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$247+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/18. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This Expedia deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:02 pm
BUF
-
PTY
2 stops16h 28m
Multiple Airlines
Sun 4/193:50 pm
PTY
-
BUF
2 stops16h 08m
Multiple Airlines
Deal found 2/22$518
This Expedia deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:39 pm
BUF
-
PTY
2 stops15h 51m
Multiple Airlines
Mon 5/183:50 pm
PTY
-
BUF
2 stops16h 10m
Multiple Airlines
Deal found 2/25$520
This Expedia deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/197:02 pm
BUF
-
PTY
2 stops16h 28m
Multiple Airlines
Fri 4/243:50 pm
PTY
-
BUF
2 stops28h 27m
Multiple Airlines
Deal found 2/25$526
This Expedia deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:25 pm
BUF
-
PTY
2 stops23h 05m
Multiple Airlines
Sun 5/173:50 pm
PTY
-
BUF
2 stops28h 35m
Multiple Airlines
Deal found 2/22$531
This Expedia deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:59 pm
BUF
-
PTY
2 stops14h 31m
Multiple Airlines
Thu 4/163:50 pm
PTY
-
BUF
2 stops16h 08m
Multiple Airlines
Deal found 2/23$538
This Orbitz deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
BUF
-
PTY
2 stops28h 30m
Multiple Airlines
Sun 3/83:50 pm
PTY
-
BUF
2 stops25h 45m
Multiple Airlines
Deal found 2/22$548
This Travelocity deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/259:54 am
BUF
-
PTY
2 stops25h 36m
Multiple Airlines
Wed 4/13:50 pm
PTY
-
BUF
2 stops15h 16m
Multiple Airlines
Deal found 2/23$553
This Expedia deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:02 pm
BUF
-
PTY
2 stops16h 28m
Multiple Airlines
Sat 5/23:50 pm
PTY
-
BUF
2 stops16h 10m
Multiple Airlines
Deal found 2/25$556
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:45 am
BUF
-
PTY
1 stop9h 46m
United Airlines
Sat 5/210:55 pm
PTY
-
BUF
1 stop10h 09m
United Airlines
Deal found 2/25$559
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1910:30 am
BUF
-
PTY
1 stop10h 01m
United Airlines
Fri 4/2410:55 pm
PTY
-
BUF
1 stop10h 07m
United Airlines
Deal found 2/24$569

Find flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated February 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$518
(Expedia)

One-way from

$247
(United Airlines)

Popular in

March

Cheapest in

April

Average price

$650
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama
Search Deals
One-way flight from Buffalo to Panama
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($61 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 5/13

7:39 pm-10:30 am

2 stops15h 51m

Panama City Tocumen Intl

Mon 5/18

3:50 pm-9:00 am

2 stops16h 10m

$520

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 5/7

10:31 am-7:31 pm

1 stop10h 00m

Panama City Tocumen Intl

Sun 5/10

10:55 pm-9:50 am

1 stop9h 55m

$569

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 4/15

6:55 pm-4:04 am

1 stop10h 09m

Panama City Tocumen Intl

Sun 4/19

10:55 pm-9:47 am

1 stop9h 52m

$569

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 8/22

5:50 pm-6:37 pm

2 stops25h 47m

Panama City Tocumen Intl

Wed 8/26

10:00 am-9:49 am

2 stops22h 49m

$573

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 5/14

10:31 am-7:31 pm

1 stop10h 00m

Panama City Tocumen Intl

Sun 5/17

3:30 pm-10:06 am

2 stops17h 36m

$573

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 5/17

7:02 pm-4:04 am

1 stop10h 02m

Panama City Tocumen Intl

Sun 5/24

9:45 am-11:59 pm

2 stops13h 14m

$573

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Wed 3/25

2:49 pm-1:45 pm

2 stops23h 56m

Panama City Tocumen Intl

Wed 4/1

10:55 pm-9:47 am

1 stop9h 52m

$573

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sun 4/26

6:00 am-6:37 pm

2 stops13h 37m

Panama City Tocumen Intl

Sat 5/2

10:55 pm-10:04 am

1 stop10h 09m

$573

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 8/4

10:34 am-7:31 pm

1 stop9h 57m

$247

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 6/18

5:52 pm-4:12 pm

2 stops23h 20m

$247

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/23

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama

What is the cheapest month to book a flight from Buffalo to Panama?

Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama (average of $453). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated February 26, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,237 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,237 reviews
Delta
7.9
Good
8,237 reviews

Comfort

7.9

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Entertainment

7.8

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • How long is the flight from Buffalo to Panama?

    For as low as $569, United Airlines can have you in Panama from Buffalo in 10h. The distance from Buffalo to Panama is about 2339 mi.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to Panama?

    Currently, April is the cheapest month in which you can book a flight from Buffalo to Panama (average of $453). Flying from Buffalo to Panama in June is currently the most expensive (average of $638). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Buffalo to Panama

Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$461Average$671FlexibilityNo cancel feeOn-timeN/A

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