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Des Moines

$70+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/275:00 amMIA - DSM
1 stop6h 47mAmerican Airlines
Wed 12/313:26 pmDSM - MIA
1 stop7h 19mAmerican Airlines
Deal found 12/11$393
This United Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:10 amMIA - DSM
1 stop8h 23mUnited Airlines
Wed 12/318:00 amDSM - MIA
2 stops11h 11mUnited Airlines
Deal found 12/11$441
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:30 amMIA - DSM
1 stop9h 55mUnited Airlines
Tue 12/303:14 pmDSM - MIA
1 stop5h 56mUnited Airlines
Deal found 12/13$473
This Southwest deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:55 pmMIA - DSM
1 stop5h 40mSouthwest
Fri 12/196:35 amDSM - MIA
1 stop11h 30mSouthwest
Deal found 12/11$482
This eDestinos deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:05 amMIA - DSM
1 stop12h 59mMultiple Airlines
Sun 12/2110:17 amDSM - MIA
2 stops33h 52mMultiple Airlines
Deal found 12/13$485
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:30 amMIA - DSM
1 stop9h 55mUnited Airlines
Wed 12/318:00 amDSM - MIA
2 stops11h 11mUnited Airlines
Deal found 12/13$507
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:45 amMIA - DSM
2 stops27h 05mUnited Airlines
Tue 12/303:14 pmDSM - MIA
1 stop5h 56mUnited Airlines
Deal found 12/13$529

Find flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$257
(Delta)

One-way from

$70
(Frontier)

Popular in

April

Cheapest in

September

Average price

$403
Provider with most accurate pricing for Miami-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Des Moines flights.
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From Key Largo to Des Moines
Search Deals
One-way flight from Key Largo to Des Moines
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 12/27

5:00 am-10:47 am

1 stop6h 47m

Des Moines

Wed 12/31

3:26 pm-11:45 pm

1 stop7h 19m

$393

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sun 1/11

5:15 am-10:50 am

1 stop6h 35m

Des Moines

Mon 1/12

6:30 am-11:00 am

Nonstop3h 30m

$438

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 1/29

3:44 pm-11:44 pm

1 stop9h 00m

Des Moines

Mon 2/2

8:00 am-3:05 pm

1 stop6h 05m

$457

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 12/27

7:10 am-2:33 pm

1 stop8h 23m

Des Moines

Tue 12/30

3:14 pm-10:10 pm

1 stop5h 56m

$473

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 2/12

6:45 am-6:47 pm

1 stop13h 02m

$97

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 2/26

6:45 am-6:42 pm

1 stop12h 57m

$97

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Wed 2/11

7:00 am-6:47 pm

2 stops36h 47m

$125

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Tue 1/13

4:55 pm-9:10 pm

1 stop5h 15m

$129

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Wed 2/11

4:55 pm-9:10 pm

1 stop5h 15m

$129

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 1/24

7:35 am-2:55 pm

1 stop8h 20m

$134

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 13 results
1
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Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

It’s typically best to fly out from Key Largo to Des Moines at noon. Doing so could potentially save you 54% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 15, 2025.
See what other customers who have flown with Delta and American Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,052 reviews
Delta
7.9
Good
8,007 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Entertainment

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 1 inbound flight from Key Largo per day.

  • How long is the flight from Key Largo to Des Moines?

    For as low as $393, American Airlines can have you in Des Moines from Key Largo in 6h 47m. The distance from Key Largo to Des Moines is about 1328 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Key Largo to Des Moines one-way?

    The cheapest airlines for a one-way flight from Key Largo to Des Moines are Southwest ($97), Delta ($119), and American Airlines ($161).

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (79%), Qatar Airways (79%), Envoy Air (79%).

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$160FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$375FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$445FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$377FlexibilityNo cancel feeOn-time63%

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