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$432+ Cheap flights from Missouri to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FLO
ago. 16 — ago. 231
sáb. 8/16
sáb. 8/23
1 adult, Economy
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Cheap flight deals from Missouri to Florence

Keep the following information in mind while searching for Missouri to Florence flight deals. Data was last updated agosto 11, 2025.

Round-trip from

$432
(American Airlines)
From Missouri to Florence
Search Deals

Find flight deals from Missouri to Florence

Cheapest flights from Missouri to Florence
Explore the most affordable flight options available from Missouri to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 11, 2025.

This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/266:26 amSTL - FLO
1 stop4h 20mAmerican Airlines
sáb. 8/3011:15 amFLO - STL
2 stops9h 06mAmerican Airlines
Deal found 8/11$432
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/203:12 pmMCI - FLO
1 stop6h 50mAmerican Airlines
mié. 8/276:20 amFLO - MCI
1 stop4h 52mAmerican Airlines
Deal found 8/10$441
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/104:27 pmMCI - FLO
1 stop6h 13mAmerican Airlines
sáb. 12/1311:14 amFLO - MCI
1 stop4h 13mAmerican Airlines
Deal found 8/9$491

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 11, 2025.
Use the filters below to find and compare flights from Missouri to Florence that are best for you.

Fly from

Missouri

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

mar. 8/26

6:26 am-11:46 am

1 stop4h 20m

Florence

sáb. 8/30

11:15 am-7:21 pm

2 stops9h 06m

$432

Kansas CityFlorence

MCI - FLO

MCIFLO

Kansas City

mié. 8/20

3:12 pm-11:02 pm

1 stop6h 50m

Florence

mié. 8/27

6:20 am-10:12 am

1 stop4h 52m

$441

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Best time to book a flight from Missouri to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florence

What is the cheapest month to book a flight from Missouri to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Missouri to Florence, South Carolina (average of $366). Flying from Missouri to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated agosto 11, 2025.
Read through reviews of airlines operating flights from Missouri to Florence, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Food

6.5

Boarding

7.5

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Crew

8.0

Food

6.5

Boarding

7.5

Entertainment

6.9

Overall

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Missouri?

    Florence (FLO) is the airport you will fly into if you book a flight from Missouri to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • Can I find deals for flights from Missouri to Florence that include hotel bookings?

    Yes. In addition to deals on Missouri to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florence.

  • Can I find deals for business class flights from Missouri to Florence?

    Yes. Cheapflights offers flight deals from Missouri to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Florence, South Carolina (average of $366). Flying from Missouri to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Missouri to Florence

Discover the top airline that operate flights from Missouri to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$414Average$504FlexibilityNo cancel feeOn-time71%

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