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Des Moines

$95+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/14. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
lut 15 — lut 221
ndz. 2/15
ndz. 2/22
1 adult, Economy
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Cheap flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated Styczeń 16, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$180
(Frontier)

One-way from

$95
(Trip.com)

Popular in

April

Cheapest in

September

Average price

$384
Provider with most accurate pricing for Miami-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Miami-Des Moines flights.
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From Key Largo to Des Moines
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One-way flight from Key Largo to Des Moines
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Highest demand for flights based on searches. 10% potential increase in price ($46 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Styczeń 16, 2026.

This Frontier deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
czw. 2/266:45 am
MIA
-
DSM
1 stop12h 57m
Frontier
pon. 3/27:17 pm
DSM
-
MIA
1 stop8h 57m
Frontier
Deal found 1/13$180
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
śr. 7/297:00 am
MIA
-
DSM
1 stop7h 22m
Delta
sob. 8/16:30 pm
DSM
-
MIA
1 stop5h 24m
Delta
Deal found 1/14$257
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
czw. 5/75:05 am
MIA
-
DSM
1 stop7h 21m
American Airlines
sob. 5/1611:58 am
DSM
-
MIA
1 stop8h 43m
American Airlines
Deal found 1/14$317
This Southwest deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
pon. 2/236:45 am
MIA
-
DSM
2 stops15h 35m
Southwest
wt. 3/36:10 am
DSM
-
MIA
1 stop4h 50m
Southwest
Deal found 1/15$341
This Southwest deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
pon. 5/186:05 am
MIA
-
DSM
1 stop6h 40m
Southwest
śr. 5/205:30 am
DSM
-
MIA
2 stops10h 20m
Southwest
Deal found 1/14$369
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sob. 1/318:39 pm
MIA
-
DSM
Nonstop3h 50m
American Airlines
śr. 2/44:00 pm
DSM
-
MIA
1 stop7h 58m
American Airlines
Deal found 1/16$383
This United Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sob. 1/316:20 am
MIA
-
DSM
1 stop9h 02m
United Airlines
śr. 2/41:35 pm
DSM
-
MIA
1 stop8h 55m
United Airlines
Deal found 1/16$393
This Southwest deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
czw. 8/277:15 am
MIA
-
DSM
1 stop5h 10m
Southwest
ndz. 8/305:40 am
DSM
-
MIA
1 stop6h 25m
Southwest
Deal found 1/14$423

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Styczeń 16, 2026.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

czw. 2/26

6:45 am-6:42 pm

1 stop12h 57m

Des Moines

pon. 3/2

7:17 pm-5:14 am

1 stop8h 57m

$180

MiamiDes Moines

MIA - DSM

MIADSM

Miami

pon. 2/23

6:45 am-9:20 pm

2 stops15h 35m

Des Moines

wt. 3/3

6:10 am-12:00 pm

1 stop4h 50m

$341

MiamiDes Moines

MIA - DSM

MIADSM

Miami

pon. 5/18

6:05 am-11:45 am

1 stop6h 40m

Des Moines

śr. 5/20

5:30 am-4:50 pm

2 stops10h 20m

$369

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sob. 1/31

8:39 pm-11:29 pm

Nonstop3h 50m

Des Moines

śr. 2/4

4:00 pm-12:58 am

1 stop7h 58m

$383

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sob. 1/31

6:20 am-2:22 pm

1 stop9h 02m

Des Moines

śr. 2/4

1:35 pm-11:30 pm

1 stop8h 55m

$393

MiamiDes Moines

MIA - DSM

MIADSM

Miami

pon. 2/23

9:08 pm-11:59 pm

Nonstop3h 51m

Des Moines

wt. 3/3

1:38 pm-8:48 pm

1 stop6h 10m

$458

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sob. 3/14

5:50 am-7:16 pm

1 stop14h 26m

$95

MiamiDes Moines

MIA - DSM

MIADSM

Miami

czw. 2/26

6:45 am-6:42 pm

1 stop12h 57m

$96

MiamiDes Moines

MIA - DSM

MIADSM

Miami

czw. 4/16

6:15 am-1:46 pm

1 stop8h 31m

$103

MiamiDes Moines

MIA - DSM

MIADSM

Miami

śr. 3/11

5:50 am-7:16 pm

1 stop14h 26m

$119

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 16 results
1
2

Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, June is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $93). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Styczeń 16, 2026.

It’s typically best to fly out from Key Largo to Des Moines at noon. Doing so could potentially save you 59% on the flight price compared to flying in the afternoon, which is usually more expensive.

Weekly flight availability from Key Largo to Des Moines

Explore weekly flight availability from Key Largo to Des Moines. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated Styczeń 16, 2026.

The most flights from KE9 to DSM are scheduled on a Monday (2 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (2 on average).

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated Styczeń 16, 2026.
See what other customers who have flown with Delta and American Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,051 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,051 reviews
Delta
7.9
Good
8,051 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,136 reviews
Delta
7.9
Good
8,051 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 2 inbound flights from Key Largo per day.

  • How long is the flight from Key Largo to Des Moines?

    For as low as $180, Frontier can have you in Des Moines from Key Largo in 12h 57m. The distance from Key Largo to Des Moines is about 1328 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Key Largo to Des Moines one-way?

    The cheapest airlines for a one-way flight from Key Largo to Des Moines are Southwest ($99), Delta ($119), and American Airlines ($155).

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (80%), Qatar Airways (80%), Envoy Air (80%).

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, June is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $93). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Styczeń 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$153FlexibilityNo cancel feeOn-time88%
DeltaCheapest$203Average$370FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$441FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$377FlexibilityNo cancel feeOn-time63%

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