$480+ Cheap flights from Buffalo (BUF) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama City
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Cheapest flights from Buffalo to Panama CityExplore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:51 am -
1 stop9h 11m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$757
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:30 am -
2 stops13h 32m
Wed 11/184:41 pm -
2 stops20h 36m
Deal found 10/30![United Airlines logo]()
$762
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
1 stop13h 02m
Mon 12/710:00 am -
1 stop8h 10m
Deal found 10/27![United Airlines logo]()
$782
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:00 am -
1 stop14h 02m
Sun 12/204:41 pm -
2 stops20h 22m
Deal found 10/30![United Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:51 am -
1 stop9h 11m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$791
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
2 stops13h 08m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$796
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:21 pm -
2 stops19h 52m
Wed 11/183:13 pm -
2 stops19h 29m
Deal found 10/27![American Airlines logo]()
$808
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am -
1 stop7h 59m
Tue 11/173:29 pm -
1 stop8h 30m
Deal found 10/26![Delta logo]()
$819
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:51 am -
1 stop9h 11m
Fri 11/2010:00 am -
1 stop12h 59m
Deal found 10/30![United Airlines logo]()
$825
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop7h 59m
Thu 11/193:29 pm -
1 stop8h 30m
Deal found 10/29![Delta logo]()
$829
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
2 stops13h 08m
Fri 11/2010:00 am -
2 stops13h 46m
Deal found 10/30![United Airlines logo]()
$830
Best flights from Buffalo to Panama CityDiscover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Buffalo to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/2011:15 am -
1 stop8h 47m
Wed 2/38:55 am -
2 stops14h 04m
Deal found 10/30![United Airlines logo]()
$672
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/137:03 am -
1 stop12h 59m
Wed 1/204:41 pm -
2 stops24h 00m
Deal found 10/28![United Airlines logo]()
$672
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:03 am -
1 stop12h 59m
Fri 2/510:00 am -
1 stop12h 59m
Deal found 10/26![United Airlines logo]()
$701
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/25:50 am -
1 stop14h 12m
Fri 2/510:00 am -
1 stop9h 32m
Deal found 10/26![United Airlines logo]()
$701
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/131:55 pm -
2 stops15h 15m
Sun 3/2110:55 pm -
1 stop22h 42m
Deal found 10/29![United Airlines logo]()
$778
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:00 am -
1 stop14h 02m
Sun 12/204:41 pm -
2 stops20h 22m
Deal found 10/30![United Airlines logo]()
$785
Last-minute flights from Buffalo to Panama CityDiscover last-minute flight deals from Buffalo to Panama City. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama City. Data last updated October 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:51 am -
1 stop9h 11m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$791
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:51 am -
1 stop9h 11m
Fri 11/2010:00 am -
1 stop12h 59m
Deal found 10/30![United Airlines logo]()
$825
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:30 am -
2 stops13h 32m
Wed 11/184:41 pm -
2 stops20h 36m
Deal found 10/30![United Airlines logo]()
$762
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am -
1 stop7h 59m
Tue 11/173:29 pm -
1 stop8h 30m
Deal found 10/26![Delta logo]()
$819
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:20 pm -
1 stop20h 39m
Wed 11/183:29 pm -
1 stop8h 30m
Deal found 10/27![Delta logo]()
$832
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/310:51 am -
1 stop9h 11m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$757
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:21 pm -
2 stops19h 52m
Wed 11/183:13 pm -
2 stops19h 29m
Deal found 10/27![American Airlines logo]()
$808
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop7h 59m
Tue 11/173:29 pm -
1 stop8h 30m
Deal found 10/29![Delta logo]()
$829
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop14h 02m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/27![United Airlines logo]()
$831
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
2 stops13h 08m
Wed 11/1810:00 am -
1 stop10h 09m
Deal found 10/30![United Airlines logo]()
$796
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:30 am -
2 stops13h 08m
Fri 11/2010:00 am -
2 stops13h 46m
Deal found 10/30![United Airlines logo]()
$830
One-way flights from Buffalo to Panama CitySearch for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Buffalo to Panama City. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Avianca deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/63:00 pm -
2 stops11h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Avianca logo]()
$480
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:41 pm -
1 stop19h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![Delta logo]()
$499
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/136:00 am -
1 stop14h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![United Airlines logo]()
$523
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/126:00 am -
1 stop8h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$577
This Gurufare deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:20 pm -
2 stops24h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Copa Airlines logo]()
$700
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:08 pm -
2 stops21h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$723
This FlightHub deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:30 pm -
3 stops19h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Multiple Airlines logo]()
$1,469
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/123:00 pm -
3 stops34h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Avianca logo]()
$1,734
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/137:36 pm -
3 stops18h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![American Airlines logo]()
$2,321
Find flight deals from Buffalo to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $667 (United Airlines) |
One-way from | $480 (Avianca) |
Popular in | August |
Cheapest in | June |
Average price | $771 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 12/6
6:41 pm-2:03 pm
1 stop19h 22m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$499
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 12/13
6:00 am-8:02 pm
1 stop14h 02m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$523
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sat 12/12
7:00 am-7:38 pm
2 stops12h 38m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$523
Quickest round-trip
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sat 12/12
6:00 am-2:03 pm
1 stop8h 03m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$577
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 1/20
11:15 am-8:02 pm
1 stop8h 47m
Panama City Tocumen Intl
Wed 2/3
8:55 am-10:59 pm
2 stops14h 04m
$672
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 1/13
7:03 am-8:02 pm
1 stop12h 59m
Panama City Tocumen Intl
Wed 1/20
4:41 pm-4:41 pm
2 stops24h 00m
$672
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 2/1
7:03 am-8:02 pm
1 stop12h 59m
Panama City Tocumen Intl
Fri 2/5
10:00 am-10:59 pm
1 stop12h 59m
$701
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Tue 2/2
5:50 am-8:02 pm
1 stop14h 12m
Panama City Tocumen Intl
Fri 2/5
10:00 am-7:32 pm
1 stop9h 32m
$701
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 11/18
12:08 pm-9:10 am
2 stops21h 02m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$723
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sat 3/13
1:55 pm-5:10 am
2 stops15h 15m
Panama City Tocumen Intl
Sun 3/21
10:55 pm-10:37 pm
1 stop22h 42m
$778
Showing 1-10 of 12 resultsSorted by cheapest first
Compare providers for flights from Buffalo to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Buffalo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Buffalo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Buffalo to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
BUF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 30, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Crew
8.5
Entertainment
7.8
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Panama City by cabin class
Find flights from Buffalo to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama City flights
Browse other Buffalo and Panama City flight options. Last updated on October 30, 2026.
Other flights from Buffalo
Browse through other flights departing from Buffalo. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Buffalo to Panama City
Discover the top airline that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$628 | Average$844 | FlexibilityNo cancel fee | On-timeN/A |