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Key West

$129+ Cheap flights from St. Louis to Key West (STL - EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — EYW
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Key West are usually found in August or December, booked 62 days in advance, depart on a Friday or Tuesday and return on a Wednesday

Cheap flight deals from St. Louis to Key West

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$223
(American Airlines)

One-way from

$129
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$388
From Lambert-St Louis to Key West
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One-way flight from Lambert-St Louis to Key West
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Highest demand for flights based on searches. 6% potential increase in price ($27 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to Key West

Cheapest flights from St. Louis to Key West
Explore the most affordable flight options available from St. Louis to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:00 amSTL - EYW
1 stop6h 52mAmerican Airlines
Tue 10/285:47 pmEYW - STL
1 stop7h 09mAmerican Airlines
Deal found 9/10$223
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/31:20 pmSTL - EYW
2 stops8h 47mAmerican Airlines
Sat 12/61:57 pmEYW - STL
2 stops8h 55mAmerican Airlines
Deal found 9/10$233
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:00 amSTL - EYW
1 stop5h 58mAmerican Airlines
Tue 10/147:52 pmEYW - STL
1 stop5h 04mAmerican Airlines
Deal found 9/9$241
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:03 amSTL - EYW
2 stops9h 04mAmerican Airlines
Thu 10/3011:22 amEYW - STL
2 stops10h 29mAmerican Airlines
Deal found 9/9$251
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:36 amSTL - EYW
1 stop4h 45mDelta
Thu 11/136:18 pmEYW - STL
1 stop6h 22mDelta
Deal found 9/9$259
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:47 pmSTL - EYW
1 stop14h 32mMultiple Airlines
Sat 10/2510:47 amEYW - STL
1 stop8h 15mMultiple Airlines
Deal found 9/9$264
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:00 amSTL - EYW
1 stop6h 59mAmerican Airlines
Sat 11/88:00 amEYW - STL
1 stop6h 17mAmerican Airlines
Deal found 9/10$266
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/38:13 amSTL - EYW
2 stops7h 48mAmerican Airlines
Thu 11/138:06 amEYW - STL
2 stops9h 30mAmerican Airlines
Deal found 9/9$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from St. Louis to Key West that are best for you.

Fly from

St. Louis

Fly to

Key West

Route

Depart

Return

Price

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 10/22

6:00 am-1:52 pm

1 stop6h 52m

Key West

Tue 10/28

5:47 pm-11:56 pm

1 stop7h 09m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 11/12

1:55 pm-7:53 pm

1 stop4h 58m

Key West

Wed 11/19

6:18 pm-9:58 pm

1 stop4h 40m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 11/4

6:00 am-3:28 pm

1 stop8h 28m

Key West

Sat 11/8

12:46 pm-9:00 pm

1 stop9h 14m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 12/3

10:13 am-5:52 pm

1 stop6h 39m

Key West

Sat 12/6

4:59 pm-10:47 pm

1 stop6h 48m

$223

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Wed 11/12

9:38 am-7:23 pm

2 stops8h 45m

Key West

Wed 11/19

2:39 pm-7:30 pm

1 stop5h 51m

$228

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 11/28

8:00 am-3:19 pm

1 stop6h 19m

Key West

Wed 12/3

3:53 pm-9:40 pm

1 stop6h 47m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 10/14

9:10 am-5:21 pm

1 stop7h 11m

Key West

Thu 10/30

1:57 pm-6:02 pm

1 stop5h 05m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Tue 10/7

6:00 am-12:58 pm

1 stop5h 58m

Key West

Tue 10/14

7:52 pm-11:56 pm

1 stop5h 04m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Fri 11/14

10:15 am-5:51 pm

1 stop6h 36m

Key West

Tue 11/18

4:10 pm-10:27 pm

1 stop7h 17m

$241

St. LouisKey West

STL - EYW

STLEYW

Lambert-St Louis

Sat 10/11

6:47 pm-10:19 am

1 stop14h 32m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Showing 1-10 of 16 results
1
2

Best time to book a flight from St. Louis to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Key West

How far ahead should I book a flight from St. Louis to Key West?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Key West. Price data was last updated on August 29, 2025.

Booking 62 days in advance of your planned departure date is, on average, the best time to get cheap flights from St. Louis to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from St. Louis to Key West?

Currently, August is the cheapest month in which you can book a flight from St. Louis to Key West (average of $328). Flying from St. Louis to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Key West

Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from St. Louis to Key West by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Crew

8.5

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mark,Jun 2024

SGF - ATL

One of the worst flights ever. I got to the airport early for my 6:48 pm flight and tried to get on the 4:30 ish flight. The gate agent was one of the worst customer service people in my 20 yrs of flying Delta. Very rude and wouldn’t even talk to me about riding standby. Then flight took off 3 hrs late and when Landed in Atlanta, the gate people wouldn’t even try to get me on the plane. It was still there but door was closed. For all of my almost 2 million miles, the worst experience from Delta. I am highly disappointed as it was not my fault I have to sleep in Atlanta and not Jacksonville Florida

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from St. Louis to Key West?

    Departing from St. Louis to Key West will take you 4h 58m. The distance between St. Louis and Key West is about 1102 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from St. Louis to Key West round-trip?

    Our cheapest airline available from St. Louis to Key West is Delta. Our recent data shows that you can find tickets from as low as $216 on this airline. An additional option worth looking into is American Airlines, starting at $240. Users have found that Delta is 49% cheaper than the other options available to this destination.

  • Can I find deals for flights from St. Louis to Key West that include hotel bookings?

    Yes. In addition to deals on St. Louis to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Key West.

  • Can I find deals for business class flights from St. Louis to Key West?

    Yes. Cheapflights offers flight deals from St. Louis to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Key West?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Key West (average of $328). Flying from St. Louis to Key West in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from St. Louis to Key West

Discover the top 2 airlines that operate flights from St. Louis to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$216Average$448FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$240Average$426FlexibilityNo cancel feeOn-time71%

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