HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$315+ Cheap flights from McAllen to Knoxville (MFE - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from McAllen to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from McAllen to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$395
(Delta)

One-way from

$315
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$508
From McAllen Miller Intl to Knoxville McGhee Tyson
Search Deals
One-way flight from McAllen Miller Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($114 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from McAllen to Knoxville

Cheapest flights from McAllen to Knoxville
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/612:31 pmMFE - TYS
2 stops10h 15mDelta
Mon 10/135:44 amTYS - MFE
2 stops7h 07mDelta
Deal found 9/10$529
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/65:27 amMFE - TYS
1 stop7h 09mAmerican Airlines
Mon 10/136:00 amTYS - MFE
1 stop4h 51mAmerican Airlines
Deal found 9/10$540

Cheapflights Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

McAllen

Fly to

Knoxville

Route

Depart

Return

Price

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 3/3

1:00 pm-11:44 pm

2 stops9h 44m

Knoxville McGhee Tyson

Sat 3/7

10:05 am-4:55 pm

2 stops7h 50m

$395

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 3/3

5:47 am-2:05 pm

1 stop7h 18m

Knoxville McGhee Tyson

Sat 3/7

4:33 pm-8:27 pm

1 stop4h 54m

$457

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 10/6

12:31 pm-11:46 pm

2 stops10h 15m

Knoxville McGhee Tyson

Mon 10/13

5:44 am-11:51 am

2 stops7h 07m

$529

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Mon 10/6

5:27 am-1:36 pm

1 stop7h 09m

Knoxville McGhee Tyson

Mon 10/13

6:00 am-9:51 am

1 stop4h 51m

$540

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 10/11

3:48 pm-9:50 pm

3 stops29h 02m

$315

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Sat 10/11

5:27 am-1:24 pm

1 stop6h 57m

$520

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Best time to book a flight from McAllen to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Food

6.4

Comfort

7.2

Entertainment

6.9

Overall

7.2

Crew

8.0

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Food

6.4

Comfort

7.2

Entertainment

6.9

Overall

7.2

Crew

8.0

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from McAllen to Knoxville?

    Departing from McAllen to Knoxville will take you 7h 18m. McAllen and Knoxville are separated by a distance of 1072 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from McAllen to Knoxville round-trip?

    American Airlines, at $242, was found to be the cheapest airline from McAllen to Knoxville.. You may be able to fly from McAllen to Knoxville for 39% less than the average price by searching for this airline.

  • Can I find deals for flights from McAllen to Knoxville that include hotel bookings?

    Yes. In addition to deals on McAllen to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from McAllen to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from McAllen to Knoxville.

  • Can I find deals for business class flights from McAllen to Knoxville?

    Yes. Cheapflights offers flight deals from McAllen to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from McAllen to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from McAllen to Knoxville (average of $294). Flying from McAllen to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Alcoa
Oak Ridge
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for McAllen to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Hobby to Nashville flights
Dallas/Fort Worth to Nashville flights
George Bush Intcntl to Nashville flights
Dallas/Fort Worth to Knoxville flights
Dallas/Fort Worth to Memphis flights
Love Field to Nashville flights
George Bush Intcntl to Knoxville flights
Austin to Nashville flights
Hobby to Knoxville flights
Love Field to Memphis flights
San Antonio to Nashville flights
Austin to Memphis flights
Hobby to Memphis flights
George Bush Intcntl to Memphis flights
Dallas/Fort Worth to Chattanooga flights
Austin to Knoxville flights
Austin to Chattanooga flights
Hobby to Chattanooga flights
Love Field to Knoxville flights
San Antonio to Memphis flights
El Paso to Nashville flights
Hobby to Blountville flights
George Bush Intcntl to Chattanooga flights
Dallas/Fort Worth to Blountville flights
George Bush Intcntl to Blountville flights
Love Field to Chattanooga flights
San Antonio to Knoxville flights
Amarillo to Knoxville flights
Corpus Christi to Nashville flights
Corpus Christi to Knoxville flights
McAllen to Nashville flights
El Paso to Knoxville flights
Austin to Blountville flights
Lubbock to Nashville flights
Harlingen to Nashville flights
Midland to Knoxville flights
Killeen to Nashville flights
Love Field to Blountville flights
San Antonio to Chattanooga flights
Midland to Nashville flights
San Antonio to Blountville flights
Waco to Nashville flights
Laredo to Nashville flights
Amarillo to Nashville flights
Corpus Christi to Memphis flights
Brownsville to Nashville flights
Texarkana to Chattanooga flights
College Station to Nashville flights
Longview to Knoxville flights

Top airline flying from McAllen to Knoxville

Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$242Average$371FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2025 Cheapflights