY - TYS
3 stops31h 59mMultiple Airlines
Deal found 6/11$568
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:36 pmTYS - PTY
1 stop19h 19mDelta
mié. 12/313:20 pmPTY - TYS
1 stop17h 46mDelta
Deal found 6/11$764
This Avianca deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/105:50 amTYS - PTY
2 stops18h 30mAvianca
mar. 12/163:19 amPTY - TYS
2 stops15h 23mAvianca
Deal found 6/12$2,710

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

lun. 7/28

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

jue. 7/31

10:00 am-11:27 pm

1 stop12h 27m

$493

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

vie. 7/25

6:05 am-2:15 pm

1 stop9h 10m

Panama City Tocumen Intl

vie. 8/1

3:10 pm-11:02 am

2 stops18h 52m

$512

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mié. 7/23

7:10 am-12:45 am

3 stops18h 35m

Panama City Tocumen Intl

mié. 7/30

11:05 am-8:04 pm

3 stops31h 59m

$568

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mié. 7/16

4:09 pm-10:25 am

3 stops19h 16m

$209

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mar. 7/15

7:00 am-2:14 pm

1 stop8h 14m

$221

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mié. 7/16

6:29 pm-12:54 pm

2 stops19h 25m

$277

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PTY?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated junio 12, 2025.
United Airlines
7.4
Good
8,790 reviews

Food

6.6

Boarding

7.7

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,790 reviews
United Airlines
7.4
Good
8,790 reviews

Food

6.6

Boarding

7.7

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,790 reviews

Food

6.6

Boarding

7.7

Entertainment

7.0

Overall

7.4

Comfort

7.3

Crew

8.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $493. Another option worth looking into is American Airlines, starting at $512 round trip. United Airlines is currently priced 19% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Knoxville to Panama City

Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$661FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$407Average$581FlexibilityNo cancel feeOn-time71%
DeltaCheapest$427Average$590FlexibilityNo cancel feeOn-timeN/A

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