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$349+ Cheap flights from Missouri to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — FLO
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Missouri to Florence

Cheapest flights from Missouri to Florence
Explore the most affordable flight options available from Missouri to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/113:54 pm
STL
-
FLO
1 stop5h 49m
American Airlines
Sun 2/155:16 am
FLO
-
STL
1 stop4h 19m
American Airlines
Deal found 1/27$349
This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:57 pm
STL
-
FLO
1 stop4h 00m
American Airlines
Tue 2/176:15 am
FLO
-
STL
2 stops10h 03m
American Airlines
Deal found 1/29$436
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/45:11 pm
MCI
-
FLO
1 stop4h 32m
American Airlines
Sat 2/76:15 am
FLO
-
MCI
1 stop4h 46m
American Airlines
Deal found 1/27$501

Find flight deals from Missouri to Florence

Keep the following information in mind while searching for Missouri to Florence flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$349
(American Airlines)
Provider with most accurate pricing for Lambert-St Louis-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Florence flights.
Search Deals
From Missouri to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to Florence that are best for you.

Fly from

Missouri

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Fri 2/13

6:57 pm-11:57 pm

1 stop4h 00m

Florence

Tue 2/17

6:15 am-9:40 am

1 stop4h 25m

$349

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Wed 2/11

3:54 pm-10:43 pm

1 stop5h 49m

Florence

Sun 2/15

5:16 am-8:35 am

1 stop4h 19m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/29

Best time to book a flight from Missouri to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Florence

What is the cheapest month to book a flight from Missouri to Florence, South Carolina?

Currently, February is the cheapest month in which you can book a flight from Missouri to Florence, South Carolina (average of $84). Flying from Missouri to Florence, South Carolina in December is currently the most expensive (average of $237). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Missouri?

    Florence (FLO) is the airport you will fly into if you book a flight from Missouri to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Missouri to Florence, South Carolina?

    A quick flight from Missouri to Florence, South Carolina can take about 4h. American Airlines provides one of the quickest options available for as low as $349. There are 669 mi between Missouri and Florence, South Carolina.

  • Can I find deals for flights from Missouri to Florence that include hotel bookings?

    Yes. In addition to deals on Missouri to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Florence.

  • Can I find deals for business class flights from Missouri to Florence?

    Yes. Cheapflights offers flight deals from Missouri to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Florence, South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Florence, South Carolina (average of $84). Flying from Missouri to Florence, South Carolina in December is currently the most expensive (average of $237). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Missouri to Florence

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Top airline flying from Missouri to Florence

Discover the top airline that operate flights from Missouri to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$414Average$482FlexibilityNo cancel feeOn-time71%

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