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$477+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Aug 22 — Aug 291
Sat 8/22
Sat 8/29
1 adult, Economy
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Cheap flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 23, 2026.

This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:15 am
MEM
-
FLO
1 stop5h 41m
American Airlines
Tue 8/256:22 am
FLO
-
MEM
1 stop4h 11m
American Airlines
Deal found 7/21$477
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:44 am
BTR
-
FLO
1 stop6h 26m
American Airlines
Sun 7/262:35 pm
FLO
-
BTR
1 stop4h 18m
American Airlines
Deal found 7/20$594
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/197:27 am
JAN
-
FLO
1 stop5h 43m
American Airlines
Wed 7/225:17 am
FLO
-
JAN
1 stop6h 11m
American Airlines
Deal found 7/18$828
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:01 pm
JAN
-
FLO
1 stop25h 55m
American Airlines
Mon 8/243:22 pm
FLO
-
JAN
1 stop21h 14m
American Airlines
Deal found 7/18$871
This American Airlines deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1412:01 pm
JAN
-
FLO
1 stop25h 55m
American Airlines
Fri 8/213:22 pm
FLO
-
JAN
1 stop21h 14m
American Airlines
Deal found 7/18$923

Find flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated July 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$477
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Florence flights.
Search Deals
From Mississippi to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Wed 8/19

5:52 pm-10:59 pm

1 stop4h 07m

Florence

Tue 8/25

6:22 am-6:15 pm

2 stops12h 53m

$538

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Fri 8/21

12:01 pm-2:56 pm

1 stop25h 55m

Florence

Mon 8/24

3:22 pm-11:36 am

1 stop21h 14m

$871

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Fri 8/14

12:01 pm-2:56 pm

1 stop25h 55m

Florence

Fri 8/21

3:22 pm-11:36 am

1 stop21h 14m

$923

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Sorted by cheapest first

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 4h 07m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 586 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Jackson-Evers Intl - Florence, Baton Rouge Ryan - Florence and Meridian Key Field - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

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