$70+ Cheap flights from Detroit (DTT) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — CHS
May 23 — May 301
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Detroit to South CarolinaExplore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Orbitz deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:55 pm
DTW
- CLT
1 stop4h 53m
Multiple Airlines
Sat 5/239:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$165
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Tue 5/127:58 pm
CLT
- DTW
1 stop16h 01m
Frontier
Deal found 4/20![Frontier logo]()
$171
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Mon 5/185:58 pm
CLT
- DTW
1 stop24h 45m
Frontier
Deal found 4/19![Frontier logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:00 am
DTW
- CLT
1 stop30h 05m
Multiple Airlines
Tue 6/91:22 pm
CLT
- DTW
1 stop22h 13m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$174
This Expedia deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:55 am
DTW
- CLT
1 stop10h 23m
Multiple Airlines
Sun 5/319:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$175
This Trip.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:52 am
DTW
- CLT
1 stop27h 49m
Frontier
Mon 5/115:58 pm
CLT
- DTW
1 stop24h 45m
Frontier
Deal found 4/20![Frontier logo]()
$176
This Booking.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
DTW
- CLT
1 stop5h 34m
Spirit Airlines
Wed 6/33:16 pm
CLT
- DTW
1 stop8h 37m
Spirit Airlines
Deal found 4/20![Spirit Airlines logo]()
$177
This Cheapflightsfares deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:42 pm
DTW
- CLT
1 stop5h 58m
Spirit Airlines
Wed 5/273:16 pm
CLT
- DTW
1 stop8h 37m
Spirit Airlines
Deal found 4/20![Spirit Airlines logo]()
$178
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/68:52 am
DTW
- CLT
1 stop7h 08m
Frontier
Tue 6/96:00 am
CLT
- DTW
1 stop12h 58m
Frontier
Deal found 4/20![Frontier logo]()
$180
This Trip.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:14 pm
DTW
- CLT
1 stop25h 34m
Frontier
Sat 5/237:58 pm
CLT
- DTW
1 stop16h 02m
Frontier
Deal found 4/18![Frontier logo]()
$182
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:52 am
DTW
- CLT
1 stop7h 08m
Frontier
Mon 5/259:10 am
CLT
- DTW
1 stop26h 39m
Frontier
Deal found 4/19![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:50 am
DTW
- CLT
2 stops31h 21m
Multiple Airlines
Fri 5/299:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$186
Best flights from Detroit to South CarolinaDiscover carefully curated flight deals from Detroit to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from Detroit to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:20 pm
DTW
- MYR
1 stop4h 10m
Southwest
Wed 6/107:05 pm
MYR
- DTW
1 stop3h 45m
Southwest
Deal found 4/22![Southwest logo]()
$281
This CheapOair deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:50 pm
DTW
- MYR
1 stop11h 56m
Spirit Airlines
Sun 5/176:00 am
MYR
- DTW
1 stop27h 03m
Spirit Airlines
Deal found 4/18![Spirit Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:00 am
DTW
- CAE
1 stop4h 44m
American Airlines
Thu 5/286:03 pm
CAE
- DTW
1 stop4h 31m
American Airlines
Deal found 4/18![American Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/235:10 am
DTW
- CLT
1 stop6h 01m
Delta
Tue 5/265:00 pm
CLT
- DTW
Nonstop1h 48m
Delta
Deal found 4/19![Delta logo]()
$313
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:50 am
DTW
- CAE
1 stop4h 56m
United Airlines
Mon 7/610:31 am
CAE
- DTW
1 stop4h 03m
United Airlines
Deal found 4/22![United Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:55 am
DTW
- SAV
2 stops9h 40m
Southwest
Tue 9/225:05 pm
SAV
- DTW
1 stop4h 10m
Southwest
Deal found 4/20![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/3010:01 am
DTW
- FLO
1 stop4h 09m
American Airlines
Sat 7/42:35 pm
FLO
- DTW
1 stop4h 43m
American Airlines
Deal found 4/19![American Airlines logo]()
$323
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:09 am
DTW
- CLT
Nonstop1h 46m
Delta
Sun 5/319:47 am
CLT
- DTW
Nonstop1h 58m
Delta
Deal found 4/22![Delta logo]()
$323
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:25 pm
DTW
- CLT
2 stops8h 40m
Southwest
Fri 6/124:00 pm
CLT
- DTW
2 stops6h 25m
Southwest
Deal found 4/20![Southwest logo]()
$299
This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:00 am
DTW
- HHH
1 stop5h 11m
United Airlines
Wed 5/133:08 pm
HHH
- DTW
1 stop5h 08m
United Airlines
Deal found 4/21![United Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:38 pm
DTW
- CAE
1 stop5h 07m
Delta
Mon 7/67:39 pm
CAE
- DTW
1 stop5h 19m
Delta
Deal found 4/20![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
DTW
- AGS
1 stop6h 18m
American Airlines
Wed 6/36:27 pm
AGS
- DTW
1 stop4h 07m
American Airlines
Deal found 4/19![American Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/234:05 pm
DTW
- SAV
1 stop5h 00m
Southwest
Sun 5/248:00 am
SAV
- DTW
1 stop4h 40m
Southwest
Deal found 4/22![Southwest logo]()
$320
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:00 am
DTW
- SAV
1 stop4h 52m
United Airlines
Fri 5/296:40 pm
SAV
- DTW
1 stop5h 17m
United Airlines
Deal found 4/22![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:30 pm
DTW
- CAE
1 stop4h 32m
Delta
Mon 6/87:39 pm
CAE
- DTW
1 stop4h 19m
Delta
Deal found 4/22![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1612:59 pm
DTW
- AGS
2 stops8h 46m
American Airlines
Tue 6/308:54 am
AGS
- DTW
2 stops6h 49m
American Airlines
Deal found 4/21![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:35 am
DTW
- SAV
2 stops9h 25m
Southwest
Sat 5/237:00 pm
SAV
- DTW
1 stop4h 10m
Southwest
Deal found 4/23![Southwest logo]()
$325
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:50 am
DTW
- SAV
1 stop5h 26m
United Airlines
Sun 7/263:14 pm
SAV
- DTW
1 stop7h 05m
United Airlines
Deal found 4/22![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/138:05 pm
DTW
- CLT
Nonstop1h 50m
Delta
Mon 6/157:48 pm
CLT
- DTW
1 stop5h 10m
Delta
Deal found 4/19![Delta logo]()
$333
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:40 am
DTW
- AGS
2 stops7h 37m
American Airlines
Sun 5/316:27 pm
AGS
- DTW
1 stop4h 07m
American Airlines
Deal found 4/21![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/28:35 am
DTW
- MYR
Nonstop1h 58m
Delta
Mon 7/611:30 am
MYR
- DTW
Nonstop2h 00m
Delta
Deal found 4/23![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:00 am
DTW
- HHH
1 stop5h 16m
United Airlines
Mon 5/43:08 pm
HHH
- DTW
1 stop5h 08m
United Airlines
Deal found 4/20![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/168:35 am
DTW
- GSP
2 stops12h 05m
Southwest
Sat 5/235:25 pm
GSP
- DTW
1 stop4h 00m
Southwest
Deal found 4/23![Southwest logo]()
$353
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/308:35 am
DTW
- MYR
Nonstop1h 58m
Delta
Sun 7/511:30 am
MYR
- DTW
Nonstop2h 00m
Delta
Deal found 4/22![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/121:43 pm
DTW
- AGS
1 stop4h 19m
American Airlines
Wed 6/246:27 pm
AGS
- DTW
1 stop4h 07m
American Airlines
Deal found 4/19![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:00 am
DTW
- CAE
1 stop4h 41m
United Airlines
Sat 5/162:20 pm
CAE
- DTW
2 stops9h 35m
United Airlines
Deal found 4/18![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:45 am
DTW
- CHS
2 stops11h 00m
Southwest
Sun 8/302:05 pm
CHS
- DTW
2 stops7h 25m
Southwest
Deal found 4/23![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:25 pm
DTW
- SAV
Nonstop2h 11m
Delta
Tue 10/206:30 pm
SAV
- DTW
Nonstop2h 15m
Delta
Deal found 4/23![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:00 am
DTW
- AGS
1 stop6h 18m
American Airlines
Tue 5/266:27 pm
AGS
- DTW
1 stop6h 06m
American Airlines
Deal found 4/18![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:13 am
DTW
- CAE
2 stops11h 03m
United Airlines
Thu 5/287:45 pm
CAE
- DTW
1 stop4h 06m
United Airlines
Deal found 4/18![United Airlines logo]()
$397
Last-minute flights from Detroit to South CarolinaDiscover last-minute flight deals from Detroit to South Carolina. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to South Carolina. Data last updated April 23, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:52 am
DTW
- CLT
1 stop27h 49m
Frontier
Mon 5/115:58 pm
CLT
- DTW
1 stop24h 45m
Frontier
Deal found 4/20![Frontier logo]()
$176
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Tue 5/127:58 pm
CLT
- DTW
1 stop16h 01m
Frontier
Deal found 4/20![Frontier logo]()
$171
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Mon 5/185:58 pm
CLT
- DTW
1 stop24h 45m
Frontier
Deal found 4/19![Frontier logo]()
$172
This Trip.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:14 pm
DTW
- CLT
1 stop25h 34m
Frontier
Sat 5/237:58 pm
CLT
- DTW
1 stop16h 02m
Frontier
Deal found 4/18![Frontier logo]()
$182
This Orbitz deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:55 pm
DTW
- CLT
1 stop4h 53m
Multiple Airlines
Sat 5/239:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:50 am
DTW
- CLT
2 stops31h 21m
Multiple Airlines
Fri 5/299:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$186
This Trip.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:52 am
DTW
- CLT
1 stop7h 08m
Frontier
Mon 5/259:10 am
CLT
- DTW
1 stop26h 39m
Frontier
Deal found 4/19![Frontier logo]()
$185
This Expedia deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/218:52 am
DTW
- CLT
1 stop7h 08m
Multiple Airlines
Thu 5/289:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$190
This Cheapflightsfares deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:42 pm
DTW
- CLT
1 stop5h 58m
Spirit Airlines
Wed 5/273:16 pm
CLT
- DTW
1 stop8h 37m
Spirit Airlines
Deal found 4/20![Spirit Airlines logo]()
$178
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:52 am
DTW
- CLT
1 stop7h 08m
Multiple Airlines
Wed 5/273:16 pm
CLT
- DTW
1 stop8h 37m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$180
This Expedia deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:55 am
DTW
- CLT
1 stop10h 23m
Multiple Airlines
Sun 5/319:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:05 pm
DTW
- CLT
2 stops17h 29m
Multiple Airlines
Sun 5/319:07 pm
CLT
- DTW
1 stop11h 56m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$187
One-way flights from Detroit to South CarolinaSearch for one-way flight options from Detroit to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from Detroit to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1712:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Deal found 4/20![Frontier logo]()
$70
This Super.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:14 pm
DTW
- CLT
1 stop25h 34m
Frontier
Deal found 4/21![Frontier logo]()
$75
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
DTW
- CLT
1 stop8h 11m
Spirit Airlines
Deal found 4/20![Spirit Airlines logo]()
$88
This Super.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Deal found 4/19![Frontier logo]()
$89
This Frontier deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:55 pm
DTW
- CLT
1 stop4h 53m
Frontier
Deal found 4/20![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/58:52 am
DTW
- CLT
1 stop7h 08m
Frontier
Deal found 4/21![Frontier logo]()
$91
This Cheapflightsfares deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:00 am
DTW
- CLT
1 stop8h 11m
Spirit Airlines
Deal found 4/19![Spirit Airlines logo]()
$94
This Priceline deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:52 am
DTW
- CLT
1 stop7h 08m
Frontier
Deal found 4/21![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:50 pm
DTW
- CHS
1 stop15h 54m
Spirit Airlines
Deal found 4/19![Spirit Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:50 am
DTW
- CLT
2 stops31h 21m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:42 pm
DTW
- CLT
1 stop5h 58m
Spirit Airlines
Deal found 4/21![Spirit Airlines logo]()
$100
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:49 pm
DTW
- SAV
1 stop4h 09m
American Airlines
Deal found 4/20![American Airlines logo]()
$101
Find flight deals from Detroit to South Carolina
Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $165 (Orbitz) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | August |
Average price | $329 |
Good round-trip deal | $389 or less |
Good one-way deal | $238 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitMyrtle Beach
DTW - MYR
DTWMYR
Detroit Metropolitan Wayne County
Sat 6/6
1:20 pm-5:30 pm
1 stop4h 10m
Myrtle Beach Intl
Wed 6/10
7:05 pm-10:50 pm
1 stop3h 45m
$281
DetroitSavannah
DTW - SAV
DTWSAV
Detroit Metropolitan Wayne County
Thu 9/17
5:55 am-3:35 pm
2 stops9h 40m
Savannah/Hilton Head
Tue 9/22
5:05 pm-9:15 pm
1 stop4h 10m
$287
DetroitMyrtle Beach
DTW - MYR
DTWMYR
Detroit Metropolitan Wayne County
Sat 5/9
9:50 pm-9:46 am
1 stop11h 56m
Myrtle Beach Intl
Sun 5/17
6:00 am-9:03 am
1 stop27h 03m
$291
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Wed 6/10
1:25 pm-10:05 pm
2 stops8h 40m
Charlotte Douglas
Fri 6/12
4:00 pm-10:25 pm
2 stops6h 25m
$299
DetroitColumbia
DTW - CAE
DTWCAE
Detroit Metropolitan Wayne County
Sat 5/23
6:00 am-10:44 am
1 stop4h 44m
Columbia Metropolitan
Thu 5/28
6:03 pm-10:34 pm
1 stop4h 31m
$312
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Sat 5/23
5:10 am-11:11 am
1 stop6h 01m
Charlotte Douglas
Tue 5/26
5:00 pm-6:48 pm
Nonstop1h 48m
$313
DetroitSavannah
DTW - SAV
DTWSAV
Detroit Metropolitan Wayne County
Sat 5/23
4:05 pm-9:05 pm
1 stop5h 00m
Savannah/Hilton Head
Sun 5/24
8:00 am-12:40 pm
1 stop4h 40m
$320
DetroitFlorence
DTW - FLO
DTWFLO
Detroit Metropolitan Wayne County
Tue 6/30
10:01 am-2:10 pm
1 stop4h 09m
Florence
Sat 7/4
2:35 pm-7:18 pm
1 stop4h 43m
$323
Quickest round-trip
DetroitCharlotte
DTW - CLT
DTWCLT
Detroit Metropolitan Wayne County
Thu 5/28
7:09 am-8:55 am
Nonstop1h 46m
Charlotte Douglas
Sun 5/31
9:47 am-11:45 am
Nonstop1h 58m
$323
DetroitColumbia
DTW - CAE
DTWCAE
Detroit Metropolitan Wayne County
Fri 7/3
6:38 pm-11:45 pm
1 stop5h 07m
Columbia Metropolitan
Mon 7/6
7:39 pm-12:58 am
1 stop5h 19m
$324
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Detroit to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
DTW-CLT
DTW-CHS
DTW-SAV
DTW-MYR
DTW-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to South Carolina
DTT-USSC
DTW-CLT
DTW-CHS
DTW-SAV
DTW-MYR
How far ahead should I book a flight from Detroit to South Carolina?
The best time to book flights from Detroit to South Carolina is 21 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Detroit to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $45). Flying from Detroit to South Carolina in May is currently the most expensive (average of $1,119). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DTT to SC?
Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 23, 2026.
When flying from Detroit to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 11% versus a flight at noon.
What is the cheapest day to fly from Detroit to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on April 18, 2026.
Travelers seeking maximum savings on their Detroit to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Detroit to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 23, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Detroit to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Detroit to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to South Carolina by cabin class
Find flights from Detroit to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and South Carolina flights
Browse other Detroit and South Carolina flight options. Last updated on April 23, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Detroit to South Carolina flights
Consider these flights traveling from Detroit to South Carolina.
Top 4 airlines flying from Detroit to South Carolina
Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$64 | Average$156 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$159 | Average$395 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$363 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$207 | Average$369 | FlexibilityNo cancel fee | On-time63% |