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Des Moines

$49+ Cheap flights from St. Louis to Des Moines (STL - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from St. Louis to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$97
(Southwest)

One-way from

$49
(Southwest)

Popular in

March

Cheapest in

June

Average price

$274

Good round-trip deal

$309 or less
From Lambert-St Louis to Des Moines
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One-way flight from Lambert-St Louis to Des Moines
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Highest demand for flights based on searches. 18% potential increase in price ($70 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Lambert-St Louis to Des Moines.
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Find flight deals from St. Louis to Des Moines

Cheapest flights from St. Louis to Des Moines
Explore the most affordable flight options available from St. Louis to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:50 amSTL - DSM
Nonstop1h 10mSouthwest
Mon 11/105:45 amDSM - STL
Nonstop1h 20mSouthwest
Deal found 9/13$97
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Mon 10/136:15 pmDSM - STL
Nonstop1h 10mSouthwest
Deal found 9/14$134
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/77:16 amSTL - DSM
1 stop6h 02mAmerican Airlines
Sat 10/113:48 pmDSM - STL
1 stop5h 05mAmerican Airlines
Deal found 9/14$159
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop7h 28mDelta
Mon 11/104:59 pmDSM - STL
1 stop6h 24mDelta
Deal found 9/13$177
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop4h 26mDelta
Tue 11/1110:21 amDSM - STL
1 stop6h 48mDelta
Deal found 9/13$228
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:22 pmSTL - DSM
2 stops28h 18mMultiple Airlines
Mon 11/102:32 pmDSM - STL
1 stop18h 35mMultiple Airlines
Deal found 9/13$231
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop4h 26mDelta
Sun 11/94:59 pmDSM - STL
1 stop6h 24mDelta
Deal found 9/13$253
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/109:50 amSTL - DSM
2 stops7h 24mMultiple Airlines
Mon 10/132:39 pmDSM - STL
1 stop18h 28mMultiple Airlines
Deal found 9/14$282
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:50 amSTL - DSM
2 stops10h 23mMultiple Airlines
Sun 11/92:32 pmDSM - STL
1 stop18h 35mMultiple Airlines
Deal found 9/13$288

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

St. Louis

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 11/6

9:50 am-11:00 am

Nonstop1h 10m

Des Moines

Mon 11/10

5:45 am-7:05 am

Nonstop1h 20m

$97

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/10

10:20 pm-11:30 pm

Nonstop1h 10m

Des Moines

Mon 10/13

6:15 pm-7:25 pm

Nonstop1h 10m

$134

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 11/6

6:00 am-1:28 pm

1 stop7h 28m

Des Moines

Mon 11/10

4:59 pm-11:23 pm

1 stop6h 24m

$177

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/31

1:45 pm-2:55 pm

Nonstop1h 10m

Des Moines

Sat 11/1

3:50 pm-5:00 pm

Nonstop1h 10m

$250

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/10

9:50 am-5:14 pm

2 stops7h 24m

Des Moines

Mon 10/13

2:39 pm-9:07 am

1 stop18h 28m

$282

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 11/7

6:00 am-10:26 am

1 stop4h 26m

Des Moines

Sun 11/9

6:50 am-11:59 am

1 stop5h 09m

$329

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 11/25

10:55 pm-12:05 am

Nonstop1h 10m

Des Moines

Sun 11/30

5:20 am-6:30 am

Nonstop1h 10m

$360

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 10/7

10:45 am-9:03 pm

2 stops10h 18m

Des Moines

Sat 10/11

5:15 pm-10:04 pm

1 stop4h 49m

$363

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 12/9

8:25 pm-9:35 pm

Nonstop1h 10m

$49

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 10/23

10:20 pm-11:30 pm

Nonstop1h 10m

$49

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 16 results
1
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Best time to book a flight from St. Louis to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Des Moines

What is the cheapest time of day to fly from STL to DSM?

Find hourly flight availability from St. Louis to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from St. Louis to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 45% versus a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 15, 2025.
Read reviews from past customers who have flown Southwest from St. Louis to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Comfort

8.0

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from St. Louis to Des Moines?

    To fly from St. Louis to Des Moines, you need to book a flight from Lambert-St Louis (STL) to Des Moines (DSM). Nonstop flights to Des Moines from Lambert-St Louis take 1h 10m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Lambert-St Louis to Des Moines offered by 1 airline.

  • How popular is this St. Louis to Des Moines flight route?

    The Lambert-St Louis to Des Moines flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Des Moines?

    Departing from St. Louis to Des Moines will take you 1h 10m. The distance between St. Louis and Des Moines is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from St. Louis to Des Moines round-trip?

    Flying on Southwest is currently your cheapest option to Des Moines, with prices starting at $97. Southwest is currently priced 69% below the average price you’ll pay for this route.

  • What are the cheapest flights from St. Louis to Des Moines?

    On average you can expect to pay $456 for a flight from St. Louis to Des Moines. The cheapest flight overall is $77 while the most popular route, (Lambert-St Louis - Des Moines) is currently priced at $97.

  • Can I find deals for flights from St. Louis to Des Moines that include hotel bookings?

    Yes. In addition to deals on St. Louis to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Des Moines.

  • Can I find deals for business class flights from St. Louis to Des Moines?

    Yes. Cheapflights offers flight deals from St. Louis to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from St. Louis to Des Moines (average of $336). Flying from St. Louis to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top airline flying from St. Louis to Des Moines

Discover the top airline that operate flights from St. Louis to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$309FlexibilityNo cancel feeOn-time63%

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