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Panama City

$427+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$487
(American Airlines)

One-way from

$427
(American Airlines)

Popular in

December

Cheapest in

November

Average price

$507
From Knoxville McGhee Tyson to Panama City Tocumen Intl
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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
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Highest demand for flights based on searches. 18% potential increase in price ($138 potential increase over avg. RT price).
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Cheapest flight prices on average. 8% potential price decrease ($46 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/266:10 amTYS - PTY
1 stop9h 21mAmerican Airlines
vie. 10/33:31 pmPTY - TYS
1 stop7h 19mAmerican Airlines
Deal found 8/12$487
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/196:15 amTYS - PTY
1 stop8h 48mAmerican Airlines
vie. 10/243:15 pmPTY - TYS
2 stops18h 16mAmerican Airlines
Deal found 8/13$492
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/136:24 pmTYS - PTY
2 stops21h 07mAmerican Airlines
mar. 9/161:45 pmPTY - TYS
2 stops21h 36mAmerican Airlines
Deal found 8/14$532
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/284:28 pmTYS - PTY
2 stops23h 03mAmerican Airlines
dom. 10/53:31 pmPTY - TYS
2 stops19h 13mAmerican Airlines
Deal found 8/14$537
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/77:01 amTYS - PTY
1 stop8h 24mAmerican Airlines
vie. 12/122:45 pmPTY - TYS
1 stop8h 35mAmerican Airlines
Deal found 8/13$557
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/34:37 pmTYS - PTY
2 stops22h 54mAmerican Airlines
jue. 10/93:15 pmPTY - TYS
2 stops21h 21mAmerican Airlines
Deal found 8/12$562
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/307:00 amTYS - PTY
2 stops13h 31mUnited Airlines
mar. 9/23:30 pmPTY - TYS
1 stop27h 23mUnited Airlines
Deal found 8/13$577
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/226:52 pmTYS - PTY
2 stops18h 28mAmerican Airlines
lun. 12/292:40 pmPTY - TYS
2 stops20h 32mAmerican Airlines
Deal found 8/14$682

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

dom. 10/19

6:15 am-2:03 pm

1 stop8h 48m

Panama City Tocumen Intl

vie. 10/24

3:15 pm-11:39 pm

1 stop7h 24m

$487

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

sáb. 10/25

7:45 am-12:56 pm

1 stop6h 11m

Panama City Tocumen Intl

jue. 10/30

2:21 pm-11:46 pm

1 stop8h 25m

$487

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

vie. 9/26

6:10 am-2:31 pm

1 stop9h 21m

Panama City Tocumen Intl

vie. 10/3

3:31 pm-11:50 pm

1 stop7h 19m

$487

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

sáb. 10/25

2:52 pm-2:03 pm

2 stops24h 11m

Panama City Tocumen Intl

jue. 10/30

3:15 pm-12:56 pm

2 stops20h 41m

$492

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

sáb. 9/13

6:24 pm-2:31 pm

2 stops21h 07m

Panama City Tocumen Intl

mar. 9/16

1:45 pm-12:21 pm

2 stops21h 36m

$532

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

dom. 9/28

6:10 am-2:31 pm

1 stop9h 21m

Panama City Tocumen Intl

dom. 10/5

3:31 pm-11:50 pm

1 stop7h 19m

$532

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mar. 12/23

7:51 pm-1:20 pm

2 stops17h 29m

$427

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

mar. 12/23

7:23 pm-7:25 pm

3 stops24h 02m

$971

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated agosto 14, 2025.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $387. Additional round-trip tickets that might be worth considering are offered by Delta and American Airlines, with the lowest prices starting at $427 and $436, respectively. United Airlines is currently priced 36% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Panama City flights
Memphis to Panama City flights
Blountville to Panama City flights

Top 3 airlines flying from Knoxville to Panama City

Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$665FlexibilityNo cancel feeOn-time69%
DeltaCheapest$427Average$628FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$436Average$582FlexibilityNo cancel feeOn-time71%

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