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Charleston

$159+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Aug 12 — Aug 191
Wed 8/12
Wed 8/19
1 adult, Economy
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Cheap flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 13, 2026.

This United Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/53:11 pm
DSM
-
CHS
1 stop5h 22m
United Airlines
Fri 10/98:00 am
CHS
-
DSM
1 stop7h 15m
United Airlines
Deal found 7/9$263
This United Airlines deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/211:35 pm
DSM
-
CHS
1 stop7h 00m
United Airlines
Fri 8/2810:14 am
CHS
-
DSM
2 stops8h 14m
United Airlines
Deal found 7/8$268
This Southwest deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:50 pm
DSM
-
CHS
1 stop4h 35m
Southwest
Tue 8/111:25 pm
CHS
-
DSM
2 stops9h 30m
Southwest
Deal found 7/9$269
This Southwest deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:35 am
DSM
-
CHS
2 stops6h 40m
Southwest
Sat 10/316:15 am
CHS
-
DSM
2 stops6h 45m
Southwest
Deal found 7/10$273
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:15 am
DSM
-
CHS
2 stops11h 00m
Southwest
Wed 9/1610:45 am
CHS
-
DSM
2 stops11h 15m
Southwest
Deal found 7/8$275
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:44 pm
DSM
-
CHS
1 stop7h 15m
American Airlines
Mon 9/217:24 pm
CHS
-
DSM
1 stop5h 17m
American Airlines
Deal found 7/11$290
This American Airlines deal was found by Cheapflights users on 7/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:08 pm
DSM
-
CHS
1 stop4h 40m
American Airlines
Mon 8/107:50 pm
CHS
-
DSM
1 stop5h 30m
American Airlines
Deal found 7/9$300
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:40 am
DSM
-
CHS
2 stops8h 45m
Southwest
Mon 8/107:00 am
CHS
-
DSM
1 stop5h 25m
Southwest
Deal found 7/8$305
This Southwest deal was found by Cheapflights users on 7/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:40 am
DSM
-
CHS
2 stops8h 45m
Southwest
Mon 8/1711:35 am
CHS
-
DSM
2 stops11h 35m
Southwest
Deal found 7/8$311
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm
DSM
-
CHS
1 stop6h 36m
American Airlines
Sat 10/37:18 am
CHS
-
DSM
1 stop7h 41m
American Airlines
Deal found 7/13$317

Find flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 13, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$263
(United Airlines)

One-way from

$159
(American Airlines)

Popular in

February

Cheapest in

September

Average price

$416
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
Search Deals
From Des Moines to Charleston
Search Deals
One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 8/21

1:35 pm-9:35 pm

1 stop7h 00m

Charleston

Fri 8/28

10:14 am-5:28 pm

2 stops8h 14m

$268

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 8/28

3:20 pm-9:34 pm

1 stop5h 14m

Charleston

Wed 9/2

11:40 am-8:26 pm

2 stops9h 46m

$268
Quickest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/2

6:00 am-1:28 pm

1 stop6h 28m

Charleston

Sun 9/6

7:43 pm-11:44 pm

1 stop5h 01m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 9/22

2:40 pm-9:10 pm

1 stop5h 30m

Charleston

Tue 9/29

10:45 am-9:00 pm

2 stops11h 15m

$322

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/2

6:00 am-3:10 pm

2 stops8h 10m

Charleston

Mon 9/7

6:45 am-10:26 am

1 stop4h 41m

$330

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 8/8

6:00 am-2:27 pm

2 stops7h 27m

Charleston

Sat 8/15

6:30 am-12:18 pm

1 stop6h 48m

$333

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/24

1:21 pm-9:34 pm

1 stop7h 13m

Charleston

Thu 9/3

7:00 am-2:16 pm

2 stops8h 16m

$348

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 9/2

6:00 am-3:10 pm

2 stops8h 10m

Charleston

Sun 9/6

10:14 am-5:28 pm

2 stops8h 14m

$365

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 8/2

5:10 am-2:45 pm

2 stops8h 35m

Charleston

Fri 8/7

7:00 am-11:25 am

1 stop5h 25m

$397

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 8/17

3:20 pm-9:34 pm

1 stop5h 14m

Charleston

Wed 8/19

6:30 am-12:20 pm

1 stop6h 50m

$397

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/13

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $286). Flying from Des Moines to Charleston in February is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Charleston?

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated July 13, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.8
Good
8,462 reviews

Overall

7.8

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
Delta
7.8
Good
8,462 reviews
Delta
7.8
Good
8,462 reviews

Overall

7.8

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
United Airlines
7.4
Good
9,983 reviews
Delta
7.8
Good
8,462 reviews

Overall

7.8

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional
American Airlines
7.1
Good
11,810 reviews
Delta
7.8
Good
8,462 reviews

Overall

7.8

Food

7.2

Entertainment

7.8

Crew

8.5

Boarding

8.1

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

Anonymous,May 2026

SEA - KOA

The snacks were not very good, not everyone was very friendly and professional

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $322, United Airlines can have you in Charleston from Des Moines in 5h 30m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on American Airlines is currently your cheapest option to Charleston, with prices starting at $236. Additional round-trip tickets that might be worth considering are offered by Delta and United Airlines, with the lowest prices starting at $258 and $266, respectively. American Airlines is currently priced 43% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $286). Flying from Des Moines to Charleston in February is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 13, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$236Average$415FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$406FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$266Average$398FlexibilityNo cancel feeOn-time69%

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