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Panama City

$205+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:08 pmTYS - PTY
2 stops20h 45mAmerican Airlines
Thu 1/14:55 pmPTY - TYS
2 stops17h 29mAmerican Airlines
Deal found 12/26$760
This Gotogate deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:50 amTYS - PTY
3 stops29h 05mAvianca
Thu 1/111:25 amPTY - TYS
3 stops23h 31mAvianca
Deal found 12/26$2,967

Find flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$460
(American Airlines)

One-way from

$205
(United Airlines)

Popular in

December

Cheapest in

September

Average price

$754
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
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From Knoxville McGhee Tyson to Panama City Tocumen Intl
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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
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Highest demand for flights based on searches. 11% potential increase in price ($79 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/24

7:53 pm-12:15 pm

2 stops17h 22m

Panama City Tocumen Intl

Fri 5/1

1:55 pm-10:01 am

2 stops19h 06m

$460

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/27

7:05 am-5:07 pm

1 stop10h 02m

Panama City Tocumen Intl

Tue 3/3

4:41 pm-7:55 pm

1 stop27h 14m

$464

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/24

5:15 pm-4:12 pm

1 stop23h 57m

Panama City Tocumen Intl

Fri 5/1

7:55 am-7:55 pm

1 stop11h 00m

$505

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 2/27

5:35 am-9:20 am

2 stops27h 45m

Panama City Tocumen Intl

Tue 3/3

10:20 am-5:56 pm

2 stops31h 36m

$5,167

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/26

4:41 pm-1:27 pm

2 stops20h 46m

$205

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/26

6:59 am-5:07 pm

1 stop10h 08m

$205

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/24

8:44 pm-12:15 pm

2 stops16h 31m

$225

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Mon 1/26

7:15 am-2:00 pm

3 stops30h 45m

$256

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/24

5:15 pm-2:14 pm

1 stop21h 59m

$291

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 4/24

1:15 pm-4:30 pm

3 stops28h 15m

$419

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $359). Flying from Knoxville to Panama City in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Knoxville to Panama City?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 28, 2025.
Read through reviews of airlines operating flights from Knoxville to Panama City, such as United Airlines and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,113 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
United Airlines
7.4
Good
9,113 reviews
United Airlines
7.4
Good
9,113 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.
American Airlines
7.2
Good
11,073 reviews
United Airlines
7.4
Good
9,113 reviews

Crew

8.1

Food

6.6

Comfort

7.3

Entertainment

7.1

Boarding

7.7

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Michelle,Dec 2025

DEN - MKE

I liked that the plane waited 5 minutes for a family whose incoming plane was late. This was the last flight of the day to MKE. Flight attendants actually checked in throughout the flight. Although, not really friendly. Happy to see screens on seat backs again. This is my first time not flying first class in over 10 years. It was economy plus.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City?

    For as low as $464, American Airlines can have you in Panama City from Knoxville in 10h 02m. The distance between Knoxville and Panama City is about 1869 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $312. Another option worth looking into is American Airlines, starting at $461 round trip. United Airlines is currently priced 49% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, December is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $359). Flying from Knoxville to Panama City in November is currently the most expensive (average of $657). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$513FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$461Average$617FlexibilityNo cancel feeOn-time71%

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