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Panama City

$195+ Cheap flights from Buffalo (BUF) to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Buffalo to Panama City

Cheapest flights from Buffalo to Panama City
Explore the most affordable flight options available from Buffalo to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This Expedia deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:30 pm
BUF
-
PTY
2 stops16h 00m
Multiple Airlines
Tue 3/173:50 pm
PTY
-
BUF
2 stops16h 14m
Multiple Airlines
Deal found 2/9$518
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:35 am
BUF
-
PTY
2 stops24h 55m
Multiple Airlines
Wed 3/1811:25 am
PTY
-
BUF
3 stops20h 39m
Multiple Airlines
Deal found 2/8$523
This Travelocity deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:35 pm
BUF
-
PTY
2 stops15h 55m
Multiple Airlines
Sun 3/157:50 pm
PTY
-
BUF
2 stops12h 14m
Multiple Airlines
Deal found 2/8$538
This United Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:50 pm
BUF
-
PTY
2 stops21h 24m
United Airlines
Wed 8/263:20 pm
PTY
-
BUF
2 stops17h 29m
United Airlines
Deal found 2/7$543
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:30 pm
BUF
-
PTY
2 stops17h 40m
American Airlines
Sun 7/261:10 pm
PTY
-
BUF
2 stops22h 44m
American Airlines
Deal found 2/9$548
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
BUF
-
PTY
1 stop8h 13m
Delta
Wed 9/92:28 pm
PTY
-
BUF
1 stop8h 30m
Delta
Deal found 2/9$549
This Gurufare deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:00 am
BUF
-
PTY
1 stop14h 02m
Copa Airlines
Tue 3/173:41 pm
PTY
-
BUF
2 stops20h 36m
Copa Airlines
Deal found 2/9$579
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:00 am
BUF
-
PTY
1 stop8h 03m
Delta
Tue 3/172:28 pm
PTY
-
BUF
1 stop19h 33m
Delta
Deal found 2/9$586
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:02 pm
BUF
-
PTY
2 stops21h 18m
American Airlines
Thu 4/21:40 pm
PTY
-
BUF
2 stops20h 18m
American Airlines
Deal found 2/9$620

Find flight deals from Buffalo to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Buffalo (BUF) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$518
(Expedia)

One-way from

$195
(Kiwi.com)

Popular in

March

Cheapest in

April

Average price

$583
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama City Tocumen Intl
Search Deals
One-way flight from Buffalo to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($45 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Buffalo to Panama City that are best for you.

Fly from

Buffalo

Fly to

Panama City

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 3/9

7:30 pm-10:30 am

2 stops16h 00m

Panama City Tocumen Intl

Tue 3/17

3:50 pm-9:04 am

2 stops16h 14m

$518

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/11

10:35 am-10:30 am

2 stops24h 55m

Panama City Tocumen Intl

Wed 3/18

11:25 am-9:04 am

3 stops20h 39m

$523

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 6/15

5:47 pm-4:12 pm

2 stops23h 25m

Panama City Tocumen Intl

Tue 6/23

3:30 pm-10:00 am

2 stops17h 30m

$543

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/11

10:23 am-7:02 pm

1 stop9h 39m

Panama City Tocumen Intl

Wed 3/18

11:35 am-9:50 am

2 stops21h 15m

$543

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 3/9

6:00 am-7:02 pm

1 stop14h 02m

Panama City Tocumen Intl

Tue 3/17

3:41 pm-1:17 pm

2 stops20h 36m

$579

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 3/9

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Tue 3/17

2:28 pm-11:01 am

1 stop19h 33m

$586

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 3/26

6:02 pm-2:20 pm

2 stops21h 18m

Panama City Tocumen Intl

Thu 4/2

1:40 pm-10:58 am

2 stops20h 18m

$620

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 4/1

5:29 pm-3:01 pm

2 stops22h 32m

Panama City Tocumen Intl

Thu 4/9

1:49 pm-10:50 am

2 stops20h 01m

$657

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/11

6:00 am-1:03 pm

1 stop8h 03m

Panama City Tocumen Intl

Wed 3/18

2:28 pm-11:46 pm

1 stop8h 18m

$673

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 6/29

7:55 pm-2:14 pm

2 stops19h 19m

Panama City Tocumen Intl

Sun 7/5

10:55 pm-4:40 pm

2 stops16h 45m

$700

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 17 results
1
2

Compare providers for flights from Buffalo to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Buffalo to Panama City in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Buffalo-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Buffalo-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Buffalo-Panama City flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Buffalo-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Buffalo-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Buffalo to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama City

What is the cheapest month to book a flight from Buffalo to Panama City?

Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $453). Flying from Buffalo to Panama City in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated February 11, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama City, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,178 reviews

Boarding

8.1

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,178 reviews
Delta
7.9
Good
8,178 reviews

Boarding

8.1

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Buffalo to Panama City?

    United Airlines can get you from Buffalo to Panama City in just under 23h 25m. Your travel time can differ by up to . Airlines will cover a distance of 2339 mi.

  • What is the cheapest airline to fly from Buffalo to Panama City round-trip?

    Delta, at $497, was found to be the cheapest airline from Buffalo to Panama City.. Delta is currently priced 23% below the average price you’ll pay for this route.

  • Can I find deals for flights from Buffalo to Panama City that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama City.

  • Can I find deals for business class flights from Buffalo to Panama City?

    Yes. Cheapflights offers flight deals from Buffalo to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama City?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama City (average of $453). Flying from Buffalo to Panama City in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Buffalo to Panama City

Discover the top airline that operate flights from Buffalo to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$497Average$632FlexibilityNo cancel feeOn-timeN/A

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