$135+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 11 — Nov 181
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Charleston
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Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/8![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:01 pm -
1 stop5h 58m
Wed 11/1111:12 am -
2 stops9h 04m
Deal found 10/8![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:25 am -
1 stop4h 59m
Tue 11/104:13 pm -
1 stop6h 41m
Deal found 10/12![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
2 stops8h 17m
Sat 11/143:29 pm -
1 stop4h 47m
Deal found 10/9![United Airlines logo]()
$330
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:05 am -
2 stops7h 23m
Fri 11/1310:23 am -
2 stops8h 05m
Deal found 10/9![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
2 stops12h 05m
Wed 11/116:35 am -
2 stops8h 40m
Deal found 10/8![Southwest logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:26 pm -
1 stop6h 43m
Sat 11/1412:17 pm -
1 stop7h 36m
Deal found 10/9![American Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/106:53 pm -
1 stop4h 11m
Sun 12/133:14 pm -
1 stop7h 17m
Deal found 10/11![Delta logo]()
$361
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
2 stops10h 10m
Sat 11/149:45 am -
2 stops11h 00m
Deal found 10/9![Southwest logo]()
$371
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 12, 2026.
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/7![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/278:00 am -
2 stops8h 14m
Sat 3/611:55 am -
1 stop6h 48m
Deal found 10/8![United Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:55 am -
2 stops9h 25m
Wed 1/201:25 pm -
2 stops9h 10m
Deal found 10/8![Southwest logo]()
$354
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:52 pm -
1 stop4h 07m
Mon 11/167:04 pm -
1 stop4h 31m
Deal found 10/10![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop4h 46m
Wed 2/312:50 pm -
1 stop8h 32m
Deal found 10/8![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:10 am -
2 stops9h 50m
Tue 12/224:45 pm -
1 stop6h 45m
Deal found 10/8![Southwest logo]()
$411
This Delta deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:54 pm -
1 stop4h 05m
Tue 10/275:30 am -
1 stop6h 12m
Deal found 10/8![Delta logo]()
$423
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/148:00 am -
1 stop4h 46m
Mon 1/184:58 pm -
1 stop7h 16m
Deal found 10/8![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:05 am -
2 stops7h 23m
Mon 11/2310:23 am -
2 stops8h 05m
Deal found 10/10![United Airlines logo]()
$406
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated October 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated October 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:26 pm -
1 stop6h 43m
Mon 11/24:13 pm -
1 stop7h 26m
Deal found 10/8![American Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:26 pm -
1 stop6h 43m
Sat 11/1412:17 pm -
1 stop7h 36m
Deal found 10/9![American Airlines logo]()
$350
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:20 am -
2 stops10h 40m
Sat 11/149:45 am -
2 stops11h 00m
Deal found 10/9![Southwest logo]()
$391
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:25 am -
1 stop4h 59m
Tue 11/104:13 pm -
1 stop6h 41m
Deal found 10/12![American Airlines logo]()
$325
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
2 stops8h 17m
Sat 11/143:29 pm -
1 stop4h 47m
Deal found 10/9![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:00 am -
2 stops10h 10m
Sat 11/149:45 am -
2 stops11h 00m
Deal found 10/9![Southwest logo]()
$371
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:01 pm -
1 stop5h 58m
Wed 11/1111:12 am -
2 stops9h 04m
Deal found 10/8![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
2 stops12h 05m
Wed 11/116:35 am -
2 stops8h 40m
Deal found 10/8![Southwest logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:05 am -
2 stops7h 23m
Fri 11/1310:23 am -
2 stops8h 05m
Deal found 10/9![United Airlines logo]()
$335
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated October 12, 2026.
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:27 am -
1 stop7h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Delta logo]()
$135
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:55 am -
1 stop7h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/10![United Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:36 am -
2 stops8h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:26 pm -
1 stop6h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![American Airlines logo]()
$172
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:48 pm -
3 stops41h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$207
This Southwest deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:00 am -
2 stops11h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Southwest logo]()
$215
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (American Airlines) |
One-way from | $135 (Delta) |
Popular in | March |
Cheapest in | January |
Average price | $406 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/31
11:27 am-7:48 pm
1 stop7h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 11/7
9:55 am-6:06 pm
1 stop7h 11m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/31
9:36 am-7:12 pm
2 stops8h 36m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$170
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 12/24
5:05 am-2:49 pm
1 stop8h 44m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$188
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 12/24
6:00 am-5:25 pm
2 stops10h 25m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$193
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/4
7:00 am-7:35 pm
2 stops11h 35m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$215
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Fri 10/30
6:05 am-2:25 pm
2 stops7h 20m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$217
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 10/29
2:26 pm-10:09 pm
1 stop6h 43m
Charleston
Mon 11/2
4:13 pm-10:39 pm
1 stop7h 26m
$269
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/31
9:00 am-2:09 pm
3 stops28h 09m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$319
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 12/24
8:35 pm-9:01 pm
3 stops23h 26m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$334
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $392). Flying from Des Moines to Charleston in March is currently the most expensive (average of $594). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Airfare is below average for this route at the moment.
Des Moines to Charleston flights typically cost between $379 and $470 in October.The cheapest round-trip price found within the last 5 days was $269 on American Airlines (Oct 29-Nov 2).
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated October 12, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Comfort
8.0
Crew
8.6
Overall
7.9
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Des Moines to Charleston
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 12, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Charleston flights
Browse other Des Moines and Charleston flight options. Last updated on October 12, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on October 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Charleston
Discover the top 4 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$305 | Average$449 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$324 | Average$408 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$356 | Average$442 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$380 | Average$474 | FlexibilityNo cancel fee | On-time63% |