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$275+ Cheap flights from McAllen to Knoxville (MFE - TYS)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
MFE — TYS
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from McAllen to Knoxville

Cheapest flights from McAllen to Knoxville
Explore the most affordable flight options available from McAllen to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/293:45 pm
MFE
-
TYS
1 stop7h 11m
American Airlines
Thu 5/74:09 pm
TYS
-
MFE
1 stop7h 36m
American Airlines
Deal found 1/25$275
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/105:25 pm
MFE
-
TYS
1 stop5h 19m
United Airlines
Sat 2/1411:41 am
TYS
-
MFE
1 stop5h 33m
United Airlines
Deal found 1/26$309
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/101:03 pm
MFE
-
TYS
2 stops9h 56m
American Airlines
Sat 2/145:40 am
TYS
-
MFE
1 stop5h 35m
American Airlines
Deal found 1/26$314
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/105:25 am
MFE
-
TYS
2 stops7h 25m
Delta
Sat 2/145:35 am
TYS
-
MFE
2 stops7h 48m
Delta
Deal found 1/26$320
This United Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/39:30 am
MFE
-
TYS
1 stop7h 35m
United Airlines
Sat 2/74:55 pm
TYS
-
MFE
1 stop6h 02m
United Airlines
Deal found 1/24$426
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:00 am
MFE
-
TYS
1 stop5h 49m
United Airlines
Thu 4/309:00 am
TYS
-
MFE
1 stop14h 59m
United Airlines
Deal found 1/25$485

Find flight deals from McAllen to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from McAllen (MFE) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$275
(American Airlines)

Popular in

January

Cheapest in

April

Average price

$763
Provider with most accurate pricing for McAllen Miller Intl-Knoxville McGhee Tyson flight deals.
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Provider most trusted by Cheapflights users for McAllen Miller Intl-Knoxville McGhee Tyson flights.
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From McAllen Miller Intl to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from McAllen to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from McAllen to Knoxville that are best for you.

Fly from

McAllen

Fly to

Knoxville

Route

Depart

Return

Price

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 4/29

3:45 pm-11:56 pm

1 stop7h 11m

Knoxville McGhee Tyson

Thu 5/7

4:09 pm-10:45 pm

1 stop7h 36m

$275

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/10

5:25 pm-11:44 pm

1 stop5h 19m

Knoxville McGhee Tyson

Sat 2/14

11:41 am-4:14 pm

1 stop5h 33m

$309

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/10

1:03 pm-11:59 pm

2 stops9h 56m

Knoxville McGhee Tyson

Sat 2/14

5:40 am-10:15 am

1 stop5h 35m

$314

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Tue 2/10

5:25 am-1:50 pm

2 stops7h 25m

Knoxville McGhee Tyson

Sat 2/14

5:35 am-12:23 pm

2 stops7h 48m

$320

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Wed 4/22

7:00 am-1:49 pm

1 stop5h 49m

Knoxville McGhee Tyson

Thu 4/30

9:00 am-10:59 pm

1 stop14h 59m

$485

McAllenKnoxville

MFE - TYS

MFETYS

McAllen Miller Intl

Thu 4/30

3:45 pm-11:56 pm

1 stop7h 11m

Knoxville McGhee Tyson

Sun 5/3

4:09 pm-10:45 pm

1 stop7h 36m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from McAllen to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from McAllen to Knoxville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on McAllen-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on McAllen-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from McAllen-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on McAllen-Knoxville flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for McAllen-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from McAllen to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from McAllen with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated January 26, 2026.
Get a feel of what it's like to fly with American Airlines from McAllen to Knoxville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,189 reviews

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation
American Airlines
7.2
Good
11,189 reviews
American Airlines
7.2
Good
11,189 reviews

Comfort

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Reviews

1 / 20
6.0
Good

sheila,Mar 2025

DFW - MSP

We were delayed for 3 hours with no real reason or offer for compensation

Related info for your journey

Find useful and relevant information for your journey from McAllen to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from McAllen to Knoxville?

    Departing from McAllen to Knoxville will take you 5h 19m. McAllen and Knoxville are separated by a distance of 1072 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from McAllen to Knoxville round-trip?

    American Airlines, at $252, was found to be the cheapest airline from McAllen to Knoxville.. You may be able to fly from McAllen to Knoxville for 47% less than the average price by searching for this airline.

  • Can I find deals for flights from McAllen to Knoxville that include hotel bookings?

    Yes. In addition to deals on McAllen to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from McAllen to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from McAllen to Knoxville.

  • Can I find deals for business class flights from McAllen to Knoxville?

    Yes. Cheapflights offers flight deals from McAllen to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Corbin
Morristown
Bryson City
Alcoa
Oak Ridge
Murphy

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Top airline flying from McAllen to Knoxville

Discover the top airline that operate flights from McAllen to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$252Average$378FlexibilityNo cancel feeOn-time71%

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