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Des Moines

$348+ Cheap flights from Gainesville to Des Moines (GNV - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — DSM
May 9 — May 161
Sat 5/9
Sat 5/16
1 adult, Economy
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Cheap flight deals from Gainesville to Des Moines

Cheapest flights from Gainesville to Des Moines
Explore the most affordable flight options available from Gainesville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 9, 2026.

This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:05 am
GNV
-
DSM
1 stop7h 47m
American Airlines
Wed 5/202:02 pm
DSM
-
GNV
1 stop7h 17m
American Airlines
Deal found 4/8$377
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:32 pm
GNV
-
DSM
1 stop5h 45m
American Airlines
Sat 5/301:48 pm
DSM
-
GNV
2 stops9h 45m
American Airlines
Deal found 4/8$431
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:03 pm
GNV
-
DSM
1 stop4h 31m
Delta
Sat 4/252:44 pm
DSM
-
GNV
1 stop6h 55m
Delta
Deal found 4/5$475
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:25 am
GNV
-
DSM
2 stops9h 22m
American Airlines
Sat 4/253:20 pm
DSM
-
GNV
1 stop6h 29m
American Airlines
Deal found 4/5$480
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/235:47 pm
GNV
-
DSM
1 stop5h 31m
American Airlines
Mon 4/273:00 pm
DSM
-
GNV
1 stop6h 19m
American Airlines
Deal found 4/7$567
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:10 am
GNV
-
DSM
1 stop4h 45m
Delta
Mon 5/42:44 pm
DSM
-
GNV
1 stop6h 55m
Delta
Deal found 4/8$637
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:15 pm
GNV
-
DSM
1 stop7h 38m
American Airlines
Sun 11/293:39 pm
DSM
-
GNV
1 stop5h 56m
American Airlines
Deal found 4/4$658

Find flight deals from Gainesville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Gainesville (GNV) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$377
(American Airlines)

One-way from

$348
(Delta)
Provider with most accurate pricing for Gainesville Regional-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Gainesville Regional-Des Moines flights.
Search Deals
From Gainesville Regional to Des Moines
Search Deals
One-way flight from Gainesville Regional to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/26

7:05 pm-10:32 pm

1 stop4h 27m

Des Moines

Sat 5/30

5:27 am-12:22 pm

1 stop5h 55m

$377

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/12

6:25 am-1:48 pm

2 stops8h 23m

Des Moines

Wed 5/20

2:24 pm-11:59 pm

2 stops8h 35m

$387

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 4/21

7:03 pm-10:34 pm

1 stop4h 31m

Des Moines

Sat 4/25

2:44 pm-10:39 pm

1 stop6h 55m

$475

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 4/21

6:25 am-2:47 pm

2 stops9h 22m

Des Moines

Sat 4/25

3:20 pm-10:49 pm

1 stop6h 29m

$480

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 4/23

5:47 pm-10:18 pm

1 stop5h 31m

Des Moines

Mon 4/27

3:00 pm-10:19 pm

1 stop6h 19m

$567

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/26

1:49 pm-11:50 pm

2 stops11h 01m

Des Moines

Sat 5/30

1:48 pm-12:33 am

2 stops9h 45m

$623

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 5/1

10:10 am-1:55 pm

1 stop4h 45m

Des Moines

Mon 5/4

2:44 pm-10:39 pm

1 stop6h 55m

$637

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Mon 8/10

6:30 am-10:53 am

1 stop5h 23m

Des Moines

Fri 8/14

7:07 am-1:30 pm

1 stop5h 23m

$695

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/26

7:05 pm-10:32 pm

1 stop4h 27m

Des Moines

Sun 5/31

5:27 am-12:22 pm

1 stop5h 55m

$751

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 5/26

7:32 pm-12:17 am

1 stop5h 45m

Des Moines

Sun 5/31

5:00 am-7:00 pm

2 stops13h 00m

$760

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/6

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

Compare providers for flights from Gainesville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Gainesville to Des Moines in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Gainesville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Gainesville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Gainesville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Gainesville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Gainesville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Gainesville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to Des Moines

What is the cheapest month to book a flight from Gainesville to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $47). Flying from Gainesville to Des Moines in December is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 9, 2026.
See what other customers who have flown with American Airlines from Gainesville to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,563 reviews

Entertainment

6.9

Boarding

7.5

Overall

7.1

Food

6.4

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,563 reviews
American Airlines
7.1
Good
11,563 reviews

Entertainment

6.9

Boarding

7.5

Overall

7.1

Food

6.4

Comfort

7.2

Crew

7.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Gainesville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Gainesville to Des Moines?

    Departing from Gainesville to Des Moines will take you 4h 27m. Airlines will cover a distance of 1036 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Gainesville to Des Moines round-trip?

    Cheapflights users have booked flights from Gainesville to Des Moines round-trip from $394.

  • Can I find deals for flights from Gainesville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Gainesville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to Des Moines.

  • Can I find deals for business class flights from Gainesville to Des Moines?

    Yes. Cheapflights offers flight deals from Gainesville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $47). Flying from Gainesville to Des Moines in December is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ames
Clive
Ankeny
Boone
West Des Moines

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Top airline flying from Gainesville to Des Moines

Discover the top airline that operate flights from Gainesville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$394Average$1,129FlexibilityNo cancel feeOn-time71%

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