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Des Moines

$49+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated September 15, 2025.

Round-trip from

$97
(Southwest)

One-way from

$49
(Southwest)

Good round-trip deal

$309 or less
From Missouri to Des Moines
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One-way flight from Missouri to Des Moines
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Price to beat on a round-trip flight from Missouri to Des Moines.
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Find flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:50 amSTL - DSM
Nonstop1h 10mSouthwest
Mon 11/105:45 amDSM - STL
Nonstop1h 20mSouthwest
Deal found 9/13$97
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1010:20 pmSTL - DSM
Nonstop1h 10mSouthwest
Mon 10/136:15 pmDSM - STL
Nonstop1h 10mSouthwest
Deal found 9/14$134
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/77:16 amSTL - DSM
1 stop6h 02mAmerican Airlines
Sat 10/113:48 pmDSM - STL
1 stop5h 05mAmerican Airlines
Deal found 9/14$159
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop7h 28mDelta
Mon 11/104:59 pmDSM - STL
1 stop6h 24mDelta
Deal found 9/13$177
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop4h 26mDelta
Tue 11/1110:21 amDSM - STL
1 stop6h 48mDelta
Deal found 9/13$228
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:22 pmSTL - DSM
2 stops28h 18mMultiple Airlines
Mon 11/102:32 pmDSM - STL
1 stop18h 35mMultiple Airlines
Deal found 9/13$231
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/66:00 amSTL - DSM
1 stop4h 26mDelta
Sun 11/94:59 pmDSM - STL
1 stop6h 24mDelta
Deal found 9/13$253
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/109:50 amSTL - DSM
2 stops7h 24mMultiple Airlines
Mon 10/132:39 pmDSM - STL
1 stop18h 28mMultiple Airlines
Deal found 9/14$282
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/69:50 amSTL - DSM
2 stops10h 23mMultiple Airlines
Sun 11/92:32 pmDSM - STL
1 stop18h 35mMultiple Airlines
Deal found 9/13$288
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/147:05 amMCI - DSM
1 stop8h 55mSouthwest
Tue 10/216:20 amDSM - MCI
1 stop5h 05mSouthwest
Deal found 9/14$327
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:55 amMCI - DSM
1 stop5h 05mSouthwest
Sun 10/266:00 amDSM - MCI
2 stops8h 30mSouthwest
Deal found 9/13$342
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:15 pmMCI - DSM
2 stops44h 25mMultiple Airlines
Sun 9/283:42 pmDSM - MCI
1 stop22h 18mMultiple Airlines
Deal found 9/13$490

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 11/6

9:50 am-11:00 am

Nonstop1h 10m

Des Moines

Mon 11/10

5:45 am-7:05 am

Nonstop1h 20m

$97

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/10

10:20 pm-11:30 pm

Nonstop1h 10m

Des Moines

Mon 10/13

6:15 pm-7:25 pm

Nonstop1h 10m

$134

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 11/6

6:00 am-1:28 pm

1 stop7h 28m

Des Moines

Mon 11/10

4:59 pm-11:23 pm

1 stop6h 24m

$177

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/31

1:45 pm-2:55 pm

Nonstop1h 10m

Des Moines

Sat 11/1

3:50 pm-5:00 pm

Nonstop1h 10m

$250

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 10/10

9:50 am-5:14 pm

2 stops7h 24m

Des Moines

Mon 10/13

2:39 pm-9:07 am

1 stop18h 28m

$282

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Sat 12/13

12:05 pm-8:25 pm

1 stop8h 20m

Des Moines

Mon 12/15

4:15 pm-9:30 pm

1 stop5h 15m

$327

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Tue 10/14

7:05 am-4:00 pm

1 stop8h 55m

Des Moines

Tue 10/21

6:20 am-11:25 am

1 stop5h 05m

$327

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Sat 10/25

6:10 am-12:10 pm

1 stop6h 00m

Des Moines

Sat 11/1

7:25 am-12:10 pm

1 stop4h 45m

$327

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 11/7

6:00 am-10:26 am

1 stop4h 26m

Des Moines

Sun 11/9

6:50 am-11:59 am

1 stop5h 09m

$329

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 10/24

5:55 am-11:00 am

1 stop5h 05m

Des Moines

Sun 10/26

6:00 am-2:30 pm

2 stops8h 30m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 24 results
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Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Missouri to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How popular is this Missouri to Des Moines flight route?

    Flights from Missouri to Des Moines have been viewed 2 times in the past calendar month.

  • How long is the flight from Missouri to Des Moines?

    For as low as $97, Southwest can have you in Des Moines from Missouri in 1h 10m. There are 259 mi between Missouri and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest flights from Missouri to Des Moines?

    Looking for the cheapest flight from Missouri to Des Moines? While on average our users pay $456, our data indicates the cheapest price to be $77. The most popular route (Lambert-St Louis - Des Moines), is priced around $97.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $336). Flying from Missouri to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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LaGuardia to Cedar Rapids flights
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Top 2 airlines flying from Missouri to Des Moines

Discover the top 2 airlines that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$97Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$298FlexibilityNo cancel feeOn-time71%

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