HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Missouri

$49+ Cheap flights from Des Moines (DSM) to Missouri

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — STL
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Missouri with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Missouri

Keep the following information in mind while searching for Des Moines to Missouri flight deals. Data was last updated July 1, 2025.

Round-trip from

$97
(Southwest)

One-way from

$49
(Southwest)

Popular in

March

Cheapest in

January

Average price

$293

Good round-trip deal

$279 or less

Good one-way deal

$151 or less
From Des Moines to Missouri
Search Deals
One-way flight from Des Moines to Missouri
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($112 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 17% potential price decrease ($58 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals
Price to beat on a round-trip flight from Des Moines to Missouri.
Search Deals
Price to beat on a one-way flight from Des Moines to Missouri.
Search Deals

Find flight deals from Des Moines to Missouri

Cheapest flights from Des Moines to Missouri
Explore the most affordable flight options available from Des Moines to Missouri. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Southwest deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/64:35 pmDSM - STL
Nonstop1h 05mSouthwest
Wed 8/69:15 pmSTL - DSM
Nonstop1h 05mSouthwest
Deal found 6/30$97
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/76:12 pmDSM - STL
1 stop5h 43mAmerican Airlines
Mon 8/117:59 pmSTL - DSM
1 stop3h 25mAmerican Airlines
Deal found 7/1$159
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1410:18 amDSM - STL
1 stop6h 17mDelta
Thu 8/215:11 pmSTL - DSM
1 stop5h 28mDelta
Deal found 6/30$208
This Booking.com deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/157:33 pmDSM - STL
1 stop13h 38mFrontier
Sun 8/177:59 pmSTL - DSM
2 stops22h 49mFrontier
Deal found 6/29$293
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/315:25 amDSM - MCI
1 stop5h 00mSouthwest
Thu 8/73:20 pmMCI - DSM
1 stop5h 00mSouthwest
Deal found 7/1$307
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2311:00 amDSM - STL
3 stops22h 52mMultiple Airlines
Sat 7/269:50 amSTL - DSM
2 stops7h 26mMultiple Airlines
Deal found 6/30$313
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2710:31 pmDSM - MCI
2 stops25h 41mMultiple Airlines
Tue 7/294:23 pmMCI - DSM
2 stops22h 03mMultiple Airlines
Deal found 6/30$386
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:24 amDSM - MCI
1 stop16h 50mUnited Airlines
Thu 8/214:48 pmMCI - DSM
1 stop4h 57mUnited Airlines
Deal found 6/30$403
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:50 pmDSM - STL
1 stop3h 55mUnited Airlines
Sun 8/175:00 amSTL - DSM
2 stops11h 15mUnited Airlines
Deal found 7/1$512

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Missouri that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Des Moines to Missouri that are best for you.

Fly from

Des Moines

Fly to

Missouri

Route

Depart

Return

Price

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 8/6

4:35 pm-5:40 pm

Nonstop1h 05m

Lambert-St Louis

Wed 8/6

9:15 pm-10:20 pm

Nonstop1h 05m

$97

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/7

6:12 pm-11:55 pm

1 stop5h 43m

Lambert-St Louis

Mon 8/11

7:59 pm-11:24 pm

1 stop3h 25m

$159

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Thu 8/14

10:18 am-4:35 pm

1 stop6h 17m

Lambert-St Louis

Thu 8/21

5:11 pm-10:39 pm

1 stop5h 28m

$208

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 8/15

7:33 pm-9:11 am

1 stop13h 38m

Lambert-St Louis

Sun 8/17

7:59 pm-6:48 pm

2 stops22h 49m

$293

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Thu 7/31

5:25 am-10:25 am

1 stop5h 00m

Kansas City

Thu 8/7

3:20 pm-8:20 pm

1 stop5h 00m

$307

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Wed 7/23

11:00 am-9:52 am

3 stops22h 52m

Lambert-St Louis

Sat 7/26

9:50 am-5:16 pm

2 stops7h 26m

$313

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Sun 7/27

10:31 pm-12:12 am

2 stops25h 41m

Kansas City

Tue 7/29

4:23 pm-2:26 pm

2 stops22h 03m

$386

Des MoinesKansas City

DSM - MCI

DSMMCI

Des Moines

Thu 8/14

6:24 am-11:14 pm

1 stop16h 50m

Kansas City

Thu 8/21

4:48 pm-9:45 pm

1 stop4h 57m

$403

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Fri 8/15

6:50 pm-10:45 pm

1 stop3h 55m

Lambert-St Louis

Sun 8/17

5:00 am-4:15 pm

2 stops11h 15m

$512

Des MoinesSt. Louis

DSM - STL

DSMSTL

Des Moines

Mon 9/8

5:30 pm-6:35 pm

Nonstop1h 05m

$49

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 17 results
1
2

Best time to book a flight from Des Moines to Missouri

Have a flexible travel schedule? Discover the best time to fly to Missouri from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Missouri

What is the cheapest month to book a flight from Des Moines to Missouri?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MO?

Find hourly flight availability from Des Moines to Missouri. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Missouri as you normally would.

Reviews of airlines servicing Missouri

Get insights into the airlines that provide service to Missouri. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Missouri. Reviews last updated July 1, 2025.
Read through reviews of airlines operating flights from Des Moines to Missouri, such as Southwest, Delta, and United Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,273 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,973 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,858 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Frontier
5.9
Fair
3,291 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Missouri. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Missouri?

    Des Moines (DSM) is the airport you will fly out of if you book a flight from Des Moines to Missouri. It is only a 3.6 mi journey to Des Moines (DSM) from Des Moines’s city center.

  • How popular is this Des Moines to Missouri flight route?

    The Des Moines to Missouri flight path was viewed by 30 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Des Moines to Missouri one-way?

    The cheapest airline one-way is Southwest, with whom users have recently found tickets for as low as $49. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Des Moines to Missouri for a low price.

  • What are the cheapest flights from Des Moines to Missouri?

    The cheapest flight price from Des Moines to Missouri is $108. On average you can expect to pay $279. The most popular route, (Des Moines - Lambert-St Louis), can usually be booked for $97.

  • Can I find deals for flights from Des Moines to Missouri that include hotel bookings?

    Yes. In addition to deals on Des Moines to Missouri flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Missouri?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Missouri.

  • Can I find deals for business class flights from Des Moines to Missouri?

    Yes. Cheapflights offers flight deals from Des Moines to Missouri by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Missouri?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Missouri (average of $311). Flying from Des Moines to Missouri in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Missouri

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Dallas/Fort Worth flights
Omaha to Seattle flights
Des Moines to Denver flights
Cedar Rapids to Seattle flights
Omaha to O'Hare Intl flights
Cedar Rapids to Denver flights
Omaha to Love Field flights
Omaha to San Francisco flights
Omaha to LaGuardia flights
Des Moines to LaGuardia flights
Omaha to Las Vegas flights
Omaha to Orlando flights
Cedar Rapids to Dallas/Fort Worth flights
Omaha to Denver flights
Des Moines to Dallas/Fort Worth flights
Des Moines to Las Vegas flights
Omaha to Key West flights
Des Moines to John F Kennedy Intl flights
Omaha to John F Kennedy Intl flights
Omaha to Nashville flights
Des Moines to Seattle flights
Des Moines to Sky Harbor Intl flights
Omaha to Newark flights
Omaha to Miami flights
Des Moines to O'Hare Intl flights
Moline to Denver flights
Omaha to Sky Harbor Intl flights
Omaha to Hobby flights
Des Moines to Orlando flights
Moline to Dallas/Fort Worth flights
Omaha to Los Angeles flights
Cedar Rapids to John F Kennedy Intl flights
Cedar Rapids to Sky Harbor Intl flights
Omaha to George Bush Intcntl flights
Omaha to Atlanta flights
Cedar Rapids to Orlando flights
Cedar Rapids to Reagan-National flights
Omaha to San Diego flights
Des Moines to George Bush Intcntl flights
Cedar Rapids to New Orleans flights
Des Moines to Hobby flights
Des Moines to Charlotte flights
Cedar Rapids to Norfolk flights
Des Moines to Redmond flights
Omaha to Burbank flights
Omaha to Dulles Intl flights
Omaha to Honolulu flights
Des Moines to Miami flights
Omaha to Salt Lake City flights
Omaha to Tampa flights

Top 3 airlines flying from Des Moines to Missouri

Discover the top 3 airlines that operate flights from Des Moines to Missouri. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$114Average$315FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$218Average$248FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$218Average$387FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.