$117+ Cheap flights from Milwaukee (MKE) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Nov 29 — Dec 61
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Milwaukee to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Milwaukee to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Milwaukee to South CarolinaExplore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:00 am -
1 stop5h 06m
Tue 12/154:54 pm -
1 stop6h 43m
Deal found 10/29![American Airlines logo]()
$233
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:00 am -
2 stops7h 28m
Tue 12/156:30 am -
1 stop5h 58m
Deal found 10/29![United Airlines logo]()
$258
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:10 pm -
1 stop4h 35m
Mon 12/218:05 pm -
1 stop4h 35m
Deal found 10/28![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:20 am -
2 stops6h 50m
Thu 1/77:15 am -
2 stops9h 30m
Deal found 10/29![Southwest logo]()
$289
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/242:55 pm -
1 stop6h 05m
Tue 12/14:10 pm -
1 stop4h 50m
Deal found 10/27![American Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:20 am -
1 stop5h 25m
Wed 12/21:30 pm -
2 stops9h 45m
Deal found 10/25![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:43 pm -
1 stop4h 08m
Tue 12/811:53 am -
1 stop6h 45m
Deal found 10/28![Delta logo]()
$303
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 am -
2 stops9h 10m
Tue 12/152:50 pm -
2 stops8h 30m
Deal found 10/29![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:20 am -
1 stop3h 57m
Fri 11/277:05 am -
1 stop5h 32m
Deal found 10/26![Delta logo]()
$315
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:40 pm -
2 stops6h 45m
Wed 12/22:50 pm -
1 stop7h 35m
Deal found 10/26![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:30 am -
1 stop4h 30m
Fri 12/47:00 am -
2 stops9h 03m
Deal found 10/26![United Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/18:00 am -
2 stops8h 25m
Fri 12/41:30 pm -
2 stops9h 00m
Deal found 10/26![Southwest logo]()
$325
Best flights from Milwaukee to South CarolinaDiscover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Milwaukee to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/216:49 pm -
1 stop4h 03m
Sat 1/235:38 am -
1 stop6h 27m
Deal found 10/28![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:31 pm -
1 stop5h 20m
Thu 1/75:29 pm -
1 stop4h 30m
Deal found 10/29![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:20 am -
2 stops6h 50m
Thu 1/77:10 pm -
1 stop4h 00m
Deal found 10/29![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:24 am -
1 stop5h 41m
Sun 1/241:50 pm -
2 stops7h 27m
Deal found 10/25![American Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:30 am -
1 stop4h 36m
Thu 1/288:01 am -
1 stop4h 10m
Deal found 10/28![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:30 am -
2 stops10h 45m
Tue 1/267:15 am -
1 stop3h 55m
Deal found 10/28![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:20 am -
1 stop5h 25m
Wed 12/25:15 pm -
1 stop5h 10m
Deal found 10/25![Southwest logo]()
$295
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/202:40 pm -
1 stop5h 23m
Sun 1/245:50 am -
2 stops10h 20m
Deal found 10/27![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/317:00 am -
1 stop5h 13m
Sun 4/45:40 am -
1 stop4h 42m
Deal found 10/28![Delta logo]()
$328
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 am -
2 stops9h 10m
Tue 12/152:50 pm -
2 stops8h 30m
Deal found 10/29![Southwest logo]()
$309
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2312:09 pm -
1 stop4h 21m
Sat 2/2711:04 am -
2 stops9h 56m
Deal found 10/27![American Airlines logo]()
$401
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/152:40 pm -
2 stops8h 19m
Wed 1/202:42 pm -
2 stops7h 17m
Deal found 10/26![United Airlines logo]()
$366
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/205:30 am -
1 stop4h 36m
Sun 1/248:01 am -
1 stop4h 10m
Deal found 10/28![Delta logo]()
$336
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:40 pm -
2 stops6h 45m
Wed 12/22:50 pm -
1 stop7h 35m
Deal found 10/26![Southwest logo]()
$318
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/177:00 am -
1 stop5h 56m
Tue 1/263:10 pm -
1 stop6h 20m
Deal found 10/28![Delta logo]()
$336
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
1 stop6h 22m
Tue 12/812:33 pm -
2 stops8h 27m
Deal found 10/25![American Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/610:35 am -
1 stop5h 23m
Tue 2/96:15 am -
1 stop6h 50m
Deal found 10/27![United Airlines logo]()
$391
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/316:20 am -
2 stops5h 55m
Mon 1/47:35 pm -
1 stop5h 00m
Deal found 10/29![Southwest logo]()
$330
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:00 am -
1 stop6h 21m
Tue 11/1712:25 pm -
2 stops11h 12m
Deal found 10/29![American Airlines logo]()
$440
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:00 am -
1 stop6h 00m
Sat 12/56:45 am -
2 stops13h 03m
Deal found 10/27![United Airlines logo]()
$400
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/184:10 pm -
1 stop4h 45m
Wed 12/239:15 pm -
1 stop4h 10m
Deal found 10/26![Southwest logo]()
$339
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:19 pm -
1 stop3h 51m
Mon 11/307:55 pm -
1 stop4h 59m
Deal found 10/29![Delta logo]()
$386
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/910:50 am -
2 stops6h 49m
Tue 3/165:29 pm -
1 stop6h 15m
Deal found 10/27![American Airlines logo]()
$442
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:45 pm -
1 stop5h 10m
Mon 11/238:55 pm -
1 stop4h 00m
Deal found 10/29![Southwest logo]()
$340
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/256:00 am -
2 stops8h 14m
Sun 2/286:00 am -
1 stop5h 02m
Deal found 10/28![United Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:00 am -
1 stop5h 46m
Sun 2/78:11 am -
1 stop7h 12m
Deal found 10/27![Delta logo]()
$391
This American Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2112:00 pm -
1 stop4h 54m
Wed 4/286:04 am -
2 stops7h 28m
Deal found 10/25![American Airlines logo]()
$442
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/86:45 am -
2 stops9h 00m
Mon 1/116:40 am -
2 stops9h 00m
Deal found 10/29![Southwest logo]()
$349
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/216:49 pm -
1 stop4h 13m
Sun 1/246:00 am -
1 stop4h 11m
Deal found 10/29![Delta logo]()
$391
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:40 am -
2 stops11h 27m
Fri 1/16:15 am -
1 stop7h 00m
Deal found 10/29![United Airlines logo]()
$444
Last-minute flights from Milwaukee to South CarolinaDiscover last-minute flight deals from Milwaukee to South Carolina. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Milwaukee to South Carolina. Data last updated October 30, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:40 am -
1 stop6h 34m
Sun 11/156:51 am -
1 stop4h 11m
Deal found 10/27![American Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:45 am -
1 stop5h 25m
Mon 11/166:45 pm -
1 stop4h 35m
Deal found 10/26![Southwest logo]()
$375
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:45 pm -
1 stop5h 10m
Mon 11/238:55 pm -
1 stop4h 00m
Deal found 10/29![Southwest logo]()
$340
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:25 pm -
1 stop4h 29m
Sun 11/225:10 am -
1 stop5h 54m
Deal found 10/26![American Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:20 am -
1 stop3h 57m
Fri 11/277:05 am -
1 stop5h 32m
Deal found 10/26![Delta logo]()
$315
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2210:47 am -
1 stop4h 21m
Fri 11/275:05 am -
1 stop5h 59m
Deal found 10/26![American Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/242:55 pm -
1 stop6h 05m
Tue 12/14:10 pm -
1 stop4h 50m
Deal found 10/27![American Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:40 pm -
2 stops6h 45m
Wed 12/22:50 pm -
1 stop7h 35m
Deal found 10/26![Southwest logo]()
$318
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:25 pm -
1 stop4h 32m
Fri 11/2710:49 am -
1 stop6h 49m
Deal found 10/29![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:55 pm -
1 stop6h 05m
Mon 11/308:29 pm -
1 stop4h 23m
Deal found 10/26![American Airlines logo]()
$376
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2611:20 am -
1 stop5h 25m
Wed 12/21:30 pm -
2 stops9h 45m
Deal found 10/25![Southwest logo]()
$300
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/264:05 pm -
1 stop5h 42m
Mon 11/305:35 am -
1 stop7h 02m
Deal found 10/28![Delta logo]()
$353
One-way flights from Milwaukee to South CarolinaSearch for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Milwaukee to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:07 pm -
1 stop4h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$117
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/174:50 pm -
2 stops5h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$122
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:12 pm -
1 stop6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:11 pm -
1 stop13h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$146
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:40 pm -
2 stops7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$153
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/13:55 pm -
1 stop4h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/30![Delta logo]()
$170
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:24 am -
1 stop5h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$176
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/272:55 pm -
1 stop5h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Delta logo]()
$180
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/12:55 pm -
2 stops6h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:25 pm -
1 stop4h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![American Airlines logo]()
$206
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/217:00 am -
2 stops10h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Southwest logo]()
$211
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:00 am -
1 stop5h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$214
Find flight deals from Milwaukee to South Carolina
Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (American Airlines) |
One-way from | $117 (American Airlines) |
Popular in | March |
Cheapest in | January |
Average price | $426 |
Cheapflights Fare Finder
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
MilwaukeeGreenville
MKE Milwaukee-Mitchell - GSP Greenville
MKEGSP
Milwaukee-Mitchell
Thu 12/17
4:50 pm-11:00 pm
2 stops5h 10m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$122
MilwaukeeMyrtle Beach
MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl
MKEMYR
Milwaukee-Mitchell
Tue 12/1
3:12 pm-10:47 pm
1 stop6h 35m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
MilwaukeeMyrtle Beach
MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl
MKEMYR
Milwaukee-Mitchell
Sat 11/21
4:40 pm-9:55 pm
1 stop4h 15m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$141
MilwaukeeCharleston
MKE Milwaukee-Mitchell - CHS Charleston
MKECHS
Milwaukee-Mitchell
Wed 11/25
3:40 pm-12:15 am
2 stops7h 35m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$153
MilwaukeeMyrtle Beach
MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl
MKEMYR
Milwaukee-Mitchell
Sat 1/9
6:24 am-1:05 pm
1 stop5h 41m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$176
MilwaukeeGreenville
MKE Milwaukee-Mitchell - GSP Greenville
MKEGSP
Milwaukee-Mitchell
Fri 11/27
2:55 pm-9:33 pm
1 stop5h 38m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$180
MilwaukeeMyrtle Beach
MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl
MKEMYR
Milwaukee-Mitchell
Tue 12/1
2:55 pm-10:03 pm
2 stops6h 08m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$194
MilwaukeeColumbia
MKE Milwaukee-Mitchell - CAE Columbia Metropolitan
MKECAE
Milwaukee-Mitchell
Wed 11/25
6:25 pm-11:57 pm
1 stop4h 32m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$206
MilwaukeeGreenville
MKE Milwaukee-Mitchell - GSP Greenville
MKEGSP
Milwaukee-Mitchell
Sat 11/28
7:00 am-1:15 pm
1 stop5h 15m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$214
MilwaukeeMyrtle Beach
MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl
MKEMYR
Milwaukee-Mitchell
Mon 11/30
6:25 pm-11:54 pm
1 stop4h 29m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Milwaukee to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
MKE-GSP
MKE-MYR
MKE-CHS
MKE-CAE
MKE-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Milwaukee to South Carolina
MKE-USSC
MKE-GSP
MKE-MYR
MKE-CHS
MKE-CAE
What is the cheapest month to book a flight from Milwaukee to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $357). Flying from Milwaukee to South Carolina in June is currently the most expensive (average of $430). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Milwaukee to South Carolina?
Airfare is below average for this route at the moment.
Milwaukee to South Carolina flights typically cost between $387 and $596 in November.The cheapest round-trip price found within the last 5 days was $295 on American Airlines (Nov 24-Dec 1).
How far ahead should I book a flight from Milwaukee to South Carolina?
The best time to book flights from Milwaukee to South Carolina is 55 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Entertainment
7.4
Boarding
8.1
Overall
7.9
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Milwaukee to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Milwaukee to South Carolina by cabin class
Find flights from Milwaukee to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Milwaukee and South Carolina flights
Browse other Milwaukee and South Carolina flight options. Last updated on October 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Milwaukee to South Carolina flights
Consider these flights traveling from Milwaukee to South Carolina.
Top 4 airlines flying from Milwaukee to South Carolina
Discover the top 4 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$216 | Average$389 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$387 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$290 | Average$439 | FlexibilityNo cancel fee | On-time63% |