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$49+ Cheap flights from Missouri to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Missouri to Iowa

Cheapest flights from Missouri to Iowa
Explore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:45 pmSTL - OMA
1 stop24h 21mFrontier
Mon 11/178:51 pmOMA - STL
1 stop12h 16mFrontier
Deal found 10/29$119
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:45 pmSTL - DSM
1 stop18h 04mFrontier
Mon 11/172:32 pmDSM - STL
1 stop18h 35mFrontier
Deal found 10/29$119
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:43 pmSTL - OMA
1 stop17h 48mFrontier
Sun 12/72:18 pmOMA - STL
1 stop19h 56mFrontier
Deal found 10/29$152
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:45 pmSTL - DSM
1 stop18h 11mFrontier
Sun 11/162:32 pmDSM - STL
1 stop18h 35mFrontier
Deal found 10/28$178
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/57:45 pmSTL - OMA
1 stop23h 06mFrontier
Fri 11/78:51 pmOMA - STL
1 stop12h 16mFrontier
Deal found 10/28$185
This Booking.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:42 amSTL - OMA
1 stop5h 46mFrontier
Sun 12/72:18 pmOMA - STL
1 stop19h 56mFrontier
Deal found 10/29$188
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:40 pmSTL - DSM
1 stop18h 07mFrontier
Mon 11/32:32 pmDSM - STL
1 stop18h 35mFrontier
Deal found 10/29$239
This Booking.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/298:40 pmSTL - DSM
1 stop17h 07mFrontier
Fri 10/312:32 pmDSM - STL
1 stop18h 35mFrontier
Deal found 10/28$240
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:05 amSTL - DSM
1 stop5h 23mDelta
Sat 1/35:55 pmDSM - STL
1 stop4h 21mDelta
Deal found 10/30$279
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:47 pmMCI - MLI
1 stop7h 14mUnited Airlines
Tue 11/188:52 amMLI - MCI
1 stop7h 13mUnited Airlines
Deal found 10/30$309
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:00 amMCI - DSM
1 stop16h 40mMultiple Airlines
Wed 12/31:25 pmDSM - MCI
1 stop26h 20mMultiple Airlines
Deal found 10/29$310
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:45 amJLN - MLI
1 stop4h 05mUnited Airlines
Sun 11/165:20 pmMLI - JLN
1 stop6h 10mUnited Airlines
Deal found 10/28$314

Cheap flight deals from Missouri to Iowa

Keep the following information in mind while searching for Missouri to Iowa flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$119
(Mytrip)

One-way from

$49
(Southwest)

Popular in

July

Cheapest in

June

Average price

$218

Good round-trip deal

$171 or less
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Missouri to Iowa
Search Deals
One-way flight from Missouri to Iowa
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from Missouri to Iowa.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Iowa that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Iowa that are best for you.

Fly from

Missouri

Fly to

Iowa

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 11/13

7:45 pm-1:49 pm

1 stop18h 04m

Des Moines

Mon 11/17

2:32 pm-9:07 am

1 stop18h 35m

$119

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Wed 12/3

7:43 pm-1:31 pm

1 stop17h 48m

Omaha Eppley Airfield

Sun 12/7

2:18 pm-10:14 am

1 stop19h 56m

$152

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 11/12

7:45 pm-1:56 pm

1 stop18h 11m

Des Moines

Sun 11/16

2:32 pm-9:07 am

1 stop18h 35m

$178

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Fri 12/5

10:42 am-4:28 pm

1 stop5h 46m

Omaha Eppley Airfield

Sun 12/7

2:18 pm-10:14 am

1 stop19h 56m

$188

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Thu 11/13

6:22 pm-8:06 pm

2 stops25h 44m

Omaha Eppley Airfield

Mon 11/17

8:51 pm-9:07 am

1 stop12h 16m

$235

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Wed 11/12

6:00 am-10:15 am

1 stop4h 15m

Moline Quad-City

Sun 11/16

1:00 pm-7:57 pm

1 stop6h 57m

$289

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Fri 11/14

1:47 pm-9:01 pm

1 stop7h 14m

Moline Quad-City

Tue 11/18

8:52 am-4:05 pm

1 stop7h 13m

$309

Kansas CityMoline

MCI - MLI

MCIMLI

Kansas City

Thu 11/13

6:00 am-10:15 am

1 stop4h 15m

Moline Quad-City

Mon 11/17

5:20 pm-9:50 pm

1 stop4h 30m

$309

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Wed 11/26

6:00 am-10:40 pm

1 stop16h 40m

Des Moines

Wed 12/3

1:25 pm-3:45 pm

1 stop26h 20m

$310

JoplinMoline

JLN - MLI

JLNMLI

Joplin

Wed 11/12

7:45 am-11:50 am

1 stop4h 05m

Moline Quad-City

Sun 11/16

5:20 pm-11:30 pm

1 stop6h 10m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Iowa

What is the cheapest month to book a flight from Missouri to Iowa?

Currently, September is the cheapest month in which you can book a flight from Missouri to Iowa (average of $84). Flying from Missouri to Iowa in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to IA?

Find hourly flight availability from Missouri to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Missouri to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 43% versus a flight in the morning.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated October 30, 2025.
Read through reviews of airlines operating flights from Missouri to Iowa, such as Southwest, American Airlines, and Southern / Mokulele. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,243 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,243 reviews
Southwest
8.0
Very good
4,243 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,035 reviews
Southwest
8.0
Very good
4,243 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southern / Mokulele
6.2
Okay
26 reviews
Southwest
8.0
Very good
4,243 reviews

Overall

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Missouri to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to Iowa flight route?

    The Missouri to Iowa flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to Iowa?

    A quick flight from Missouri to Iowa can take about 4h 15m. Frontier provides one of the quickest options available for as low as $289. Missouri and Iowa are separated by a distance of 267 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Iowa that include hotel bookings?

    Yes. In addition to deals on Missouri to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Iowa?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Iowa.

  • Can I find deals for business class flights from Missouri to Iowa?

    Yes. Cheapflights offers flight deals from Missouri to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Iowa?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Iowa (average of $84). Flying from Missouri to Iowa in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Iowa

Discover the top 3 airlines that operate flights from Missouri to Iowa. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Southern / MokuleleCheapest$49Average$92FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$142Average$288FlexibilityNo cancel feeOn-time71%

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