$153+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Oct 12 — Oct 191
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Charleston
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Best
Last-minute
One-way
Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 12, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:54 pm -
1 stop4h 05m
Wed 10/215:30 am -
1 stop6h 12m
Deal found 9/10![Delta logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:54 pm -
1 stop28h 07m
Fri 10/233:14 pm -
1 stop7h 54m
Deal found 9/12![Multiple Airlines logo]()
$326
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:00 am -
1 stop5h 04m
Tue 10/136:00 am -
2 stops9h 15m
Deal found 9/8![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
2 stops10h 05m
Tue 12/81:25 pm -
2 stops9h 35m
Deal found 9/7![Southwest logo]()
$335
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:54 pm -
1 stop4h 05m
Fri 10/96:30 am -
1 stop5h 12m
Deal found 9/8![Delta logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:25 am -
2 stops31h 13m
Fri 10/233:14 pm -
1 stop7h 54m
Deal found 9/11![Multiple Airlines logo]()
$345
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:26 pm -
1 stop6h 43m
Sat 10/108:08 pm -
1 stop4h 50m
Deal found 9/10![American Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:54 pm -
1 stop4h 05m
Wed 10/219:32 am -
1 stop5h 37m
Deal found 9/10![Delta logo]()
$371
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:05 am -
1 stop5h 11m
Wed 10/77:16 am -
1 stop7h 14m
Deal found 9/8![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
1 stop9h 30m
Sun 11/85:30 am -
2 stops8h 40m
Deal found 9/9![Southwest logo]()
$382
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop4h 26m
Sat 10/310:27 am -
2 stops8h 00m
Deal found 9/9![American Airlines logo]()
$385
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 12, 2026.
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/218:00 am -
1 stop4h 51m
Sun 1/244:45 pm -
1 stop5h 56m
Deal found 9/9![United Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/215:55 am -
2 stops9h 25m
Sun 1/241:25 pm -
2 stops9h 10m
Deal found 9/9![Southwest logo]()
$381
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:54 pm -
1 stop4h 05m
Sat 10/244:35 pm -
1 stop6h 58m
Deal found 9/11![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:55 am -
2 stops9h 25m
Sun 1/241:25 pm -
2 stops9h 10m
Deal found 9/10![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/171:26 pm -
2 stops9h 33m
Tue 10/206:50 pm -
1 stop5h 45m
Deal found 9/10![United Airlines logo]()
$410
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:54 pm -
1 stop4h 05m
Thu 10/225:30 am -
1 stop6h 12m
Deal found 9/12![Delta logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop4h 51m
Wed 2/310:12 am -
2 stops13h 18m
Deal found 9/9![United Airlines logo]()
$410
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/47:00 am -
2 stops9h 25m
Sun 12/62:00 pm -
1 stop9h 00m
Deal found 9/11![Southwest logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:00 am -
2 stops8h 00m
Tue 10/65:05 pm -
1 stop6h 10m
Deal found 9/9![United Airlines logo]()
$416
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:30 am -
2 stops10h 50m
Wed 10/77:15 am -
1 stop5h 15m
Deal found 9/8![Southwest logo]()
$442
This United Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops8h 00m
Fri 10/26:50 pm -
1 stop5h 45m
Deal found 9/11![United Airlines logo]()
$457
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated September 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated September 12, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop4h 26m
Sat 10/310:27 am -
2 stops8h 00m
Deal found 9/9![American Airlines logo]()
$385
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:05 am -
1 stop5h 11m
Wed 10/77:16 am -
1 stop7h 14m
Deal found 9/8![American Airlines logo]()
$381
This Delta deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:54 pm -
1 stop4h 05m
Fri 10/96:30 am -
1 stop5h 12m
Deal found 9/8![Delta logo]()
$340
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:00 am -
1 stop5h 04m
Tue 10/136:00 am -
2 stops9h 15m
Deal found 9/8![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:26 pm -
1 stop6h 43m
Sat 10/108:08 pm -
1 stop4h 50m
Deal found 9/10![American Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:54 pm -
1 stop4h 05m
Tue 10/205:30 am -
1 stop6h 12m
Deal found 9/10![Delta logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:54 pm -
1 stop28h 07m
Fri 10/233:14 pm -
1 stop7h 54m
Deal found 9/12![Multiple Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:54 pm -
1 stop4h 05m
Thu 10/225:30 am -
1 stop6h 12m
Deal found 9/10![Delta logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:25 am -
2 stops31h 13m
Fri 10/233:14 pm -
1 stop7h 54m
Deal found 9/11![Multiple Airlines logo]()
$345
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated September 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:40 am -
2 stops48h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:04 pm -
1 stop30h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$159
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:00 am -
1 stop6h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
2 stops8h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![United Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/93:58 pm -
1 stop15h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:42 pm -
1 stop26h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$194
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:25 am -
2 stops12h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Southwest logo]()
$205
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:10 am -
2 stops10h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Southwest logo]()
$208
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/66:00 am -
1 stop7h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![American Airlines logo]()
$209
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $325 (Delta) |
One-way from | $153 (Kiwi.com) |
Popular in | February |
Cheapest in | April |
Average price | $450 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 10/7
6:00 am-2:04 pm
1 stop7h 04m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sun 10/4
6:40 am-9:01 pm
3 stops37h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$179
Quickest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Mon 11/9
3:31 pm-10:26 pm
1 stop5h 55m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$194
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 10/8
5:42 pm-9:01 pm
1 stop26h 19m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$194
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 10/10
11:22 am-6:18 pm
1 stop5h 56m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$204
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Mon 11/9
5:25 am-6:30 pm
2 stops12h 05m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$205
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Mon 10/5
5:10 am-4:10 pm
2 stops10h 00m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$208
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/4
7:00 am-5:25 pm
2 stops9h 25m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$209
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sun 12/6
6:00 am-2:39 pm
1 stop7h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$209
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 1/21
8:00 am-1:51 pm
1 stop4h 51m
Charleston
Sun 1/24
4:45 pm-9:41 pm
1 stop5h 56m
$371
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, April is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $380). Flying from Des Moines to Charleston in February is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Airfare is below average for this route at the moment.
Des Moines to Charleston flights typically cost between $410 and $578 in October.The cheapest round-trip price found within the last 5 days was $325 on Delta (Oct 13-Oct 20).
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated September 12, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Comfort
7.8
Overall
7.8
Entertainment
7.8
Boarding
8.1
Food
7.2
Crew
8.5
Reviews
1 / 20
4.0
OkayJennifer,Sep 2026
ORD - LGA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
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Alternative routes for Des Moines to Charleston
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 12, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Charleston flights
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Other flights from Des Moines
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Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Charleston
Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$266 | Average$406 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$451 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$356 | Average$442 | FlexibilityNo cancel fee | On-timeN/A |