HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$63+ Cheap flights from Detroit (DTT) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/15. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — CHS
Aug 21 — Aug 281
Fri 8/21
Fri 8/28
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Detroit to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Detroit to South Carolina

Cheapest flights from Detroit to South Carolina
Explore the most affordable flight options available from Detroit to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 22, 2026.

This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/221:01 pm
DTW
-
CHS
1 stop19h 37m
Multiple Airlines
Tue 9/291:21 pm
CHS
-
DTW
1 stop21h 41m
Multiple Airlines
Deal found 7/20$193
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2311:58 am
DTW
-
GSP
1 stop7h 46m
Multiple Airlines
Mon 9/2812:11 pm
GSP
-
DTW
1 stop24h 56m
Multiple Airlines
Deal found 7/20$196
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/81:40 pm
DTW
-
CHS
1 stop23h 44m
Multiple Airlines
Sat 9/126:00 am
CHS
-
DTW
2 stops18h 42m
Multiple Airlines
Deal found 7/19$200
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/204:37 pm
DTW
-
GSP
1 stop25h 02m
Multiple Airlines
Mon 8/244:55 pm
GSP
-
DTW
1 stop24h 27m
Multiple Airlines
Deal found 7/20$202
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:18 am
DTW
-
SAV
1 stop7h 37m
Multiple Airlines
Wed 8/2612:19 pm
SAV
-
DTW
1 stop24h 36m
Multiple Airlines
Deal found 7/18$206
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:18 am
DTW
-
GSP
1 stop21h 39m
Multiple Airlines
Sun 8/308:37 am
GSP
-
DTW
1 stop28h 18m
Multiple Airlines
Deal found 7/20$212
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:18 am
DTW
-
CHS
1 stop26h 46m
Multiple Airlines
Tue 8/253:13 pm
CHS
-
DTW
1 stop17h 41m
Multiple Airlines
Deal found 7/17$217
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/55:21 pm
DTW
-
CHS
1 stop15h 17m
Multiple Airlines
Tue 9/84:04 pm
CHS
-
DTW
1 stop18h 58m
Multiple Airlines
Deal found 7/19$220
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:58 am
DTW
-
GSP
1 stop7h 46m
Multiple Airlines
Sun 10/119:39 pm
GSP
-
DTW
1 stop15h 28m
Multiple Airlines
Deal found 7/20$221
This Kiwi.com deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:00 am
DTW
-
SAV
1 stop26h 00m
Multiple Airlines
Wed 9/1612:23 pm
SAV
-
DTW
1 stop24h 44m
Multiple Airlines
Deal found 7/19$222
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1910:18 am
DTW
-
SAV
1 stop7h 37m
Multiple Airlines
Thu 8/2710:05 am
SAV
-
DTW
1 stop26h 50m
Multiple Airlines
Deal found 7/18$223
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2210:18 am
DTW
-
SAV
1 stop7h 37m
Multiple Airlines
Wed 8/2612:19 pm
SAV
-
DTW
1 stop24h 36m
Multiple Airlines
Deal found 7/18$224

Find flight deals from Detroit to South Carolina

Keep the following information in mind while searching for Detroit to South Carolina flight deals. Data was last updated July 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$193
(Kiwi.com)

One-way from

$63
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$438

Good round-trip deal

$339 or less

Good one-way deal

$333 or less
Provider with most accurate pricing for Detroit (DTT)-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit (DTT)-Myrtle Beach Intl flights.
Search Deals
From Detroit (DTT) to South Carolina
Search Deals
One-way flight from Detroit (DTT) to South Carolina
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($58 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($17 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals
Price to beat on a round-trip flight from Detroit (DTT) to South Carolina.
Search Deals
Price to beat on a one-way flight from Detroit (DTT) to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
Use the filters below to find and compare flights from Detroit to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Fri 12/4

8:30 am-10:29 am

Nonstop1h 59m

Myrtle Beach Intl

Tue 12/8

11:10 am-1:09 pm

Nonstop1h 59m

$299

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Sat 8/29

8:41 am-10:38 am

Nonstop1h 57m

Myrtle Beach Intl

Sat 9/5

11:33 am-1:30 pm

Nonstop1h 57m

$299

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Wed 8/19

7:30 am-2:03 pm

1 stop6h 33m

Hilton Head Island

Wed 8/26

2:58 pm-8:29 pm

1 stop5h 31m

$309

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Fri 8/14

9:15 am-2:03 pm

1 stop4h 48m

Hilton Head Island

Wed 8/19

2:58 pm-10:25 pm

1 stop7h 27m

$309

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Thu 8/13

7:20 am-11:09 am

1 stop3h 49m

Columbia Metropolitan

Sun 8/16

6:08 pm-10:33 pm

1 stop4h 25m

$309

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Fri 9/11

9:15 am-2:03 pm

1 stop4h 48m

Hilton Head Island

Wed 9/16

2:48 pm-10:25 pm

1 stop7h 37m

$309

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Wed 8/19

8:41 am-10:38 am

Nonstop1h 57m

Myrtle Beach Intl

Mon 8/24

7:02 pm-12:59 am

1 stop5h 57m

$309

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Thu 9/10

2:54 pm-9:41 pm

1 stop6h 47m

Myrtle Beach Intl

Sun 9/13

11:34 am-1:28 pm

Nonstop1h 54m

$309
Quickest round-trip

DetroitMyrtle Beach

DTW - MYR

DTWMYR

Detroit Metropolitan Wayne County

Wed 9/23

8:40 am-10:36 am

Nonstop1h 56m

Myrtle Beach Intl

Wed 9/30

11:34 am-1:28 pm

Nonstop1h 54m

$309

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Mon 10/19

8:00 am-3:02 pm

1 stop7h 02m

Charleston

Sat 10/31

10:50 am-3:50 pm

1 stop5h 00m

$312

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/21

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Detroit to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Detroit to South Carolina

What is the cheapest month to book a flight from Detroit to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $288). Flying from Detroit to South Carolina in March is currently the most expensive (average of $457). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DTT to SC?

Find hourly flight availability from Detroit to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 22, 2026.

When flying from Detroit to South Carolina, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 16% versus a flight in the morning.

Weekly flight availability from Detroit to South Carolina

Explore weekly flight availability from Detroit to South Carolina. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 22, 2026.

The most flights from DTT to USSC are scheduled on a Monday (13 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (5 on average).

How much does it cost to fly round-trip from Detroit to South Carolina?

How far ahead should I book a flight from Detroit to South Carolina?

The best time to book flights from Detroit to South Carolina is 14 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest day to fly from Detroit to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Detroit to South Carolina. Price data was last updated on July 18, 2026.

Travelers seeking maximum savings on their Detroit to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 22, 2026.
Read reviews from past customers who have flown Southwest,Delta, andAmerican Airlines from Detroit to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,239 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
Southwest
8.0
Very good
4,239 reviews
Southwest
8.0
Very good
4,239 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
Delta
7.8
Good
8,472 reviews
Southwest
8.0
Very good
4,239 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.
American Airlines
7.1
Good
11,836 reviews
Southwest
8.0
Very good
4,239 reviews

Entertainment

7.5

Food

7.0

Boarding

8.1

Crew

8.6

Overall

8.0

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Libby,Jun 2026

TUS - LAS

One delay in a 2 layover flight=a good trip. The crew was great.

Related info for your journey

Find useful and relevant information for your journey from Detroit to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Detroit to South Carolina?

    Most people fly from Detroit All airports (DTT) if they book a flight from Detroit to South Carolina. Detroit All airports is conveniently located just 0.6 mi from Detroit’s city center.

  • How long is the flight from Detroit to South Carolina?

    There are many flights that can get you from Detroit to South Carolina in 1h 59m. Fly via Delta, United Airlines, or JetBlue to get the fastest option. There are 637 mi between Detroit and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Detroit to South Carolina one-way?

    $96 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on American Airlines and Volaris, with prices starting from $130 and $137, respectively.

  • What are the most popular routes from Detroit to South Carolina?

    The most popular route from Detroit to South Carolina is Detroit Metropolitan Wayne County - Charlotte Douglas. You may also consider Detroit Metropolitan Wayne County - Myrtle Beach Intl or Detroit Metropolitan Wayne County - Charleston.

  • What are the most reliable airlines from Detroit to South Carolina?

    The top 3 most reliable airlines when flying from Detroit to South Carolina are WestJet (81%), Endeavor Airlines (80%) and Delta (79%).

  • What are the cheapest flights from Detroit to South Carolina?

    Looking for the cheapest flight from Detroit to South Carolina? While on average our users pay $511, our data indicates the cheapest price to be $238. The most popular route (Detroit Metropolitan Wayne County - Charlotte Douglas), is priced around $247.

  • Can I find deals for flights from Detroit to South Carolina that include hotel bookings?

    Yes. In addition to deals on Detroit to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to South Carolina.

  • Can I find deals for business class flights from Detroit to South Carolina?

    Yes. Cheapflights offers flight deals from Detroit to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Detroit to South Carolina (average of $288). Flying from Detroit to South Carolina in March is currently the most expensive (average of $457). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Detroit to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
O'Hare Intl to Seattle flights
O'Hare Intl to Newark flights
O'Hare Intl to Los Angeles flights
O'Hare Intl to Orlando flights
O'Hare Intl to John F Kennedy Intl flights
O'Hare Intl to Las Vegas flights
O'Hare Intl to LaGuardia flights
Detroit to Las Vegas flights
Detroit to Dallas/Fort Worth flights
O'Hare Intl to Dallas/Fort Worth flights
O'Hare Intl to Fort Lauderdale flights
O'Hare Intl to Denver flights
O'Hare Intl to Boston flights
Detroit to Orlando flights
O'Hare Intl to San Francisco flights
Detroit to Seattle flights
O'Hare Intl to Miami flights
O'Hare Intl to Tampa flights
Midway to Newark flights
O'Hare Intl to Sky Harbor Intl flights
Detroit to LaGuardia flights
Detroit to John F Kennedy Intl flights
Detroit to Fort Lauderdale flights
Detroit to Newark flights
Detroit to Denver flights
O'Hare Intl to Atlanta flights
O'Hare Intl to San Diego flights
Detroit to Miami flights
O'Hare Intl to Ontario flights
O'Hare Intl to Reagan-National flights
O'Hare Intl to Philadelphia flights
O'Hare Intl to New Orleans flights
Midway to Las Vegas flights
O'Hare Intl to Nashville flights
O'Hare Intl to Baltimore flights
Detroit to Los Angeles flights
O'Hare Intl to Dulles Intl flights
O'Hare Intl to Hobby flights
Detroit to Tampa flights
Midway to Dallas/Fort Worth flights
O'Hare Intl to George Bush Intcntl flights
Detroit to Boston flights
O'Hare Intl to Fort Myers flights
Midway to Seattle flights
O'Hare Intl to Honolulu flights
Detroit to San Francisco flights
Detroit to Sky Harbor Intl flights
Midway to John F Kennedy Intl flights
O'Hare Intl to Salt Lake City flights
Midway to Miami flights

Top 4 airlines flying from Detroit to South Carolina

Discover the top 4 airlines that operate flights from Detroit to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$190Average$434FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$230Average$406FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$233Average$397FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$283Average$338FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.