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$40+ Cheap flights from South Carolina to Louisville (SDF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SDF
Mar 17 — Mar 241
Tue 3/17
Tue 3/24
1 adult, Economy
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Cheap flight deals from South Carolina to Louisville

Cheapest flights from South Carolina to Louisville
Explore the most affordable flight options available from South Carolina to Louisville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:11 pm
CHS
-
SDF
1 stop13h 44m
Breeze Airways
Mon 9/78:28 pm
SDF
-
CHS
Nonstop1h 38m
Breeze Airways
Deal found 2/15$190
This Kiwi.com deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:55 am
CLT
-
SDF
1 stop10h 03m
Multiple Airlines
Mon 4/207:48 pm
SDF
-
CLT
1 stop14h 29m
Multiple Airlines
Deal found 2/13$197
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:00 am
CHS
-
SDF
Nonstop1h 46m
Breeze Airways
Sun 5/176:55 pm
SDF
-
CHS
1 stop22h 26m
Breeze Airways
Deal found 2/12$203
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/169:00 pm
CLT
-
SDF
1 stop14h 47m
Multiple Airlines
Mon 3/239:13 pm
SDF
-
CLT
1 stop17h 04m
Multiple Airlines
Deal found 2/14$226
This CheapOair deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:17 pm
CLT
-
SDF
1 stop16h 24m
Spirit Airlines
Sun 4/193:33 pm
SDF
-
CLT
1 stop18h 44m
Spirit Airlines
Deal found 2/12$236
This CheapOair deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 am
CLT
-
SDF
1 stop5h 11m
Spirit Airlines
Sun 4/193:33 pm
SDF
-
CLT
1 stop7h 00m
Spirit Airlines
Deal found 2/13$237
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/268:25 pm
CHS
-
SDF
1 stop4h 02m
American Airlines
Mon 3/28:02 pm
SDF
-
CHS
1 stop3h 49m
American Airlines
Deal found 2/12$239
This CheapOair deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:17 pm
CLT
-
SDF
1 stop24h 15m
Spirit Airlines
Mon 5/1812:36 pm
SDF
-
CLT
1 stop11h 11m
Spirit Airlines
Deal found 2/14$239
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:49 pm
CLT
-
SDF
1 stop18h 32m
Spirit Airlines
Sat 3/712:00 pm
SDF
-
CLT
1 stop6h 18m
Spirit Airlines
Deal found 2/11$246
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2411:05 am
CLT
-
SDF
1 stop5h 45m
Southwest
Sat 2/285:10 am
SDF
-
CLT
1 stop5h 00m
Southwest
Deal found 2/11$247
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:13 pm
CAE
-
SDF
1 stop3h 30m
Delta
Fri 3/205:35 pm
SDF
-
CAE
1 stop3h 45m
Delta
Deal found 2/13$249
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 am
CLT
-
SDF
1 stop5h 11m
Spirit Airlines
Sun 4/263:33 pm
SDF
-
CLT
1 stop7h 00m
Spirit Airlines
Deal found 2/14$250

Find flight deals from South Carolina to Louisville

Keep the following information in mind while searching for South Carolina to Louisville flight deals. Data was last updated February 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$197
(Kiwi.com)

One-way from

$40
(Booking.com)

Popular in

March

Cheapest in

May

Average price

$256
Provider with most accurate pricing for Myrtle Beach Intl-Louisville Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Louisville Intl flights.
Search Deals
From South Carolina to Louisville Intl
Search Deals
One-way flight from South Carolina to Louisville Intl
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($59 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from South Carolina to Louisville that are best for you.

Fly from

South Carolina

Fly to

Louisville

Route

Depart

Return

Price

Myrtle BeachLouisville

MYR - SDF

MYRSDF

Myrtle Beach Intl

Thu 3/5

9:09 am-8:40 am

1 stop23h 31m

Louisville Intl

Thu 3/12

3:33 pm-5:33 pm

1 stop26h 00m

$239

CharlestonLouisville

CHS - SDF

CHSSDF

Charleston

Fri 2/27

5:27 am-9:28 am

1 stop4h 01m

Louisville Intl

Tue 3/3

10:46 am-5:38 pm

1 stop6h 52m

$239

CharlestonLouisville

CHS - SDF

CHSSDF

Charleston

Thu 2/26

8:25 pm-12:27 am

1 stop4h 02m

Louisville Intl

Mon 3/2

8:02 pm-11:51 pm

1 stop3h 49m

$239

CharlestonLouisville

CHS - SDF

CHSSDF

Charleston

Thu 3/5

5:10 am-9:02 am

1 stop3h 52m

Louisville Intl

Mon 3/9

6:33 am-11:34 am

1 stop5h 01m

$239

CharlestonLouisville

CHS - SDF

CHSSDF

Charleston

Fri 3/6

7:00 pm-10:57 pm

1 stop3h 57m

Louisville Intl

Mon 3/9

5:35 pm-10:31 pm

1 stop4h 56m

$239

CharlotteLouisville

CLT - SDF

CLTSDF

Charlotte Douglas

Tue 2/24

11:05 am-4:50 pm

1 stop5h 45m

Louisville Intl

Sat 2/28

5:10 am-10:10 am

1 stop5h 00m

$247

ColumbiaLouisville

CAE - SDF

CAESDF

Columbia Metropolitan

Wed 6/17

2:29 pm-10:30 pm

1 stop8h 01m

Louisville Intl

Sun 6/21

6:00 am-9:54 am

1 stop3h 54m

$249

ColumbiaLouisville

CAE - SDF

CAESDF

Columbia Metropolitan

Sat 3/21

6:15 am-1:17 pm

1 stop7h 02m

Louisville Intl

Wed 3/25

9:00 am-2:56 pm

1 stop5h 56m

$249

ColumbiaLouisville

CAE - SDF

CAESDF

Columbia Metropolitan

Mon 6/8

5:40 am-8:45 am

1 stop3h 05m

Louisville Intl

Thu 6/18

7:30 pm-11:55 pm

1 stop4h 25m

$249

ColumbiaLouisville

CAE - SDF

CAESDF

Columbia Metropolitan

Mon 3/23

8:11 pm-12:27 am

1 stop4h 16m

Louisville Intl

Sat 3/28

3:49 pm-9:21 pm

1 stop5h 32m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/13

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Louisville

Have a flexible travel schedule? Discover the best time to fly to Louisville from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Louisville

What is the cheapest month to book a flight from South Carolina to Louisville?

Currently, May is the cheapest month in which you can book a flight from South Carolina to Louisville (average of $31). Flying from South Carolina to Louisville in January is currently the most expensive (average of $105). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SDF?

Find hourly flight availability from South Carolina to Louisville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 15, 2026.

It’s optimal to fly from South Carolina to Louisville at noon. By choosing this option you can save up to 69% on the cost of your flight, compared to a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Louisville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Louisville from South Carolina?

    Louisville Intl (SDF) is the airport you will fly into if you book a flight from South Carolina to Louisville. It is only a 5.3 mi journey from Louisville Intl (SDF) to Louisville’s city center.

  • How popular is this South Carolina to Louisville flight route?

    Within the past month, 1 users have taken a look at flights from South Carolina to Louisville Intl.

  • How long is the flight from South Carolina to Louisville?

    A quick flight from South Carolina to Louisville can take about 4h 01m. Delta provides one of the quickest options available for as low as $239. The distance between South Carolina and Louisville is about 485 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to Louisville one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $42. Users have also found prices from $55 and $88 on Breeze Airways and Delta, respectively.

  • What are the most popular routes from South Carolina to Louisville?

    Most travelers choose Charlotte Douglas - Louisville Intl, Savannah/Hilton Head - Louisville Intl or Columbia Metropolitan - Louisville Intl when deciding on the best route from South Carolina to Louisville.

  • Can I find deals for flights from South Carolina to Louisville that include hotel bookings?

    Yes. In addition to deals on South Carolina to Louisville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Louisville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Louisville.

  • Can I find deals for business class flights from South Carolina to Louisville?

    Yes. Cheapflights offers flight deals from South Carolina to Louisville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Louisville?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to Louisville (average of $31). Flying from South Carolina to Louisville in January is currently the most expensive (average of $105). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
Shepherdsville
Jeffersonville
Elizabethtown
Corydon
Bardstown

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Top 3 airlines flying from South Carolina to Louisville

Discover the top 3 airlines that operate flights from South Carolina to Louisville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$49Average$132FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$125Average$350FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$321FlexibilityNo cancel feeOn-time71%

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