HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Buffalo

$320+ Cheap flights from Panama to Buffalo (BUF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — BUF
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to Buffalo with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to Buffalo

Keep the following information in mind while searching for Panama to Buffalo flight deals. Data was last updated July 1, 2025.

Round-trip from

$535
(Delta)

One-way from

$320
(American Airlines)

Popular in

October

Cheapest in

June

Average price

$480
From Panama to Buffalo
Search Deals
One-way flight from Panama to Buffalo
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($172 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 17% potential price decrease ($90 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Panama to Buffalo

Cheapest flights from Panama to Buffalo
Explore the most affordable flight options available from Panama to Buffalo. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/122:05 pmPTY - BUF
1 stop8h 52mDelta
Thu 9/46:00 amBUF - PTY
1 stop7h 50mDelta
Deal found 6/30$535
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/147:55 amPTY - BUF
2 stops14h 43mUnited Airlines
Wed 9/36:30 amBUF - PTY
2 stops13h 07mUnited Airlines
Deal found 6/29$564
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/163:40 pmPTY - BUF
2 stops29h 26mAmerican Airlines
Sat 9/66:50 pmBUF - PTY
2 stops20h 41mAmerican Airlines
Deal found 6/29$644
This Avianca deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/183:25 amPTY - BUF
2 stops14h 36mMultiple Airlines
Mon 9/88:25 pmBUF - PTY
2 stops13h 30mMultiple Airlines
Deal found 6/30$1,792

Cheapflights Fare Finder

Customize your flight search to find flights from Panama to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Panama to Buffalo that are best for you.

Fly from

Panama

Fly to

Buffalo

Route

Depart

Return

Price

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Tue 8/12

2:05 pm-11:57 pm

1 stop8h 52m

Buffalo

Wed 9/3

6:00 am-12:50 pm

1 stop7h 50m

$535

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 8/14

7:55 am-11:38 pm

2 stops14h 43m

Buffalo

Wed 9/3

6:30 am-6:37 pm

2 stops13h 07m

$564

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/16

3:40 pm-10:06 pm

2 stops29h 26m

Buffalo

Sat 9/6

6:50 pm-2:31 pm

2 stops20h 41m

$644

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 8/18

3:25 am-7:01 pm

2 stops14h 36m

Buffalo

Mon 9/8

8:25 pm-8:55 am

2 stops13h 30m

$1,792

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/16

3:30 pm-11:04 am

2 stops18h 34m

$320

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/16

10:05 pm-7:47 am

3 stops32h 42m

$410

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/16

2:05 pm-11:57 pm

1 stop8h 52m

$485

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/29

Best time to book a flight from Panama to Buffalo

Have a flexible travel schedule? Discover the best time to fly to Buffalo from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Buffalo
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Buffalo

Get insights into the airlines that provide service to Buffalo. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Buffalo. Reviews last updated July 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Panama to Buffalo to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
United Airlines
7.4
Good
8,858 reviews
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Boarding

8.2

Food

7.3

Crew

8.5

Entertainment

7.9

Overall

8.0

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Lucy,Nov 2023

ATL - JFK

On time flights; courteous staff; efficient boarding system! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Panama to Buffalo. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Buffalo from Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly into when you book flights from Panama to Buffalo.

  • Can I find deals for flights from Panama to Buffalo that include hotel bookings?

    Yes. In addition to deals on Panama to Buffalo flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Buffalo?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Buffalo.

  • Can I find deals for business class flights from Panama to Buffalo?

    Yes. Cheapflights offers flight deals from Panama to Buffalo by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Buffalo?

    Currently, January is the cheapest month in which you can book a flight from Panama to Buffalo (average of $256). Flying from Panama to Buffalo in December is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama?

Book flights to Panama if you plan to visit one of these locations
Williamsville
Orchard Park
Batavia
Eden
Amherst
West Seneca

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to Buffalo

See prices for flight routes from nearby airports that may be better suited for you.
San José to Newark flights
San José to John F Kennedy Intl flights
Guatemala City to Newark flights
San José to LaGuardia flights
Guatemala City to John F Kennedy Intl flights
Panama City to John F Kennedy Intl flights
San Salvador to John F Kennedy Intl flights
San Salvador to Newark flights
Guatemala City to LaGuardia flights
Panama City to Newark flights
San Salvador to LaGuardia flights
San Pedro Sula to John F Kennedy Intl flights
Panama City to LaGuardia flights
San Pedro Sula to Newark flights
San Pedro Sula to LaGuardia flights
Liberia to Newark flights
Philip S.W.Goldson to LaGuardia flights
Philip S.W.Goldson to John F Kennedy Intl flights
Liberia to John F Kennedy Intl flights
Philip S.W.Goldson to Newark flights
Liberia to LaGuardia flights
Managua to John F Kennedy Intl flights
Guatemala City to Buffalo flights
San José to Rochester flights
Managua to Newark flights
Managua to LaGuardia flights
Panama City to Buffalo flights
Panama City to Rochester flights
San José to Buffalo flights
Guatemala City to Albany flights
Guatemala City to Stewart flights
San José to Albany flights
San José to White Plains flights
Coxen Hole to Newark flights
San José to Syracuse flights
Panama City to Syracuse flights
Guatemala City to Islip flights
Tegucigalpa to LaGuardia flights
Guatemala City to Rochester flights
Liberia to Islip flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.