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$136+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or August, booked 64 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 29, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$271
(American Airlines)

One-way from

$136
(Delta)

Popular in

March

Cheapest in

September

Average price

$366
Provider with most accurate pricing for Des Moines-Charleston flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
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From Des Moines to Charleston
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One-way flight from Des Moines to Charleston
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Highest demand for flights based on searches. 11% potential increase in price ($50 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/302:15 pmDSM - CHS
1 stop5h 33mAmerican Airlines
Tue 10/78:00 pmCHS - DSM
1 stop4h 45mAmerican Airlines
Deal found 4/29$271
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/3010:17 amDSM - CHS
1 stop6h 43mDelta
Tue 6/34:59 pmCHS - DSM
1 stop6h 31mDelta
Deal found 4/28$284
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/135:19 pmDSM - CHS
2 stops14h 18mMultiple Airlines
Fri 6/206:00 amCHS - DSM
1 stop9h 45mMultiple Airlines
Deal found 4/29$348
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:15 pmDSM - CHS
1 stop4h 49mUnited Airlines
Sat 11/810:23 amCHS - DSM
2 stops8h 10mUnited Airlines
Deal found 4/29$372
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/171:35 pmDSM - CHS
2 stops10h 20mSouthwest
Sun 7/205:50 amCHS - DSM
2 stops6h 25mSouthwest
Deal found 4/27$387

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 9/30

2:15 pm-8:48 pm

1 stop5h 33m

Charleston

Tue 10/7

8:00 pm-11:45 pm

1 stop4h 45m

$271

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/30

10:17 am-6:00 pm

1 stop6h 43m

Charleston

Tue 6/3

4:59 pm-10:30 pm

1 stop6h 31m

$284

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 6/13

5:19 pm-8:37 am

2 stops14h 18m

Charleston

Fri 6/20

6:00 am-2:45 pm

1 stop9h 45m

$348

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 7/17

1:35 pm-12:55 am

2 stops10h 20m

Charleston

Sun 7/20

5:50 am-11:15 am

2 stops6h 25m

$387

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/13

5:45 am-3:01 pm

1 stop8h 16m

Charleston

Sat 5/17

7:00 am-2:39 pm

1 stop8h 39m

$497

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 5/28

2:15 pm-9:04 pm

1 stop5h 49m

$136

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/16

4:04 pm-12:15 am

2 stops7h 11m

$219

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/16

11:30 am-11:50 pm

2 stops11h 20m

$254

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on April 25, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 64 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in Charleston by month

Plan your trip to Charleston by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Charleston ranges from 2.4 - 7.2 inches per month. August is typically the wettest month, when rainfall can reach 7.2 in. November is typically the driest time to visit Charleston when rainfall is around 2.4 in.

Temperature in Charleston by month

Plan your trip to Charleston by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Charleston, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 82.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated April 29, 2025.
Southwest
8.0
Very good
4,295 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.0

Crew

8.6

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,295 reviews
Southwest
8.0
Very good
4,295 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.0

Crew

8.6

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,936 reviews
Southwest
8.0
Very good
4,295 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.0

Crew

8.6

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,295 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.0

Crew

8.6

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,295 reviews

Entertainment

7.6

Boarding

8.2

Overall

8.0

Crew

8.6

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on American Airlines is currently your cheapest option to Charleston, with prices starting at $271. Additional round-trip tickets that might be worth considering are offered by Delta and Southwest, with the lowest prices starting at $284 and $387, respectively. American Airlines is currently priced 31% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Des Moines to Charleston one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $136. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Des Moines to Charleston for a low price.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
North Charleston
Summerville
Mount Pleasant
Walterboro
Isle of Palms
Folly Beach
Santee
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$249Average$406FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$381FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$311Average$553FlexibilityNo cancel feeOn-time69%

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