HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Key West

$94+ Cheap flights from South Carolina to Key West (EYW)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — EYW
Jun 6 — Jun 131
Sat 6/6
Sat 6/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Key West with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Key West

Cheapest flights from South Carolina to Key West
Explore the most affordable flight options available from South Carolina to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
CHS
-
EYW
1 stop3h 24m
Breeze Airways
Sat 9/1210:04 am
EYW
-
CHS
1 stop3h 20m
Breeze Airways
Deal found 5/4$128
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:00 am
CHS
-
EYW
1 stop3h 24m
Breeze Airways
Sat 9/1910:04 am
EYW
-
CHS
1 stop3h 20m
Breeze Airways
Deal found 5/5$138
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
CHS
-
EYW
1 stop3h 24m
Breeze Airways
Mon 9/1412:59 pm
EYW
-
CHS
1 stop23h 32m
Breeze Airways
Deal found 5/4$142
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:00 am
CHS
-
EYW
1 stop3h 24m
Breeze Airways
Fri 9/1110:59 am
EYW
-
CHS
1 stop21h 39m
Breeze Airways
Deal found 5/4$157
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:00 am
CHS
-
EYW
1 stop3h 24m
Breeze Airways
Sat 10/310:04 am
EYW
-
CHS
1 stop3h 20m
Breeze Airways
Deal found 5/5$161
This Breeze Airways deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:40 pm
GSP
-
EYW
1 stop20h 51m
Breeze Airways
Thu 6/411:04 am
EYW
-
GSP
1 stop8h 35m
Breeze Airways
Deal found 5/4$167
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/204:34 pm
CHS
-
EYW
1 stop18h 51m
Breeze Airways
Fri 5/2212:07 pm
EYW
-
CHS
1 stop20h 41m
Breeze Airways
Deal found 5/5$183
This Breeze Airways deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:20 pm
CHS
-
EYW
1 stop16h 11m
Breeze Airways
Fri 8/2812:07 pm
EYW
-
CHS
1 stop20h 41m
Breeze Airways
Deal found 5/4$184
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:56 pm
CHS
-
EYW
1 stop22h 17m
Breeze Airways
Wed 8/1211:46 am
EYW
-
CHS
1 stop3h 42m
Breeze Airways
Deal found 5/4$193
This Breeze Airways deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/313:40 pm
GSP
-
EYW
1 stop20h 51m
Breeze Airways
Fri 6/512:07 pm
EYW
-
GSP
1 stop3h 36m
Breeze Airways
Deal found 5/4$195
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/67:58 pm
CLT
-
EYW
1 stop17h 18m
Multiple Airlines
Fri 6/123:25 pm
EYW
-
CLT
1 stop20h 09m
Multiple Airlines
Deal found 5/2$208
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:23 am
GSP
-
EYW
1 stop5h 01m
Allegiant Air
Thu 6/49:16 pm
EYW
-
GSP
1 stop10h 23m
Allegiant Air
Deal found 5/7$212

Find flight deals from South Carolina to Key West

Keep the following information in mind while searching for South Carolina to Key West flight deals. Data was last updated May 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$128
(Kiwi.com)

One-way from

$94
(Kiwi.com)

Popular in

March

Cheapest in

January

Average price

$398
Provider with most accurate pricing for Myrtle Beach Intl-Key West flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Key West flights.
Search Deals
From South Carolina to Key West
Search Deals
One-way flight from South Carolina to Key West
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sun 5/31

3:40 pm-12:31 pm

1 stop20h 51m

Key West

Thu 6/4

11:04 am-7:39 pm

1 stop8h 35m

$214

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 5/12

10:17 am-11:06 am

1 stop24h 49m

Key West

Wed 5/20

11:46 am-1:58 pm

1 stop26h 12m

$214

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Mon 10/19

7:03 pm-12:36 pm

1 stop17h 33m

Key West

Fri 10/23

10:59 am-3:47 pm

1 stop4h 48m

$238

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 7/22

8:56 pm-7:13 pm

1 stop22h 17m

Key West

Mon 7/27

1:11 pm-9:37 am

1 stop20h 26m

$240

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sun 6/7

2:53 pm-11:27 am

1 stop20h 34m

Key West

Wed 6/10

11:46 am-3:28 pm

1 stop3h 42m

$246

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Sun 5/31

2:53 pm-11:27 am

1 stop20h 34m

Key West

Thu 6/4

12:05 pm-8:45 am

1 stop20h 40m

$260

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Mon 5/18

9:28 pm-12:34 pm

1 stop15h 06m

Key West

Wed 5/20

11:46 am-1:58 pm

1 stop26h 12m

$276

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Tue 6/16

4:04 pm-11:06 am

1 stop19h 02m

Key West

Sun 6/21

12:05 pm-8:45 am

1 stop20h 40m

$277

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Wed 10/28

3:42 pm-7:43 pm

1 stop4h 01m

Key West

Tue 11/3

6:00 pm-11:37 pm

1 stop5h 37m

$293

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sat 8/8

8:54 am-2:07 pm

1 stop5h 13m

Key West

Wed 8/12

7:40 am-1:55 pm

1 stop6h 15m

$293

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/6

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from South Carolina to Key West

Have a flexible travel schedule? Discover the best time to fly to Key West from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Key West

How far ahead should I book a flight from South Carolina to Key West?

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to Key West. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from South Carolina to Key West?

Currently, September is the cheapest month in which you can book a flight from South Carolina to Key West (average of $65). Flying from South Carolina to Key West in April is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to Key West?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Key West from South Carolina?

    For a flight from South Carolina to Key West, you will be flying into Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from South Carolina to Key West?

    For as low as $293, Breeze Airways can have you in Key West from South Carolina in 4h 01m. There are 714 mi between South Carolina and Key West. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Key West one-way?

    $70 is the cheapest one-way deal found within the past few days, from Breeze Airways. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $125 and $148, respectively.

  • What are the most popular routes from South Carolina to Key West?

    When deciding which route to take from South Carolina to Key West consider Charlotte Douglas - Key West, Greenville - Key West or Charleston - Key West as they are the most popular.

  • Can I find deals for flights from South Carolina to Key West that include hotel bookings?

    Yes. In addition to deals on South Carolina to Key West flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Key West?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Key West.

  • Can I find deals for business class flights from South Carolina to Key West?

    Yes. Cheapflights offers flight deals from South Carolina to Key West by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Key West?

    Currently, September is the cheapest month in which you can book a flight from South Carolina to Key West (average of $65). Flying from South Carolina to Key West in April is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Key West

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Orlando flights
LaGuardia to Miami flights
John F Kennedy Intl to Miami flights
LaGuardia to Orlando flights
LaGuardia to Fort Lauderdale flights
Newark to Fort Lauderdale flights
Newark to Miami flights
John F Kennedy Intl to Fort Lauderdale flights
John F Kennedy Intl to Orlando flights
Dallas/Fort Worth to Orlando flights
O'Hare Intl to Orlando flights
John F Kennedy Intl to West Palm Beach flights
Philadelphia to Orlando flights
Atlanta to Miami flights
Dallas/Fort Worth to Miami flights
Philadelphia to Fort Lauderdale flights
Dallas/Fort Worth to Fort Lauderdale flights
Newark to Tampa flights
Philadelphia to Miami flights
O'Hare Intl to Miami flights
Hobby to Orlando flights
Dulles Intl to Orlando flights
Detroit to Orlando flights
Hobby to Miami flights
Newark to West Palm Beach flights
Baltimore to Orlando flights
Boston to Orlando flights
Baltimore to Miami flights
Reagan-National to Miami flights
O'Hare Intl to Fort Lauderdale flights
Reagan-National to Orlando flights
Dulles Intl to Miami flights
Los Angeles to Miami flights
Boston to Miami flights
Baltimore to Fort Lauderdale flights
Los Angeles to Orlando flights
John F Kennedy Intl to Tampa flights
O'Hare Intl to Tampa flights
George Bush Intcntl to Miami flights
LaGuardia to Tampa flights
Boston to Fort Lauderdale flights
Dulles Intl to Fort Lauderdale flights
Hobby to Fort Lauderdale flights
White Plains to Orlando flights
Dulles Intl to Tampa flights
George Bush Intcntl to Orlando flights
LaGuardia to West Palm Beach flights
Los Angeles to Fort Lauderdale flights
Cleveland to Orlando flights
Detroit to Fort Lauderdale flights

Top 3 airlines flying from South Carolina to Key West

Discover the top 3 airlines that operate flights from South Carolina to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$106Average$224FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$125Average$447FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$488FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.