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$79+ Cheap flights from Missouri to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Missouri to Iowa

Cheapest flights from Missouri to Iowa
Explore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:20 am
STL
-
DSM
1 stop6h 55m
Southwest
Thu 3/264:20 pm
DSM
-
STL
1 stop6h 50m
Southwest
Deal found 1/28$159
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:20 am
STL
-
DSM
1 stop4h 25m
Southwest
Thu 5/71:55 pm
DSM
-
STL
1 stop10h 35m
Southwest
Deal found 1/27$196
This Southwest deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:15 am
STL
-
DSM
Nonstop1h 10m
Southwest
Thu 3/55:35 am
DSM
-
STL
1 stop3h 25m
Southwest
Deal found 1/26$241
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:41 am
STL
-
DSM
1 stop6h 46m
United Airlines
Sat 2/283:24 pm
DSM
-
STL
1 stop5h 41m
United Airlines
Deal found 1/27$244
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/148:00 am
MCI
-
MLI
1 stop3h 46m
United Airlines
Wed 2/185:22 pm
MLI
-
MCI
1 stop4h 37m
United Airlines
Deal found 1/27$244
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/217:41 am
STL
-
FOD
1 stop6h 25m
United Airlines
Wed 2/252:41 pm
FOD
-
STL
1 stop6h 24m
United Airlines
Deal found 1/28$283
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1211:32 am
MCI
-
MLI
1 stop5h 15m
United Airlines
Mon 2/165:22 pm
MLI
-
MCI
1 stop4h 37m
United Airlines
Deal found 1/27$283
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 am
STL
-
OMA
1 stop5h 46m
American Airlines
Wed 2/257:01 am
OMA
-
STL
1 stop6h 15m
American Airlines
Deal found 1/27$289
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:50 pm
STL
-
OMA
Nonstop1h 20m
Southwest
Wed 2/253:55 pm
OMA
-
STL
Nonstop1h 15m
Southwest
Deal found 1/27$298
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/113:24 pm
MCI
-
MLI
1 stop6h 12m
United Airlines
Sun 2/155:22 pm
MLI
-
MCI
1 stop4h 37m
United Airlines
Deal found 1/27$309
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/181:25 pm
SGF
-
MLI
1 stop7h 29m
United Airlines
Tue 3/33:52 pm
MLI
-
SGF
1 stop6h 07m
United Airlines
Deal found 1/26$309
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/143:15 pm
SGF
-
MLI
1 stop3h 47m
United Airlines
Wed 2/183:52 pm
MLI
-
SGF
1 stop6h 07m
United Airlines
Deal found 1/28$314

Find flight deals from Missouri to Iowa

Keep the following information in mind while searching for Missouri to Iowa flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$159
(Southwest)

One-way from

$79
(Delta)

Popular in

January

Cheapest in

June

Average price

$680

Good round-trip deal

$467 or less
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Missouri to Iowa
Search Deals
One-way flight from Missouri to Iowa
Search Deals
Highest demand for flights based on searches. 36% potential increase in price ($218 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Missouri to Iowa.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to Iowa that are best for you.

Fly from

Missouri

Fly to

Iowa

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 3/24

6:20 am-1:15 pm

1 stop6h 55m

Des Moines

Thu 3/26

4:20 pm-11:10 pm

1 stop6h 50m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 5/4

7:20 am-11:45 am

1 stop4h 25m

Des Moines

Thu 5/7

1:55 pm-12:30 am

1 stop10h 35m

$196

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 3/4

10:15 am-11:25 am

Nonstop1h 10m

Des Moines

Thu 3/5

5:35 am-9:00 am

1 stop3h 25m

$241

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 2/25

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$244

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Sat 2/14

8:00 am-11:46 am

1 stop3h 46m

Moline Quad-City

Wed 2/18

5:22 pm-9:59 pm

1 stop4h 37m

$244

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 3/4

9:37 am-1:05 pm

1 stop3h 28m

Des Moines

Thu 3/5

7:44 pm-11:48 pm

1 stop4h 04m

$251

St. LouisFort Dodge

STL - FOD

STLFOD

Lambert-St Louis

Sat 2/21

7:41 am-2:06 pm

1 stop6h 25m

Fort Dodge

Wed 2/25

2:41 pm-9:05 pm

1 stop6h 24m

$283

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Thu 2/12

11:32 am-4:47 pm

1 stop5h 15m

Moline Quad-City

Mon 2/16

5:22 pm-9:59 pm

1 stop4h 37m

$283

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Mon 2/23

8:50 pm-10:10 pm

Nonstop1h 20m

Omaha Eppley Airfield

Wed 2/25

5:50 am-11:15 am

1 stop5h 25m

$308

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Wed 2/11

3:24 pm-9:36 pm

1 stop6h 12m

Moline Quad-City

Sun 2/15

5:22 pm-9:59 pm

1 stop4h 37m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 53 results
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Best time to book a flight from Missouri to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Iowa

What is the cheapest time of day to fly from MO to IA?

Find hourly flight availability from Missouri to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Missouri to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 45% versus a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated January 29, 2026.
Read through reviews of airlines operating flights from Missouri to Iowa, such as Southwest and American Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,205 reviews
Southwest
8.0
Very good
4,267 reviews

Overall

8.0

Food

7.0

Boarding

8.1

Comfort

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Missouri to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to Iowa flight route?

    The Missouri to Iowa flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to Iowa?

    A quick flight from Missouri to Iowa can take about 3h 46m. Southwest provides one of the quickest options available for as low as $244. Missouri and Iowa are separated by a distance of 267 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Iowa that include hotel bookings?

    Yes. In addition to deals on Missouri to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Iowa.

  • Can I find deals for business class flights from Missouri to Iowa?

    Yes. Cheapflights offers flight deals from Missouri to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Iowa

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Iowa

Discover the top 2 airlines that operate flights from Missouri to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$142Average$298FlexibilityNo cancel feeOn-time71%

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