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Des Moines

$106+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — DSM
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$243
(Southwest)

One-way from

$106
(Southwest)

Good round-trip deal

$203 or less
Provider with most accurate pricing for Kansas City-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Des Moines flights.
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From Missouri to Des Moines
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One-way flight from Missouri to Des Moines
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Price to beat on a round-trip flight from Missouri to Des Moines.
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Find flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1810:05 pmSTL - DSM
Nonstop1h 10mSouthwest
Fri 6/205:25 amDSM - STL
Nonstop1h 05mSouthwest
Deal found 4/29$243
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/56:30 amSTL - DSM
1 stop3h 50mUnited Airlines
Sat 6/76:45 pmDSM - STL
1 stop4h 00mUnited Airlines
Deal found 4/30$247
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/59:50 amSTL - DSM
2 stops12h 47mMultiple Airlines
Sat 6/71:15 pmDSM - STL
2 stops29h 26mMultiple Airlines
Deal found 4/30$269
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/56:00 amSTL - DSM
1 stop4h 41mDelta
Sat 6/71:07 pmDSM - STL
2 stops8h 24mDelta
Deal found 4/30$283
This Southwest deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/305:40 pmMCI - DSM
1 stop4h 30mSouthwest
Fri 6/66:30 pmDSM - MCI
1 stop5h 15mSouthwest
Deal found 4/30$293
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/17:35 amSTL - DSM
1 stop6h 06mAmerican Airlines
Thu 5/811:53 amDSM - STL
1 stop3h 28mAmerican Airlines
Deal found 4/30$539
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:00 amMCI - DSM
1 stop4h 40mUnited Airlines
Mon 5/195:45 amDSM - MCI
1 stop17h 59mUnited Airlines
Deal found 4/30$713

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 6/18

10:05 pm-11:15 pm

Nonstop1h 10m

Des Moines

Fri 6/20

5:25 am-6:30 am

Nonstop1h 05m

$243

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/5

6:30 am-10:20 am

1 stop3h 50m

Des Moines

Sat 6/7

6:45 pm-10:45 pm

1 stop4h 00m

$247

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/5

9:50 am-10:37 pm

2 stops12h 47m

Des Moines

Sat 6/7

1:15 pm-6:41 pm

2 stops29h 26m

$269

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/5

6:00 am-10:41 am

1 stop4h 41m

Des Moines

Sat 6/7

1:07 pm-9:31 pm

2 stops8h 24m

$283

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 5/30

5:40 pm-10:10 pm

1 stop4h 30m

Des Moines

Fri 6/6

6:30 pm-11:45 pm

1 stop5h 15m

$293

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Thu 5/15

6:00 am-10:40 am

1 stop4h 40m

Des Moines

Mon 5/19

5:45 am-11:44 pm

1 stop17h 59m

$713

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/3

8:55 pm-10:05 pm

Nonstop1h 10m

$106

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 7/29

2:15 pm-8:38 pm

1 stop6h 23m

$111

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 5/30

3:58 pm-10:56 pm

1 stop6h 58m

$129

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/5

9:50 am-10:37 pm

2 stops12h 47m

$137

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 12 results
1
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Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest month to book a flight from Missouri to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $336). Flying from Missouri to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Missouri to Des Moines, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated May 1, 2025.
Read through reviews of airlines operating flights from Missouri to Des Moines, such as Southwest, Delta and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Entertainment

7.6

Food

7.1

Crew

8.6

Comfort

8.0

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How popular is this Missouri to Des Moines flight route?

    Flights from Missouri to Des Moines have been viewed 1 times in the past calendar month.

  • What are the cheapest airlines to fly from Missouri to Des Moines one-way?

    To fly one-way, consider booking your trip with Southwest, which is currently one of the cheapest options available, starting at $106. Delta flights start at $111 while deals on American Airlines start at $129 one-way.

  • What are the cheapest flights from Missouri to Des Moines?

    Looking for the cheapest flight from Missouri to Des Moines? While on average our users pay $280, our data indicates the cheapest price to be $127. The most popular route (Lambert-St Louis - Des Moines), is priced around $221.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Missouri to Des Moines (average of $336). Flying from Missouri to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Missouri?

Book flights to Missouri if you plan to visit one of these locations
Ames
Altoona
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Des Moines

Discover the top 2 airlines that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$127Average$310FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$360FlexibilityNo cancel feeOn-time71%

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