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$492+ Cheap flights from Denver to Florence, SC (DEN - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Denver to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$365
(American Airlines)
From Denver Intl to Florence
Search Deals

Find flight deals from Denver to Florence

Cheapest flights from Denver to Florence
Explore the most affordable flight options available from Denver to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/61:52 pmDEN - FLO
1 stop8h 11mAmerican Airlines
Wed 10/226:14 amFLO - DEN
1 stop5h 59mAmerican Airlines
Deal found 9/8$492
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/137:09 amDEN - FLO
1 stop8h 03mAmerican Airlines
Wed 9/245:37 pmFLO - DEN
1 stop6h 36mAmerican Airlines
Deal found 9/11$519
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/268:10 amDEN - FLO
1 stop7h 02mAmerican Airlines
Fri 10/312:27 pmFLO - DEN
1 stop6h 35mAmerican Airlines
Deal found 9/9$541
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/161:52 pmDEN - FLO
1 stop8h 11mAmerican Airlines
Sun 10/195:14 amFLO - DEN
1 stop5h 48mAmerican Airlines
Deal found 9/11$565
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/210:32 amDEN - FLO
2 stops11h 41mAmerican Airlines
Sun 10/511:18 amFLO - DEN
2 stops11h 08mAmerican Airlines
Deal found 9/10$699

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Denver to Florence that are best for you.

Fly from

Denver

Fly to

Florence

Route

Depart

Return

Price

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 10/8

7:26 am-2:54 pm

1 stop5h 28m

Florence

Sat 10/25

11:11 am-3:10 pm

1 stop5h 59m

$492

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Mon 10/6

1:52 pm-12:03 am

1 stop8h 11m

Florence

Wed 10/22

6:14 am-10:13 am

1 stop5h 59m

$492

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 10/2

3:57 pm-12:13 am

1 stop6h 16m

Florence

Sun 10/5

4:57 pm-11:08 pm

1 stop8h 11m

$519

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 9/26

8:10 am-5:12 pm

1 stop7h 02m

Florence

Fri 10/3

12:27 pm-5:02 pm

1 stop6h 35m

$541

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Thu 10/16

5:28 pm-10:46 am

2 stops15h 18m

Florence

Sun 10/19

5:14 am-9:02 am

1 stop5h 48m

$621

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Denver to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Denver to Florence

What is the cheapest month to book a flight from Denver to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Denver to Florence, South Carolina (average of $366). Flying from Denver to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Denver to Florence, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Entertainment

6.9

Overall

7.2

Comfort

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Boarding

7.5

Crew

8.0

Entertainment

6.9

Overall

7.2

Comfort

7.2

Food

6.4

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from Denver to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Florence, South Carolina?

    A quick flight from Denver to Florence, South Carolina can take about 5h 28m. American Airlines provides one of the quickest options available for as low as $492. Airlines will cover a distance of 1425 mi.

  • What is the cheapest airline to fly from Denver to Florence, South Carolina round-trip?

    According to our current data, American Airlines ($385), offers the cheapest pricing from Denver to Florence, South Carolina.

  • Can I find deals for flights from Denver to Florence that include hotel bookings?

    Yes. In addition to deals on Denver to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Florence.

  • Can I find deals for business class flights from Denver to Florence?

    Yes. Cheapflights offers flight deals from Denver to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Denver to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Denver to Florence, South Carolina (average of $366). Flying from Denver to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Denver to Florence

Discover the top airline that operate flights from Denver to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$385Average$481FlexibilityNo cancel feeOn-time71%

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