$353+ Cheap flights from Florence, SC (FLO) to Missouri
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/7. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — STL
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Last-minute
Cheapest flights from Florence to MissouriExplore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Florence to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:34 pm -
1 stop5h 44m
Wed 10/149:27 am -
1 stop3h 42m
Deal found 9/6![American Airlines logo]()
$353
Best flights from Florence to MissouriDiscover carefully curated flight deals from Florence to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Florence to Missouri that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:34 pm -
1 stop5h 44m
Wed 10/149:27 am -
1 stop3h 42m
Deal found 9/6![American Airlines logo]()
$353
Last-minute flights from Florence to MissouriDiscover last-minute flight deals from Florence to Missouri. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to Missouri. Data last updated September 7, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:34 pm -
1 stop5h 44m
Wed 10/149:27 am -
1 stop3h 42m
Deal found 9/6![American Airlines logo]()
$353
Find flight deals from Florence to Missouri
Keep the following information in mind while searching for Florence to Missouri flight deals. Data was last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $353 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Florence to Missouri that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
FlorenceSt. Louis
FLO Florence - STL Lambert-St Louis
FLOSTL
Florence
Wed 10/7
2:34 pm-7:18 pm
1 stop5h 44m
Lambert-St Louis
Wed 10/14
9:27 am-2:09 pm
1 stop3h 42m
$353
Sorted by cheapest first
Best time to book a flight from Florence to Missouri
Have a flexible travel schedule? Discover the best time to fly to Missouri from Florence with our price prediction graph.
FLO-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to Missouri
FLO-USMO
FLO-STL
No data available for this route at this time. Please check back soon.
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