$194+ Cheap flights from Durham, NC to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — DSM
Mar 7 — Mar 141
1 adult, Economy
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Cheapest flights from Durham to Des MoinesExplore the most affordable flight options available from Durham to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
Explore the most affordable flight options available from Durham to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:40 am
RDU
- DSM
1 stop9h 25m
Southwest
Wed 4/153:15 pm
DSM
- RDU
1 stop4h 40m
Southwest
Deal found 2/1![Southwest logo]()
$271
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:38 pm
RDU
- DSM
1 stop11h 52m
Frontier
Tue 3/1710:40 am
DSM
- RDU
1 stop10h 13m
Frontier
Deal found 2/2![Frontier logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/193:08 pm
RDU
- DSM
1 stop9h 04m
Multiple Airlines
Mon 2/237:17 pm
DSM
- RDU
2 stops27h 53m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$316
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
RDU
- DSM
2 stops7h 29m
United Airlines
Wed 4/156:20 am
DSM
- RDU
2 stops6h 46m
United Airlines
Deal found 2/1![United Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:20 pm
RDU
- DSM
1 stop5h 07m
United Airlines
Wed 4/83:04 pm
DSM
- RDU
1 stop6h 23m
United Airlines
Deal found 2/4![United Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:38 pm
RDU
- DSM
1 stop11h 47m
Multiple Airlines
Sat 3/78:21 pm
DSM
- RDU
2 stops10h 36m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:10 am
RDU
- DSM
2 stops7h 00m
Southwest
Wed 4/85:30 am
DSM
- RDU
2 stops6h 35m
Southwest
Deal found 2/4![Southwest logo]()
$339
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:07 pm
RDU
- DSM
2 stops37h 28m
Multiple Airlines
Mon 3/98:21 pm
DSM
- RDU
1 stop20h 27m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/105:20 pm
RDU
- DSM
1 stop5h 07m
United Airlines
Mon 4/133:21 pm
DSM
- RDU
1 stop5h 02m
United Airlines
Deal found 2/4![United Airlines logo]()
$348
Best flights from Durham to Des MoinesDiscover carefully curated flight deals from Durham to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
Discover carefully curated flight deals from Durham to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/87:13 am
RDU
- DSM
1 stop7h 33m
American Airlines
Wed 4/155:01 pm
DSM
- RDU
1 stop5h 58m
American Airlines
Deal found 2/4![American Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:40 am
RDU
- DSM
1 stop9h 25m
Southwest
Wed 4/153:15 pm
DSM
- RDU
1 stop4h 40m
Southwest
Deal found 2/1![Southwest logo]()
$271
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
RDU
- DSM
2 stops7h 29m
United Airlines
Wed 4/156:20 am
DSM
- RDU
2 stops6h 46m
United Airlines
Deal found 2/1![United Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:43 pm
RDU
- DSM
1 stop25h 33m
Multiple Airlines
Mon 3/236:00 am
DSM
- RDU
2 stops32h 17m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:02 am
RDU
- DSM
2 stops10h 17m
Frontier
Sun 2/227:45 pm
DSM
- RDU
1 stop19h 31m
Frontier
Deal found 2/3![Frontier logo]()
$387
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:35 pm
RDU
- DSM
1 stop8h 46m
American Airlines
Wed 4/222:02 pm
DSM
- RDU
1 stop6h 53m
American Airlines
Deal found 2/2![American Airlines logo]()
$271
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:15 am
RDU
- DSM
1 stop7h 14m
United Airlines
Wed 4/86:20 am
DSM
- RDU
2 stops6h 46m
United Airlines
Deal found 2/4![United Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/107:00 am
RDU
- DSM
2 stops8h 15m
United Airlines
Mon 4/133:04 pm
DSM
- RDU
1 stop6h 23m
United Airlines
Deal found 2/4![United Airlines logo]()
$353
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:00 am
RDU
- DSM
1 stop7h 07m
American Airlines
Mon 4/65:00 am
DSM
- RDU
1 stop7h 02m
American Airlines
Deal found 2/2![American Airlines logo]()
$387
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:15 pm
RDU
- DSM
1 stop5h 25m
United Airlines
Mon 3/232:04 pm
DSM
- RDU
1 stop6h 04m
United Airlines
Deal found 2/4![United Airlines logo]()
$387
Last-minute flights from Durham to Des MoinesDiscover last-minute flight deals from Durham to Des Moines. Data last updated February 5, 2026 and is based on user searches.
Discover last-minute flight deals from Durham to Des Moines. Data last updated February 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/193:08 pm
RDU
- DSM
1 stop9h 04m
Multiple Airlines
Mon 2/237:17 pm
DSM
- RDU
2 stops27h 53m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:17 pm
RDU
- DSM
1 stop13h 08m
Multiple Airlines
Mon 2/238:38 pm
DSM
- RDU
2 stops16h 20m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/209:02 am
RDU
- DSM
2 stops10h 17m
Frontier
Sun 2/227:45 pm
DSM
- RDU
1 stop19h 31m
Frontier
Deal found 2/3![Frontier logo]()
$387
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:07 am
RDU
- DSM
2 stops10h 57m
Frontier
Sun 3/17:27 pm
DSM
- RDU
1 stop19h 49m
Frontier
Deal found 2/3![Frontier logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:07 pm
RDU
- DSM
2 stops37h 28m
Multiple Airlines
Mon 3/98:21 pm
DSM
- RDU
1 stop20h 27m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/24:47 pm
RDU
- DSM
1 stop6h 33m
United Airlines
Mon 3/93:28 pm
DSM
- RDU
1 stop4h 40m
United Airlines
Deal found 2/1![United Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/610:38 pm
RDU
- DSM
1 stop11h 47m
Multiple Airlines
Sat 3/78:21 pm
DSM
- RDU
2 stops10h 36m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$336
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:38 pm
RDU
- DSM
1 stop11h 52m
Frontier
Tue 3/1710:40 am
DSM
- RDU
1 stop10h 13m
Frontier
Deal found 2/2![Frontier logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:00 am
RDU
- DSM
2 stops15h 14m
Multiple Airlines
Tue 3/171:23 pm
DSM
- RDU
1 stop28h 21m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:43 pm
RDU
- DSM
1 stop25h 33m
Multiple Airlines
Mon 3/236:00 am
DSM
- RDU
2 stops32h 17m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:22 am
RDU
- DSM
1 stop5h 02m
United Airlines
Wed 3/252:59 pm
DSM
- RDU
1 stop6h 38m
United Airlines
Deal found 2/3![United Airlines logo]()
$402
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:40 am
RDU
- DSM
1 stop8h 35m
Southwest
Tue 3/313:40 pm
DSM
- RDU
2 stops6h 15m
Southwest
Deal found 2/3![Southwest logo]()
$392
One-way flights from Durham to Des MoinesSearch for one-way flight options from Durham to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
Search for one-way flight options from Durham to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:15 pm
RDU
- DSM
1 stop5h 25m
United Airlines
Deal found 2/2![United Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/25:28 pm
RDU
- DSM
1 stop5h 23m
American Airlines
Deal found 2/1![American Airlines logo]()
$204
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
RDU
- DSM
2 stops9h 27m
United Airlines
Deal found 2/1![United Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:36 pm
RDU
- DSM
3 stops36h 59m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$220
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/303:10 pm
RDU
- DSM
2 stops9h 05m
Southwest
Deal found 2/2![Southwest logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:16 pm
RDU
- DSM
3 stops39h 26m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$237
This deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1110:00 am
RDU
- DSM
1 stop5h 33m
United Airlines
Deal found 2/3![United Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/166:00 am
RDU
- DSM
2 stops9h 27m
United Airlines
Deal found 2/3![United Airlines logo]()
$354
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:46 pm
RDU
- DSM
3 stops38h 45m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/1611:23 am
RDU
- DSM
3 stops32h 43m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$470
Find flight deals from Durham to Des Moines
Keep the following information in mind while searching for Durham to Des Moines flight deals. Data was last updated February 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Southwest) |
One-way from | $194 (United Airlines) |
Popular in | February |
Cheapest in | December |
Average price | $624 |
Cheapflights Fare Finder
Customize your flight search to find flights from Durham to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Durham to Des Moines that are best for you.
Fly from
Durham
Fly to
Des Moines
Route
Depart
Return
Price
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Wed 4/8
7:13 am-1:46 pm
1 stop7h 33m
Des Moines
Wed 4/15
5:01 pm-11:59 pm
1 stop5h 58m
$271
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Wed 4/8
5:40 am-2:05 pm
1 stop9h 25m
Des Moines
Wed 4/15
3:15 pm-8:55 pm
1 stop4h 40m
$271
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Wed 4/15
12:35 pm-8:21 pm
1 stop8h 46m
Des Moines
Wed 4/22
2:02 pm-9:55 pm
1 stop6h 53m
$271
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Wed 4/8
6:00 am-12:29 pm
2 stops7h 29m
Des Moines
Wed 4/15
6:20 am-2:06 pm
2 stops6h 46m
$319
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Mon 4/6
6:15 am-12:29 pm
1 stop7h 14m
Des Moines
Wed 4/8
6:20 am-2:06 pm
2 stops6h 46m
$334
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Fri 4/10
7:00 am-2:15 pm
2 stops8h 15m
Des Moines
Mon 4/13
3:04 pm-10:27 pm
1 stop6h 23m
$353
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Fri 3/13
6:43 pm-7:16 pm
1 stop25h 33m
Des Moines
Mon 3/23
6:00 am-3:17 pm
2 stops32h 17m
$376
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Fri 2/20
9:02 am-6:19 pm
2 stops10h 17m
Des Moines
Sun 2/22
7:45 pm-4:16 pm
1 stop19h 31m
$387
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Fri 4/3
7:00 am-1:07 pm
1 stop7h 07m
Des Moines
Mon 4/6
5:00 am-1:02 pm
1 stop7h 02m
$387
RaleighDes Moines
RDU - DSM
RDUDSM
Raleigh-Durham
Fri 3/13
5:15 pm-9:40 pm
1 stop5h 25m
Des Moines
Mon 3/23
2:04 pm-9:08 pm
1 stop6h 04m
$387
Showing 1-10 of 18 results
Best time to book a flight from Durham to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Durham with our price prediction graph.
RDU-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Durham to Des Moines
DU8-DSM
RDU-DSM
How far ahead should I book a flight from Durham to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from Durham to Des Moines. Price data was last updated on January 30, 2026.
To ensure you get the cheapest price possible for a flight from Durham to Des Moines, you should look to book at least 64 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Durham to Des Moines?
Currently, May is the cheapest month in which you can book a flight from Durham to Des Moines (average of $209). Flying from Durham to Des Moines in November is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 5, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Durham to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Food
7.0
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Durham to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
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Other flights to Des Moines
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Durham and Des Moines flights
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Top 4 airlines flying from Durham to Des Moines
Discover the top 4 airlines that operate flights from Durham to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$238 | Average$357 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$374 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$292 | Average$384 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$320 | Average$418 | FlexibilityNo cancel fee | On-time69% |