To save up to 9% on this flight, we recommend booking at least 58 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Indiana to Panama City from $567 1-2 weeks out and tickets from $602 for flights departing within the next 72 hours.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, February can be a great choice for travel to Panama City. Flights to Panama City from Indiana in February are about $564 on average during February, but can be found for as low as $357.