HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$457+ Cheap flights from Detroit to Florence, SC (DTT - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/24. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — FLO
juin 27 — juil. 41
sam. 6/27
sam. 7/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Detroit to Florence

Cheapest flights from Detroit to Florence
Explore the most affordable flight options available from Detroit to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on mai 28, 2026.

This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 6/247:00 am
DTW
-
FLO
2 stops15h 00m
American Airlines
mer. 7/15:05 am
FLO
-
DTW
2 stops11h 36m
American Airlines
Deal found 5/27$457
This American Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sam. 11/76:00 am
DTW
-
FLO
2 stops12h 07m
American Airlines
dim. 11/811:11 am
FLO
-
DTW
2 stops11h 03m
American Airlines
Deal found 5/26$512
This American Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer. 6/310:01 am
DTW
-
FLO
1 stop4h 09m
American Airlines
sam. 6/135:05 am
FLO
-
DTW
1 stop4h 12m
American Airlines
Deal found 5/25$541
This American Airlines deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/2210:01 am
DTW
-
FLO
1 stop4h 09m
American Airlines
jeu. 7/22:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Deal found 5/23$555
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 7/276:10 am
DTW
-
FLO
2 stops8h 00m
American Airlines
lun. 8/32:35 pm
FLO
-
DTW
2 stops8h 14m
American Airlines
Deal found 5/27$565

Find flight deals from Detroit to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated mai 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$457
(American Airlines)
Provider with most accurate pricing for Detroit (DTT)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Florence flights.
Search Deals
From Detroit (DTT) to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated mai 28, 2026.
Use the filters below to find and compare flights from Detroit to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

mer. 6/24

7:00 am-10:00 pm

2 stops15h 00m

Florence

mer. 7/1

5:05 am-4:41 pm

2 stops11h 36m

$457

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

sam. 11/7

6:00 am-6:07 pm

2 stops12h 07m

Florence

dim. 11/8

11:11 am-10:14 pm

2 stops11h 03m

$512

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

lun. 6/22

10:01 am-2:10 pm

1 stop4h 09m

Florence

jeu. 7/2

2:35 pm-7:18 pm

1 stop4h 43m

$555

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

lun. 7/27

7:58 pm-11:37 pm

1 stop3h 39m

Florence

lun. 8/3

2:35 pm-7:18 pm

1 stop4h 43m

$555
Quickest round-trip

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

lun. 6/15

10:01 am-2:10 pm

1 stop4h 09m

Florence

lun. 6/22

5:05 am-9:17 am

1 stop4h 12m

$639

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

ven. 6/12

10:50 am-10:00 pm

2 stops11h 10m

Florence

lun. 6/15

2:35 pm-10:44 pm

2 stops8h 09m

$895
Cheapest one-way
Quickest one-way

DetroitFlorence

DTW - FLO

DTWFLO

Detroit Metropolitan Wayne County

dim. 6/28

10:01 am-2:10 pm

1 stop4h 09m

$478

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/24

Sorted by cheapest first

Compare providers for flights from Detroit to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Florence in May.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit to Florence, South Carolina?

    Airlines like American Airlines fly from Detroit to Florence, South Carolina in about 15h. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 589 mi.

  • Can I find deals for flights from Detroit to Florence that include hotel bookings?

    Yes. In addition to deals on Detroit to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Florence.

  • Can I find deals for business class flights from Detroit to Florence?

    Yes. Cheapflights offers flight deals from Detroit to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Detroit to Florence

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Charlotte flights
O'Hare Intl to Myrtle Beach flights
Detroit to Charlotte flights
O'Hare Intl to Charleston flights
O'Hare Intl to Savannah flights
Detroit to Myrtle Beach flights
Detroit to Charleston flights
O'Hare Intl to Hilton Head Island flights
O'Hare Intl to Greenville flights
Detroit to Savannah flights
Midway to Charlotte flights
Midway to Charleston flights
Midway to Myrtle Beach flights
O'Hare Intl to Columbia flights
Grand Rapids to Charlotte flights
Midway to Savannah flights
Detroit to Greenville flights
Grand Rapids to Charleston flights
Midway to Greenville flights
Detroit to Columbia flights
South Bend to Charlotte flights
Grand Rapids to Savannah flights
South Bend to Myrtle Beach flights
Midway to Columbia flights
Grand Rapids to Myrtle Beach flights
Traverse City to Charlotte flights
South Bend to Savannah flights
Flint to Charlotte flights
Flint to Charleston flights
Detroit to Hilton Head Island flights
Grand Rapids to Hilton Head Island flights
O'Hare Intl to Augusta flights
South Bend to Charleston flights
Traverse City to Charleston flights
Flint to Myrtle Beach flights
Grand Rapids to Greenville flights
South Bend to Greenville flights
Kalamazoo to Myrtle Beach flights
Detroit to Augusta flights
Flint to Savannah flights
Grand Rapids to Columbia flights
Midway to Augusta flights
Lansing to Myrtle Beach flights
Kalamazoo to Savannah flights
Lansing to Greenville flights
South Bend to Columbia flights
Traverse City to Savannah flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.