$551+ Cheap flights from Detroit to Florence, SC (DTT - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — FLO
Sep 25 — Oct 21
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Florence with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Florence
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Last-minute
Cheapest flights from Detroit to FlorenceExplore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 26, 2026.
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:43 pm -
1 stop4h 16m
Sat 9/121:43 pm -
1 stop4h 52m
Deal found 8/24![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:15 am -
1 stop6h 55m
Sun 9/275:09 am -
1 stop4h 07m
Deal found 8/21![American Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:43 pm -
1 stop4h 16m
Thu 9/176:24 am -
2 stops13h 12m
Deal found 8/24![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:30 am -
1 stop5h 48m
Sun 9/205:09 am -
1 stop4h 07m
Deal found 8/21![American Airlines logo]()
$608
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:56 pm -
2 stops10h 02m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:30 am -
1 stop5h 48m
Sat 9/196:24 am -
2 stops9h 07m
Deal found 8/24![American Airlines logo]()
$679
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:30 am -
1 stop5h 48m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$683
Best flights from Detroit to FlorenceDiscover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
Discover carefully curated flight deals from Detroit to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 26, 2026.
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:30 am -
1 stop5h 48m
Sun 9/205:09 am -
1 stop4h 07m
Deal found 8/21![American Airlines logo]()
$608
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:30 am -
1 stop5h 48m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:43 pm -
1 stop4h 16m
Thu 9/171:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/127:30 am -
1 stop5h 48m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$629
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:30 am -
1 stop5h 48m
Sat 9/191:43 pm -
2 stops7h 50m
Deal found 8/24![American Airlines logo]()
$732
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/2010:05 am -
1 stop4h 05m
Sun 9/272:36 pm -
2 stops8h 58m
Deal found 8/21![American Airlines logo]()
$736
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:36 am -
2 stops6h 42m
Thu 9/176:24 am -
2 stops7h 17m
Deal found 8/24![American Airlines logo]()
$795
This American Airlines deal was found by Cheapflights users on 8/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:43 pm -
1 stop4h 16m
Fri 9/111:43 pm -
1 stop3h 47m
Deal found 8/23![American Airlines logo]()
$965
Last-minute flights from Detroit to FlorenceDiscover last-minute flight deals from Detroit to Florence. Data last updated August 26, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Florence. Data last updated August 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:43 pm -
1 stop4h 16m
Sat 9/121:43 pm -
1 stop4h 52m
Deal found 8/24![American Airlines logo]()
$551
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:43 pm -
1 stop4h 16m
Thu 9/176:24 am -
2 stops13h 12m
Deal found 8/24![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 8/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:30 am -
1 stop5h 48m
Mon 9/141:43 pm -
1 stop3h 47m
Deal found 8/26![American Airlines logo]()
$610
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:30 am -
1 stop5h 48m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$683
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/117:30 am -
1 stop5h 48m
Sat 9/196:24 am -
2 stops9h 07m
Deal found 8/24![American Airlines logo]()
$679
This American Airlines deal was found by Cheapflights users on 8/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1212:56 pm -
2 stops10h 02m
Sat 9/191:43 pm -
1 stop3h 47m
Deal found 8/24![American Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:15 am -
1 stop6h 55m
Sun 9/275:09 am -
1 stop4h 07m
Deal found 8/21![American Airlines logo]()
$565
Find flight deals from Detroit to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $521 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 26, 2026.
Use the filters below to find and compare flights from Detroit to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Fri 9/18
7:30 am-1:18 pm
1 stop5h 48m
Florence
Sun 9/20
5:09 am-9:16 am
1 stop4h 07m
$608
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Fri 9/11
7:30 am-1:18 pm
1 stop5h 48m
Florence
Sat 9/19
1:43 pm-5:30 pm
1 stop3h 47m
$629
Quickest round-trip
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Tue 9/8
6:43 pm-10:59 pm
1 stop4h 16m
Florence
Thu 9/17
1:43 pm-5:30 pm
1 stop3h 47m
$629
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sat 9/12
7:30 am-1:18 pm
1 stop5h 48m
Florence
Sat 9/19
1:43 pm-5:30 pm
1 stop3h 47m
$629
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Thu 9/10
7:30 am-1:18 pm
1 stop5h 48m
Florence
Sat 9/19
1:43 pm-9:33 pm
2 stops7h 50m
$732
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sun 9/20
10:05 am-2:10 pm
1 stop4h 05m
Florence
Sun 9/27
2:36 pm-11:34 pm
2 stops8h 58m
$736
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Sat 9/12
6:36 am-1:18 pm
2 stops6h 42m
Florence
Thu 9/17
6:24 am-1:41 pm
2 stops7h 17m
$795
DetroitFlorence
DTW Detroit Metropolitan Wayne County - FLO Florence
DTWFLO
Detroit Metropolitan Wayne County
Mon 9/7
6:43 pm-10:59 pm
1 stop4h 16m
Florence
Fri 9/11
1:43 pm-5:30 pm
1 stop3h 47m
$965
Sorted by cheapest first
Compare providers for flights from Detroit to Florence
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
DTT-FLO
DTW-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Florence
DTT-FLO
DTW-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
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