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Des Moines

$77+ Cheap flights from Missouri to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/17. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — DSM
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Missouri to Des Moines

Cheapest flights from Missouri to Des Moines
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:53 pmSTL - DSM
1 stop6h 53mAmerican Airlines
Wed 12/311:09 pmDSM - STL
1 stop6h 13mAmerican Airlines
Deal found 12/15$296
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:10 pmSTL - DSM
1 stop6h 30mUnited Airlines
Sun 1/46:46 pmDSM - STL
1 stop3h 57mUnited Airlines
Deal found 12/16$406
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amSTL - DSM
1 stop4h 38mDelta
Wed 12/315:55 pmDSM - STL
1 stop4h 21mDelta
Deal found 12/17$497
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:30 pmSTL - DSM
1 stop5h 29mAmerican Airlines
Tue 12/236:56 pmDSM - STL
1 stop4h 56mAmerican Airlines
Deal found 12/16$521
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:10 pmSTL - DSM
1 stop4h 19mUnited Airlines
Sun 12/286:46 pmDSM - STL
1 stop3h 57mUnited Airlines
Deal found 12/16$555
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/189:34 amSTL - DSM
1 stop5h 34mAmerican Airlines
Mon 12/226:35 pmDSM - STL
1 stop5h 09mAmerican Airlines
Deal found 12/16$589
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1811:51 amSTL - DSM
1 stop10h 45mMultiple Airlines
Mon 12/228:29 pmDSM - STL
2 stops24h 56mMultiple Airlines
Deal found 12/16$624
This Southwest deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2610:55 pmSTL - DSM
Nonstop1h 10mSouthwest
Sun 12/285:30 amDSM - STL
Nonstop1h 20mSouthwest
Deal found 12/15$635
This Southwest deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:45 amMCI - DSM
1 stop5h 15mSouthwest
Mon 12/225:30 amDSM - MCI
1 stop5h 30mSouthwest
Deal found 12/15$637
This Southwest deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2410:15 amSTL - DSM
Nonstop1h 10mSouthwest
Sun 12/286:50 pmDSM - STL
Nonstop1h 05mSouthwest
Deal found 12/16$661
This Delta deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1810:45 amSTL - DSM
2 stops10h 30mDelta
Mon 12/2212:08 pmDSM - STL
1 stop6h 12mDelta
Deal found 12/16$669

Find flight deals from Missouri to Des Moines

Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$157
(Delta)

One-way from

$77
(Southwest)

Popular in

July

Cheapest in

June
Provider with most accurate pricing for Lambert-St Louis-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Des Moines flights.
Search Deals
From Missouri to Des Moines
Search Deals
One-way flight from Missouri to Des Moines
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($32 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Missouri

Fly to

Des Moines

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Wed 1/14

10:59 am-4:45 pm

1 stop5h 46m

$157

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

3:37 pm-11:23 pm

1 stop7h 46m

Des Moines

Tue 1/27

11:42 am-6:16 pm

1 stop6h 34m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Sun 1/25

6:54 am-10:43 am

1 stop3h 49m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 1/15

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Thu 1/22

10:59 am-4:45 pm

1 stop5h 46m

$159

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 1/6

12:25 pm-7:20 pm

1 stop6h 55m

Des Moines

Wed 1/14

6:10 am-7:30 am

Nonstop1h 20m

$162

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 1/18

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Tue 1/20

5:35 am-11:54 am

1 stop6h 19m

$188

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/9

6:10 am-10:19 am

1 stop4h 09m

Des Moines

Mon 1/12

5:16 pm-11:39 pm

1 stop6h 23m

$189

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Fri 1/23

2:35 pm-7:20 pm

1 stop4h 45m

Des Moines

Tue 1/27

6:10 am-7:30 am

Nonstop1h 20m

$231

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 1/21

9:57 am-2:33 pm

1 stop4h 36m

Des Moines

Sat 1/24

7:50 am-2:28 pm

1 stop6h 38m

$241

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Fri 1/23

6:10 am-11:25 am

1 stop5h 15m

Des Moines

Sun 1/25

5:20 am-10:55 am

1 stop5h 35m

$327

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 25 results
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Best time to book a flight from Missouri to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Des Moines

What is the cheapest time of day to fly from MO to DSM?

Find hourly flight availability from Missouri to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Missouri to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 48% versus a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Missouri?

    If you book a flight to Des Moines from Missouri, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Missouri to Des Moines?

    For as low as $157, Delta can have you in Des Moines from Missouri in 4h 09m. There are 259 mi between Missouri and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Missouri to Des Moines that include hotel bookings?

    Yes. In addition to deals on Missouri to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Des Moines.

  • Can I find deals for business class flights from Missouri to Des Moines?

    Yes. Cheapflights offers flight deals from Missouri to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Missouri to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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O'Hare Intl to Omaha flights
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Los Angeles to Moline flights
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Las Vegas to Omaha flights
Dulles Intl to Cedar Rapids flights

Top 2 airlines flying from Missouri to Des Moines

Discover the top 2 airlines that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$77Average$309FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$278FlexibilityNo cancel feeOn-time71%

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