HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Charleston

$194+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Charleston with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or January, booked 90 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:35 amDSM - CHS
1 stop7h 21mDelta
Fri 1/29:23 amCHS - DSM
1 stop5h 15mDelta
Deal found 12/26$677
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:25 pmDSM - CHS
2 stops7h 46mAmerican Airlines
Fri 1/212:25 pmCHS - DSM
1 stop7h 02mAmerican Airlines
Deal found 12/26$682
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:34 pmDSM - CHS
2 stops7h 37mAmerican Airlines
Thu 1/112:51 pmCHS - DSM
2 stops6h 31mAmerican Airlines
Deal found 12/26$747
This United Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/299:00 amDSM - CHS
2 stops9h 18mUnited Airlines
Fri 1/211:40 amCHS - DSM
2 stops9h 50mUnited Airlines
Deal found 12/27$1,054

Find flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$293
(Delta)

One-way from

$194
(Delta)

Popular in

March

Cheapest in

September

Average price

$426
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
Search Deals
From Des Moines to Charleston
Search Deals
One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

12:04 pm-5:43 pm

1 stop4h 39m

Charleston

Sat 1/24

9:00 am-12:15 pm

1 stop4h 15m

$293

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

1:55 pm-9:43 pm

1 stop6h 48m

Charleston

Sat 1/24

6:10 am-12:46 pm

2 stops7h 36m

$298

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

5:35 am-11:48 am

1 stop5h 13m

Charleston

Thu 1/22

12:53 pm-4:28 pm

1 stop4h 35m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 1/20

11:26 am-7:18 pm

1 stop6h 52m

Charleston

Thu 1/22

11:28 am-7:34 pm

1 stop9h 06m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

11:42 am-9:11 pm

2 stops8h 29m

Charleston

Thu 1/22

7:42 pm-11:08 pm

1 stop4h 26m

$310

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 1/24

10:15 am-7:42 pm

1 stop8h 27m

Charleston

Sat 1/31

6:30 am-12:15 pm

1 stop6h 45m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 1/24

4:00 pm-10:34 pm

1 stop5h 34m

Charleston

Sat 1/31

10:18 am-4:24 pm

2 stops7h 06m

$322

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 2/10

7:10 am-4:53 pm

2 stops8h 43m

Charleston

Tue 2/17

3:54 pm-10:26 pm

2 stops7h 32m

$328

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 1/17

7:50 am-2:02 pm

1 stop5h 12m

Charleston

Tue 1/20

5:13 pm-10:30 pm

1 stop6h 17m

$339

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 5/3

5:15 pm-12:21 am

1 stop6h 06m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 13 results
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on December 26, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated December 28, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,019 reviews
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,113 reviews
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,072 reviews
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $293, Delta can have you in Charleston from Des Moines in 4h 39m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $166. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $258 and $266, respectively. Delta is currently priced 57% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Charlotte flights
Omaha to Charleston flights
Cedar Rapids to Charlotte flights
Moline to Charlotte flights
Omaha to Savannah flights
Moline to Charleston flights
Cedar Rapids to Charleston flights
Omaha to Charlotte flights
Cedar Rapids to Myrtle Beach flights
Des Moines to Savannah flights
Cedar Rapids to Savannah flights
Moline to Myrtle Beach flights
Moline to Savannah flights
Omaha to Myrtle Beach flights
Des Moines to Myrtle Beach flights
Cedar Rapids to Greenville flights
Des Moines to Greenville flights
Omaha to Greenville flights
Omaha to Hilton Head Island flights
Omaha to Columbia flights
Moline to Hilton Head Island flights
Moline to Greenville flights
Cedar Rapids to Columbia flights
La Crosse to Savannah flights
Sioux City to Charlotte flights
Moline to Augusta flights
Moline to Columbia flights
La Crosse to Charlotte flights
Des Moines to Columbia flights
Sioux City to Charleston flights
Sioux City to Columbia flights
Waterloo to Charlotte flights
Des Moines to Hilton Head Island flights
Moline to Florence flights
La Crosse to Greenville flights
Cedar Rapids to Hilton Head Island flights
Cedar Rapids to Florence flights
Waterloo to Greenville flights
La Crosse to Charleston flights
Dubuque to Savannah flights
Omaha to Florence flights
Dubuque to Myrtle Beach flights
Dubuque to Greenville flights
Dubuque to Charlotte flights
Waterloo to Myrtle Beach flights

Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$343FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$259Average$371FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$437FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.