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$267+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/5. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Jun 28 — Jul 51
Sun 6/28
Sun 7/5
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.

This Avianca deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 pm
BUF
-
PTY
2 stops14h 30m
Multiple Airlines
Sat 11/147:50 pm
PTY
-
BUF
2 stops12h 37m
Multiple Airlines
Deal found 5/28$498
This Orbitz deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:00 pm
BUF
-
PTY
2 stops19h 30m
Multiple Airlines
Sat 10/243:50 pm
PTY
-
BUF
2 stops15h 37m
Multiple Airlines
Deal found 5/29$570
This Expedia deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/138:00 pm
BUF
-
PTY
2 stops22h 55m
Multiple Airlines
Wed 11/253:50 pm
PTY
-
BUF
2 stops17h 09m
Multiple Airlines
Deal found 5/29$607
This Expedia deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:52 pm
BUF
-
PTY
2 stops19h 38m
Multiple Airlines
Tue 9/83:50 pm
PTY
-
BUF
2 stops21h 36m
Multiple Airlines
Deal found 5/27$611
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:40 pm
BUF
-
PTY
1 stop18h 25m
Delta
Thu 11/263:30 pm
PTY
-
BUF
1 stop8h 25m
Delta
Deal found 5/29$643
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:55 am
BUF
-
PTY
2 stops12h 42m
United Airlines
Wed 9/210:00 am
PTY
-
BUF
2 stops22h 28m
United Airlines
Deal found 5/26$657
This Travelocity deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:05 am
BUF
-
PTY
2 stops29h 25m
Multiple Airlines
Thu 6/43:50 pm
PTY
-
BUF
2 stops26h 15m
Multiple Airlines
Deal found 5/28$670
This United Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:00 pm
BUF
-
PTY
1 stop10h 04m
United Airlines
Wed 7/2210:55 pm
PTY
-
BUF
1 stop9h 58m
United Airlines
Deal found 5/28$673
This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:40 pm
BUF
-
PTY
1 stop18h 25m
Delta
Thu 11/263:30 pm
PTY
-
BUF
2 stops16h 59m
Delta
Deal found 5/29$674
This United Airlines deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:58 pm
BUF
-
PTY
2 stops21h 16m
United Airlines
Sat 8/223:30 pm
PTY
-
BUF
2 stops16h 58m
United Airlines
Deal found 5/29$687

Find flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated May 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$498
(Avianca)

One-way from

$267
(Expedia)
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama
Search Deals
One-way flight from Buffalo to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 11/16

7:40 pm-2:05 pm

2 stops18h 25m

Panama City Tocumen Intl

Tue 11/24

3:30 pm-11:15 am

1 stop19h 45m

$643

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 8/31

7:40 pm-4:04 am

1 stop9h 24m

Panama City Tocumen Intl

Wed 9/2

10:00 am-9:28 am

2 stops22h 28m

$657
Quickest round-trip

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 7/8

7:00 pm-4:04 am

1 stop10h 04m

Panama City Tocumen Intl

Wed 7/22

10:55 pm-9:53 am

1 stop9h 58m

$673

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 8/17

4:50 pm-12:39 pm

2 stops20h 49m

Panama City Tocumen Intl

Sat 8/22

1:39 pm-9:39 am

2 stops19h 00m

$687

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 8/6

6:00 am-6:37 pm

2 stops13h 37m

Panama City Tocumen Intl

Fri 8/7

10:55 pm-9:57 am

1 stop10h 02m

$687

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 8/17

6:00 am-4:04 am

1 stop23h 04m

Panama City Tocumen Intl

Sat 8/22

3:30 pm-9:28 am

2 stops16h 58m

$695

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 10/17

7:00 am-7:31 pm

2 stops13h 31m

Panama City Tocumen Intl

Sat 10/24

9:45 am-7:08 pm

1 stop8h 23m

$717

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 11/7

11:40 am-8:02 pm

1 stop8h 22m

Panama City Tocumen Intl

Sat 11/14

10:00 am-9:49 am

2 stops23h 49m

$717

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 7/11

6:04 pm-2:14 pm

2 stops21h 10m

Panama City Tocumen Intl

Sat 7/18

10:00 am-10:00 am

2 stops23h 00m

$720
Cheapest one-way

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Fri 6/5

10:34 am-7:31 pm

1 stop9h 57m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/28

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated May 29, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,419 reviews

Comfort

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work
Delta
7.9
Good
8,419 reviews
Delta
7.9
Good
8,419 reviews

Comfort

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • How long is the flight from Buffalo to Panama?

    For as low as $657, Delta can have you in Panama from Buffalo in 9h 24m. The distance from Buffalo to Panama is about 2339 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Buffalo to Panama

Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$517Average$671FlexibilityNo cancel feeOn-timeN/A

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