$406+ Cheap flights from Florence, SC (FLO) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Nov 23 — Nov 301
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Florence to Missouri with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to Missouri
Cheapest
Best
Last-minute
Cheapest flights from Florence to MissouriExplore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
Explore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:35 pm -
1 stop5h 33m
Sat 11/286:31 am -
1 stop6h 38m
Deal found 10/24![American Airlines logo]()
$406
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/73:37 pm -
2 stops20h 15m
Thu 12/108:24 pm -
2 stops16h 53m
Deal found 10/23![American Airlines logo]()
$876
Best flights from Florence to MissouriDiscover carefully curated flight deals from Florence to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
Discover carefully curated flight deals from Florence to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 24, 2026.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:09 am -
2 stops15h 18m
Sat 11/286:31 am -
1 stop6h 38m
Deal found 10/24![American Airlines logo]()
$495
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/73:37 pm -
2 stops20h 15m
Thu 12/106:47 am -
1 stop6h 30m
Deal found 10/23![American Airlines logo]()
$930
Last-minute flights from Florence to MissouriDiscover last-minute flight deals from Florence to Missouri. Data last updated October 24, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Missouri. Data last updated October 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:35 pm -
1 stop5h 33m
Sat 11/286:31 am -
1 stop6h 38m
Deal found 10/24![American Airlines logo]()
$406
Find flight deals from Florence to Missouri
Keep the following information in mind while searching for Florence to Missouri flight deals. Data was last updated October 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $406 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 24, 2026.
Use the filters below to find and compare flights from Florence to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
FlorenceSt. Louis
FLO Florence - STL Lambert-St Louis
FLOSTL
Florence
Sat 11/21
5:09 am-7:27 pm
2 stops15h 18m
Lambert-St Louis
Sat 11/28
6:31 am-2:09 pm
1 stop6h 38m
$495
FlorenceSt. Louis
FLO Florence - STL Lambert-St Louis
FLOSTL
Florence
Mon 12/7
3:37 pm-10:52 am
2 stops20h 15m
Lambert-St Louis
Thu 12/10
6:47 am-2:17 pm
1 stop6h 30m
$930
Sorted by cheapest first
Best time to book a flight from Florence to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Florence with our price prediction graph.
FLO-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Missouri
FLO-USMO
FLO-STL
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Florence to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations