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Des Moines

$49+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
Aug 2 — Aug 91
Sat 8/2
Sat 8/9
1 adult, Economy
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Cheap flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated July 28, 2025.

Round-trip from

$205
(FlightHub)

One-way from

$49
(Southwest)

Good round-trip deal

$381 or less
From Missouri to Des Moines
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One-way flight from Missouri to Des Moines
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Price to beat on a round-trip flight from Missouri to Des Moines.
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Find flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2025.

This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/257:55 pmSTL - DSM
1 stop17h 45mFrontier
Mon 9/292:25 pmDSM - STL
1 stop18h 41mFrontier
Deal found 7/27$205
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/223:20 pmMCI - DSM
1 stop5h 00mSouthwest
Tue 9/238:25 amDSM - MCI
1 stop6h 00mSouthwest
Deal found 7/28$252
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2510:00 amSTL - DSM
Nonstop1h 05mSouthwest
Mon 9/15:30 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 7/26$309
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/257:23 amSTL - DSM
1 stop5h 16mAmerican Airlines
Mon 9/15:12 amDSM - STL
1 stop6h 38mAmerican Airlines
Deal found 7/28$320
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/286:40 amSTL - DSM
2 stops10h 32mDelta
Sun 8/315:44 amDSM - STL
1 stop6h 47mDelta
Deal found 7/27$349
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/289:50 amSTL - DSM
2 stops8h 35mMultiple Airlines
Sun 8/312:14 pmDSM - STL
3 stops26h 21mMultiple Airlines
Deal found 7/27$408
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/52:32 pmMCI - DSM
2 stops22h 59mMultiple Airlines
Fri 8/82:42 pmDSM - MCI
3 stops23h 02mMultiple Airlines
Deal found 7/27$593
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/275:30 pmSTL - DSM
1 stop5h 30mUnited Airlines
Mon 7/2811:23 amDSM - STL
1 stop5h 08mUnited Airlines
Deal found 7/27$663
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1211:31 amMCI - DSM
1 stop10h 16mUnited Airlines
Sat 8/168:00 amDSM - MCI
1 stop13h 43mUnited Airlines
Deal found 7/28$685

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 9/25

7:55 pm-1:40 pm

1 stop17h 45m

Des Moines

Mon 9/29

2:25 pm-9:06 am

1 stop18h 41m

$205

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Mon 9/22

3:20 pm-8:20 pm

1 stop5h 00m

Des Moines

Tue 9/23

8:25 am-2:25 pm

1 stop6h 00m

$252

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 8/25

10:00 am-11:05 am

Nonstop1h 05m

Des Moines

Mon 9/1

5:30 pm-6:35 pm

Nonstop1h 05m

$309

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 8/25

7:23 am-12:39 pm

1 stop5h 16m

Des Moines

Mon 9/1

5:12 am-11:50 am

1 stop6h 38m

$320

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 8/28

6:40 am-5:12 pm

2 stops10h 32m

Des Moines

Sun 8/31

5:44 am-12:31 pm

1 stop6h 47m

$349

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 8/28

9:50 am-6:25 pm

2 stops8h 35m

Des Moines

Sun 8/31

2:14 pm-4:35 pm

3 stops26h 21m

$408

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Tue 8/5

2:32 pm-1:31 pm

2 stops22h 59m

Des Moines

Fri 8/8

2:42 pm-1:44 pm

3 stops23h 02m

$593

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 8/16

6:23 am-2:16 pm

1 stop7h 53m

Des Moines

Sat 8/16

6:50 pm-9:28 am

2 stops14h 38m

$622

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Tue 8/12

11:31 am-9:47 pm

1 stop10h 16m

Des Moines

Sat 8/16

8:00 am-9:43 pm

1 stop13h 43m

$685

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 8/27

10:15 am-11:25 am

Nonstop1h 10m

$49

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 16 results
1
2

Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest month to book a flight from Missouri to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $336). Flying from Missouri to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2025.

When flying from Missouri to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 28, 2025.
Get a feel of what it's like to fly with Southwest, Delta, and United Airlines from Missouri to Des Moines by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,975 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,892 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Overall

8.0

Crew

8.6

Entertainment

7.5

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How popular is this Missouri to Des Moines flight route?

    Flights from Missouri to Des Moines have been viewed 1 times in the past calendar month.

  • What are the cheapest airlines to fly from Missouri to Des Moines one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $49. American Airlines flights start at $79 while deals on Delta start at $84 one-way.

  • What are the cheapest flights from Missouri to Des Moines?

    Looking for the cheapest flight from Missouri to Des Moines? While on average our users pay $492, our data indicates the cheapest price to be $97. The most popular route (Lambert-St Louis - Des Moines), is priced around $77.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $336). Flying from Missouri to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

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Top 2 airlines flying from Missouri to Des Moines

Discover the top 2 airlines that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$127Average$310FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$318FlexibilityNo cancel feeOn-time71%

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