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Des Moines

$77+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/9. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated septiembre 11, 2025.

Round-trip from

$174
(Frontier)

One-way from

$77
(Southwest)

Popular in

April

Cheapest in

September

Average price

$267
From Key Largo to Des Moines
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One-way flight from Key Largo to Des Moines
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Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:00 amMIA - DSM
1 stop8h 40mFrontier
dom. 10/52:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$174
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/116:00 amMIA - DSM
1 stop5h 05mDelta
sáb. 10/1812:30 pmDSM - MIA
1 stop7h 57mDelta
Deal found 9/11$217
This Frontier deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/186:00 amMIA - DSM
1 stop8h 40mFrontier
vie. 9/192:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/11$231
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:00 amMIA - DSM
1 stop8h 40mMultiple Airlines
dom. 10/52:25 pmDSM - MIA
2 stops20h 35mMultiple Airlines
Deal found 9/10$236
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/185:59 pmMIA - DSM
1 stop20h 33mMultiple Airlines
lun. 9/228:25 amDSM - MIA
1 stop7h 37mMultiple Airlines
Deal found 9/10$250
This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/156:00 amMIA - DSM
1 stop8h 40mFrontier
vie. 9/192:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$260
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/17:54 pmMIA - DSM
2 stops18h 46mMultiple Airlines
dom. 10/58:47 pmDSM - MIA
1 stop13h 58mMultiple Airlines
Deal found 9/11$261
This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/116:00 amMIA - DSM
1 stop8h 40mFrontier
vie. 9/192:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$270
This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/156:00 amMIA - DSM
1 stop8h 40mFrontier
dom. 9/212:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$278
This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/146:00 amMIA - DSM
1 stop8h 40mFrontier
vie. 9/192:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$285
This Frontier deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/116:00 amMIA - DSM
1 stop8h 40mFrontier
dom. 9/212:25 pmDSM - MIA
1 stop9h 19mFrontier
Deal found 9/10$288

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

jue. 10/2

6:00 am-1:40 pm

1 stop8h 40m

Des Moines

dom. 10/5

2:25 pm-12:44 am

1 stop9h 19m

$174

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 10/11

6:00 am-10:05 am

1 stop5h 05m

Des Moines

sáb. 10/18

12:30 pm-9:27 pm

1 stop7h 57m

$217

MiamiDes Moines

MIA - DSM

MIADSM

Miami

jue. 10/2

6:00 am-1:40 pm

1 stop8h 40m

Des Moines

dom. 10/5

2:25 pm-12:00 pm

2 stops20h 35m

$236

MiamiDes Moines

MIA - DSM

MIADSM

Miami

mié. 10/1

7:54 pm-1:40 pm

2 stops18h 46m

Des Moines

dom. 10/5

8:47 pm-11:45 am

1 stop13h 58m

$261

MiamiDes Moines

MIA - DSM

MIADSM

Miami

sáb. 10/11

5:45 am-3:05 pm

1 stop10h 20m

Des Moines

sáb. 10/18

7:25 am-9:50 pm

2 stops13h 25m

$294

MiamiDes Moines

MIA - DSM

MIADSM

Miami

vie. 10/17

7:00 am-2:35 pm

1 stop8h 35m

Des Moines

dom. 10/19

11:06 am-5:53 pm

1 stop5h 47m

$314

MiamiDes Moines

MIA - DSM

MIADSM

Miami

dom. 9/21

7:25 am-9:48 pm

2 stops15h 23m

Des Moines

vie. 9/26

2:22 pm-12:21 pm

1 stop20h 59m

$324

MiamiDes Moines

MIA - DSM

MIADSM

Miami

dom. 10/12

7:51 am-5:01 pm

2 stops34h 10m

Des Moines

vie. 10/17

6:04 pm-12:21 pm

1 stop17h 17m

$343

MiamiDes Moines

MIA - DSM

MIADSM

Miami

mié. 9/24

7:20 pm-10:41 pm

1 stop28h 21m

Des Moines

dom. 9/28

5:49 pm-6:28 pm

1 stop23h 39m

$356

MiamiDes Moines

MIA - DSM

MIADSM

Miami

mié. 10/1

9:00 am-10:20 pm

2 stops14h 20m

Des Moines

dom. 10/5

6:00 am-6:05 pm

2 stops11h 05m

$403

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 20 results
1
2

Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $336). Flying from Key Largo to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key Largo to Des Moines as you normally would.

How much does it cost to fly round-trip from Key Largo to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated septiembre 11, 2025.
See what other customers who have flown with Delta and American Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Food

7.3

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 0 inbound flights from Key Largo per day.

  • How long is the flight from Key Largo to Des Moines?

    For as low as $217, Frontier can have you in Des Moines from Key Largo in 5h 05m. The distance from Key Largo to Des Moines is about 1328 mi. This flight may include one or multiple stops.

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (56%), Republic Airways (56%), Qatar Airways (53%).

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $336). Flying from Key Largo to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$160FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$383FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$300Average$468FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$377FlexibilityNo cancel feeOn-time63%

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