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$375+ Cheap flights from Minnesota to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
MSP — FLO
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Minnesota to Florence

Cheapest flights from Minnesota to Florence
Explore the most affordable flight options available from Minnesota to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:16 amMSP - FLO
1 stop5h 10mAmerican Airlines
Sun 1/45:15 amFLO - MSP
1 stop5h 11mAmerican Airlines
Deal found 12/16$395
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:10 pmMSP - FLO
1 stop4h 43mAmerican Airlines
Wed 12/245:15 amFLO - MSP
1 stop5h 11mAmerican Airlines
Deal found 12/17$422

Find flight deals from Minnesota to Florence

Keep the following information in mind while searching for Minnesota to Florence flight deals. Data was last updated December 18, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$375
(American Airlines)
Provider with most accurate pricing for Minneapolis St Paul-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Minneapolis St Paul-Florence flights.
Search Deals
From Minnesota to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Minnesota to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Minnesota to Florence that are best for you.

Fly from

Minnesota

Fly to

Florence

Route

Depart

Return

Price

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Thu 3/5

10:07 am-5:45 pm

1 stop6h 38m

Florence

Sat 3/7

6:18 pm-11:28 pm

1 stop6h 10m

$375

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Wed 12/31

6:16 am-12:26 pm

1 stop5h 10m

Florence

Sun 1/4

5:15 am-9:26 am

1 stop5h 11m

$395

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Thu 3/5

6:00 am-5:45 pm

2 stops10h 45m

Florence

Mon 3/9

6:20 pm-11:19 pm

1 stop5h 59m

$400

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Fri 3/6

4:52 pm-11:58 pm

1 stop6h 06m

Florence

Sat 3/7

5:15 am-5:16 pm

2 stops13h 01m

$436

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Fri 3/6

6:28 am-5:45 pm

2 stops10h 17m

Florence

Mon 3/9

6:20 pm-11:19 pm

1 stop5h 59m

$456

MinneapolisFlorence

MSP - FLO

MSPFLO

Minneapolis St Paul

Thu 3/5

10:07 am-5:45 pm

1 stop6h 38m

Florence

Sun 3/8

6:20 pm-11:19 pm

1 stop5h 59m

$471

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Best time to book a flight from Minnesota to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Minnesota with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Minnesota to Florence

What is the cheapest month to book a flight from Minnesota to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Minnesota to Florence, South Carolina (average of $69). Flying from Minnesota to Florence, South Carolina in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Minnesota to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Minnesota?

    Located just 2.3 mi from the city center, Florence (FLO) is the airport most travelers will use when flying to Florence from Minnesota.

  • How long is the flight from Minnesota to Florence, South Carolina?

    A quick flight from Minnesota to Florence, South Carolina can take about 6h 38m. American Airlines provides one of the quickest options available for as low as $375. The distance between Minnesota and Florence, South Carolina is about 1027 mi.

  • Can I find deals for flights from Minnesota to Florence that include hotel bookings?

    Yes. In addition to deals on Minnesota to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Minnesota to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Minnesota to Florence.

  • Can I find deals for business class flights from Minnesota to Florence?

    Yes. Cheapflights offers flight deals from Minnesota to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Minnesota to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Minnesota to Florence, South Carolina (average of $69). Flying from Minnesota to Florence, South Carolina in December is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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