$457+ Cheap flights from Columbia, MO to Key West (COU - EYW)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
COU — EYW
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to Key West with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to Key West
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Best
Last-minute
One-way
Cheapest flights from Columbia to Key WestExplore the most affordable flight options available from Columbia to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Columbia to Key West. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
2 stops9h 11m
Wed 10/142:34 pm -
1 stop8h 19m
Deal found 9/8![American Airlines logo]()
$534
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Fri 9/183:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Tue 9/153:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Thu 9/171:47 pm -
2 stops7h 59m
Deal found 9/7![American Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:30 am -
1 stop7h 48m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$650
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:16 am -
1 stop5h 33m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$662
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Tue 9/153:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$666
Best flights from Columbia to Key WestDiscover carefully curated flight deals from Columbia to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Columbia to Key West that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2010:29 am -
1 stop25h 07m
Thu 2/259:18 am -
2 stops10h 55m
Deal found 9/7![Allegiant Air logo]()
$457
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:12 am -
2 stops11h 21m
Wed 10/141:43 pm -
2 stops9h 56m
Deal found 9/8![American Airlines logo]()
$616
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:00 am -
1 stop6h 29m
Thu 11/122:50 pm -
2 stops44h 55m
Deal found 9/9![United Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:24 am -
1 stop24h 29m
Thu 11/121:14 pm -
1 stop10h 01m
Deal found 9/9![American Airlines logo]()
$752
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:12 am -
2 stops8h 03m
Sun 11/157:18 pm -
2 stops15h 30m
Deal found 9/9![American Airlines logo]()
$758
Last-minute flights from Columbia to Key WestDiscover last-minute flight deals from Columbia to Key West. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to Key West. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:16 am -
1 stop5h 33m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$662
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Fri 9/183:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$634
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:16 am -
1 stop5h 33m
Tue 9/153:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$666
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Wed 9/163:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$598
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Tue 9/153:30 pm -
1 stop7h 38m
Deal found 9/7![American Airlines logo]()
$630
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Fri 9/181:47 pm -
2 stops7h 25m
Deal found 9/7![American Airlines logo]()
$640
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:06 am -
1 stop5h 05m
Sat 9/194:39 pm -
1 stop6h 29m
Deal found 9/7![American Airlines logo]()
$650
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
2 stops9h 11m
Wed 10/142:34 pm -
1 stop8h 19m
Deal found 9/8![American Airlines logo]()
$534
One-way flights from Columbia to Key WestSearch for one-way flight options from Columbia to Key West. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Columbia to Key West. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:16 am -
1 stop5h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![American Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:15 am -
3 stops30h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![United Airlines logo]()
$771
Find flight deals from Columbia to Key West
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to Key West (EYW). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $356 (Kiwi.com) |
Popular in | November |
Cheapest in | December |
Average price | $730 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Columbia to Key West that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Sat 2/20
10:29 am-12:36 pm
1 stop25h 07m
Key West
Thu 2/25
9:18 am-7:13 pm
2 stops10h 55m
$457
Quickest round-trip
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Tue 9/15
8:16 am-2:49 pm
1 stop5h 33m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$464
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Wed 10/7
7:12 am-7:33 pm
2 stops11h 21m
Key West
Wed 10/14
1:43 pm-10:39 pm
2 stops9h 56m
$616
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Mon 11/9
8:00 am-3:29 pm
1 stop6h 29m
Key West
Thu 11/12
2:50 pm-10:45 am
2 stops44h 55m
$736
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Mon 11/9
10:24 am-11:53 am
1 stop24h 29m
Key West
Thu 11/12
1:14 pm-10:15 pm
1 stop10h 01m
$752
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Wed 11/11
8:12 am-5:15 pm
2 stops8h 03m
Key West
Sun 11/15
7:18 pm-9:48 am
2 stops15h 30m
$758
ColumbiaKey West
COU Columbia Regional - EYW Key West
COUEYW
Columbia Regional
Tue 9/15
6:15 am-1:29 pm
3 stops30h 14m
Key West
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$771
Sorted by cheapest first
Compare providers for flights from Columbia to Key West
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to Key West in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-Key West flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-Key West flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-Key West flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-Key West flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-Key West flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to Key West
Have a flexible travel schedule? Discover the best time to fly to Key West from Columbia with our price prediction graph.
COU-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Key West
Get insights into the airlines that provide service to Key West. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Key West. Reviews last updated September 10, 2026.
See what other customers who have flown with American Airlines from Columbia to Key West have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Crew
7.9
Overall
7.1
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Comfort
7.2
Entertainment
6.8
Boarding
7.5
Crew
7.9
Overall
7.1
Food
6.4
Reviews
1 / 20
4.0
OkayElizabeth,Mar 2026
ORD - MIA
Related info for your journey
Find useful and relevant information for your journey from Columbia to Key West. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Key West by adding a car rental and/or hotel reservation to your travel itinerary.
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Other flights to Key West
Explore flights to Key West departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Columbia and Key West flights
Browse other Columbia and Key West flight options. Last updated on September 10, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top airline flying from Columbia to Key West
Discover the top airline that operate flights from Columbia to Key West. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$410 | Average$596 | FlexibilityNo cancel fee | On-time71% |