HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$264+ Cheap flights from Gainesville to Des Moines (GNV - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/23. Fares are subject to change and may not be available on all flights or dates of travel.
GNV — DSM
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Gainesville to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Gainesville to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Gainesville (GNV) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$418
(Delta)

One-way from

$264
(American Airlines)
Provider with most accurate pricing for Gainesville Regional-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Gainesville Regional-Des Moines flights.
Search Deals
From Gainesville Regional to Des Moines
Search Deals
One-way flight from Gainesville Regional to Des Moines
Search Deals

Find flight deals from Gainesville to Des Moines

Best flights from Gainesville to Des Moines
Discover carefully curated flight deals from Gainesville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 19, 2025.

This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/31:15 pmGNV - DSM
1 stop4h 13mDelta
Sat 2/75:35 amDSM - GNV
1 stop5h 51mDelta
Deal found 11/16$418
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/36:58 pmGNV - DSM
1 stop5h 10mAmerican Airlines
Sat 2/71:16 pmDSM - GNV
2 stops9h 41mAmerican Airlines
Deal found 11/16$422

Cheapflights Fare Finder

 
Customize your flight search to find flights from Gainesville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Gainesville to Des Moines that are best for you.

Fly from

Gainesville

Fly to

Des Moines

Route

Depart

Return

Price

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 2/3

1:15 pm-4:28 pm

1 stop4h 13m

Des Moines

Sat 2/7

5:35 am-12:26 pm

1 stop5h 51m

$418

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 2/3

6:58 pm-11:08 pm

1 stop5h 10m

Des Moines

Sat 2/7

1:16 pm-11:57 pm

2 stops9h 41m

$422

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Tue 12/23

4:59 pm-12:37 am

1 stop8h 38m

$264

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 1/1

6:45 am-12:28 pm

1 stop6h 43m

$264

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Mon 1/5

6:27 pm-10:29 pm

1 stop5h 02m

$264

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sat 1/3

8:02 pm-12:37 am

1 stop5h 35m

$264

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Fri 1/2

6:00 am-10:38 am

1 stop5h 38m

$264

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sun 1/4

8:02 pm-12:37 am

1 stop5h 35m

$304

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Thu 1/1

6:00 am-2:53 pm

2 stops9h 53m

$309

GainesvilleDes Moines

GNV - DSM

GNVDSM

Gainesville Regional

Sun 1/4

12:00 pm-8:02 pm

2 stops9h 02m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Compare providers for flights from Gainesville to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Gainesville to Des Moines in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Gainesville-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Gainesville-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Gainesville-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Gainesville-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Gainesville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Gainesville to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Gainesville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Gainesville to Des Moines

What is the cheapest month to book a flight from Gainesville to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $49). Flying from Gainesville to Des Moines in January is currently the most expensive (average of $206). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GNV to DSM?

Find hourly flight availability from Gainesville to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 19, 2025.

It’s optimal to fly from Gainesville to Des Moines at noon. By choosing this option you can save up to 43% on the cost of your flight, compared to a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 19, 2025.
See what other customers who have flown with American Airlines from Gainesville to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,046 reviews

Overall

7.2

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.
American Airlines
7.2
Good
11,046 reviews
American Airlines
7.2
Good
11,046 reviews

Overall

7.2

Comfort

7.2

Boarding

7.5

Food

6.4

Crew

8.0

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Anonymous,Aug 2025

MIA - DCA

Flight delayed 5 hours and was told it was due to mechanical issues. Instead of providing lodging due to missed connecting flight, American changed the cause of delay to weather, which meant they were not able required to provide a hotel. To make matters worse, one of our checked bags was lost even though its status said it was “by the plane” but no one at the service desk seemed able to locate it.

Related info for your journey

Find useful and relevant information for your journey from Gainesville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Gainesville to Des Moines?

    Departing from Gainesville to Des Moines will take you 4h 13m. Airlines will cover a distance of 1036 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Gainesville to Des Moines round-trip?

    Cheapflights users have booked flights from Gainesville to Des Moines round-trip from $394.

  • Can I find deals for flights from Gainesville to Des Moines that include hotel bookings?

    Yes. In addition to deals on Gainesville to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Gainesville to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Gainesville to Des Moines.

  • Can I find deals for business class flights from Gainesville to Des Moines?

    Yes. Cheapflights offers flight deals from Gainesville to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Gainesville to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Gainesville to Des Moines (average of $49). Flying from Gainesville to Des Moines in January is currently the most expensive (average of $206). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Gainesville to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Orlando to Omaha flights
Orlando to Des Moines flights
Miami to Des Moines flights
Miami to Cedar Rapids flights
Tampa to Des Moines flights
Jacksonville to Des Moines flights
Miami to Omaha flights
Tampa to Omaha flights
Orlando to Moline flights
Fort Myers to Des Moines flights
Fort Lauderdale to Omaha flights
Tampa to Cedar Rapids flights
Jacksonville to Omaha flights
Fort Myers to Cedar Rapids flights
West Palm Beach to Des Moines flights
Jacksonville to Moline flights
Orlando to Cedar Rapids flights
Fort Lauderdale to Des Moines flights
Tampa to Moline flights
Jacksonville to Cedar Rapids flights
Fort Myers to Moline flights
West Palm Beach to Cedar Rapids flights
Fort Myers to Omaha flights
West Palm Beach to Omaha flights
Pensacola to Cedar Rapids flights
Fort Lauderdale to Cedar Rapids flights
Fort Lauderdale to Moline flights
Sarasota to Cedar Rapids flights
Sarasota to Moline flights
Sarasota to Des Moines flights
Panama City to Omaha flights
Daytona Beach to Cedar Rapids flights
Melbourne to Cedar Rapids flights
Orlando Sanford Intl to Moline flights
Panama City to Moline flights
Sarasota to Omaha flights
Pensacola to Omaha flights
Pensacola to Des Moines flights
Valparaiso to Omaha flights
Tallahassee to Cedar Rapids flights
Daytona Beach to Des Moines flights
Orlando to Mason City flights
West Palm Beach to Moline flights
Valdosta to Cedar Rapids flights
Key West to Moline flights
Gainesville to Omaha flights
Tallahassee to Omaha flights
Orlando to La Crosse flights
Melbourne to Moline flights
Melbourne to Des Moines flights

Top airline flying from Gainesville to Des Moines

Discover the top airline that operate flights from Gainesville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$394Average$1,129FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.