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Des Moines

$67+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
nov. 15 — nov. 221
sáb. 11/15
sáb. 11/22
1 adult, Economy
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Find flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 16, 2025.

This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/157:00 amMIA - DSM
1 stop7h 32mDelta
mar. 11/186:50 amDSM - MIA
1 stop5h 42mDelta
Deal found 10/16$217
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/12:33 pmMIA - DSM
1 stop7h 30mDelta
sáb. 11/85:15 pmDSM - MIA
1 stop6h 14mDelta
Deal found 10/14$233
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/152:32 pmMIA - DSM
1 stop8h 38mAmerican Airlines
mar. 11/186:00 amDSM - MIA
Nonstop3h 22mAmerican Airlines
Deal found 10/16$235
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/78:55 pmMIA - DSM
Nonstop3h 43mAmerican Airlines
vie. 11/1411:30 amDSM - MIA
1 stop7h 50mAmerican Airlines
Deal found 10/14$240
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/319:35 amMIA - DSM
1 stop11h 20mSouthwest
mar. 11/46:15 amDSM - MIA
1 stop5h 10mSouthwest
Deal found 10/15$254
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/156:50 amMIA - DSM
2 stops9h 05mSouthwest
mar. 11/188:20 amDSM - MIA
1 stop6h 40mSouthwest
Deal found 10/16$269
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/76:00 amMIA - DSM
1 stop8h 47mFrontier
vie. 11/142:34 pmDSM - MIA
1 stop14h 45mFrontier
Deal found 10/14$273
This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/246:00 amMIA - DSM
1 stop11h 59mMultiple Airlines
lun. 10/278:30 amDSM - MIA
1 stop7h 35mMultiple Airlines
Deal found 10/16$277
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/76:00 amMIA - DSM
1 stop8h 47mMultiple Airlines
vie. 11/148:00 amDSM - MIA
2 stops49h 11mMultiple Airlines
Deal found 10/14$281
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/3111:50 amMIA - DSM
1 stop8h 30mDelta
mar. 11/410:50 amDSM - MIA
1 stop5h 20mDelta
Deal found 10/15$284

Cheap flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated octubre 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$217
(Delta)

One-way from

$67
(Kiwi.com)

Popular in

April

Cheapest in

September

Average price

$451
Provider with most accurate pricing for Miami-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Des Moines flights.
Search Deals
From Key Largo to Des Moines
Search Deals
One-way flight from Key Largo to Des Moines
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 11/15

7:00 am-1:32 pm

1 stop7h 32m

Des Moines

mar. 11/18

6:50 am-1:32 pm

1 stop5h 42m

$217

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 11/1

2:33 pm-9:03 pm

1 stop7h 30m

Des Moines

sáb. 11/8

5:15 pm-12:29 am

1 stop6h 14m

$233

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 11/15

2:32 pm-10:10 pm

1 stop8h 38m

Des Moines

mar. 11/18

6:00 am-10:22 am

Nonstop3h 22m

$235

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 11/7

8:55 pm-11:38 pm

Nonstop3h 43m

Des Moines

vie. 11/14

11:30 am-8:20 pm

1 stop7h 50m

$240

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 10/31

9:35 am-7:55 pm

1 stop11h 20m

Des Moines

mar. 11/4

6:15 am-12:25 pm

1 stop5h 10m

$254

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 11/15

6:50 am-2:55 pm

2 stops9h 05m

Des Moines

mar. 11/18

8:20 am-4:00 pm

1 stop6h 40m

$269

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 11/7

6:00 am-1:47 pm

1 stop8h 47m

Des Moines

vie. 11/14

8:00 am-10:11 am

2 stops49h 11m

$281

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 10/31

11:50 am-7:20 pm

1 stop8h 30m

Des Moines

mar. 11/4

10:50 am-5:10 pm

1 stop5h 20m

$284

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 10/31

5:48 pm-11:59 pm

1 stop7h 11m

Des Moines

mar. 11/4

6:00 am-10:22 am

Nonstop3h 22m

$289

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 11/1

5:45 am-3:05 pm

1 stop10h 20m

Des Moines

sáb. 11/8

6:25 am-9:25 pm

2 stops14h 00m

$300

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 23 results
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Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 16, 2025.

It’s typically best to fly out from Key Largo to Des Moines at noon. Doing so could potentially save you 48% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated octubre 16, 2025.
See what other customers who have flown with Delta and American Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Food

7.3

Comfort

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 0 inbound flights from Key Largo per day.

  • How long is the flight from Key Largo to Des Moines?

    For as low as $217, Delta can have you in Des Moines from Key Largo in 7h 32m. The distance from Key Largo to Des Moines is about 1328 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (33%), Qatar Airways (33%), Republic Airways (33%).

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$160FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$390FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$429FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$377FlexibilityNo cancel feeOn-time63%

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