$517+ Cheap flights from Mississippi to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to Florence
Cheapest
Best
Last-minute
Cheapest flights from Mississippi to FlorenceExplore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:14 am -
1 stop4h 04m
Sat 10/31:43 pm -
1 stop4h 31m
Deal found 9/7![American Airlines logo]()
$517
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:01 am -
1 stop3h 53m
Thu 10/155:09 am -
1 stop6h 17m
Deal found 9/8![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/217:05 am -
1 stop6h 05m
Thu 12/315:09 am -
1 stop6h 16m
Deal found 9/8![American Airlines logo]()
$525
This American Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/62:53 pm -
1 stop5h 27m
Sat 9/121:43 pm -
1 stop4h 31m
Deal found 9/5![American Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:04 am -
1 stop6h 05m
Mon 10/265:09 am -
1 stop5h 41m
Deal found 9/7![American Airlines logo]()
$606
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:30 pm -
1 stop4h 24m
Sat 11/282:35 pm -
1 stop7h 06m
Deal found 9/9![American Airlines logo]()
$656
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:44 am -
1 stop5h 34m
Mon 9/281:43 pm -
2 stops10h 02m
Deal found 9/7![American Airlines logo]()
$725
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:27 pm -
1 stop6h 31m
Fri 9/116:24 am -
1 stop6h 25m
Deal found 9/8![American Airlines logo]()
$838
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:34 am -
2 stops24h 44m
Thu 10/16:24 am -
2 stops17h 34m
Deal found 9/6![American Airlines logo]()
$988
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:34 am -
2 stops24h 44m
Sun 9/275:09 am -
2 stops18h 49m
Deal found 9/8![American Airlines logo]()
$990
Best flights from Mississippi to FlorenceDiscover carefully curated flight deals from Mississippi to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Mississippi to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:14 am -
1 stop4h 04m
Sat 10/31:43 pm -
1 stop4h 31m
Deal found 9/7![American Airlines logo]()
$517
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:01 am -
1 stop3h 53m
Thu 10/155:09 am -
1 stop6h 17m
Deal found 9/8![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:44 am -
1 stop5h 34m
Mon 9/281:43 pm -
1 stop4h 31m
Deal found 9/7![American Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:30 pm -
1 stop4h 24m
Sat 11/282:35 pm -
1 stop7h 06m
Deal found 9/9![American Airlines logo]()
$656
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2111:46 am -
2 stops11h 11m
Thu 12/315:09 am -
2 stops13h 10m
Deal found 9/8![American Airlines logo]()
$763
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:35 am -
2 stops7h 34m
Mon 10/262:34 pm -
2 stops10h 25m
Deal found 9/7![American Airlines logo]()
$843
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:34 am -
2 stops24h 44m
Thu 10/16:24 am -
2 stops17h 34m
Deal found 9/6![American Airlines logo]()
$988
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:34 am -
2 stops24h 44m
Sun 9/275:09 am -
2 stops18h 49m
Deal found 9/8![American Airlines logo]()
$990
Last-minute flights from Mississippi to FlorenceDiscover last-minute flight deals from Mississippi to Florence. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to Florence. Data last updated September 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:34 am -
2 stops24h 44m
Sun 9/275:09 am -
2 stops18h 49m
Deal found 9/8![American Airlines logo]()
$990
This American Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:34 am -
2 stops24h 44m
Thu 10/16:24 am -
2 stops17h 34m
Deal found 9/6![American Airlines logo]()
$988
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:44 am -
1 stop5h 34m
Mon 9/281:43 pm -
1 stop4h 31m
Deal found 9/7![American Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:14 am -
1 stop4h 04m
Sat 10/31:43 pm -
1 stop4h 31m
Deal found 9/7![American Airlines logo]()
$517
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/610:01 am -
1 stop3h 53m
Thu 10/155:09 am -
1 stop6h 17m
Deal found 9/8![American Airlines logo]()
$521
This American Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:04 am -
1 stop6h 05m
Mon 10/265:09 am -
1 stop5h 41m
Deal found 9/7![American Airlines logo]()
$606
Find flight deals from Mississippi to Florence
Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $517 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MemphisFlorence
MEM Memphis - FLO Florence
MEMFLO
Memphis
Wed 9/30
8:14 am-1:18 pm
1 stop4h 04m
Florence
Sat 10/3
1:43 pm-5:14 pm
1 stop4h 31m
$517
JacksonFlorence
JAN Jackson-Evers Intl - FLO Florence
JANFLO
Jackson-Evers Intl
Tue 10/6
10:01 am-2:54 pm
1 stop3h 53m
Florence
Thu 10/15
5:09 am-10:26 am
1 stop6h 17m
$521
MemphisFlorence
MEM Memphis - FLO Florence
MEMFLO
Memphis
Fri 9/25
6:44 am-1:18 pm
1 stop5h 34m
Florence
Mon 9/28
1:43 pm-5:14 pm
1 stop4h 31m
$652
JacksonFlorence
JAN Jackson-Evers Intl - FLO Florence
JANFLO
Jackson-Evers Intl
Sat 11/21
6:30 pm-11:54 pm
1 stop4h 24m
Florence
Sat 11/28
2:35 pm-8:41 pm
1 stop7h 06m
$656
MemphisFlorence
MEM Memphis - FLO Florence
MEMFLO
Memphis
Mon 12/21
11:46 am-11:57 pm
2 stops11h 11m
Florence
Thu 12/31
5:09 am-5:19 pm
2 stops13h 10m
$763
MemphisFlorence
MEM Memphis - FLO Florence
MEMFLO
Memphis
Fri 10/23
5:35 am-2:09 pm
2 stops7h 34m
Florence
Mon 10/26
2:34 pm-11:59 pm
2 stops10h 25m
$843
MobileFlorence
MOB Mobile - FLO Florence
MOBFLO
Mobile
Thu 9/24
11:34 am-1:18 pm
2 stops24h 44m
Florence
Thu 10/1
6:24 am-10:58 pm
2 stops17h 34m
$988
MobileFlorence
MOB Mobile - FLO Florence
MOBFLO
Mobile
Wed 9/23
11:34 am-1:18 pm
2 stops24h 44m
Florence
Sun 9/27
5:09 am-10:58 pm
2 stops18h 49m
$990
Sorted by cheapest first
Best time to book a flight from Mississippi to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
MEM-FLO
JAN-FLO
MOB-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to Florence
USMS-FLO
MEM-FLO
JAN-FLO
MOB-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Florence if you plan to visit one of these locationsSumter
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