$170+ Cheap flights from McAllen to Knoxville (MFE - TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
Apr 9 — Apr 161
Round-trip
1 adult, Economy
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Find cheap flights from McAllen to Knoxville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from McAllen to Knoxville
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Best
Last-minute
One-way
Cheapest flights from McAllen to KnoxvilleExplore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 pm
MFE
- TYS
1 stop26h 24m
Allegiant Air
Sun 5/38:20 am
TYS
- MFE
1 stop10h 20m
Allegiant Air
Deal found 3/6![Allegiant Air logo]()
$325
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Tue 3/245:05 am
TYS
- MFE
1 stop6h 10m
American Airlines
Deal found 3/5![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:00 am
MFE
- TYS
1 stop5h 17m
United Airlines
Wed 8/267:15 am
TYS
- MFE
1 stop7h 06m
United Airlines
Deal found 3/8![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:00 am
MFE
- TYS
1 stop7h 02m
American Airlines
Wed 6/35:36 am
TYS
- MFE
1 stop5h 23m
American Airlines
Deal found 3/9![American Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/311:00 am
MFE
- TYS
1 stop5h 31m
American Airlines
Mon 4/65:40 am
TYS
- MFE
1 stop5h 35m
American Airlines
Deal found 3/10![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/253:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Sun 3/295:40 am
TYS
- MFE
1 stop5h 35m
American Airlines
Deal found 3/9![American Airlines logo]()
$434
Best flights from McAllen to KnoxvilleDiscover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
Discover carefully curated flight deals from McAllen to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 10, 2026.
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:00 am
MFE
- TYS
1 stop5h 17m
United Airlines
Wed 8/267:15 am
TYS
- MFE
1 stop7h 06m
United Airlines
Deal found 3/7![United Airlines logo]()
$371
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Tue 3/248:50 am
TYS
- MFE
2 stops10h 35m
American Airlines
Deal found 3/5![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/311:00 am
MFE
- TYS
1 stop5h 31m
American Airlines
Mon 4/64:15 pm
TYS
- MFE
2 stops8h 53m
American Airlines
Deal found 3/10![American Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:00 am
MFE
- TYS
2 stops10h 51m
United Airlines
Wed 6/36:30 am
TYS
- MFE
2 stops10h 29m
United Airlines
Deal found 3/9![United Airlines logo]()
$471
Last-minute flights from McAllen to KnoxvilleDiscover last-minute flight deals from McAllen to Knoxville. Data last updated March 10, 2026 and is based on user searches.
Discover last-minute flight deals from McAllen to Knoxville. Data last updated March 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Tue 3/245:05 am
TYS
- MFE
1 stop6h 10m
American Airlines
Deal found 3/5![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/203:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Sun 3/225:40 am
TYS
- MFE
1 stop5h 35m
American Airlines
Deal found 3/5![American Airlines logo]()
$476
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:20 pm
MFE
- TYS
2 stops9h 37m
Delta
Tue 3/2411:18 am
TYS
- MFE
2 stops13h 41m
Delta
Deal found 3/5![Delta logo]()
$514
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/253:48 pm
MFE
- TYS
1 stop7h 03m
American Airlines
Sun 3/295:40 am
TYS
- MFE
1 stop5h 35m
American Airlines
Deal found 3/9![American Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/311:00 am
MFE
- TYS
1 stop5h 31m
American Airlines
Mon 4/65:40 am
TYS
- MFE
1 stop5h 35m
American Airlines
Deal found 3/10![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:45 pm
MFE
- TYS
1 stop7h 11m
American Airlines
Mon 4/271:20 pm
TYS
- MFE
1 stop6h 32m
American Airlines
Deal found 3/6![American Airlines logo]()
$535
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/307:00 pm
MFE
- TYS
1 stop26h 24m
Allegiant Air
Sun 5/38:20 am
TYS
- MFE
1 stop10h 20m
Allegiant Air
Deal found 3/6![Allegiant Air logo]()
$325
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 pm
MFE
- TYS
1 stop4h 56m
American Airlines
Sun 5/36:00 am
TYS
- MFE
1 stop5h 02m
American Airlines
Deal found 3/6![American Airlines logo]()
$539
One-way flights from McAllen to KnoxvilleSearch for one-way flight options from McAllen to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
Search for one-way flight options from McAllen to Knoxville. Find affordable one-way fares based on user searches. Data last updated March 10, 2026.
This United Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
MFE
- TYS
1 stop5h 49m
United Airlines
Deal found 3/6![United Airlines logo]()
$170
This Delta deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/111:20 pm
MFE
- TYS
2 stops9h 37m
Delta
Deal found 3/6![Delta logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:11 pm
MFE
- TYS
1 stop24h 36m
Allegiant Air
Deal found 3/9![Allegiant Air logo]()
$231
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:37 am
MFE
- TYS
1 stop6h 54m
American Airlines
Deal found 3/9![American Airlines logo]()
$268
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:11 pm
MFE
- TYS
3 stops38h 01m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2312:13 pm
MFE
- TYS
3 stops45h 27m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/231:20 pm
MFE
- TYS
2 stops9h 37m
Delta
Deal found 3/9![Delta logo]()
$335
Find flight deals from McAllen to Knoxville
Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (Kiwi.com) |
One-way from | $170 (United Airlines) |
Popular in | January |
Cheapest in | April |
Average price | $612 |
Cheapflights Fare Finder
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 8/22
5:00 am-11:17 am
1 stop5h 17m
Knoxville McGhee Tyson
Wed 8/26
7:15 am-1:21 pm
1 stop7h 06m
$371
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Fri 3/20
3:48 pm-11:51 pm
1 stop7h 03m
Knoxville McGhee Tyson
Tue 3/24
8:50 am-6:25 pm
2 stops10h 35m
$446
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Fri 4/3
11:00 am-5:31 pm
1 stop5h 31m
Knoxville McGhee Tyson
Mon 4/6
4:15 pm-12:08 am
2 stops8h 53m
$464
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 5/30
5:00 am-4:51 pm
2 stops10h 51m
Knoxville McGhee Tyson
Wed 6/3
6:30 am-3:59 pm
2 stops10h 29m
$471
Cheapest one-way
Quickest one-way
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 4/11
7:00 am-1:49 pm
1 stop5h 49m
$170
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sat 4/11
1:20 pm-11:57 pm
2 stops9h 37m
$205
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sun 3/22
8:11 pm-9:47 pm
1 stop24h 36m
$231
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Mon 3/23
9:37 am-5:31 pm
1 stop6h 54m
$268
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Sun 3/22
8:11 pm-11:12 am
3 stops38h 01m
$273
McAllenKnoxville
MFE - TYS
MFETYS
McAllen Miller Intl
Mon 3/23
1:20 pm-11:57 pm
2 stops9h 37m
$335
Sorted by cheapest first
Compare providers for flights from McAllen to Knoxville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from McAllen to Knoxville in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on McAllen-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on McAllen-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from McAllen-Knoxville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on McAllen-Knoxville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for McAllen-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from McAllen to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
MFE-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated March 10, 2026.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Entertainment
6.9
Food
6.4
Boarding
7.5
Comfort
7.2
Overall
7.1
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Crew
7.9
Entertainment
6.9
Food
6.4
Boarding
7.5
Comfort
7.2
Overall
7.1
Reviews
1 / 20
6.0
Goodsheila,Mar 2025
DFW - MSP
Related info for your journey
Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Murphy
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Explore flights to Knoxville departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 10, 2026.
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Top airline flying from McAllen to Knoxville
Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$252 | Average$449 | FlexibilityNo cancel fee | On-time71% |