$418+ Cheap flights from South Carolina to La Crosse (LSE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — LSE
Aug 23 — Aug 301
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from South Carolina to La Crosse with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from South Carolina to La Crosse
Keep the following information in mind while searching for South Carolina to La Crosse flight deals. Data was last updated August 18, 2025.
Round-trip from | $418 (American Airlines) |
|---|
Find flight deals from South Carolina to La Crosse
Cheapest flights from South Carolina to La CrosseExplore the most affordable flight options available from South Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.
Explore the most affordable flight options available from South Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 18, 2025.
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/175:50 pmCLT - LSE
1 stop5h 14mAmerican Airlines
Wed 10/19:50 amLSE - CLT
1 stop4h 48mAmerican Airlines
Deal found 8/18![American Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/172:47 pmCLT - LSE
1 stop4h 04mAmerican Airlines
Sun 9/216:39 pmLSE - CLT
1 stop4h 16mAmerican Airlines
Deal found 8/18![American Airlines logo]()
$451
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/97:45 pmCHS - LSE
1 stop4h 41mAmerican Airlines
Sun 10/196:15 pmLSE - CHS
1 stop5h 00mAmerican Airlines
Deal found 8/17![American Airlines logo]()
$464
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/64:30 pmCLT - LSE
1 stop6h 15mAmerican Airlines
Tue 12/92:48 pmLSE - CLT
1 stop6h 01mAmerican Airlines
Deal found 8/16![American Airlines logo]()
$488
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/164:17 pmCLT - LSE
1 stop6h 51mAmerican Airlines
Wed 10/16:21 pmLSE - CLT
1 stop4h 32mAmerican Airlines
Deal found 8/18![American Airlines logo]()
$495
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/21:01 pmCLT - LSE
1 stop6h 01mAmerican Airlines
Sat 9/610:09 amLSE - CLT
1 stop4h 29mAmerican Airlines
Deal found 8/18![American Airlines logo]()
$637
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from South Carolina to La Crosse that are best for you.
Fly from
South Carolina
Fly to
La Crosse
Route
Depart
Return
Price
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
Wed 9/17
5:50 pm-10:04 pm
1 stop5h 14m
La Crosse
Wed 10/1
9:50 am-3:38 pm
1 stop4h 48m
$418
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
Wed 9/17
2:47 pm-5:51 pm
1 stop4h 04m
La Crosse
Sun 9/21
6:39 pm-11:55 pm
1 stop4h 16m
$451
CharlestonLa Crosse
CHS - LSE
CHSLSE
Charleston
Thu 10/9
7:45 pm-11:26 pm
1 stop4h 41m
La Crosse
Sun 10/19
6:15 pm-12:15 am
1 stop5h 00m
$464
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
Sat 12/6
4:30 pm-9:45 pm
1 stop6h 15m
La Crosse
Tue 12/9
5:58 am-11:08 am
1 stop4h 10m
$488
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
Tue 9/16
4:17 pm-10:08 pm
1 stop6h 51m
La Crosse
Wed 10/1
6:21 pm-11:53 pm
1 stop4h 32m
$495
Best time to book a flight from South Carolina to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to La Crosse
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from South Carolina to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsDecorah
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for South Carolina to La Crosse
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from South Carolina to La Crosse
Discover the top airline that operate flights from South Carolina to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 18, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$520 | Average$597 | FlexibilityNo cancel fee | On-time71% |