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$292+ Cheap flights from Knoxville (TYS) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — PTY
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Find cheap flights from Knoxville to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$435
(United Airlines)

One-way from

$292
(American Airlines)

Popular in

December

Cheapest in

September

Average price

$562
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City Tocumen Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City Tocumen Intl flights.
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From Knoxville McGhee Tyson to Panama City Tocumen Intl
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One-way flight from Knoxville McGhee Tyson to Panama City Tocumen Intl
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Highest demand for flights based on searches. 31% potential increase in price ($286 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($39 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/177:00 amTYS - PTY
1 stop8h 14mUnited Airlines
Sun 9/2110:00 amPTY - TYS
1 stop12h 44mUnited Airlines
Deal found 4/28$435
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/125:57 pmTYS - PTY
2 stops20h 03mAmerican Airlines
Thu 6/191:50 pmPTY - TYS
2 stops20h 57mAmerican Airlines
Deal found 4/28$440
This Mytrip deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/129:34 pmTYS - PTY
3 stops28h 11mMultiple Airlines
Wed 6/183:20 amPTY - TYS
3 stops27h 44mMultiple Airlines
Deal found 4/28$669

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Wed 9/17

7:00 am-2:14 pm

1 stop8h 14m

Panama City Tocumen Intl

Sun 9/21

10:00 am-11:44 pm

1 stop12h 44m

$435

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 6/12

5:57 pm-1:00 pm

2 stops20h 03m

Panama City Tocumen Intl

Thu 6/19

1:50 pm-11:47 am

2 stops20h 57m

$440

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Thu 6/12

9:34 pm-12:45 am

3 stops28h 11m

Panama City Tocumen Intl

Wed 6/18

3:20 am-8:04 am

3 stops27h 44m

$669

KnoxvillePanama City

TYS - PTY

TYSPTY

Knoxville McGhee Tyson

Fri 5/23

7:54 pm-12:19 pm

2 stops17h 25m

$292

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City flights, users find the pricing of AranGrant to be most consistent on Cheapflights vs. AranGrant Users can find the same prices on Knoxville-Panama City flight deals on Cheapflights vs. AranGrant >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City flights, Cheapflights users trust AranGrant the most. AranGrant has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City?

Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to PTY?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Panama City as you normally would.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 29, 2025.
United Airlines
7.4
Good
8,696 reviews

Crew

8.1

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
United Airlines
7.4
Good
8,696 reviews
United Airlines
7.4
Good
8,696 reviews

Crew

8.1

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??
American Airlines
7.2
Good
10,000 reviews
United Airlines
7.4
Good
8,696 reviews

Crew

8.1

Boarding

7.7

Comfort

7.3

Food

6.6

Overall

7.4

Entertainment

7.1

Reviews

1 / 20
4.0
Okay

Thomas,Mar 2025

SFO - TPE

When I asked for an extra snack, I got an unhappy look from the stewardess. Geez, does one extra snack really affect the bottom line??

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Panama City round-trip?

    Flying on United Airlines is currently your cheapest option to Panama City, with prices starting at $435. Another option worth looking into is American Airlines, starting at $440 round trip. United Airlines is currently priced 29% below the average price you’ll pay for this route.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City?

    Currently, October is the cheapest month in which you can book a flight from Knoxville to Panama City (average of $478). Flying from Knoxville to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Knoxville to Panama City

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Top 3 airlines flying from Knoxville to Panama City

Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$387Average$661FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$407Average$649FlexibilityNo cancel feeOn-time71%
DeltaCheapest$427Average$580FlexibilityNo cancel feeOn-timeN/A

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