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$286+ Cheap flights from Detroit to Florence, SC (DTT - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — FLO
Nov 12 — Nov 191
Wed 11/12
Wed 11/19
1 adult, Economy
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Find flight deals from Detroit to Florence

Cheapest flights from Detroit to Florence
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2025.

This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:01 amDTW - FLO
1 stop6h 25mAmerican Airlines
Tue 12/306:30 pmFLO - DTW
1 stop6h 14mAmerican Airlines
Deal found 10/11$421
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:57 pmDTW - FLO
1 stop5h 57mAmerican Airlines
Fri 11/710:29 amFLO - DTW
2 stops11h 47mAmerican Airlines
Deal found 10/11$494
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:12 pmDTW - FLO
2 stops21h 34mAmerican Airlines
Sat 11/85:15 amFLO - DTW
2 stops12h 26mAmerican Airlines
Deal found 10/11$497
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:40 pmDTW - FLO
1 stop4h 33mAmerican Airlines
Thu 11/65:15 amFLO - DTW
1 stop4h 33mAmerican Airlines
Deal found 10/11$499
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amDTW - FLO
1 stop4h 46mAmerican Airlines
Sat 11/85:15 amFLO - DTW
1 stop4h 33mAmerican Airlines
Deal found 10/11$511
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3112:57 pmDTW - FLO
1 stop5h 57mAmerican Airlines
Sun 11/95:15 amFLO - DTW
1 stop5h 58mAmerican Airlines
Deal found 10/11$520

Cheap flight deals from Detroit to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$421
(American Airlines)

One-way from

$286
(American Airlines)
Provider with most accurate pricing for Detroit (DTT)-Florence flight deals.
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Provider most trusted by Cheapflights users for Detroit (DTT)-Florence flights.
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From Detroit (DTT) to Florence
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One-way flight from Detroit (DTT) to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Detroit to Florence that are best for you.

Fly from

Detroit

Fly to

Florence

Route

Depart

Return

Price

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 12/25

11:12 am-6:05 pm

2 stops6h 53m

Florence

Tue 12/30

5:15 am-9:21 am

1 stop4h 06m

$426

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

12:57 pm-6:54 pm

1 stop5h 57m

Florence

Sat 11/8

5:15 am-5:41 pm

2 stops12h 26m

$494

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

1:12 pm-10:46 am

2 stops21h 34m

Florence

Fri 11/7

6:15 am-4:57 pm

2 stops10h 42m

$497

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Thu 10/30

6:40 pm-11:13 pm

1 stop4h 33m

Florence

Thu 11/6

5:15 am-9:48 am

1 stop4h 33m

$499

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 11/1

6:00 am-10:46 am

1 stop4h 46m

Florence

Sat 11/8

5:15 am-9:48 am

1 stop4h 33m

$511

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Fri 10/31

12:57 pm-6:54 pm

1 stop5h 57m

Florence

Sun 11/9

5:15 am-11:13 am

1 stop5h 58m

$520

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

Sat 10/25

6:00 am-10:46 am

1 stop4h 46m

$286

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/12

Compare providers for flights from Detroit to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Florence

What is the cheapest month to book a flight from Detroit to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from Detroit to Florence, South Carolina (average of $91). Flying from Detroit to Florence, South Carolina in January is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit to Florence, South Carolina?

    Airlines like American Airlines fly from Detroit to Florence, South Carolina in about 6h 53m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 589 mi.

  • Can I find deals for flights from Detroit to Florence that include hotel bookings?

    Yes. In addition to deals on Detroit to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Florence.

  • Can I find deals for business class flights from Detroit to Florence?

    Yes. Cheapflights offers flight deals from Detroit to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Detroit to Florence, South Carolina (average of $91). Flying from Detroit to Florence, South Carolina in January is currently the most expensive (average of $159). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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