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$126+ Cheap flights from Des Moines to Memphis (DSM - MEM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MEM
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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Find flight deals from Des Moines to Memphis

Cheapest flights from Des Moines to Memphis
Explore the most affordable flight options available from Des Moines to Memphis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:18 pmDSM - MEM
1 stop5h 37mAmerican Airlines
Wed 12/174:40 pmMEM - DSM
1 stop7h 08mAmerican Airlines
Deal found 10/26$250
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:34 amDSM - MEM
1 stop6h 08mDelta
Thu 12/187:00 amMEM - DSM
1 stop6h 31mDelta
Deal found 10/27$251
This Mytrip deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - MEM
2 stops11h 20mMultiple Airlines
Fri 11/1412:23 pmMEM - DSM
1 stop10h 17mMultiple Airlines
Deal found 10/26$299
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1112:15 pmDSM - MEM
1 stop6h 42mAmerican Airlines
Thu 12/187:05 amMEM - DSM
2 stops8h 19mAmerican Airlines
Deal found 10/27$303
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/127:28 pmDSM - MEM
1 stop19h 26mMultiple Airlines
Fri 12/199:17 pmMEM - DSM
2 stops22h 27mMultiple Airlines
Deal found 10/28$311
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:00 amDSM - MEM
2 stops37h 27mMultiple Airlines
Thu 12/188:40 pmMEM - DSM
1 stop21h 51mMultiple Airlines
Deal found 10/27$316
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:34 amDSM - MEM
1 stop6h 08mDelta
Fri 12/195:55 amMEM - DSM
1 stop4h 26mDelta
Deal found 10/28$327
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:32 pmDSM - MEM
2 stops8h 27mAmerican Airlines
Sun 11/235:24 pmMEM - DSM
1 stop5h 29mAmerican Airlines
Deal found 10/27$328
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:32 pmDSM - MEM
1 stop4h 32mDelta
Sun 11/236:00 amMEM - DSM
1 stop4h 42mDelta
Deal found 10/27$347

Cheap flight deals from Des Moines to Memphis

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Memphis (MEM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$250
(American Airlines)

One-way from

$126
(Delta)

Popular in

March

Cheapest in

June

Average price

$389
Provider with most accurate pricing for Des Moines-Memphis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Memphis flights.
Search Deals
From Des Moines to Memphis
Search Deals
One-way flight from Des Moines to Memphis
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($97 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($40 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Memphis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Memphis that are best for you.

Fly from

Des Moines

Fly to

Memphis

Route

Depart

Return

Price

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Wed 12/10

3:18 pm-8:55 pm

1 stop5h 37m

Memphis

Wed 12/17

4:40 pm-11:48 pm

1 stop7h 08m

$250

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 12/12

7:28 pm-2:54 pm

1 stop19h 26m

Memphis

Fri 12/19

3:01 pm-2:42 pm

1 stop23h 41m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 11/10

8:40 am-8:00 pm

2 stops11h 20m

Memphis

Fri 11/14

12:23 pm-10:40 pm

1 stop10h 17m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Sat 11/22

11:30 am-4:31 pm

1 stop5h 01m

Memphis

Sun 11/23

6:06 am-12:24 pm

1 stop6h 18m

$299

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/11

12:15 pm-6:57 pm

1 stop6h 42m

Memphis

Thu 12/18

7:05 am-3:24 pm

2 stops8h 19m

$303

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Thu 12/11

7:00 am-8:27 pm

2 stops37h 27m

Memphis

Thu 12/18

8:40 pm-6:31 pm

1 stop21h 51m

$316

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Mon 4/20

5:15 pm-9:42 pm

1 stop4h 27m

Memphis

Fri 4/24

3:35 pm-10:24 pm

1 stop6h 49m

$327

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 12/12

5:34 am-11:42 am

1 stop6h 08m

Memphis

Fri 12/19

5:55 am-10:21 am

1 stop4h 26m

$327

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Fri 11/21

6:32 pm-11:04 pm

1 stop4h 32m

Memphis

Sun 11/23

6:00 am-10:42 am

1 stop4h 42m

$347

Des MoinesMemphis

DSM - MEM

DSMMEM

Des Moines

Tue 11/18

5:35 am-11:43 am

1 stop6h 08m

$126

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 11 results
1
2

Compare providers for flights from Des Moines to Memphis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Memphis in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Memphis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Memphis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Memphis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Memphis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Memphis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Memphis

Have a flexible travel schedule? Discover the best time to fly to Memphis from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Memphis

Get insights into the airlines that provide service to Memphis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Memphis. Reviews last updated October 28, 2025.
See what other customers who have flown with Delta and American Airlines from Des Moines to Memphis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,994 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,994 reviews

Overall

7.9

Food

7.3

Entertainment

7.9

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Memphis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Memphis?

    American Airlines can get you from Des Moines to Memphis in just under 5h 37m. Your travel time can differ by up to . Des Moines and Memphis are separated by a distance of 491 mi.

  • What are the cheapest airlines flying from Des Moines to Memphis round-trip?

    Our cheapest airline available from Des Moines to Memphis is American Airlines. Our recent data shows that you can find tickets from as low as $252 on this airline. An additional option worth looking into is Delta, starting at $257. You may be able to fly from Des Moines to Memphis for 42% less than the average price by searching for these airlines.

  • Can I find deals for flights from Des Moines to Memphis that include hotel bookings?

    Yes. In addition to deals on Des Moines to Memphis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Memphis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Memphis.

  • Can I find deals for business class flights from Des Moines to Memphis?

    Yes. Cheapflights offers flight deals from Des Moines to Memphis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Memphis?

Book flights to Memphis if you plan to visit one of these locations
Batesville
Southaven
West Memphis
Forrest City
Marion
Germantown
Horn Lake

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Top 2 airlines flying from Des Moines to Memphis

Discover the top 2 airlines that operate flights from Des Moines to Memphis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$252Average$341FlexibilityNo cancel feeOn-time71%
DeltaCheapest$257Average$426FlexibilityNo cancel feeOn-timeN/A

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