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$346+ Cheap flights from Panama to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — IND
Apr 23 — Apr 301
Thu 4/23
Thu 4/30
1 adult, Economy
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Cheap flight deals from Panama to Indianapolis

Cheapest flights from Panama to Indianapolis
Explore the most affordable flight options available from Panama to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:40 pm
PTY
-
IND
2 stops21h 56m
American Airlines
Thu 10/87:26 pm
IND
-
PTY
2 stops19h 34m
American Airlines
Deal found 3/21$479
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:40 pm
PTY
-
IND
2 stops20h 04m
American Airlines
Sun 10/118:11 pm
IND
-
PTY
2 stops18h 49m
American Airlines
Deal found 3/21$518
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:49 pm
PTY
-
IND
1 stop9h 10m
American Airlines
Wed 5/136:36 pm
IND
-
PTY
2 stops19h 10m
American Airlines
Deal found 3/21$522
This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:15 pm
PTY
-
IND
1 stop9h 18m
Delta
Thu 5/146:00 am
IND
-
PTY
1 stop7h 50m
Delta
Deal found 3/23$530
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:49 pm
PTY
-
IND
1 stop20h 37m
American Airlines
Wed 9/306:36 am
IND
-
PTY
1 stop8h 34m
American Airlines
Deal found 3/23$552
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:14 pm
PTY
-
IND
2 stops21h 44m
American Airlines
Mon 6/157:27 pm
IND
-
PTY
1 stop17h 46m
American Airlines
Deal found 3/21$561

Find flight deals from Panama to Indianapolis

Keep the following information in mind while searching for Panama to Indianapolis flight deals. Data was last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$522
(American Airlines)

One-way from

$346
(Kiwi.com)

Popular in

March

Cheapest in

November

Average price

$772
Provider with most accurate pricing for Panama City Tocumen Intl-Indianapolis flight deals.
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Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Indianapolis flights.
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From Panama to Indianapolis
Search Deals
One-way flight from Panama to Indianapolis
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
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Average for round-trip flights in March 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Panama to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Fri 5/15

1:49 pm-11:26 am

1 stop20h 37m

Indianapolis

Thu 5/21

7:27 pm-12:14 pm

1 stop17h 47m

$483

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Thu 5/28

1:14 pm-12:51 pm

2 stops22h 37m

Indianapolis

Thu 6/4

8:49 pm-12:13 pm

2 stops16h 24m

$571

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Wed 7/22

10:55 pm-12:54 pm

2 stops12h 59m

Indianapolis

Wed 7/29

4:25 pm-4:04 am

2 stops12h 39m

$624

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Mon 7/6

10:55 pm-12:54 pm

2 stops12h 59m

Indianapolis

Mon 7/13

7:00 am-4:12 pm

1 stop10h 12m

$637

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sat 5/30

1:14 pm-11:47 am

2 stops21h 33m

Indianapolis

Sun 6/14

7:27 pm-12:13 pm

1 stop17h 46m

$640

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Mon 6/1

10:00 am-11:26 pm

1 stop12h 26m

Indianapolis

Sun 6/14

7:00 am-4:12 pm

1 stop10h 12m

$645

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Fri 6/12

9:45 am-10:15 pm

1 stop11h 30m

Indianapolis

Wed 7/8

7:00 am-4:12 pm

1 stop10h 12m

$654

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sun 7/5

3:30 pm-10:28 am

2 stops17h 58m

Indianapolis

Mon 7/13

7:00 am-2:14 pm

1 stop8h 14m

$659
Quickest round-trip

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sat 5/23

9:45 am-10:15 pm

1 stop11h 30m

Indianapolis

Sat 5/30

6:55 pm-4:04 am

1 stop10h 09m

$666

Panama CityIndianapolis

PTY - IND

PTYIND

Panama City Tocumen Intl

Sun 5/31

7:55 am-11:26 pm

1 stop14h 31m

Indianapolis

Sun 6/14

7:00 am-2:14 pm

1 stop8h 14m

$666

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Showing 1-10 of 19 resultsSorted by cheapest first
1
2

Best time to book a flight from Panama to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to Indianapolis

What is the cheapest month to book a flight from Panama to Indianapolis?

Currently, June is the cheapest month in which you can book a flight from Panama to Indianapolis (average of $254). Flying from Panama to Indianapolis in February is currently the most expensive (average of $678). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated March 24, 2026.
See what other customers who have flown with Delta and United Airlines from Panama to Indianapolis have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,320 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,320 reviews
Delta
7.9
Good
8,320 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,469 reviews
Delta
7.9
Good
8,320 reviews

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Panama to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Indianapolis from Panama?

    For a flight from Panama to Indianapolis, you will be flying into Indianapolis. Indianapolis (IND) is just 8.3 mi from the center of the city.

  • How long is the flight from Panama to Indianapolis?

    A quick flight from Panama to Indianapolis can take about 12h 59m. American Airlines provides one of the quickest options available for as low as $624. Panama and Indianapolis are separated by a distance of 2158 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Panama to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Panama to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to Indianapolis.

  • Can I find deals for business class flights from Panama to Indianapolis?

    Yes. Cheapflights offers flight deals from Panama to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to Indianapolis?

    Currently, June is the cheapest month in which you can book a flight from Panama to Indianapolis (average of $254). Flying from Panama to Indianapolis in February is currently the most expensive (average of $678). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Kokomo
Greenwood
Plainfield
Mooresville
Anderson
Franklin
Carmel
Crawfordsville
Bloomington

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Panama to Indianapolis

Discover the top 2 airlines that operate flights from Panama to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$311Average$590FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$496Average$666FlexibilityNo cancel feeOn-time69%

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