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$136+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
jun. 17 — jun. 241
mar. 6/17
mar. 6/24
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in May or September, booked 86 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated junio 12, 2025.

Round-trip from

$271
(American Airlines)

One-way from

$136
(Delta)

Popular in

March

Cheapest in

May

Average price

$419
From Des Moines to Charleston
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One-way flight from Des Moines to Charleston
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Highest demand for flights based on searches. 12% potential increase in price ($54 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/106:00 amDSM - CHS
1 stop8h 17mAmerican Airlines
mié. 9/245:37 pmCHS - DSM
1 stop6h 30mAmerican Airlines
Deal found 6/11$271
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 7/125:59 pmDSM - CHS
1 stop5h 00mDelta
sáb. 7/196:30 pmCHS - DSM
1 stop5h 03mDelta
Deal found 6/11$297
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 7/278:30 amDSM - CHS
2 stops28h 45mMultiple Airlines
jue. 7/312:28 pmCHS - DSM
2 stops28h 37mMultiple Airlines
Deal found 6/11$299
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/205:35 amDSM - CHS
2 stops12h 05mSouthwest
jue. 10/236:15 amCHS - DSM
2 stops5h 45mSouthwest
Deal found 6/10$335
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/168:15 amDSM - CHS
2 stops9h 46mUnited Airlines
lun. 10/2011:31 amCHS - DSM
1 stop6h 53mUnited Airlines
Deal found 6/10$346

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

mié. 9/10

6:00 am-3:17 pm

1 stop8h 17m

Charleston

mié. 9/24

5:37 pm-11:07 pm

1 stop6h 30m

$271

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

sáb. 7/12

5:59 pm-11:59 pm

1 stop5h 00m

Charleston

sáb. 7/19

6:30 pm-10:33 pm

1 stop5h 03m

$297

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

dom. 7/27

8:30 am-2:15 pm

2 stops28h 45m

Charleston

jue. 7/31

2:28 pm-6:05 pm

2 stops28h 37m

$299

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

lun. 10/20

5:35 am-6:40 pm

2 stops12h 05m

Charleston

jue. 10/23

6:15 am-11:00 am

2 stops5h 45m

$335

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

jue. 10/16

8:15 am-7:01 pm

2 stops9h 46m

Charleston

lun. 10/20

11:31 am-5:24 pm

1 stop6h 53m

$346

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

mar. 9/30

7:00 am-2:08 pm

1 stop6h 08m

$136

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

sáb. 8/2

6:03 pm-11:59 pm

1 stop4h 56m

$149

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

vie. 11/14

8:00 am-3:10 pm

1 stop6h 10m

$169

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

mar. 9/30

11:28 am-11:44 pm

3 stops11h 16m

$269

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

mar. 7/1

2:23 pm-8:37 am

3 stops41h 14m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on June 9, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Charleston by month

Plan your trip to Charleston by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Charleston ranges from 2.4 - 7.2 inches per month. August is typically the wettest month, when rainfall can reach 7.2 in. November is typically the driest time to visit Charleston when rainfall is around 2.4 in.

Temperature in Charleston by month

Plan your trip to Charleston by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Charleston, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated junio 12, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta and United Airlines from Des Moines to Charleston to help guide your decision. In addition to providing an overall rating, users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,287 reviews

Crew

8.6

Overall

8.0

Food

7.1

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,287 reviews
Southwest
8.0
Very good
4,287 reviews

Crew

8.6

Overall

8.0

Food

7.1

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,946 reviews
Southwest
8.0
Very good
4,287 reviews

Crew

8.6

Overall

8.0

Food

7.1

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,790 reviews
Southwest
8.0
Very good
4,287 reviews

Crew

8.6

Overall

8.0

Food

7.1

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,287 reviews

Crew

8.6

Overall

8.0

Food

7.1

Comfort

8.0

Entertainment

7.6

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on American Airlines is currently your cheapest option to Charleston, with prices starting at $271. Additional round-trip tickets that might be worth considering are offered by Delta and Southwest, with the lowest prices starting at $297 and $335, respectively. American Airlines is currently priced 31% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Des Moines to Charleston one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $136. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Des Moines to Charleston for a low price.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Mount Pleasant
Isle of Palms
Folly Beach
Santee
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated junio 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$248Average$397FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$267Average$378FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$315Average$565FlexibilityNo cancel feeOn-time69%

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