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Florence

$477+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/29. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Jun 15 — Jun 221
Mon 6/15
Mon 6/22
1 adult, Economy
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Cheap flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 16, 2026.

This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:21 pm
JAN
-
FLO
1 stop4h 39m
American Airlines
Tue 6/25:05 am
FLO
-
JAN
1 stop6h 21m
American Airlines
Deal found 5/15$477
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/118:15 am
JAN
-
FLO
1 stop4h 55m
American Airlines
Wed 6/172:35 pm
FLO
-
JAN
1 stop6h 24m
American Airlines
Deal found 5/12$481
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:44 am
BTR
-
FLO
1 stop6h 26m
American Airlines
Thu 7/162:35 pm
FLO
-
BTR
1 stop4h 18m
American Airlines
Deal found 5/15$541
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:35 pm
MOB
-
FLO
1 stop6h 23m
American Airlines
Tue 9/83:22 pm
FLO
-
MOB
1 stop6h 14m
American Airlines
Deal found 5/15$561
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:15 am
JAN
-
FLO
1 stop4h 55m
American Airlines
Sun 5/315:05 am
FLO
-
JAN
1 stop6h 21m
American Airlines
Deal found 5/12$567
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/262:56 pm
MEM
-
FLO
1 stop6h 04m
American Airlines
Sat 5/305:05 am
FLO
-
MEM
1 stop6h 30m
American Airlines
Deal found 5/11$585
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/34:35 pm
MOB
-
FLO
1 stop6h 23m
American Airlines
Mon 9/73:22 pm
FLO
-
MOB
1 stop6h 14m
American Airlines
Deal found 5/15$665
This American Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:20 am
JAN
-
FLO
1 stop5h 50m
American Airlines
Thu 8/65:09 am
FLO
-
JAN
1 stop6h 12m
American Airlines
Deal found 5/14$828
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:03 am
MEM
-
FLO
1 stop5h 47m
American Airlines
Thu 5/212:35 pm
FLO
-
MEM
1 stop4h 44m
American Airlines
Deal found 5/12$828
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:40 am
MOB
-
FLO
1 stop15h 19m
American Airlines
Tue 9/83:22 pm
FLO
-
MOB
1 stop6h 14m
American Airlines
Deal found 5/15$886
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/41:44 pm
MOB
-
FLO
1 stop23h 28m
American Airlines
Tue 9/83:22 pm
FLO
-
MOB
1 stop6h 14m
American Airlines
Deal found 5/15$908
This American Airlines deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:30 am
MOB
-
FLO
2 stops16h 29m
American Airlines
Sun 9/62:37 pm
FLO
-
MOB
2 stops28h 12m
American Airlines
Deal found 5/15$945

Find flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated May 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$477
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Florence flights.
Search Deals
From Mississippi to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 16, 2026.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Fri 5/29

4:21 pm-10:00 pm

1 stop4h 39m

Florence

Tue 6/2

5:05 am-10:26 am

1 stop6h 21m

$477

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Thu 6/11

8:15 am-2:10 pm

1 stop4h 55m

Florence

Wed 6/17

2:35 pm-7:59 pm

1 stop6h 24m

$481
Quickest round-trip

Baton RougeFlorence

BTR - FLO

BTRFLO

Baton Rouge Ryan

Fri 7/10

6:44 am-2:10 pm

1 stop6h 26m

Florence

Thu 7/16

2:35 pm-5:53 pm

1 stop4h 18m

$541

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Fri 5/29

8:15 am-2:10 pm

1 stop4h 55m

Florence

Sun 5/31

5:05 am-10:26 am

1 stop6h 21m

$567

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 5/26

2:56 pm-10:00 pm

1 stop6h 04m

Florence

Sat 5/30

5:05 am-10:35 am

1 stop6h 30m

$585

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Tue 8/4

7:20 am-2:10 pm

1 stop5h 50m

Florence

Thu 8/6

5:09 am-10:21 am

1 stop6h 12m

$828

MobileFlorence

MOB - FLO

MOBFLO

Mobile

Wed 9/2

6:40 am-10:59 pm

1 stop15h 19m

Florence

Tue 9/8

3:22 pm-8:36 pm

1 stop6h 14m

$886

MobileFlorence

MOB - FLO

MOBFLO

Mobile

Fri 9/4

11:36 am-2:12 pm

2 stops25h 36m

Florence

Tue 9/8

3:22 pm-5:44 pm

2 stops27h 22m

$970

MobileFlorence

MOB - FLO

MOBFLO

Mobile

Fri 9/4

6:19 pm-2:12 pm

2 stops18h 53m

Florence

Sun 9/6

2:37 pm-11:06 am

2 stops21h 29m

$975

MobileFlorence

MOB - FLO

MOBFLO

Mobile

Wed 9/2

6:40 am-2:56 pm

1 stop7h 16m

Florence

Mon 9/7

3:22 pm-8:36 pm

1 stop6h 14m

$990

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/15

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 4h 39m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 611 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Jackson-Evers Intl - Florence, Baton Rouge Ryan - Florence and Meridian Key Field - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville

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