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$417+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/27. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
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Find flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:16 pmJAN - FLO
1 stop4h 59mAmerican Airlines
Sat 1/36:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 11/17$417
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:58 pmMEM - FLO
1 stop4h 17mAmerican Airlines
Sun 1/46:30 pmFLO - MEM
1 stop6h 26mAmerican Airlines
Deal found 11/17$435
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:36 pmJAN - FLO
1 stop6h 17mAmerican Airlines
Sat 12/66:31 pmFLO - JAN
1 stop6h 49mAmerican Airlines
Deal found 11/17$447
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:10 amJAN - FLO
1 stop6h 16mAmerican Airlines
Fri 1/26:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 11/17$476
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:16 pmJAN - FLO
1 stop4h 59mAmerican Airlines
Fri 1/26:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 11/17$482
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:58 pmMEM - FLO
1 stop4h 17mAmerican Airlines
Fri 1/25:15 amFLO - MEM
2 stops11h 59mAmerican Airlines
Deal found 11/17$532
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:55 pmMEM - FLO
1 stop3h 58mAmerican Airlines
Thu 11/206:33 pmFLO - MEM
1 stop6h 26mAmerican Airlines
Deal found 11/16$748

Cheap flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated November 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$435
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Florence flights.
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From Mississippi to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Mississippi

Fly to

Florence

Route

Depart

Return

Price

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Sat 12/27

6:16 pm-12:15 am

1 stop4h 59m

Florence

Sat 1/3

6:30 pm-12:12 am

1 stop6h 42m

$417

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

6:58 pm-12:15 am

1 stop4h 17m

Florence

Sun 1/4

5:15 am-8:47 am

1 stop4h 32m

$435

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

5:00 am-12:26 pm

1 stop6h 26m

Florence

Fri 1/2

5:15 am-10:25 am

1 stop6h 10m

$435

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Tue 12/2

3:36 pm-10:53 pm

1 stop6h 17m

Florence

Sat 12/6

6:31 pm-12:20 am

1 stop6h 49m

$447

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Sat 2/7

3:39 pm-11:11 pm

1 stop6h 32m

Florence

Wed 2/11

6:15 am-12:25 pm

1 stop7h 10m

$457

Baton RougeFlorence

BTR - FLO

BTRFLO

Baton Rouge Ryan

Sat 1/10

5:31 pm-11:11 pm

1 stop4h 40m

Florence

Tue 1/13

5:36 pm-8:59 pm

1 stop4h 23m

$469

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 12/22

5:10 am-12:26 pm

1 stop6h 16m

Florence

Fri 1/2

6:30 pm-12:12 am

1 stop6h 42m

$476

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Sat 12/27

6:16 pm-12:15 am

1 stop4h 59m

Florence

Fri 1/2

6:30 pm-12:12 am

1 stop6h 42m

$482

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in March is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 4h 59m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 611 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Jackson-Evers Intl - Florence, Memphis - Florence and Mobile - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in March is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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