$335+ Cheap flights from Missouri to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FLO
Nov 29 — Dec 61
1 adult, Economy
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Cheapest flights from Missouri to FlorenceExplore the most affordable flight options available from Missouri to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
Explore the most affordable flight options available from Missouri to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:00 amSTL - FLO
1 stop4h 45mAmerican Airlines
Sun 11/165:15 amFLO - STL
1 stop4h 12mAmerican Airlines
Deal found 10/27![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/295:09 pmSTL - FLO
2 stops20h 45mAmerican Airlines
Sat 11/156:33 pmFLO - STL
1 stop6h 32mAmerican Airlines
Deal found 10/29![American Airlines logo]()
$730
Cheap flight deals from Missouri to Florence
Keep the following information in mind while searching for Missouri to Florence flight deals. Data was last updated October 30, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $335 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Florence that are best for you.
Fly from
Missouri
Fly to
Florence
Route
Depart
Return
Price
St. LouisFlorence
STL - FLO
STLFLO
Lambert-St Louis
Fri 11/14
10:15 am-5:09 pm
1 stop5h 54m
Florence
Sun 11/16
5:15 am-8:27 am
1 stop4h 12m
$355
Best time to book a flight from Missouri to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Florence
What is the cheapest month to book a flight from Missouri to Florence, South Carolina?
Currently, February is the cheapest month in which you can book a flight from Missouri to Florence, South Carolina (average of $84). Flying from Missouri to Florence, South Carolina in March is currently the most expensive (average of $234). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
Hartsville
Darlington
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Alternative routes for Missouri to Florence
See prices for flight routes from nearby airports that may be better suited for you.
Top airline flying from Missouri to Florence
Discover the top airline that operate flights from Missouri to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$414 | Average$504 | FlexibilityNo cancel fee | On-time71% |