How long is the flight from Missouri to Iowa?

A quick flight from Missouri to Iowa can take about 4h 09m. Delta provides one of the quickest options available for as low as $157. Missouri and Iowa are separated by a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Iowa ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Iowa when rainfall is around 1.0 in.

If weather is an important factor for your trip to Iowa, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Can I find deals for flights from Missouri to Iowa that include hotel bookings?

Yes. In addition to deals on Missouri to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Iowa?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Iowa.

Can I find deals for business class flights from Missouri to Iowa?

Yes. Cheapflights offers flight deals from Missouri to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$72+ Flights from Missouri to Iowa

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Missouri to Iowa with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Iowa

Cheapest flights from Missouri to Iowa
Explore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Sat 12/205:05 amMCI - MLI

1 stop5h 34mAmerican Airlines

Mon 12/226:00 amMLI - MCI

1 stop5h 13mAmerican Airlines

Deal found 12/16

$289

Mon 12/294:53 pmSTL - DSM

1 stop6h 53mAmerican Airlines

Wed 12/311:09 pmDSM - STL

1 stop6h 13mAmerican Airlines

Deal found 12/15

$296

Wed 12/316:00 amMCI - MLI

1 stop6h 13mUnited Airlines

Thu 1/16:30 amMLI - MCI

1 stop4h 13mUnited Airlines

Deal found 12/17

$309

Tue 12/307:40 amMCI - MLI

1 stop4h 33mUnited Airlines

Thu 1/16:30 amMLI - MCI

1 stop4h 13mUnited Airlines

Deal found 12/17

$319

Tue 12/1610:00 amSTL - FOD

1 stop4h 01mUnited Airlines

Tue 12/2310:05 amFOD - STL

1 stop4h 21mUnited Airlines

Deal found 12/15

$361

Mon 12/297:40 amMCI - MLI

1 stop4h 33mUnited Airlines

Thu 1/16:30 amMLI - MCI

1 stop4h 13mUnited Airlines

Deal found 12/17

$374

Wed 12/316:00 amMCI - MLI

1 stop4h 12mUnited Airlines

Sun 1/45:33 pmMLI - MCI

1 stop4h 17mUnited Airlines

Deal found 12/16

$404

Wed 12/313:10 pmSTL - DSM

1 stop6h 30mUnited Airlines

Sun 1/46:46 pmDSM - STL

1 stop3h 57mUnited Airlines

Deal found 12/16

$406

Tue 12/307:40 amMCI - MLI

1 stop4h 33mUnited Airlines

Fri 1/210:47 amMLI - MCI

1 stop3h 51mUnited Airlines

Deal found 12/17

$414

Fri 12/266:00 amMCI - MLI

1 stop4h 12mUnited Airlines

Thu 1/16:30 amMLI - MCI

1 stop4h 13mUnited Airlines

Deal found 12/17

$434

Wed 12/318:45 pmMCI - OMA

1 stop23h 02mFrontier

Sun 1/48:59 pmOMA - MCI

1 stop22h 51mFrontier

Deal found 12/16

$437

Fri 12/266:00 amMCI - MLI

1 stop4h 12mUnited Airlines

Tue 12/305:33 pmMLI - MCI

1 stop4h 17mUnited Airlines

Deal found 12/17

$444

Best flights from Missouri to Iowa
Discover carefully curated flight deals from Missouri to Iowa that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 18, 2025.

Tue 1/66:10 amSTL - DSM

1 stop4h 09mDelta

Wed 1/1410:59 amDSM - STL

1 stop5h 46mDelta

Deal found 12/16

$157

Fri 1/233:37 pmSTL - DSM

1 stop7h 46mAmerican Airlines

Tue 1/2711:42 amDSM - STL

1 stop6h 34mAmerican Airlines

Deal found 12/16

$159

Tue 1/612:25 pmSTL - DSM

1 stop6h 55mSouthwest

Wed 1/146:10 amDSM - STL

Nonstop1h 20mSouthwest

Deal found 12/16

$162

Sat 1/101:15 pmSTL - OMA

1 stop4h 21mUnited Airlines

Sat 1/243:21 pmOMA - STL

1 stop4h 06mUnited Airlines

Deal found 12/16

$191

Thu 1/158:33 pmMCI - OMA

1 stop23h 19mMultiple Airlines

Thu 1/229:58 amOMA - MCI

1 stop22h 54mMultiple Airlines

Deal found 12/16

$262

Fri 1/236:10 amSTL - DSM

1 stop4h 09mDelta

Sun 1/256:54 amDSM - STL

1 stop3h 49mDelta

Deal found 12/15

$159

Thu 1/156:10 amSTL - DSM

1 stop4h 09mDelta

Thu 1/2210:59 amDSM - STL

1 stop5h 46mDelta

Deal found 12/16

$159

Wed 12/318:45 pmMCI - OMA

1 stop23h 02mFrontier

Sun 1/48:59 pmOMA - MCI

1 stop22h 51mFrontier

Deal found 12/16

$437

Sun 1/186:10 amSTL - DSM

1 stop4h 09mDelta

Tue 1/205:35 amDSM - STL

1 stop6h 19mDelta

Deal found 12/17

$188

Fri 1/232:35 pmSTL - DSM

1 stop4h 45mSouthwest

Tue 1/276:10 amDSM - STL

Nonstop1h 20mSouthwest

Deal found 12/16

$231

Sun 1/182:38 pmMCI - OMA

1 stop23h 33mAlaska Airlines

Thu 1/223:07 pmOMA - MCI

1 stop22h 43mAlaska Airlines

Deal found 12/15

$464

Wed 1/219:57 amSTL - DSM

1 stop4h 36mUnited Airlines

Sat 1/247:50 amDSM - STL

1 stop6h 38mUnited Airlines

Deal found 12/16

$241

Fri 1/96:10 amSTL - DSM

1 stop4h 09mDelta

Mon 1/125:16 pmDSM - STL

1 stop6h 23mDelta

Deal found 12/17

$189

Thu 1/86:30 amSTL - OMA

1 stop4h 00mUnited Airlines

Mon 1/126:35 pmOMA - STL

1 stop4h 23mUnited Airlines

Deal found 12/15

$251

Sun 1/115:11 pmSTL - OMA

1 stop25h 45mMultiple Airlines

Sun 1/2512:58 pmOMA - STL

2 stops23h 52mMultiple Airlines

Deal found 12/17

$280

Tue 1/133:01 pmMCI - OMA

1 stop7h 55mAmerican Airlines

Tue 1/207:00 amOMA - MCI

1 stop11h 03mAmerican Airlines

Deal found 12/16

$315

Sat 1/107:43 pmSTL - OMA

1 stop16h 33mMultiple Airlines

Sun 1/2512:58 pmOMA - STL

2 stops23h 52mMultiple Airlines

Deal found 12/17

$304

Sat 1/171:15 pmSTL - OMA

1 stop4h 21mUnited Airlines

Sun 1/1811:26 amOMA - STL

1 stop4h 37mUnited Airlines

Deal found 12/17

$281

Tue 1/610:15 amSTL - OMA

Nonstop1h 20mSouthwest

Thu 1/83:55 pmOMA - STL

Nonstop1h 15mSouthwest

Deal found 12/16

$313

Sat 1/319:57 amSTL - FOD

1 stop4h 04mUnited Airlines

Tue 2/310:15 amFOD - STL

1 stop4h 15mUnited Airlines

Deal found 12/16

$281

Sat 1/1010:25 amSTL - OMA

1 stop4h 40mSouthwest

Sat 1/246:40 amOMA - STL

Nonstop1h 25mSouthwest

Deal found 12/16

$323

Mon 1/196:34 pmMCI - OMA

1 stop41h 07mAmerican Airlines

Thu 1/226:19 pmOMA - MCI

1 stop44h 11mAmerican Airlines

Deal found 12/16

$372

Fri 1/236:10 amMCI - DSM

1 stop5h 15mSouthwest

Sun 1/255:20 amDSM - MCI

1 stop5h 35mSouthwest

Deal found 12/15

$327

Sat 2/141:50 pmMCI - MLI

1 stop7h 24mUnited Airlines

Wed 2/185:22 pmMLI - MCI

1 stop4h 37mUnited Airlines

Deal found 12/15

$299

Tue 1/1310:00 amMCI - MLI

1 stop6h 54mUnited Airlines

Tue 1/208:46 amMLI - MCI

1 stop7h 22mUnited Airlines

Deal found 12/16

$299

Tue 1/136:10 amMCI - DSM

1 stop5h 15mSouthwest

Tue 1/208:35 amDSM - MCI

1 stop4h 40mSouthwest

Deal found 12/16

$347

Sat 2/148:54 amJLN - MLI

1 stop6h 23mUnited Airlines

Tue 2/1710:46 amMLI - JLN

1 stop6h 52mUnited Airlines

Deal found 12/16

$304

Wed 12/316:00 amMCI - MLI

1 stop6h 13mUnited Airlines

Thu 1/16:30 amMLI - MCI

1 stop4h 13mUnited Airlines

Deal found 12/17

$309

Thu 1/13:19 pmMCI - MLI

1 stop6h 02mUnited Airlines

Mon 1/510:47 amMLI - MCI

1 stop3h 51mUnited Airlines

Deal found 12/17

$309

Mon 1/195:45 amMCI - OMA

1 stop5h 15mSouthwest

Thu 1/226:55 amOMA - MCI

2 stops7h 40mSouthwest

Deal found 12/16

$436

Last-minute flights from Missouri to Iowa
Discover last-minute flight deals from Missouri to Iowa. Data last updated December 18, 2025 and is based on user searches.

Tue 1/66:10 amSTL - DSM

1 stop4h 09mDelta

Wed 1/1410:59 amDSM - STL

1 stop5h 46mDelta

Deal found 12/16

$157

Tue 1/612:25 pmSTL - DSM

1 stop6h 55mSouthwest

Wed 1/146:10 amDSM - STL

Nonstop1h 20mSouthwest

Deal found 12/16

$162

Tue 1/68:13 amSTL - OMA

1 stop6h 01mAmerican Airlines

Thu 1/83:07 pmOMA - STL

1 stop8h 05mAmerican Airlines

Deal found 12/16

$175

Fri 1/96:10 amSTL - DSM

1 stop4h 09mDelta

Mon 1/125:16 pmDSM - STL

1 stop6h 23mDelta

Deal found 12/17

$189

Sat 1/101:15 pmSTL - OMA

1 stop4h 21mUnited Airlines

Sat 1/243:21 pmOMA - STL

1 stop4h 06mUnited Airlines

Deal found 12/16

$191

Sat 1/107:43 pmSTL - OMA

1 stop16h 33mMultiple Airlines

Fri 1/2312:31 pmOMA - STL

1 stop8h 17mMultiple Airlines

Deal found 12/16

$241

Thu 1/156:35 amSTL - DSM

1 stop4h 49mDelta

Thu 1/2210:59 amDSM - STL

2 stops9h 44mDelta

Deal found 12/16

$164

Thu 1/159:40 amSTL - DSM

Nonstop1h 10mSouthwest

Thu 1/223:20 pmDSM - STL

Nonstop1h 15mSouthwest

Deal found 12/16

$171

Sun 1/186:10 amSTL - DSM

1 stop4h 09mDelta

Tue 1/205:35 amDSM - STL

1 stop6h 19mDelta

Deal found 12/17

$188

Wed 1/219:57 amSTL - DSM

1 stop4h 36mUnited Airlines

Sat 1/247:50 amDSM - STL

1 stop6h 38mUnited Airlines

Deal found 12/16

$241

Fri 1/236:10 amSTL - DSM

1 stop4h 09mDelta

Sun 1/256:54 amDSM - STL

1 stop3h 49mDelta

Deal found 12/15

$159

Fri 1/232:35 pmSTL - DSM

1 stop4h 45mSouthwest

Tue 1/276:10 amDSM - STL

Nonstop1h 20mSouthwest

Deal found 12/16

$231

One-way flights from Missouri to Iowa
Search for one-way flight options from Missouri to Iowa. Find affordable one-way fares based on user searches. Data last updated December 18, 2025.

Sat 1/173:43 pmSTL - OMA

1 stop27h 11mFrontier

Deal found 12/17

$72

Tue 2/173:00 pmSTL - DSM

1 stop6h 20mSouthwest

Deal found 12/17

$77

Sat 2/142:51 pmSTL - OMA

1 stop21h 57mFrontier

Deal found 12/17

$79

Wed 2/186:00 amSTL - DSM

1 stop4h 40mDelta

Deal found 12/17

$79

Tue 1/68:13 amSTL - OMA

1 stop8h 01mAmerican Airlines

Deal found 12/16

$80

Sat 2/146:10 amSTL - DSM

1 stop4h 07mDelta

Deal found 12/17

$80

Tue 1/136:35 amSTL - DSM

2 stops9h 06mDelta

Deal found 12/17

$84

Thu 1/159:40 amSTL - DSM

Nonstop1h 10mSouthwest

Deal found 12/16

$86

Thu 1/158:13 amSTL - OMA

1 stop8h 01mAmerican Airlines

Deal found 12/16

$96

Tue 1/138:13 amSTL - OMA

1 stop8h 01mAmerican Airlines

Deal found 12/16

$110

Thu 2/1910:11 pmSTL - OMA

1 stop13h 33mMultiple Airlines

Deal found 12/17

$119

Mon 1/196:00 pmSTL - DSM

1 stop5h 44mUnited Airlines

Deal found 12/16

$121

Find flight deals from Missouri to Iowa

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$157 (Delta)
One-way from	$72 (Kiwi.com)
Popular in	July
Cheapest in	June

Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.

Search Deals

From Missouri to Iowa

Search Deals

One-way flight from Missouri to Iowa

Search Deals

Highest demand for flights based on searches. 11% potential increase in price ($47 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 10% potential price decrease ($32 potential savings vs. average RT price).

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Wed 1/14

10:59 am-4:45 pm

1 stop5h 46m

$157

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

3:37 pm-11:23 pm

1 stop7h 46m

Des Moines

Tue 1/27

11:42 am-6:16 pm

1 stop6h 34m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Sun 1/25

6:54 am-10:43 am

1 stop3h 49m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/15

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Thu 1/22

10:59 am-4:45 pm

1 stop5h 46m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

12:25 pm-7:20 pm

1 stop6h 55m

Des Moines

Wed 1/14

6:10 am-7:30 am

Nonstop1h 20m

$162

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 1/18

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Tue 1/20

5:35 am-11:54 am

1 stop6h 19m

$188

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/9

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Mon 1/12

5:16 pm-11:39 pm

1 stop6h 23m

$189

St. LouisOmaha

STL - OMA

STLOMA

Lambert-St Louis

Sat 1/10

1:15 pm-5:36 pm

1 stop4h 21m

Omaha Eppley Airfield

Sat 1/24

3:21 pm-7:27 pm

1 stop4h 06m

$191

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

2:35 pm-7:20 pm

1 stop4h 45m

Des Moines

Tue 1/27

6:10 am-7:30 am

Nonstop1h 20m

$231

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/21

9:57 am-2:33 pm

1 stop4h 36m

Des Moines

Sat 1/24

7:50 am-2:28 pm

1 stop6h 38m

$241

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 55 results

...

Best time to book a flight from Missouri to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Iowa

What is the cheapest time of day to fly from MO to IA?

When flying from Missouri to Iowa, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 45% versus a flight in the morning.

Reviews of airlines servicing Iowa

Read through reviews of airlines operating flights from Missouri to Iowa, such as Southwest, American Airlines, and Southern / Mokulele. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southwest

7.9

Good

4,250 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

American Airlines

7.2

Good

11,054 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Southern / Mokulele

6.8

Okay

30 reviews

Southwest

7.9

Good

4,250 reviews

Reviews

1 / 20

2.0

Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

How long is the flight from Missouri to Iowa?
A quick flight from Missouri to Iowa can take about 4h 09m. Delta provides one of the quickest options available for as low as $157. Missouri and Iowa are separated by a distance of 259 mi. Both multi-stop and nonstop flights can be found to your destination and back.
Can I find deals for flights from Missouri to Iowa that include hotel bookings?
Yes. In addition to deals on Missouri to Iowa flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Iowa?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Iowa.
Can I find deals for business class flights from Missouri to Iowa?
Yes. Cheapflights offers flight deals from Missouri to Iowa by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 3 airlines flying from Missouri to Iowa

Airline	Cheapest	Average	Flexibility	On-time
Southern / Mokulele	Cheapest$49	Average$108	FlexibilityNo cancel fee	On-timeN/A
Southwest	Cheapest$77	Average$309	FlexibilityNo cancel fee	On-time63%
American Airlines	Cheapest$142	Average$288	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$72+ Cheap flights from Missouri to Iowa

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Missouri to Iowa with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Missouri to Iowa

Cheapest flights from Missouri to IowaExplore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Explore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

Find flight deals from Missouri to Iowa

Keep the following information in mind while searching for Missouri to Iowa flight deals. Data was last updated December 18, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Iowa that are best for you.

Best time to book a flight from Missouri to Iowa

Have a flexible travel schedule? Discover the best time to fly to Iowa from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Iowa

What is the cheapest time of day to fly from MO to IA?

Find hourly flight availability from Missouri to Iowa. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Reviews of airlines servicing Iowa

Get insights into the airlines that provide service to Iowa. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Iowa. Reviews last updated December 18, 2025.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Iowa. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Missouri to Iowa?

Can I find deals for flights from Missouri to Iowa that include hotel bookings?

How can I find direct flights from Missouri to Iowa?

Can I find deals for business class flights from Missouri to Iowa?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Iowa

See prices for flight routes from nearby airports that may be better suited for you.

Top 3 airlines flying from Missouri to Iowa

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Missouri to Iowa
Explore the most affordable flight options available from Missouri to Iowa. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.