$445+ Cheap flights from South Carolina to La Crosse (LSE)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — LSE
ene. 11 — ene. 181
1 adult, Economy
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Cheapest flights from South Carolina to La CrosseExplore the most affordable flight options available from South Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.
Explore the most affordable flight options available from South Carolina to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 12, 2025.
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/259:00 amCHS - LSE
1 stop5h 13mAmerican Airlines
jue. 1/16:00 amLSE - CHS
1 stop4h 55mAmerican Airlines
Deal found 12/10![American Airlines logo]()
$514
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/259:00 amCHS - LSE
1 stop5h 13mAmerican Airlines
lun. 12/296:00 amLSE - CHS
1 stop4h 55mAmerican Airlines
Deal found 12/11![American Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/259:00 amCHS - LSE
1 stop5h 13mAmerican Airlines
mar. 12/306:00 amLSE - CHS
1 stop4h 55mAmerican Airlines
Deal found 12/11![American Airlines logo]()
$698
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:10 amCHS - LSE
2 stops9h 03mAmerican Airlines
mar. 12/306:00 amLSE - CHS
1 stop4h 55mAmerican Airlines
Deal found 12/11![American Airlines logo]()
$704
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 12/1411:30 amCLT - LSE
1 stop7h 08mAmerican Airlines
mar. 12/166:00 amLSE - CLT
1 stop4h 29mAmerican Airlines
Deal found 12/10![American Airlines logo]()
$913
Find flight deals from South Carolina to La Crosse
Keep the following information in mind while searching for South Carolina to La Crosse flight deals. Data was last updated diciembre 12, 2025.
Round-trip from | $445 (American Airlines) |
|---|
Cheapflights Fare Finder
Customize your flight search to find flights from South Carolina to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
Use the filters below to find and compare flights from South Carolina to La Crosse that are best for you.
Fly from
South Carolina
Fly to
La Crosse
Route
Depart
Return
Price
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
jue. 1/1
1:03 pm-7:36 pm
1 stop7h 33m
La Crosse
mar. 1/6
6:00 am-11:16 am
1 stop4h 16m
$445
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
sáb. 1/3
6:00 pm-11:38 pm
1 stop6h 38m
La Crosse
mar. 1/6
6:00 am-1:10 pm
1 stop6h 10m
$472
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
jue. 4/23
7:43 am-10:56 am
1 stop4h 13m
La Crosse
dom. 4/26
6:13 am-11:31 am
1 stop4h 18m
$484
CharlestonLa Crosse
CHS - LSE
CHSLSE
Charleston
jue. 12/25
9:00 am-1:13 pm
1 stop5h 13m
La Crosse
jue. 1/1
6:00 am-11:55 am
1 stop4h 55m
$514
CharlotteLa Crosse
CLT - LSE
CLTLSE
Charlotte Douglas
vie. 1/2
2:52 pm-7:36 pm
1 stop5h 44m
La Crosse
mar. 1/6
6:00 am-1:10 pm
1 stop6h 10m
$550
SavannahLa Crosse
SAV - LSE
SAVLSE
Savannah/Hilton Head
vie. 1/9
3:45 pm-10:16 pm
1 stop7h 31m
La Crosse
dom. 1/11
6:00 am-2:10 pm
2 stops7h 10m
$606
CharlestonLa Crosse
CHS - LSE
CHSLSE
Charleston
jue. 12/25
6:44 am-1:13 pm
2 stops7h 29m
La Crosse
lun. 12/29
6:00 am-11:55 am
1 stop4h 55m
$643
CharlestonLa Crosse
CHS - LSE
CHSLSE
Charleston
jue. 12/25
9:00 am-1:13 pm
1 stop5h 13m
La Crosse
mar. 12/30
6:00 am-11:55 am
1 stop4h 55m
$698
CharlestonLa Crosse
CHS - LSE
CHSLSE
Charleston
mié. 12/24
5:10 am-1:13 pm
2 stops9h 03m
La Crosse
mar. 12/30
6:00 am-11:55 am
1 stop4h 55m
$704
Best time to book a flight from South Carolina to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from South Carolina to La Crosse
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Related info for your journey
Find useful and relevant information for your journey from South Carolina to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsWinona
Decorah
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Alternative routes for South Carolina to La Crosse
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from South Carolina to La Crosse
Discover the top airline that operate flights from South Carolina to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$507 | Average$618 | FlexibilityNo cancel fee | On-time71% |