$291+ Cheap flights from Buffalo (BUF) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Nov 9 — Nov 161
Round-trip
1 adult, Economy
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Find cheap flights from Buffalo to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Buffalo to Panama
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Cheapest flights from Buffalo to PanamaExplore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 10, 2026.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop7h 59m
Wed 10/142:24 pm -
1 stop8h 35m
Deal found 10/6![Delta logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:59 pm -
2 stops24h 32m
Wed 10/143:30 pm -
2 stops20h 41m
Deal found 10/6![United Airlines logo]()
$722
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 pm -
2 stops20h 22m
Wed 10/142:02 pm -
2 stops20h 21m
Deal found 10/6![American Airlines logo]()
$727
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:55 pm -
1 stop19h 04m
Wed 10/142:24 pm -
1 stop8h 35m
Deal found 10/6![Delta logo]()
$729
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:51 am -
1 stop9h 11m
Thu 11/2610:00 am -
1 stop24h 08m
Deal found 10/5![United Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:30 am -
1 stop14h 01m
Tue 10/279:30 am -
1 stop9h 39m
Deal found 10/9![United Airlines logo]()
$737
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:45 pm -
2 stops26h 46m
Mon 10/123:30 pm -
2 stops20h 41m
Deal found 10/5![United Airlines logo]()
$739
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:30 am -
1 stop10h 01m
Thu 10/153:30 pm -
2 stops16h 59m
Deal found 10/7![United Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/73:52 pm -
1 stop28h 39m
Wed 10/149:45 am -
1 stop12h 26m
Deal found 10/7![United Airlines logo]()
$745
Best flights from Buffalo to PanamaDiscover carefully curated flight deals from Buffalo to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
Discover carefully curated flight deals from Buffalo to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 10, 2026.
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:51 am -
1 stop9h 11m
Thu 11/2610:00 am -
1 stop24h 08m
Deal found 10/5![United Airlines logo]()
$736
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am -
1 stop7h 59m
Wed 10/282:24 pm -
1 stop8h 35m
Deal found 10/9![Delta logo]()
$771
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:58 pm -
2 stops26h 04m
Fri 11/2710:00 am -
2 stops23h 34m
Deal found 10/6![United Airlines logo]()
$745
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am -
1 stop7h 59m
Mon 10/262:24 pm -
2 stops20h 11m
Deal found 10/9![Delta logo]()
$852
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:00 am -
2 stops14h 31m
Tue 10/279:30 am -
1 stop12h 29m
Deal found 10/9![United Airlines logo]()
$776
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am -
1 stop14h 01m
Sun 10/259:30 am -
2 stops22h 51m
Deal found 10/9![United Airlines logo]()
$776
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/212:20 pm -
1 stop9h 25m
Fri 1/83:20 pm -
1 stop8h 35m
Deal found 10/7![Delta logo]()
$893
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
2 stops12h 37m
Wed 10/287:55 am -
2 stops14h 04m
Deal found 10/7![United Airlines logo]()
$816
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/185:45 pm -
2 stops21h 29m
Sat 10/319:30 am -
2 stops23h 51m
Deal found 10/7![United Airlines logo]()
$863
Last-minute flights from Buffalo to PanamaDiscover last-minute flight deals from Buffalo to Panama. Data last updated October 10, 2026 and is based on user searches.
Discover last-minute flight deals from Buffalo to Panama. Data last updated October 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop7h 59m
Wed 10/142:24 pm -
1 stop8h 35m
Deal found 10/6![Delta logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/810:10 am -
2 stops10h 21m
Tue 10/133:30 pm -
2 stops20h 41m
Deal found 10/7![United Airlines logo]()
$742
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:30 am -
1 stop14h 01m
Fri 10/169:45 am -
1 stop12h 26m
Deal found 10/5![United Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:10 am -
2 stops10h 21m
Tue 10/139:45 am -
2 stops13h 05m
Deal found 10/5![United Airlines logo]()
$756
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/185:45 pm -
2 stops21h 29m
Thu 10/299:30 am -
1 stop12h 29m
Deal found 10/7![United Airlines logo]()
$759
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:30 am -
1 stop14h 01m
Tue 10/279:30 am -
1 stop9h 39m
Deal found 10/9![United Airlines logo]()
$737
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:35 pm -
2 stops18h 27m
Wed 10/282:02 pm -
2 stops19h 12m
Deal found 10/9![American Airlines logo]()
$747
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:30 am -
1 stop14h 01m
Tue 10/279:30 am -
1 stop12h 29m
Deal found 10/7![United Airlines logo]()
$754
This United Airlines deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1910:51 am -
1 stop9h 11m
Thu 11/2610:00 am -
1 stop24h 08m
Deal found 10/5![United Airlines logo]()
$736
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Fri 11/205:58 pm -
2 stops26h 04m
Fri 11/2710:00 am -
2 stops23h 34m
Deal found 10/6![United Airlines logo]()
$745
One-way flights from Buffalo to PanamaSearch for one-way flight options from Buffalo to Panama. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
Search for one-way flight options from Buffalo to Panama. Find affordable one-way fares based on user searches. Data last updated October 10, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:47 pm -
2 stops19h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![American Airlines logo]()
$291
This BusinessClass deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:52 pm -
2 stops17h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![GOL logo]()
$395
This Expedia deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:02 pm -
2 stops33h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/47:41 pm -
3 stops36h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Multiple Airlines logo]()
$439
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:00 am -
1 stop8h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Delta logo]()
$503
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
1 stop7h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Delta logo]()
$994
This Flysmarter deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:30 am -
2 stops14h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![Multiple Airlines logo]()
$2,256
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/48:15 am -
3 stops23h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/9![United Airlines logo]()
$5,229
Find flight deals from Buffalo to Panama
Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated October 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $736 (United Airlines) |
One-way from | $291 (American Airlines) |
Popular in | August |
Cheapest in | June |
Average price | $771 |
Cheapflights Fare Finder
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 1/4
7:52 pm-1:41 pm
2 stops17h 49m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$395
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 11/15
5:02 pm-2:10 am
2 stops33h 08m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$425
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Mon 1/4
7:41 pm-7:49 am
3 stops36h 08m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$439
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 11/15
6:00 am-2:02 pm
1 stop8h 02m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$503
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Thu 11/19
10:51 am-8:02 pm
1 stop9h 11m
Panama City Tocumen Intl
Thu 11/26
10:00 am-10:08 am
1 stop24h 08m
$736
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Fri 11/20
5:58 pm-8:02 pm
2 stops26h 04m
Panama City Tocumen Intl
Fri 11/27
10:00 am-9:34 am
2 stops23h 34m
$745
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 10/18
6:00 am-12:59 pm
1 stop7h 59m
Panama City Tocumen Intl
Wed 10/28
2:24 pm-11:59 pm
1 stop8h 35m
$771
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Sun 10/18
6:00 am-7:31 pm
2 stops14h 31m
Panama City Tocumen Intl
Tue 10/27
9:30 am-10:59 pm
1 stop12h 29m
$776
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Thu 10/22
6:30 am-7:31 pm
1 stop14h 01m
Panama City Tocumen Intl
Sun 10/25
9:30 am-9:21 am
2 stops22h 51m
$776
BuffaloPanama City
BUF Buffalo - PTY Panama City Tocumen Intl
BUFPTY
Buffalo
Tue 10/20
7:00 am-6:37 pm
2 stops12h 37m
Panama City Tocumen Intl
Wed 10/28
7:55 am-10:59 pm
2 stops14h 04m
$816
Showing 1-10 of 16 resultsSorted by cheapest first
Best time to book a flight from Buffalo to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
BUF-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Buffalo to Panama
BUF-PA0
BUF-PTY
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 10, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Crew
8.5
Entertainment
7.8
Overall
7.8
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Buffalo to Panama
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Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Buffalo to Panama by cabin class
Find flights from Buffalo to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Buffalo and Panama flights
Browse other Buffalo and Panama flight options. Last updated on October 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Buffalo to Panama
Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$628 | Average$782 | FlexibilityNo cancel fee | On-timeN/A |