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Des Moines

$128+ Cheap flights from Durham, NC to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — DSM
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheapflights Tip: The best prices from Durham to Des Moines are usually found in August or January, booked 57 days in advance, depart on a Friday or Wednesday and return on a Wednesday

Cheap flight deals from Durham to Des Moines

Keep the following information in mind while searching for Durham to Des Moines flight deals. Data was last updated September 16, 2025.

Round-trip from

$251
(Kiwi.com)

One-way from

$128
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$429
From Durham to Des Moines
Search Deals
One-way flight from Durham to Des Moines
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Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Durham to Des Moines

Cheapest flights from Durham to Des Moines
Explore the most affordable flight options available from Durham to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:14 pmRDU - DSM
2 stops20h 46mMultiple Airlines
Sun 11/162:32 pmDSM - RDU
1 stop25h 04mMultiple Airlines
Deal found 9/13$251
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:06 amRDU - DSM
1 stop5h 55mMultiple Airlines
Sun 11/28:47 pmDSM - RDU
2 stops35h 46mMultiple Airlines
Deal found 9/14$259
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:35 amRDU - DSM
2 stops22h 55mMultiple Airlines
Sun 10/126:30 amDSM - RDU
1 stop11h 42mMultiple Airlines
Deal found 9/14$273
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/179:37 pmRDU - DSM
1 stop11h 52mMultiple Airlines
Sun 10/196:30 amDSM - RDU
1 stop11h 42mMultiple Airlines
Deal found 9/15$276
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:52 pmRDU - DSM
2 stops42h 39mMultiple Airlines
Mon 12/16:53 pmDSM - RDU
1 stop20h 31mMultiple Airlines
Deal found 9/14$279
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:00 amRDU - DSM
2 stops12h 08mMultiple Airlines
Sun 11/97:30 amDSM - RDU
1 stop10h 42mMultiple Airlines
Deal found 9/15$289
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/215:24 pmRDU - DSM
1 stop6h 44mAmerican Airlines
Thu 10/236:07 pmDSM - RDU
1 stop4h 46mAmerican Airlines
Deal found 9/14$305
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:00 amRDU - DSM
2 stops17h 40mMultiple Airlines
Sun 11/167:30 amDSM - RDU
1 stop10h 42mMultiple Airlines
Deal found 9/15$307
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/39:45 amRDU - DSM
2 stops8h 29mMultiple Airlines
Sun 10/58:47 pmDSM - RDU
2 stops20h 23mMultiple Airlines
Deal found 9/15$310
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amRDU - DSM
1 stop5h 05mDelta
Mon 11/35:56 pmDSM - RDU
1 stop4h 02mDelta
Deal found 9/15$313
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amRDU - DSM
1 stop5h 26mDelta
Mon 11/36:39 pmDSM - RDU
1 stop4h 38mDelta
Deal found 9/14$315

Cheapflights Fare Finder

 
Customize your flight search to find flights from Durham to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Durham to Des Moines that are best for you.

Fly from

Durham

Fly to

Des Moines

Route

Depart

Return

Price

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Thu 10/30

9:06 am-2:01 pm

1 stop5h 55m

Des Moines

Sun 11/2

8:47 pm-9:33 am

2 stops35h 46m

$259

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Thu 10/9

10:35 am-8:30 am

2 stops22h 55m

Des Moines

Sun 10/12

6:30 am-7:12 pm

1 stop11h 42m

$273

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Fri 10/17

9:37 pm-8:29 am

1 stop11h 52m

Des Moines

Sun 10/19

6:30 am-7:12 pm

1 stop11h 42m

$276

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Sun 11/23

7:52 pm-1:31 pm

2 stops42h 39m

Des Moines

Mon 12/1

6:53 pm-4:24 pm

1 stop20h 31m

$279

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Fri 11/7

6:00 am-5:08 pm

2 stops12h 08m

Des Moines

Sun 11/9

7:30 am-7:12 pm

1 stop10h 42m

$289

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Tue 10/21

5:24 pm-11:08 pm

1 stop6h 44m

Des Moines

Thu 10/23

6:07 pm-11:53 pm

1 stop4h 46m

$305

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Fri 11/14

6:00 am-10:40 pm

2 stops17h 40m

Des Moines

Sun 11/16

7:30 am-7:12 pm

1 stop10h 42m

$307

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Fri 10/31

6:00 am-10:26 am

1 stop5h 26m

Des Moines

Mon 11/3

6:39 pm-12:17 am

1 stop4h 38m

$315

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Fri 10/3

5:43 pm-8:29 am

2 stops15h 46m

Des Moines

Sun 10/5

8:47 pm-6:10 pm

2 stops20h 23m

$321

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Sat 11/15

6:00 am-1:47 pm

2 stops32h 47m

$128

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 19 results
1
2

Best time to book a flight from Durham to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Durham with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Durham to Des Moines

How far ahead should I book a flight from Durham to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from Durham to Des Moines. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Durham to Des Moines, you should look to book at least 56 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Durham to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Durham to Des Moines (average of $336). Flying from Durham to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DU8 to DSM?

Find hourly flight availability from Durham to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Durham to Des Moines as you normally would.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 16, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Durham to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Overall

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Durham to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Durham?

    If you book a flight to Des Moines from Durham, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines. There are 0 flights from Durham to Des Moines per day from 4 different airlines.

  • What are the cheapest airlines to fly from Durham to Des Moines one-way?

    To fly one-way, consider booking your trip with Frontier, which is currently one of the cheapest options available, starting at $128. American Airlines flights start at $149 while deals on Delta start at $149 one-way.

  • Can I find deals for flights from Durham to Des Moines that include hotel bookings?

    Yes. In addition to deals on Durham to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Durham to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Durham to Des Moines.

  • Can I find deals for business class flights from Durham to Des Moines?

    Yes. Cheapflights offers flight deals from Durham to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Durham to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Durham to Des Moines (average of $336). Flying from Durham to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 4 airlines flying from Durham to Des Moines

Discover the top 4 airlines that operate flights from Durham to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$353FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$449FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$450FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$296Average$376FlexibilityNo cancel feeOn-time63%

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