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$121+ Cheap flights from Iowa to Charleston (CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Cheap flight deals from Iowa to Charleston

Keep the following information in mind while searching for Iowa to Charleston flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$235
(Kiwi.com)

One-way from

$121
(Kiwi.com)

Popular in

November

Cheapest in

September

Average price

$365
Provider with most accurate pricing for Des Moines-Charleston flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
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From Iowa to Charleston
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One-way flight from Iowa to Charleston
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Highest demand for flights based on searches. 18% potential increase in price ($87 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Iowa to Charleston

Cheapest flights from Iowa to Charleston
Explore the most affordable flight options available from Iowa to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CHS
1 stop7h 26mMultiple Airlines
Fri 11/149:02 amCHS - DSM
1 stop6h 53mMultiple Airlines
Deal found 10/29$235
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:50 amCID - CHS
1 stop6h 33mDelta
Sat 12/65:00 pmCHS - CID
1 stop6h 19mDelta
Deal found 10/30$249
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:13 pmCID - CHS
2 stops6h 57mAmerican Airlines
Sat 12/65:10 amCHS - CID
2 stops9h 10mAmerican Airlines
Deal found 10/30$259
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:27 pmCID - CHS
1 stop7h 30mAmerican Airlines
Mon 1/58:08 pmCHS - CID
1 stop4h 50mAmerican Airlines
Deal found 10/30$266
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/218:00 amCID - CHS
1 stop4h 55mUnited Airlines
Tue 12/24:38 pmCHS - CID
1 stop5h 41mUnited Airlines
Deal found 10/30$273
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CHS
1 stop7h 26mMultiple Airlines
Wed 11/193:09 pmCHS - DSM
2 stops31h 05mMultiple Airlines
Deal found 10/30$277
This Delta deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:12 pmMLI - CHS
1 stop4h 38mDelta
Tue 11/1810:40 amCHS - MLI
1 stop6h 48mDelta
Deal found 10/30$279
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/133:13 pmCID - CHS
1 stop5h 37mAmerican Airlines
Sat 11/1512:26 pmCHS - CID
1 stop5h 55mAmerican Airlines
Deal found 10/30$279
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:00 pmMLI - CHS
2 stops9h 42mUnited Airlines
Tue 11/186:15 amCHS - MLI
1 stop5h 00mUnited Airlines
Deal found 10/30$284
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:50 amDSM - CHS
1 stop10h 52mMultiple Airlines
Mon 11/179:02 amCHS - DSM
1 stop6h 53mMultiple Airlines
Deal found 10/29$289
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1211:08 amOMA - CHS
1 stop26h 21mMultiple Airlines
Wed 12/175:48 pmCHS - OMA
2 stops39h 17mMultiple Airlines
Deal found 10/29$299
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amOMA - CHS
1 stop5h 09mUnited Airlines
Thu 12/254:59 pmCHS - OMA
1 stop5h 59mUnited Airlines
Deal found 10/29$309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Iowa to Charleston that are best for you.

Fly from

Iowa

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/10

8:40 am-5:06 pm

1 stop7h 26m

Charleston

Fri 11/14

9:02 am-2:55 pm

1 stop6h 53m

$235

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

11:28 am-11:07 pm

2 stops10h 39m

Charleston

Sun 1/18

3:16 pm-9:58 pm

1 stop7h 42m

$244

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Sat 4/11

3:52 pm-9:04 pm

1 stop4h 12m

Charleston

Wed 4/15

11:55 am-3:05 pm

1 stop4h 10m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Tue 12/2

5:50 am-1:23 pm

1 stop6h 33m

Charleston

Sat 12/6

5:00 pm-10:19 pm

1 stop6h 19m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Sat 2/28

7:00 am-2:06 pm

1 stop6h 06m

Charleston

Tue 3/3

5:00 pm-10:16 pm

1 stop6h 16m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

3:45 pm-9:17 pm

1 stop4h 32m

Charleston

Sun 1/18

6:05 am-10:12 am

1 stop5h 07m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

3:45 pm-9:17 pm

1 stop4h 32m

Charleston

Mon 1/19

6:05 am-10:12 am

1 stop5h 07m

$249

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 1/16

1:26 pm-10:34 pm

1 stop8h 08m

Charleston

Sun 1/25

9:13 am-2:42 pm

1 stop6h 29m

$249

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

11:28 am-9:11 pm

2 stops8h 43m

Charleston

Mon 1/19

5:41 pm-9:33 pm

1 stop4h 52m

$254

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Fri 12/5

3:14 pm-11:13 pm

2 stops6h 59m

Charleston

Sun 12/7

7:00 am-12:43 pm

1 stop6h 43m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 49 results
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Best time to book a flight from Iowa to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Charleston

What is the cheapest month to book a flight from Iowa to Charleston?

Currently, February is the cheapest month in which you can book a flight from Iowa to Charleston (average of $159). Flying from Iowa to Charleston in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IA to CHS?

Find hourly flight availability from Iowa to Charleston. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Iowa to Charleston is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight at noon could potentially save you up to 35% on airfare.

How much does it cost to fly round-trip from Iowa to Charleston?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Charleston from Iowa?

    If you book a flight to Charleston from Iowa, you will be flying to Charleston, which is the city’s only airport. Charleston (CHS) is located 10.2 mi from the center of Charleston.

  • How long is the flight from Iowa to Charleston?

    Airlines like American Airlines, United Airlines, and Delta fly from Iowa to Charleston in about 4h 12m. The time it takes to get you to your destination can typically vary by up to 6h 27m. Airlines will cover a distance of 824 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Iowa to Charleston one-way?

    $157 is the cheapest one-way deal found within the past few days, from United Airlines. You may also be able to find cheap deals on Southwest and American Airlines, with prices starting from $162 and $239, respectively.

  • What are the most popular routes from Iowa to Charleston?

    The most popular route from Iowa to Charleston is Omaha Eppley Airfield - Charleston. You may also consider Des Moines - Charleston or Cedar Rapids - Charleston.

  • Can I find deals for flights from Iowa to Charleston that include hotel bookings?

    Yes. In addition to deals on Iowa to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Charleston.

  • Can I find deals for business class flights from Iowa to Charleston?

    Yes. Cheapflights offers flight deals from Iowa to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Charleston?

    Currently, February is the cheapest month in which you can book a flight from Iowa to Charleston (average of $159). Flying from Iowa to Charleston in January is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Isle of Palms
Santee
Mount Pleasant
Edisto Beach

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Alternative routes for Iowa to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Iowa to Charleston

Discover the top 3 airlines that operate flights from Iowa to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$345FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$372FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$369FlexibilityNo cancel feeOn-time71%

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