South Carolina

$129+ Cheap flights from Milwaukee (MKE) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/23. Fares are subject to change and may not be available on all flights or dates of travel.
MKE — CHS
Jun 30 — Jul 71
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Milwaukee to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Milwaukee to South Carolina

Cheapest flights from Milwaukee to South Carolina
Explore the most affordable flight options available from Milwaukee to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 31, 2026.

This Delta deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/159:38 am
MKE
-
SAV
1 stop6h 41m
Delta
Wed 9/238:00 am
SAV
-
MKE
1 stop4h 53m
Delta
Deal found 5/29$253
This Frontier deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:43 am
MKE
-
CLT
1 stop7h 10m
Frontier
Mon 8/178:02 pm
CLT
-
MKE
1 stop12h 56m
Frontier
Deal found 5/29$258
This Delta deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:45 am
MKE
-
AGS
1 stop6h 31m
Delta
Sat 10/3111:35 am
AGS
-
MKE
1 stop4h 29m
Delta
Deal found 5/30$261
This American Airlines deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:24 am
MKE
-
CAE
1 stop5h 41m
American Airlines
Sat 10/315:18 pm
CAE
-
MKE
1 stop5h 00m
American Airlines
Deal found 5/28$261
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/217:01 am
MKE
-
HHH
1 stop6h 15m
American Airlines
Tue 7/2811:47 am
HHH
-
MKE
1 stop6h 50m
American Airlines
Deal found 5/30$261
This Frontier deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:53 am
MKE
-
CLT
1 stop6h 37m
Frontier
Mon 8/178:02 pm
CLT
-
MKE
1 stop12h 56m
Frontier
Deal found 5/28$263
This Frontier deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:43 am
MKE
-
CLT
1 stop7h 15m
Frontier
Mon 7/208:02 pm
CLT
-
MKE
1 stop12h 56m
Frontier
Deal found 5/29$268
This Booking.com deal was found by Cheapflights users on 5/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:43 am
MKE
-
CLT
1 stop7h 10m
Frontier
Wed 8/191:12 pm
CLT
-
MKE
1 stop19h 46m
Frontier
Deal found 5/29$270
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:03 pm
MKE
-
CAE
1 stop4h 47m
Delta
Tue 8/1810:04 am
CAE
-
MKE
1 stop4h 49m
Delta
Deal found 5/28$271
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2110:11 am
MKE
-
HHH
1 stop4h 18m
Delta
Tue 7/2812:11 pm
HHH
-
MKE
2 stops11h 19m
Delta
Deal found 5/27$276
This Booking.com deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/258:53 am
MKE
-
CLT
1 stop6h 37m
Frontier
Mon 6/297:58 pm
CLT
-
MKE
1 stop13h 00m
Frontier
Deal found 5/30$281
This Frontier deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:43 am
MKE
-
CLT
1 stop6h 55m
Frontier
Wed 7/228:02 pm
CLT
-
MKE
1 stop12h 56m
Frontier
Deal found 5/30$284

Find flight deals from Milwaukee to South Carolina

Keep the following information in mind while searching for Milwaukee to South Carolina flight deals. Data was last updated May 31, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$253
(Delta)

One-way from

$129
(Frontier)

Popular in

March

Cheapest in

January

Average price

$406
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
From Milwaukee-Mitchell to South Carolina
One-way flight from Milwaukee-Mitchell to South Carolina
Highest demand for flights based on searches. 12% potential increase in price ($53 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in May 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Milwaukee to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 31, 2026.
Use the filters below to find and compare flights from Milwaukee to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeAugusta

MKE - AGS

MKEAGS

Milwaukee-Mitchell

Wed 10/28

5:45 am-1:16 pm

1 stop6h 31m

Augusta Bush Field

Sat 10/31

11:35 am-3:04 pm

1 stop4h 29m

$261

MilwaukeeAugusta

MKE - AGS

MKEAGS

Milwaukee-Mitchell

Wed 10/28

7:24 am-2:15 pm

1 stop5h 51m

Augusta Bush Field

Sat 10/31

6:18 pm-12:11 am

1 stop6h 53m

$261

MilwaukeeAugusta

MKE - AGS

MKEAGS

Milwaukee-Mitchell

Tue 11/24

12:20 pm-6:47 pm

1 stop5h 27m

Augusta Bush Field

Sat 11/28

7:45 pm-11:49 pm

1 stop5h 04m

$261

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 11/11

12:30 pm-6:32 pm

1 stop5h 02m

Columbia Metropolitan

Wed 11/18

5:18 pm-11:05 pm

1 stop6h 47m

$261

MilwaukeeHilton Head Island

MKE - HHH

MKEHHH

Milwaukee-Mitchell

Tue 7/21

10:11 am-3:29 pm

1 stop4h 18m

Hilton Head Island

Tue 7/28

12:11 pm-10:30 pm

2 stops11h 19m

$276

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 6/24

10:00 am-4:52 pm

1 stop5h 52m

Columbia Metropolitan

Sat 7/11

6:03 pm-11:54 pm

1 stop6h 51m

$292

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Sat 9/26

5:00 am-2:16 pm

2 stops8h 16m

Savannah/Hilton Head

Wed 9/30

6:20 am-10:53 am

1 stop5h 33m

$295

MilwaukeeSavannah

MKE - SAV

MKESAV

Milwaukee-Mitchell

Wed 8/26

5:00 am-10:40 am

1 stop4h 40m

Savannah/Hilton Head

Sat 8/29

9:50 am-6:55 pm

2 stops10h 05m

$295

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Mon 6/22

6:40 pm-11:46 pm

1 stop4h 06m

Columbia Metropolitan

Tue 8/18

11:55 am-4:13 pm

1 stop5h 18m

$297

MilwaukeeColumbia

MKE - CAE

MKECAE

Milwaukee-Mitchell

Wed 6/24

6:20 am-1:46 pm

1 stop6h 26m

Columbia Metropolitan

Sat 7/11

10:31 am-7:26 pm

2 stops9h 55m

$300

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/27

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Milwaukee to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Milwaukee with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Milwaukee to South Carolina

What is the cheapest month to book a flight from Milwaukee to South Carolina?

Currently, March is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $100). Flying from Milwaukee to South Carolina in April is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Milwaukee to South Carolina?

How far ahead should I book a flight from Milwaukee to South Carolina?

The best time to book flights from Milwaukee to South Carolina is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated May 31, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Milwaukee to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Walter,May 2026

LAS - BUR

Short but excellent flight. Everyone was friendly and professional it was a great flight!

Related info for your journey

Find useful and relevant information for your journey from Milwaukee to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Milwaukee to South Carolina?

    Milwaukee-Mitchell (MKE), located 6.4 mi from the city center, is the airport you fly out of when you book flights from Milwaukee to South Carolina.

  • How long is the flight from Milwaukee to South Carolina?

    Delta, American Airlines, and United Airlines can get you from Milwaukee to South Carolina in just under 5h 31m. Your travel time can differ by up to 2h 45m. There are 735 mi between Milwaukee and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Milwaukee to South Carolina?

  • Can I find deals for flights from Milwaukee to South Carolina that include hotel bookings?

    Yes. In addition to deals on Milwaukee to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Milwaukee to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Milwaukee to South Carolina.

  • Can I find deals for business class flights from Milwaukee to South Carolina?

    Yes. Cheapflights offers flight deals from Milwaukee to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Milwaukee to South Carolina?

    Currently, March is the cheapest month in which you can book a flight from Milwaukee to South Carolina (average of $100). Flying from Milwaukee to South Carolina in April is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Milwaukee to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Milwaukee to South Carolina

Discover the top 4 airlines that operate flights from Milwaukee to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 31, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$201Average$409FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$203Average$377FlexibilityNo cancel feeOn-time71%
DeltaCheapest$209Average$366FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$370FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.