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South Carolina

$127+ Cheap flights from Key West (EYW) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel.
EYW — CHS
Jul 22 — Jul 291
Wed 7/22
Wed 7/29
1 adult, Economy
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Cheap flight deals from Key West to South Carolina

Cheapest flights from Key West to South Carolina
Explore the most affordable flight options available from Key West to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:07 pm
EYW
-
CHS
1 stop20h 41m
Breeze Airways
Thu 7/232:53 pm
CHS
-
EYW
1 stop20h 34m
Breeze Airways
Deal found 6/20$234
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1712:07 pm
EYW
-
CHS
1 stop20h 41m
Multiple Airlines
Thu 7/237:25 am
CHS
-
EYW
2 stops11h 48m
Multiple Airlines
Deal found 6/20$306
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1412:07 pm
EYW
-
CLT
1 stop4h 51m
Multiple Airlines
Mon 8/176:41 pm
CLT
-
EYW
2 stops17h 53m
Multiple Airlines
Deal found 6/20$321
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:27 pm
EYW
-
CLT
1 stop20h 02m
Multiple Airlines
Mon 7/136:41 pm
CLT
-
EYW
2 stops17h 53m
Multiple Airlines
Deal found 6/20$325
This Breeze Airways deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:59 am
EYW
-
CHS
1 stop21h 39m
Breeze Airways
Sun 10/252:13 pm
CHS
-
EYW
1 stop20h 06m
Breeze Airways
Deal found 6/20$333
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1412:07 pm
EYW
-
CLT
1 stop4h 51m
Multiple Airlines
Sun 8/166:41 pm
CLT
-
EYW
2 stops17h 50m
Multiple Airlines
Deal found 6/20$342
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3112:07 pm
EYW
-
CLT
1 stop9h 57m
Multiple Airlines
Mon 8/36:41 pm
CLT
-
EYW
2 stops17h 53m
Multiple Airlines
Deal found 6/20$357
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:00 pm
EYW
-
CLT
1 stop12h 04m
American Airlines
Sun 11/811:39 am
CLT
-
EYW
Nonstop2h 35m
American Airlines
Deal found 6/21$383
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2312:05 pm
EYW
-
SAV
2 stops22h 01m
Multiple Airlines
Sun 7/266:12 pm
SAV
-
EYW
1 stop16h 55m
Multiple Airlines
Deal found 6/20$396
This Breeze Airways deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:59 am
EYW
-
CHS
1 stop21h 49m
Breeze Airways
Sun 10/252:13 pm
CHS
-
EYW
1 stop20h 06m
Breeze Airways
Deal found 6/20$403
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:50 am
EYW
-
SAV
1 stop5h 22m
Delta
Tue 7/286:43 am
SAV
-
EYW
1 stop6h 40m
Delta
Deal found 6/22$409
This Kiwi.com deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:36 pm
EYW
-
CLT
1 stop16h 02m
Multiple Airlines
Wed 11/1812:10 pm
CLT
-
EYW
2 stops22h 09m
Multiple Airlines
Deal found 6/21$418

Find flight deals from Key West to South Carolina

Keep the following information in mind while searching for Key West to South Carolina flight deals. Data was last updated June 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$234
(Kiwi.com)

One-way from

$127
(Kiwi.com)
Provider with most accurate pricing for Key West-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Key West-Myrtle Beach Intl flights.
Search Deals
From Key West to South Carolina
Search Deals
One-way flight from Key West to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key West to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
Use the filters below to find and compare flights from Key West to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 7/17

12:07 pm-8:48 am

1 stop20h 41m

Charleston

Thu 7/23

2:53 pm-11:27 am

1 stop20h 34m

$234

Key WestCharleston

EYW - CHS

EYWCHS

Key West

Fri 7/17

12:07 pm-8:48 am

1 stop20h 41m

Charleston

Thu 7/23

7:25 am-7:13 pm

2 stops11h 48m

$306

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 7/23

7:50 am-1:12 pm

1 stop5h 22m

Savannah/Hilton Head

Tue 7/28

6:43 am-1:23 pm

1 stop6h 40m

$409

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Thu 7/2

7:53 pm-12:14 pm

2 stops16h 21m

Charlotte Douglas

Sun 7/5

10:59 pm-11:27 am

1 stop12h 28m

$488

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sat 11/7

5:09 pm-6:28 am

1 stop13h 19m

Charlotte Douglas

Sun 11/8

8:55 am-1:01 pm

1 stop4h 06m

$518
Quickest round-trip

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sat 7/18

5:53 pm-8:24 pm

Nonstop2h 31m

Charlotte Douglas

Fri 7/24

4:32 pm-6:48 pm

Nonstop2h 16m

$551

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Fri 8/14

7:40 am-1:26 pm

1 stop5h 46m

Charlotte Douglas

Mon 8/17

8:10 am-1:00 pm

1 stop4h 50m

$575

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Thu 7/23

1:47 pm-10:11 pm

2 stops8h 24m

Savannah/Hilton Head

Tue 7/28

11:00 am-7:06 pm

2 stops8h 06m

$634

Key WestCharlotte

EYW - CLT

EYWCLT

Key West

Sat 11/7

4:05 pm-12:50 am

1 stop8h 45m

Charlotte Douglas

Sun 11/8

6:00 am-1:02 pm

2 stops31h 02m

$636

Key WestSavannah

EYW - SAV

EYWSAV

Key West

Mon 7/6

7:33 pm-11:57 pm

1 stop4h 24m

Savannah/Hilton Head

Fri 7/10

5:00 am-1:14 pm

2 stops8h 14m

$740

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/17

Showing 1-10 of 24 resultsSorted by cheapest first
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Best time to book a flight from Key West to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Key West with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key West to South Carolina
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Key West to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Key West to South Carolina?

    For a flight from Key West to South Carolina, you will be flying from Key West. Key West (EYW) is just 2.6 mi from the center of the city.

  • How long is the flight from Key West to South Carolina?

    A quick flight from Key West to South Carolina can take about 5h 22m. Breeze Airways provides one of the quickest options available for as low as $409. There are 524 mi between Key West and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Key West to South Carolina?

    When deciding which route to take from Key West to South Carolina consider Key West - Charlotte Douglas, Key West - Savannah/Hilton Head or Key West - Augusta Bush Field as they are the most popular.

  • Can I find deals for flights from Key West to South Carolina that include hotel bookings?

    Yes. In addition to deals on Key West to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key West to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key West to South Carolina.

  • Can I find deals for business class flights from Key West to South Carolina?

    Yes. Cheapflights offers flight deals from Key West to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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