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Des Moines

$97+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
Jan 15 — Jan 221
Thu 1/15
Thu 1/22
1 adult, Economy
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Cheap flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:30 amMIA - DSM
2 stops18h 40mMultiple Airlines
Sat 1/38:35 amDSM - MIA
1 stop24h 00mMultiple Airlines
Deal found 12/15$424
This Southwest deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:20 pmMIA - DSM
1 stop5h 45mSouthwest
Sun 12/216:35 amDSM - MIA
2 stops10h 55mSouthwest
Deal found 12/15$550
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:15 pmMIA - DSM
Nonstop3h 43mAmerican Airlines
Sun 12/2112:56 pmDSM - MIA
1 stop6h 22mAmerican Airlines
Deal found 12/15$551
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:15 amMIA - DSM
1 stop8h 18mUnited Airlines
Sun 12/211:30 pmDSM - MIA
1 stop9h 00mUnited Airlines
Deal found 12/15$561
This Mytrip deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:59 pmMIA - DSM
2 stops26h 11mMultiple Airlines
Fri 1/26:44 pmDSM - MIA
2 stops25h 20mMultiple Airlines
Deal found 12/13$573
This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amMIA - DSM
2 stops9h 33mUnited Airlines
Fri 1/211:35 amDSM - MIA
1 stop6h 00mUnited Airlines
Deal found 12/13$575
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:45 amMIA - DSM
2 stops13h 55mUnited Airlines
Fri 1/23:14 pmDSM - MIA
1 stop5h 56mUnited Airlines
Deal found 12/15$613
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:05 pmMIA - DSM
Nonstop3h 43mAmerican Airlines
Sun 12/286:26 pmDSM - MIA
1 stop5h 21mAmerican Airlines
Deal found 12/15$616

Find flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated December 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$247
(American Airlines)

One-way from

$97
(Frontier)

Popular in

April

Cheapest in

September

Average price

$403
Provider with most accurate pricing for Miami-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Des Moines flights.
Search Deals
From Key Largo to Des Moines
Search Deals
One-way flight from Key Largo to Des Moines
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($47 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 1/24

9:45 am-4:24 pm

1 stop7h 39m

Des Moines

Tue 1/27

6:30 am-11:00 am

Nonstop3h 30m

$247

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 1/24

9:00 am-2:33 pm

1 stop6h 33m

Des Moines

Tue 1/27

8:00 am-3:05 pm

1 stop6h 05m

$257

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 1/24

7:35 am-2:55 pm

1 stop8h 20m

Des Moines

Tue 1/27

6:10 am-6:35 pm

2 stops11h 25m

$268

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 1/29

7:00 am-10:46 pm

2 stops16h 46m

Des Moines

Thu 2/5

4:30 pm-7:46 pm

3 stops26h 16m

$322

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Tue 1/13

4:55 pm-9:10 pm

1 stop5h 15m

Des Moines

Wed 1/14

8:35 am-4:30 pm

1 stop6h 55m

$325

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Fri 1/23

3:45 pm-11:45 am

1 stop21h 00m

Des Moines

Tue 1/27

12:25 pm-10:03 pm

1 stop8h 38m

$327

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Mon 1/12

1:07 pm-7:22 pm

1 stop7h 15m

$112

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sun 1/18

9:26 pm-7:23 pm

2 stops22h 57m

$118

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Wed 1/14

9:26 pm-10:19 am

2 stops37h 53m

$128

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sat 2/14

6:00 am-10:55 am

1 stop5h 55m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Showing 1-10 of 15 results
1
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Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 16, 2025.

It’s typically best to fly out from Key Largo to Des Moines at noon. Doing so could potentially save you 54% on the flight price compared to flying in the afternoon, which is usually more expensive.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated December 16, 2025.
See what other customers who have flown with Delta and American Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,008 reviews

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Entertainment

7.9

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 0 inbound flights from Key Largo per day.

  • How long is the flight from Key Largo to Des Moines?

    For as low as $257, American Airlines can have you in Des Moines from Key Largo in 6h 33m. The distance from Key Largo to Des Moines is about 1328 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Key Largo to Des Moines one-way?

    The cheapest airlines for a one-way flight from Key Largo to Des Moines are Southwest ($97), Delta ($119), and American Airlines ($161).

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (79%), Qatar Airways (79%), Envoy Air (79%).

  • What are the cheapest flights from Key Largo to Des Moines?

    While on average a flight from Key Largo to Des Moines is generally $640, our data shows the cheapest flight currently is $389. When looking at the most popular route, (Miami - Des Moines), you can expect to pay $257 for that flight.

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, January is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $79). Flying from Key Largo to Des Moines in September is currently the most expensive (average of $217). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$160FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$375FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$260Average$445FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$316Average$377FlexibilityNo cancel feeOn-time63%

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