HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$329+ Cheap flights from Gainesville to Des Moines (GNV - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — DSM
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Gainesville to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Gainesville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Gainesville (GNV) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$441
(Delta)

One-way from

$329
(American Airlines)

Popular in

June

Cheapest in

February

Average price

$471
From Gainesville Regional to Des Moines
Search Deals
One-way flight from Gainesville Regional to Des Moines
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($113 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($66 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Gainesville to Des Moines

Cheapest flights from Gainesville to Des Moines
Explore the most affordable flight options available from Gainesville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/292:10 pmGNV - DSM
1 stop4h 35mDelta
mar. 9/25:12 pmDSM - GNV
1 stop4h 34mDelta
Deal found 8/14$441
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/294:20 pmGNV - DSM
1 stop7h 39mAmerican Airlines
mar. 9/212:44 pmDSM - GNV
2 stops9h 54mAmerican Airlines
Deal found 8/14$446
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/264:20 pmGNV - DSM
1 stop7h 57mAmerican Airlines
vie. 8/293:49 pmDSM - GNV
1 stop5h 41mAmerican Airlines
Deal found 8/12$703

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Gainesville

Fly to

Des Moines

Route

Depart

Return

Price

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

vie. 8/29

2:10 pm-5:45 pm

1 stop4h 35m

Des Moines

mar. 9/2

5:12 pm-10:46 pm

1 stop4h 34m

$441

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

vie. 8/29

4:20 pm-10:59 pm

1 stop7h 39m

Des Moines

mar. 9/2

12:44 pm-11:38 pm

2 stops9h 54m

$446

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

mar. 8/26

4:20 pm-11:17 pm

1 stop7h 57m

Des Moines

vie. 8/29

3:49 pm-10:30 pm

1 stop5h 41m

$703

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

mié. 9/3

10:52 am-4:49 pm

1 stop6h 57m

$329

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

mar. 8/26

10:17 am-1:27 pm

1 stop4h 10m

$345

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

mar. 8/26

6:00 am-2:35 pm

2 stops9h 35m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/11

Best time to book a flight from Gainesville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to Des Moines

What is the cheapest month to book a flight from Gainesville to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $336). Flying from Gainesville to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GNV to DSM?

Find hourly flight availability from Gainesville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

It’s optimal to fly from Gainesville to Des Moines at noon. By choosing this option you can save up to 17% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated agosto 14, 2025.
See what other customers who have flown with Delta and American Airlines from Gainesville to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Gainesville to Des Moines round-trip?

    Cheapflights users have booked flights from Gainesville to Des Moines round-trip from $336. Another airline that can offer you cheap pricing is American Airlines. Delta is 43% cheaper than the average price of flights available within the next 90 days to this destination.

  • Can I find deals for flights from Gainesville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Gainesville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to Des Moines.

  • Can I find deals for business class flights from Gainesville to Des Moines?

    Yes. Cheapflights offers flight deals from Gainesville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $336). Flying from Gainesville to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Gainesville to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Sarasota to Des Moines flights
Tampa to Omaha flights
Orlando to Omaha flights
Jacksonville to Cedar Rapids flights
West Palm Beach to Omaha flights
Jacksonville to Omaha flights
Fort Lauderdale to Des Moines flights
Fort Myers to Omaha flights
Orlando to Cedar Rapids flights
Orlando to Des Moines flights
Orlando to Moline flights
Fort Lauderdale to Cedar Rapids flights
Pensacola to Moline flights
Miami to Omaha flights
Miami to Cedar Rapids flights
Pensacola to Omaha flights
Tampa to Cedar Rapids flights
Panama City to Moline flights
Fort Lauderdale to Omaha flights
Sarasota to Cedar Rapids flights
Jacksonville to Des Moines flights
Miami to Des Moines flights
Fort Myers to Moline flights
Sarasota to Omaha flights
Tampa to Moline flights
Valparaiso to Cedar Rapids flights
Tampa to Des Moines flights
West Palm Beach to Des Moines flights
West Palm Beach to Cedar Rapids flights
Miami to Moline flights
Pensacola to Des Moines flights
Fort Lauderdale to Moline flights
Panama City to Omaha flights
Jacksonville to Moline flights
Tallahassee to Omaha flights
Pensacola to Cedar Rapids flights
West Palm Beach to Moline flights
Fort Myers to Des Moines flights
Daytona Beach to Des Moines flights
Fort Myers to Cedar Rapids flights
Valparaiso to Omaha flights
Valparaiso to Moline flights
Daytona Beach to Moline flights
Daytona Beach to Omaha flights
Orlando to Mason City flights
Melbourne to Omaha flights
Sarasota to Sioux City flights
Sarasota to Moline flights
Orlando to Waterloo flights
Orlando to La Crosse flights

Top 2 airlines flying from Gainesville to Des Moines

Discover the top 2 airlines that operate flights from Gainesville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$336Average$491FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$363Average$467FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.