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Des Moines

$59+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Find flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:14 amSTL - DSM
1 stop5h 16mAmerican Airlines
Mon 12/85:00 amDSM - STL
1 stop5h 36mAmerican Airlines
Deal found 11/1$158
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:25 pmSTL - DSM
Nonstop1h 10mSouthwest
Mon 12/84:15 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 10/31$171
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amSTL - DSM
1 stop4h 38mDelta
Mon 12/86:33 pmDSM - STL
1 stop5h 09mDelta
Deal found 11/1$181
This Southwest deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/28:25 pmSTL - DSM
Nonstop1h 10mSouthwest
Tue 12/94:15 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 11/2$223
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/168:25 pmSTL - DSM
Nonstop1h 10mSouthwest
Sat 12/206:45 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 11/1$234
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:34 pmSTL - DSM
1 stop3h 41mDelta
Tue 12/910:20 amDSM - STL
1 stop6h 50mDelta
Deal found 11/2$243
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:28 pmMCI - DSM
1 stop17h 19mMultiple Airlines
Mon 11/178:40 amDSM - MCI
2 stops27h 48mMultiple Airlines
Deal found 10/30$317
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:15 pmMCI - DSM
1 stop5h 20mSouthwest
Sun 11/307:50 pmDSM - MCI
1 stop4h 15mSouthwest
Deal found 10/31$367
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:23 pmMCI - DSM
1 stop9h 17mMultiple Airlines
Sun 11/162:32 pmDSM - MCI
2 stops19h 45mMultiple Airlines
Deal found 11/1$508
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:15 pmMCI - DSM
1 stop5h 20mSouthwest
Sun 11/166:15 pmDSM - MCI
1 stop5h 25mSouthwest
Deal found 11/1$524
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/56:49 pmMCI - DSM
2 stops26h 23mMultiple Airlines
Fri 11/73:45 pmDSM - MCI
1 stop8h 39mMultiple Airlines
Deal found 11/1$609
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/31:40 pmMCI - DSM
1 stop6h 15mSouthwest
Wed 11/58:20 amDSM - MCI
1 stop4h 40mSouthwest
Deal found 10/30$717

Cheap flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated November 2, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$158
(American Airlines)

One-way from

$59
(Southwest)

Popular in

July

Cheapest in

June

Average price

$225

Good round-trip deal

$501 or less
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Missouri to Des Moines
Search Deals
One-way flight from Missouri to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($65 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals
Price to beat on a round-trip flight from Missouri to Des Moines.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 12/4

5:14 am-10:30 am

1 stop5h 16m

Des Moines

Mon 12/8

5:00 am-10:36 am

1 stop5h 36m

$158

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 12/4

8:25 pm-9:35 pm

Nonstop1h 10m

Des Moines

Mon 12/8

4:15 pm-5:20 pm

Nonstop1h 05m

$171

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 12/4

6:00 am-10:38 am

1 stop4h 38m

Des Moines

Mon 12/8

6:33 pm-11:42 pm

1 stop5h 09m

$181

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 12/2

10:15 am-11:25 am

Nonstop1h 10m

Des Moines

Tue 12/9

8:20 am-1:20 pm

1 stop5h 00m

$233

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 12/16

8:25 pm-9:35 pm

Nonstop1h 10m

Des Moines

Sat 12/20

6:45 pm-7:50 pm

Nonstop1h 05m

$234

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 12/2

5:34 pm-9:15 pm

1 stop3h 41m

Des Moines

Tue 12/9

10:20 am-5:10 pm

1 stop6h 50m

$243

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Sat 11/15

8:28 pm-1:47 pm

1 stop17h 19m

Des Moines

Mon 11/17

8:40 am-12:28 pm

2 stops27h 48m

$317

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 11/28

6:15 pm-11:35 pm

1 stop5h 20m

Des Moines

Sun 11/30

7:50 pm-12:05 am

1 stop4h 15m

$367

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 11/14

1:23 pm-10:40 pm

1 stop9h 17m

Des Moines

Sun 11/16

2:32 pm-10:17 am

2 stops19h 45m

$508

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 11/14

5:45 am-11:00 am

1 stop5h 15m

Des Moines

Sun 11/16

5:45 am-11:10 am

1 stop5h 25m

$524

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/1

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest month to book a flight from Missouri to Des Moines?

Currently, September is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $84). Flying from Missouri to Des Moines in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

When flying from Missouri to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 45% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How popular is this Missouri to Des Moines flight route?

    Flights from Missouri to Des Moines have been viewed 3 times in the past calendar month.

  • How long is the flight from Missouri to Des Moines?

    For as low as $171, American Airlines can have you in Des Moines from Missouri in 1h 10m. There are 259 mi between Missouri and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Missouri to Des Moines?

    Looking for the cheapest flight from Missouri to Des Moines? While on average our users pay $795, our data indicates the cheapest price to be $234. The most popular route (Lambert-St Louis - Des Moines), is priced around $171.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Des Moines?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $84). Flying from Missouri to Des Moines in July is currently the most expensive (average of $663). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Des Moines

Discover the top 2 airlines that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time71%

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