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$323+ Cheap flights from Detroit to Florence, SC (DTT - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — FLO
Apr 24 — May 11
Fri 4/24
Fri 5/1
1 adult, Economy
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Cheap flight deals from Detroit to Florence

Cheapest flights from Detroit to Florence
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2026.

This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/610:11 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Sat 5/95:20 am
FLO
-
DTW
1 stop4h 07m
American Airlines
Deal found 3/25$323
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:11 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Mon 5/184:16 pm
FLO
-
DTW
1 stop6h 12m
American Airlines
Deal found 3/25$363
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/810:11 am
DTW
-
FLO
1 stop5h 39m
American Airlines
Sun 4/125:20 am
FLO
-
DTW
1 stop4h 07m
American Airlines
Deal found 3/24$422
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:56 pm
DTW
-
FLO
1 stop4h 17m
American Airlines
Sun 10/411:20 am
FLO
-
DTW
1 stop3h 31m
American Airlines
Deal found 3/22$426

Find flight deals from Detroit to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 25, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$323
(American Airlines)
Provider with most accurate pricing for Detroit (DTT)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Florence flights.
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From Detroit (DTT) to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Detroit to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 5/6

3:30 pm-9:47 pm

1 stop6h 17m

Florence

Sat 5/9

5:20 am-12:49 pm

2 stops7h 29m

$328

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/14

10:11 am-3:50 pm

1 stop5h 39m

Florence

Mon 5/18

4:16 pm-10:28 pm

1 stop6h 12m

$363

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Wed 4/8

10:11 am-3:50 pm

1 stop5h 39m

Florence

Sun 4/12

5:20 am-9:27 am

1 stop4h 07m

$422

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Mon 3/30

8:20 am-5:50 pm

2 stops9h 30m

Florence

Mon 4/6

6:20 pm-11:03 pm

1 stop4h 43m

$624

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 5/7

11:57 am-3:50 pm

1 stop3h 53m

Florence

Sun 5/10

4:16 pm-12:45 am

2 stops8h 29m

$624
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sun 4/5

7:55 pm-11:57 pm

1 stop4h 02m

Florence

Thu 4/9

5:20 am-9:27 am

1 stop4h 07m

$935

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/25

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Detroit-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Florence

What is the cheapest month to book a flight from Detroit to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit to Florence, South Carolina (average of $87). Flying from Detroit to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit to Florence, South Carolina?

    Airlines like American Airlines fly from Detroit to Florence, South Carolina in about 6h 17m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 589 mi.

  • Can I find deals for flights from Detroit to Florence that include hotel bookings?

    Yes. In addition to deals on Detroit to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Florence.

  • Can I find deals for business class flights from Detroit to Florence?

    Yes. Cheapflights offers flight deals from Detroit to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit to Florence, South Carolina (average of $87). Flying from Detroit to Florence, South Carolina in December is currently the most expensive (average of $151). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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