HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$289+ Cheap flights from Milwaukee to Florence, SC (MKE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — FLO
Jul 10 — Jul 171
Fri 7/10
Fri 7/17
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Milwaukee to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Milwaukee to Florence

Cheapest flights from Milwaukee to Florence
Explore the most affordable flight options available from Milwaukee to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.

This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:25 pm
MKE
-
FLO
1 stop5h 42m
American Airlines
Tue 7/142:35 pm
FLO
-
MKE
1 stop4h 02m
American Airlines
Deal found 6/8$289
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:26 pm
MKE
-
FLO
1 stop6h 37m
American Airlines
Thu 10/2911:07 am
FLO
-
MKE
1 stop5h 42m
American Airlines
Deal found 6/9$345
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:01 am
MKE
-
FLO
1 stop6h 09m
American Airlines
Mon 7/132:35 pm
FLO
-
MKE
1 stop4h 02m
American Airlines
Deal found 6/6$390
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:00 am
MKE
-
FLO
1 stop6h 10m
American Airlines
Wed 6/242:35 pm
FLO
-
MKE
1 stop4h 02m
American Airlines
Deal found 6/8$509

Find flight deals from Milwaukee to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Milwaukee (MKE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$289
(American Airlines)
Provider with most accurate pricing for Milwaukee-Mitchell-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Florence flights.
Search Deals
From Milwaukee-Mitchell to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Milwaukee to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Wed 7/8

1:25 pm-8:07 pm

1 stop5h 42m

Florence

Tue 7/14

2:35 pm-5:37 pm

1 stop4h 02m

$289

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Thu 10/22

4:26 pm-12:03 am

1 stop6h 37m

Florence

Thu 10/29

11:07 am-3:49 pm

1 stop5h 42m

$345

MilwaukeeFlorence

MKE - FLO

MKEFLO

Milwaukee-Mitchell

Sun 7/5

7:01 am-2:10 pm

1 stop6h 09m

Florence

Mon 7/13

2:35 pm-5:37 pm

1 stop4h 02m

$390

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/8

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Milwaukee-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Milwaukee-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Milwaukee-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Milwaukee-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Milwaukee-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Milwaukee to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Milwaukee to Florence, South Carolina?

    A quick flight from Milwaukee to Florence, South Carolina can take about 5h 42m. American Airlines provides one of the quickest options available for as low as $289. The distance from Milwaukee to Florence, South Carolina is about 748 mi.

  • Can I find deals for flights from Milwaukee to Florence that include hotel bookings?

    Yes. In addition to deals on Milwaukee to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to Florence.

  • Can I find deals for business class flights from Milwaukee to Florence?

    Yes. Cheapflights offers flight deals from Milwaukee to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.