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Des Moines

$72+ Cheap flights from St. Louis to Des Moines (STL - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from St. Louis to Des Moines

Cheapest flights from St. Louis to Des Moines
Explore the most affordable flight options available from St. Louis to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Delta deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:47 amSTL - DSM
1 stop7h 28mDelta
Tue 1/66:54 amDSM - STL
1 stop3h 49mDelta
Deal found 12/23$387
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:05 amSTL - DSM
1 stop6h 28mUnited Airlines
Sat 12/2711:35 amDSM - STL
1 stop6h 19mUnited Airlines
Deal found 12/21$555
This Southwest deal was found by Cheapflights users on 12/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:55 pmSTL - DSM
Nonstop1h 10mSouthwest
Tue 1/68:35 amDSM - STL
1 stop5h 20mSouthwest
Deal found 12/23$567
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/269:36 amSTL - DSM
1 stop7h 29mAmerican Airlines
Sun 12/286:52 pmDSM - STL
1 stop4h 52mAmerican Airlines
Deal found 12/22$589
This Delta deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:29 amSTL - DSM
2 stops10h 12mDelta
Wed 12/315:55 pmDSM - STL
1 stop4h 21mDelta
Deal found 12/20$620
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:29 amSTL - DSM
2 stops10h 12mDelta
Fri 1/212:08 pmDSM - STL
2 stops8h 33mDelta
Deal found 12/22$625
This Southwest deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:50 amSTL - DSM
Nonstop1h 10mSouthwest
Fri 1/26:50 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 12/22$635
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:25 pmSTL - DSM
Nonstop1h 10mSouthwest
Sat 12/275:40 amDSM - STL
Nonstop1h 20mSouthwest
Deal found 12/21$725
This Kiwi.com deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/267:43 pmSTL - DSM
1 stop24h 01mMultiple Airlines
Sun 12/289:31 amDSM - STL
2 stops9h 05mMultiple Airlines
Deal found 12/22$1,046

Find flight deals from St. Louis to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$189
(Delta)

One-way from

$72
(Kiwi.com)

Popular in

July

Cheapest in

June
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Lambert-St Louis to Des Moines
Search Deals
One-way flight from Lambert-St Louis to Des Moines
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($32 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from St. Louis to Des Moines that are best for you.

Fly from

St. Louis

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 1/18

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Tue 1/20

5:35 am-11:54 am

1 stop6h 19m

$189

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/9

6:00 am-2:22 pm

1 stop8h 22m

Des Moines

Mon 1/12

3:04 pm-10:00 pm

1 stop6h 56m

$276

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

5:00 pm-10:29 pm

1 stop5h 29m

Des Moines

Sat 1/10

12:25 pm-4:53 pm

1 stop4h 28m

$329

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/2

6:35 am-2:05 pm

1 stop7h 30m

Des Moines

Thu 6/4

5:10 am-1:50 pm

2 stops8h 40m

$354

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/28

3:46 pm-3:40 pm

2 stops23h 54m

Des Moines

Fri 1/30

8:30 am-8:48 pm

1 stop12h 18m

$371

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/2

9:50 am-11:00 am

Nonstop1h 10m

Des Moines

Tue 1/6

6:10 am-7:30 am

Nonstop1h 20m

$567

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 2/23

6:10 am-10:17 am

1 stop4h 07m

$80

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/21

11:05 am-4:24 pm

1 stop5h 19m

$80

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 2/1

6:10 am-10:19 am

1 stop4h 09m

$80

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/22

6:10 am-10:19 am

1 stop4h 09m

$80

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 15 results
1
2

Compare providers for flights from St. Louis to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Des Moines in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on St. Louis-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on St. Louis-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from St. Louis-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on St. Louis-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from St. Louis to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Des Moines

What is the cheapest time of day to fly from STL to DSM?

Find hourly flight availability from St. Louis to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

When flying from St. Louis to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 74% versus a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 23, 2025.
Read reviews from past customers who have flown Southwest from St. Louis to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,255 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,255 reviews
Southwest
8.0
Very good
4,255 reviews

Comfort

8.0

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from St. Louis to Des Moines?

    To fly from St. Louis to Des Moines, you need to book a flight from Lambert-St Louis (STL) to Des Moines (DSM). Nonstop flights to Des Moines from Lambert-St Louis take 1h 10m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Lambert-St Louis to Des Moines offered by 1 airline.

  • How popular is this St. Louis to Des Moines flight route?

    The Lambert-St Louis to Des Moines flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from St. Louis to Des Moines?

    Departing from St. Louis to Des Moines will take you 4h 09m. The distance between St. Louis and Des Moines is about 259 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from St. Louis to Des Moines round-trip?

    Flying on Southwest is currently your cheapest option to Des Moines, with prices starting at $77. Southwest is currently priced 77% below the average price you’ll pay for this route.

  • Can I find deals for flights from St. Louis to Des Moines that include hotel bookings?

    Yes. In addition to deals on St. Louis to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Des Moines.

  • Can I find deals for business class flights from St. Louis to Des Moines?

    Yes. Cheapflights offers flight deals from St. Louis to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top airline flying from St. Louis to Des Moines

Discover the top airline that operate flights from St. Louis to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%

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