$133+ Cheap flights from Des Moines to Cleveland (DSM - CLE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CLE
Sep 5 — Sep 121
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Cleveland with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Cleveland
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Cheapest flights from Des Moines to ClevelandExplore the most affordable flight options available from Des Moines to Cleveland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
Explore the most affordable flight options available from Des Moines to Cleveland. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
This Frontier deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm -
1 stop24h 28m
Mon 8/317:25 am -
1 stop7h 09m
Deal found 8/3![Frontier logo]()
$236
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:40 pm -
1 stop4h 40m
Sat 8/296:45 am -
1 stop8h 25m
Deal found 8/4![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:00 am -
1 stop4h 09m
Wed 9/910:52 am -
1 stop4h 28m
Deal found 8/4![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am -
2 stops6h 00m
Wed 9/95:25 pm -
1 stop5h 35m
Deal found 8/4![Southwest logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:07 pm -
1 stop27h 50m
Wed 8/199:47 pm -
2 stops23h 07m
Deal found 8/6![Multiple Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:35 am -
1 stop7h 24m
Tue 10/207:00 am -
1 stop4h 11m
Deal found 8/3![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:25 pm -
1 stop8h 05m
Tue 9/15:25 pm -
1 stop5h 30m
Deal found 8/6![Southwest logo]()
$338
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 am -
2 stops6h 30m
Mon 8/315:25 pm -
1 stop5h 45m
Deal found 8/3![Southwest logo]()
$340
Best flights from Des Moines to ClevelandDiscover carefully curated flight deals from Des Moines to Cleveland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
Discover carefully curated flight deals from Des Moines to Cleveland that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 am -
1 stop4h 49m
Mon 9/76:00 am -
1 stop5h 18m
Deal found 8/2![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/512:10 pm -
2 stops7h 15m
Sat 9/128:55 am -
1 stop3h 35m
Deal found 8/6![Southwest logo]()
$327
This United Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:24 am -
1 stop5h 44m
Sun 9/209:00 am -
1 stop4h 16m
Deal found 8/3![United Airlines logo]()
$366
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am -
2 stops9h 50m
Wed 9/912:50 pm -
2 stops9h 15m
Deal found 8/6![Southwest logo]()
$332
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:58 pm -
1 stop4h 48m
Mon 12/71:00 pm -
1 stop6h 05m
Deal found 8/5![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:25 pm -
1 stop8h 05m
Tue 9/15:25 pm -
1 stop5h 30m
Deal found 8/6![Southwest logo]()
$338
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:29 pm -
1 stop5h 24m
Mon 12/72:19 pm -
1 stop3h 30m
Deal found 8/5![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 am -
2 stops6h 30m
Mon 8/3111:00 am -
2 stops12h 10m
Deal found 8/3![Southwest logo]()
$351
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:00 am -
1 stop6h 39m
Sun 10/186:10 am -
1 stop4h 32m
Deal found 8/3![Delta logo]()
$366
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:50 pm -
2 stops5h 20m
Mon 8/315:25 pm -
1 stop5h 45m
Deal found 8/6![Southwest logo]()
$356
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:50 pm -
1 stop4h 56m
Sun 10/186:10 am -
1 stop4h 32m
Deal found 8/3![Delta logo]()
$382
Last-minute flights from Des Moines to ClevelandDiscover last-minute flight deals from Des Moines to Cleveland. Data last updated August 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Cleveland. Data last updated August 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:07 pm -
1 stop27h 50m
Wed 8/199:47 pm -
2 stops23h 07m
Deal found 8/6![Multiple Airlines logo]()
$334
This Frontier deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm -
1 stop24h 28m
Mon 8/317:25 am -
1 stop7h 09m
Deal found 8/3![Frontier logo]()
$236
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:40 am -
2 stops6h 30m
Mon 8/315:25 pm -
1 stop5h 45m
Deal found 8/3![Southwest logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:19 pm -
1 stop24h 28m
Fri 8/285:15 pm -
2 stops44h 50m
Deal found 8/4![Multiple Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:40 pm -
1 stop4h 40m
Sat 8/296:45 am -
1 stop8h 25m
Deal found 8/4![Southwest logo]()
$309
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:25 pm -
1 stop8h 05m
Tue 9/15:25 pm -
1 stop5h 30m
Deal found 8/6![Southwest logo]()
$338
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:00 am -
1 stop4h 09m
Wed 9/910:52 am -
1 stop4h 28m
Deal found 8/4![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am -
2 stops6h 00m
Wed 9/95:25 pm -
1 stop5h 35m
Deal found 8/4![Southwest logo]()
$327
One-way flights from Des Moines to ClevelandSearch for one-way flight options from Des Moines to Cleveland. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
Search for one-way flight options from Des Moines to Cleveland. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:04 pm -
1 stop27h 46m
Deal found 8/2![Multiple Airlines logo]()
$133
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/195:45 am -
1 stop5h 48m
Deal found 8/5![Delta logo]()
$168
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:20 am -
2 stops8h 25m
Deal found 8/5![Southwest logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/162:31 pm -
2 stops29h 06m
Deal found 8/2![Frontier logo]()
$198
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3010:23 am -
1 stop3h 45m
Deal found 8/3![Delta logo]()
$201
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:00 am -
2 stops9h 30m
Deal found 8/3![Southwest logo]()
$224
This deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:21 pm -
1 stop5h 50m
Deal found 8/5![United Airlines logo]()
$241
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:10 am -
1 stop3h 50m
Deal found 8/6![Southwest logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:00 am -
2 stops39h 57m
Deal found 8/5![Multiple Airlines logo]()
$277
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/1310:23 am -
1 stop3h 45m
Deal found 8/5![Delta logo]()
$316
Find flight deals from Des Moines to Cleveland
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Cleveland (CLE). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $236 (Frontier) |
One-way from | $133 (Kiwi.com) |
Popular in | April |
Cheapest in | November |
Average price | $673 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Cleveland that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Des Moines to Cleveland that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Tue 9/1
5:40 am-11:29 am
1 stop4h 49m
Cleveland Hopkins Intl
Mon 9/7
6:00 am-10:18 am
1 stop5h 18m
$322
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Sat 9/5
12:10 pm-8:25 pm
2 stops7h 15m
Cleveland Hopkins Intl
Sat 9/12
8:55 am-11:30 am
1 stop3h 35m
$327
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Wed 9/2
6:10 am-5:00 pm
2 stops9h 50m
Cleveland Hopkins Intl
Wed 9/9
12:50 pm-9:05 pm
2 stops9h 15m
$332
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Thu 12/3
2:58 pm-8:46 pm
1 stop4h 48m
Cleveland Hopkins Intl
Mon 12/7
1:00 pm-6:05 pm
1 stop6h 05m
$335
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Fri 8/28
2:25 pm-11:30 pm
1 stop8h 05m
Cleveland Hopkins Intl
Tue 9/1
5:25 pm-9:55 pm
1 stop5h 30m
$338
Quickest round-trip
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Fri 12/4
5:29 pm-11:53 pm
1 stop5h 24m
Cleveland Hopkins Intl
Mon 12/7
2:19 pm-4:49 pm
1 stop3h 30m
$351
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Mon 8/24
5:40 am-1:10 pm
2 stops6h 30m
Cleveland Hopkins Intl
Mon 8/31
11:00 am-10:10 pm
2 stops12h 10m
$351
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Fri 8/28
3:50 pm-10:10 pm
2 stops5h 20m
Cleveland Hopkins Intl
Mon 8/31
5:25 pm-10:10 pm
1 stop5h 45m
$356
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Thu 9/17
6:24 am-1:08 pm
1 stop5h 44m
Cleveland Hopkins Intl
Sun 9/20
9:00 am-12:16 pm
1 stop4h 16m
$366
Des MoinesCleveland
DSM Des Moines - CLE Cleveland Hopkins Intl
DSMCLE
Des Moines
Sat 10/17
6:00 am-1:39 pm
1 stop6h 39m
Cleveland Hopkins Intl
Sun 10/18
6:10 am-9:42 am
1 stop4h 32m
$366
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Cleveland
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Cleveland in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Cleveland flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Cleveland flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Cleveland flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Cleveland flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Cleveland flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Cleveland
Have a flexible travel schedule? Discover the best time to fly to Cleveland from Des Moines with our price prediction graph.
DSM-CLE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Cleveland
Reviews of airlines servicing Cleveland
Get insights into the airlines that provide service to Cleveland. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Cleveland. Reviews last updated August 6, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Cleveland have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Entertainment
7.8
Food
7.2
Overall
7.8
Crew
8.5
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Cleveland. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Cleveland?
Book flights to Cleveland if you plan to visit one of these locationsSandusky
Beachwood
Independence
Mansfield
Avon
Strongsville
Lakewood
Streetsboro
Medina
Cuyahoga Falls
North Olmsted
Macedonia
Kent
Westlake
Elyria
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Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Des Moines and Cleveland flights
Browse other Des Moines and Cleveland flight options. Last updated on August 6, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Cleveland
Discover the top 3 airlines that operate flights from Des Moines to Cleveland. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$256 | Average$293 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$296 | Average$426 | FlexibilityNo cancel fee | On-time69% |