$344+ Cheap flights from Buffalo (BUF) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/28. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Sep 27 — Oct 41
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama
Cheapest
Best
Last-minute
One-way
Cheapest flights from Buffalo to PanamaExplore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:30 am -
1 stop14h 01m
Wed 10/149:45 am -
1 stop12h 26m
Deal found 8/23![United Airlines logo]()
$733
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
1 stop14h 02m
Fri 10/309:30 am -
1 stop12h 29m
Deal found 8/26![United Airlines logo]()
$743
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:30 am -
1 stop14h 01m
Wed 9/309:45 am -
1 stop12h 26m
Deal found 8/24![United Airlines logo]()
$753
This Expedia deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:50 pm -
3 stops20h 05m
Wed 10/145:30 am -
2 stops25h 30m
Deal found 8/23![Multiple Airlines logo]()
$786
This United Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:45 pm -
2 stops21h 29m
Sat 10/179:45 am -
2 stops22h 44m
Deal found 8/26![United Airlines logo]()
$797
This Ovago deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:51 am -
1 stop9h 11m
Sat 11/1410:00 am -
1 stop13h 49m
Deal found 8/27![Copa Airlines logo]()
$823
This Expedia deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/229:20 am -
2 stops16h 50m
Sun 11/295:30 am -
2 stops30h 29m
Deal found 8/23![Multiple Airlines logo]()
$825
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:23 pm -
2 stops22h 53m
Fri 9/181:16 pm -
2 stops21h 02m
Deal found 8/24![American Airlines logo]()
$827
Best flights from Buffalo to PanamaDiscover carefully curated flight deals from Buffalo to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
Discover carefully curated flight deals from Buffalo to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:45 pm -
2 stops24h 53m
Wed 2/310:00 am -
1 stop12h 37m
Deal found 8/25![United Airlines logo]()
$717
This American Airlines deal was found by Cheapflights users on 8/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:21 am -
1 stop10h 17m
Wed 2/32:27 pm -
1 stop8h 29m
Deal found 8/25![American Airlines logo]()
$718
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:50 pm -
2 stops26h 12m
Thu 1/284:41 pm -
2 stops24h 06m
Deal found 8/23![United Airlines logo]()
$724
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:45 pm -
2 stops25h 52m
Wed 10/149:45 am -
2 stops22h 44m
Deal found 8/23![United Airlines logo]()
$737
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:00 am -
1 stop14h 02m
Fri 10/309:30 am -
1 stop12h 29m
Deal found 8/27![United Airlines logo]()
$743
Last-minute flights from Buffalo to PanamaDiscover last-minute flight deals from Buffalo to Panama. Data last updated August 28, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama. Data last updated August 28, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 pm -
2 stops19h 59m
Fri 9/41:39 pm -
2 stops24h 17m
Deal found 8/27![American Airlines logo]()
$879
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:53 am -
1 stop18h 11m
Fri 9/410:55 pm -
2 stops19h 05m
Deal found 8/27![United Airlines logo]()
$883
This Gurufare deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
1 stop14h 31m
Fri 9/410:55 pm -
1 stop23h 17m
Deal found 8/27![Copa Airlines logo]()
$979
This Flightnetwork deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:59 pm -
3 stops19h 56m
Fri 9/43:50 pm -
2 stops26h 10m
Deal found 8/27![Avianca logo]()
$1,286
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:23 pm -
2 stops22h 53m
Fri 9/181:16 pm -
2 stops21h 02m
Deal found 8/24![American Airlines logo]()
$827
This Delta deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:05 am -
1 stop7h 53m
Fri 9/182:23 pm -
1 stop8h 29m
Deal found 8/24![Delta logo]()
$853
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:55 am -
2 stops13h 36m
Fri 9/189:45 am -
1 stop12h 27m
Deal found 8/24![United Airlines logo]()
$857
This FlightHub deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:50 pm -
3 stops20h 05m
Fri 9/1811:25 am -
3 stops19h 45m
Deal found 8/24![Multiple Airlines logo]()
$3,574
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:30 am -
1 stop14h 01m
Wed 9/309:45 am -
1 stop12h 26m
Deal found 8/24![United Airlines logo]()
$753
One-way flights from Buffalo to PanamaSearch for one-way flight options from Buffalo to Panama. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
Search for one-way flight options from Buffalo to Panama. Find affordable one-way fares based on user searches. Data last updated August 28, 2026.
This United Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:30 am -
1 stop10h 01m
Deal found 8/23![United Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/186:45 pm -
1 stop25h 17m
Deal found 8/24![United Airlines logo]()
$357
This Expedia deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:50 pm -
2 stops15h 40m
Deal found 8/24![Multiple Airlines logo]()
$361
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:01 pm -
2 stops20h 44m
Deal found 8/24![United Airlines logo]()
$374
This Travelocity deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:35 am -
3 stops28h 25m
Deal found 8/24![Multiple Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:30 am -
1 stop10h 01m
Deal found 8/24![United Airlines logo]()
$394
This FlightHub deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:33 am -
3 stops29h 22m
Deal found 8/24![Avianca logo]()
$479
This Booking.com deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1810:20 am -
3 stops28h 40m
Deal found 8/24![Avianca logo]()
$1,552
Find flight deals from Buffalo to Panama
Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated August 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $713 (United Airlines) |
One-way from | $344 (United Airlines) |
Popular in | February |
Cheapest in | June |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 1/20
6:45 pm-7:38 pm
2 stops24h 53m
Panama City Tocumen Intl
Wed 2/3
10:00 am-10:37 pm
1 stop12h 37m
$717
Quickest round-trip
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 1/20
5:21 am-3:38 pm
1 stop10h 17m
Panama City Tocumen Intl
Wed 2/3
2:27 pm-10:56 pm
1 stop8h 29m
$718
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 1/17
5:50 pm-8:02 pm
2 stops26h 12m
Panama City Tocumen Intl
Thu 1/28
4:41 pm-4:47 pm
2 stops24h 06m
$724
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Wed 10/7
5:45 pm-6:37 pm
2 stops25h 52m
Panama City Tocumen Intl
Wed 10/14
9:45 am-9:29 am
2 stops22h 44m
$737
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Tue 10/27
6:00 am-7:02 pm
1 stop14h 02m
Panama City Tocumen Intl
Fri 10/30
9:30 am-10:59 pm
1 stop12h 29m
$743
Cheapest one-way
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 9/28
7:34 pm-12:26 pm
2 stops17h 52m
$344
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 1/18
5:50 pm-5:12 pm
2 stops23h 22m
$344
Quickest one-way
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 1/18
6:00 am-1:55 pm
1 stop7h 55m
$344
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 9/28
10:30 am-7:31 pm
1 stop10h 01m
$344
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sat 9/12
10:33 am-2:55 pm
3 stops29h 22m
$479
Sorted by cheapest first
Best time to book a flight from Buffalo to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
BUF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Panama
BUF-PA0
BUF-PTY
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 28, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Panama by cabin class
Find flights from Buffalo to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama flights
Browse other Buffalo and Panama flight options. Last updated on August 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Buffalo to Panama
Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$517 | Average$752 | FlexibilityNo cancel fee | On-timeN/A |