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Des Moines

$79+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:20 am
STL
-
DSM
1 stop6h 55m
Southwest
Thu 3/264:20 pm
DSM
-
STL
1 stop6h 50m
Southwest
Deal found 1/28$159
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:20 am
STL
-
DSM
1 stop4h 25m
Southwest
Thu 5/71:55 pm
DSM
-
STL
1 stop10h 35m
Southwest
Deal found 1/27$196
This Southwest deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:15 am
STL
-
DSM
Nonstop1h 10m
Southwest
Thu 3/55:35 am
DSM
-
STL
1 stop3h 25m
Southwest
Deal found 1/26$241
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:41 am
STL
-
DSM
1 stop6h 46m
United Airlines
Sat 2/283:24 pm
DSM
-
STL
1 stop5h 41m
United Airlines
Deal found 1/27$244
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/273:10 pm
MCI
-
DSM
1 stop7h 25m
Southwest
Sat 2/286:10 am
DSM
-
MCI
1 stop6h 15m
Southwest
Deal found 1/27$327
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:41 am
STL
-
DSM
1 stop5h 42m
United Airlines
Sun 3/88:00 am
DSM
-
STL
1 stop6h 42m
United Airlines
Deal found 1/28$327
This Southwest deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:45 am
STL
-
DSM
Nonstop1h 10m
Southwest
Sun 3/85:25 am
DSM
-
STL
1 stop4h 05m
Southwest
Deal found 1/27$329
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:35 am
STL
-
DSM
2 stops9h 05m
Delta
Sun 3/86:15 am
DSM
-
STL
1 stop6h 43m
Delta
Deal found 1/27$332
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/64:45 pm
STL
-
DSM
1 stop6h 30m
Southwest
Sun 3/85:25 am
DSM
-
STL
2 stops10h 15m
Southwest
Deal found 1/28$334
This Southwest deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/92:10 pm
MCI
-
DSM
2 stops8h 55m
Southwest
Sun 4/124:20 pm
DSM
-
MCI
2 stops7h 50m
Southwest
Deal found 1/28$337
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1810:24 am
MCI
-
DSM
1 stop11h 17m
United Airlines
Thu 2/193:24 pm
DSM
-
MCI
1 stop19h 12m
United Airlines
Deal found 1/27$573
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:00 am
MCI
-
DSM
1 stop14h 52m
United Airlines
Sun 6/213:15 pm
DSM
-
MCI
1 stop23h 16m
United Airlines
Deal found 1/27$689

Find flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$159
(Southwest)

One-way from

$79
(Delta)

Popular in

January

Cheapest in

June

Average price

$680

Good round-trip deal

$467 or less
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Missouri to Des Moines
Search Deals
One-way flight from Missouri to Des Moines
Search Deals
Highest demand for flights based on searches. 36% potential increase in price ($218 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($30 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Missouri to Des Moines.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 3/24

6:20 am-1:15 pm

1 stop6h 55m

Des Moines

Thu 3/26

4:20 pm-11:10 pm

1 stop6h 50m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 5/4

7:20 am-11:45 am

1 stop4h 25m

Des Moines

Thu 5/7

1:55 pm-12:30 am

1 stop10h 35m

$196

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 3/4

10:15 am-11:25 am

Nonstop1h 10m

Des Moines

Thu 3/5

5:35 am-9:00 am

1 stop3h 25m

$241

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 2/25

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$244

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 3/4

9:37 am-1:05 pm

1 stop3h 28m

Des Moines

Thu 3/5

7:44 pm-11:48 pm

1 stop4h 04m

$251

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 3/6

7:41 am-2:24 pm

1 stop6h 43m

Des Moines

Sun 3/8

8:00 am-2:42 pm

1 stop6h 42m

$327

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Wed 5/20

2:55 pm-9:15 pm

1 stop6h 20m

Des Moines

Fri 5/22

5:25 am-9:20 am

1 stop3h 55m

$327

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Thu 4/9

6:40 am-1:15 pm

1 stop6h 35m

Des Moines

Sun 4/12

4:20 pm-11:05 pm

1 stop6h 45m

$327

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 2/27

5:45 am-10:55 am

1 stop5h 10m

Des Moines

Sat 2/28

5:10 am-2:45 pm

2 stops9h 35m

$332

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Wed 2/18

10:24 am-9:41 pm

1 stop11h 17m

Des Moines

Thu 2/19

3:24 pm-10:36 am

1 stop19h 12m

$573

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

When flying from Missouri to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How popular is this Missouri to Des Moines flight route?

    Flights from Missouri to Des Moines have been viewed 3 times in the past calendar month.

  • How long is the flight from Missouri to Des Moines?

    For as low as $159, Southwest can have you in Des Moines from Missouri in 6h 55m. There are 259 mi between Missouri and Des Moines.

  • What are the cheapest flights from Missouri to Des Moines?

    Looking for the cheapest flight from Missouri to Des Moines? While on average our users pay $468, our data indicates the cheapest price to be $316. The most popular route (Lambert-St Louis - Des Moines), is priced around $159.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Missouri to Des Moines

Discover the top airline that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%

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