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$405+ Cheap flights from Florence, SC (FLO) to Missouri

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Jun 15 — Jun 221
Mon 6/15
Mon 6/22
1 adult, Economy
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Cheap flight deals from Florence to Missouri

Cheapest flights from Florence to Missouri
Explore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 16, 2026.

This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/82:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$405
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/292:35 pm
FLO
-
STL
1 stop3h 45m
American Airlines
Tue 6/27:30 am
STL
-
FLO
1 stop5h 40m
American Airlines
Deal found 5/14$419
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:09 am
FLO
-
STL
1 stop4h 22m
American Airlines
Sat 8/86:25 pm
STL
-
FLO
1 stop4h 33m
American Airlines
Deal found 5/12$438
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Sun 8/99:21 am
STL
-
FLO
1 stop3h 51m
American Airlines
Deal found 5/14$453
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Mon 8/1010:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$471
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$474
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:17 am
FLO
-
MCI
1 stop7h 07m
American Airlines
Sat 8/16:30 am
MCI
-
FLO
1 stop6h 40m
American Airlines
Deal found 5/15$481
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Tue 8/1110:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$502
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:37 pm
FLO
-
STL
1 stop3h 57m
American Airlines
Sun 8/99:21 am
STL
-
FLO
1 stop3h 51m
American Airlines
Deal found 5/12$507
This deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/56:24 am
FLO
-
STL
1 stop4h 08m
American Airlines
Mon 8/1010:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 5/12$535

Find flight deals from Florence to Missouri

Keep the following information in mind while searching for Florence to Missouri flight deals. Data was last updated May 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$405
Provider with most accurate pricing for Florence-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Lambert-St Louis flights.
Search Deals
From Florence to Missouri
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Florence to Missouri that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 5/29

2:35 pm-5:20 pm

1 stop3h 45m

Lambert-St Louis

Tue 6/2

7:30 am-2:10 pm

1 stop5h 40m

$419

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Thu 8/6

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Sat 8/8

6:25 pm-11:58 pm

1 stop4h 33m

$438

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 8/7

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Sun 8/9

9:21 am-2:12 pm

1 stop3h 51m

$453

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Fri 8/7

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Sat 8/8

7:34 am-2:12 pm

1 stop5h 38m

$474

FlorenceKansas City

FLO - MCI

FLOMCI

Florence

Wed 7/29

5:17 am-11:24 am

1 stop7h 07m

Kansas City

Sat 8/1

5:08 pm-11:37 pm

1 stop5h 29m

$481

FlorenceKansas City

FLO - MCI

FLOMCI

Florence

Tue 7/28

2:35 pm-9:58 pm

2 stops8h 23m

Kansas City

Sat 8/1

5:30 am-2:10 pm

2 stops7h 40m

$491
Quickest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Wed 8/5

6:24 am-9:32 am

1 stop4h 08m

Lambert-St Louis

Mon 8/10

10:22 am-2:56 pm

1 stop3h 34m

$535

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Sun 8/9

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Tue 8/11

8:34 am-2:56 pm

1 stop5h 22m

$941

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Thu 8/6

5:09 am-8:31 am

1 stop4h 22m

Lambert-St Louis

Fri 8/7

8:34 am-2:56 pm

1 stop5h 22m

$955

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/14

Sorted by cheapest first

Best time to book a flight from Florence to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Missouri
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Missouri?

    Located just 2.3 mi from the city center, Florence (FLO) is the airport most travelers will use when flying to Missouri from Florence.

  • How long is the flight from Florence, South Carolina to Missouri?

    Airlines like American Airlines fly from Florence, South Carolina to Missouri in about 3h 57m. The time it takes to get you to your destination can typically vary by up to . There are 669 mi between Florence, South Carolina and Missouri.

  • What are the most popular routes from Florence, South Carolina to Missouri?

    While some choose either Florence - Lambert-St Louis or Florence - Springfield-Branson, Florence - Kansas City is the most popular route from Florence, South Carolina to Missouri.

  • Can I find deals for flights from Florence to Missouri that include hotel bookings?

    Yes. In addition to deals on Florence to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Missouri.

  • Can I find deals for business class flights from Florence to Missouri?

    Yes. Cheapflights offers flight deals from Florence to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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