$159+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:53 pm
DSM
- CHS
1 stop16h 45m
Multiple Airlines
Fri 9/43:54 pm
CHS
- DSM
1 stop7h 14m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:53 pm
DSM
- CHS
1 stop16h 45m
Multiple Airlines
Thu 9/38:20 pm
CHS
- DSM
1 stop23h 36m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/239:28 am
DSM
- CHS
2 stops46h 10m
Multiple Airlines
Fri 9/43:54 pm
CHS
- DSM
1 stop7h 14m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:19 pm
DSM
- CHS
1 stop21h 12m
Multiple Airlines
Thu 10/89:39 pm
CHS
- DSM
1 stop11h 20m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:57 am
DSM
- CHS
1 stop4h 35m
Delta
Sat 10/37:10 am
CHS
- DSM
1 stop4h 33m
Delta
Deal found 6/10![Delta logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:53 pm
DSM
- CHS
1 stop16h 45m
Multiple Airlines
Sun 9/62:53 pm
CHS
- DSM
1 stop20h 51m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$292
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:15 am
DSM
- CHS
2 stops6h 58m
United Airlines
Tue 11/106:43 pm
CHS
- DSM
1 stop5h 18m
United Airlines
Deal found 6/11![United Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:20 am
DSM
- CHS
2 stops6h 55m
Southwest
Tue 11/101:25 pm
CHS
- DSM
2 stops9h 40m
Southwest
Deal found 6/11![Southwest logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:04 pm
DSM
- CHS
1 stop29h 25m
Multiple Airlines
Thu 9/109:39 pm
CHS
- DSM
1 stop19h 26m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Sun 8/27:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:40 am
DSM
- CHS
1 stop5h 14m
Delta
Wed 9/23:14 pm
CHS
- DSM
1 stop6h 45m
Delta
Deal found 6/14![Delta logo]()
$317
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:20 am
DSM
- CHS
1 stop5h 01m
Delta
Sat 10/105:30 am
CHS
- DSM
1 stop5h 48m
Delta
Deal found 6/11![Delta logo]()
$290
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:15 am
DSM
- CHS
2 stops6h 58m
United Airlines
Tue 11/106:43 pm
CHS
- DSM
1 stop5h 18m
United Airlines
Deal found 6/11![United Airlines logo]()
$295
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:35 am
DSM
- CHS
1 stop9h 55m
Southwest
Fri 10/95:15 pm
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 6/14![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/233:22 pm
DSM
- CHS
1 stop5h 12m
United Airlines
Sun 9/278:00 am
CHS
- DSM
1 stop7h 15m
United Airlines
Deal found 6/10![United Airlines logo]()
$335
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:15 pm
DSM
- CHS
1 stop5h 26m
Delta
Thu 10/86:30 am
CHS
- DSM
1 stop4h 48m
Delta
Deal found 6/14![Delta logo]()
$336
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:04 am
DSM
- CHS
1 stop4h 47m
Delta
Tue 11/105:55 pm
CHS
- DSM
1 stop5h 34m
Delta
Deal found 6/14![Delta logo]()
$336
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- CHS
1 stop5h 15m
Southwest
Fri 7/2412:00 pm
CHS
- DSM
2 stops11h 25m
Southwest
Deal found 6/10![Southwest logo]()
$412
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
DSM
- CHS
1 stop6h 58m
United Airlines
Wed 9/211:40 am
CHS
- DSM
1 stop6h 48m
United Airlines
Deal found 6/14![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:50 pm
DSM
- CHS
1 stop4h 35m
Southwest
Sun 9/202:05 pm
CHS
- DSM
2 stops9h 30m
Southwest
Deal found 6/10![Southwest logo]()
$413
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:37 pm
DSM
- CHS
1 stop4h 49m
Delta
Fri 7/247:20 am
CHS
- DSM
1 stop7h 14m
Delta
Deal found 6/13![Delta logo]()
$407
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:37 pm
DSM
- CHS
1 stop4h 49m
Delta
Mon 8/35:06 pm
CHS
- DSM
1 stop6h 31m
Delta
Deal found 6/13![Delta logo]()
$407
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated June 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:30 pm
DSM
- CHS
2 stops38h 08m
Multiple Airlines
Thu 7/97:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/31:41 pm
DSM
- CHS
1 stop4h 36m
American Airlines
Tue 7/78:56 am
CHS
- DSM
1 stop5h 09m
American Airlines
Deal found 6/14![American Airlines logo]()
$336
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:40 pm
DSM
- CHS
1 stop5h 10m
Southwest
Tue 7/73:00 pm
CHS
- DSM
2 stops8h 50m
Southwest
Deal found 6/14![Southwest logo]()
$373
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:41 pm
DSM
- CHS
1 stop5h 09m
American Airlines
Mon 7/134:15 pm
CHS
- DSM
1 stop6h 42m
American Airlines
Deal found 6/14![American Airlines logo]()
$372
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Sun 7/197:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Deal found 6/14![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/214:14 pm
DSM
- CHS
1 stop15h 54m
Multiple Airlines
Thu 7/238:20 pm
CHS
- DSM
2 stops20h 30m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/244:40 pm
DSM
- CHS
1 stop5h 15m
Southwest
Tue 7/286:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 6/12![Southwest logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Sun 8/27:47 pm
CHS
- DSM
1 stop21h 03m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$314
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/242:44 pm
DSM
- CHS
1 stop7h 15m
American Airlines
Deal found 6/10![American Airlines logo]()
$159
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:30 pm
DSM
- CHS
1 stop6h 36m
American Airlines
Deal found 6/10![American Airlines logo]()
$186
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:04 pm
DSM
- CHS
2 stops22h 58m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$207
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:12 am
DSM
- CHS
1 stop8h 38m
American Airlines
Deal found 6/11![American Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:29 am
DSM
- CHS
2 stops36h 27m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$218
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/281:37 pm
DSM
- CHS
1 stop7h 28m
American Airlines
Deal found 6/13![American Airlines logo]()
$244
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:10 am
DSM
- CHS
2 stops8h 35m
Southwest
Deal found 6/13![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:00 am
DSM
- CHS
2 stops7h 27m
United Airlines
Deal found 6/15![United Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:02 pm
DSM
- CHS
3 stops38h 36m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$297
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Kiwi.com) |
One-way from | $159 (American Airlines) |
Popular in | February |
Cheapest in | September |
Average price | $450 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 10/6
6:20 am-12:21 pm
1 stop5h 01m
Charleston
Sat 10/10
5:30 am-10:18 am
1 stop5h 48m
$290
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 11/7
6:15 am-2:13 pm
2 stops6h 58m
Charleston
Tue 11/10
6:43 pm-11:01 pm
1 stop5h 18m
$295
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 9/23
3:22 pm-9:34 pm
1 stop5h 12m
Charleston
Sun 9/27
8:00 am-2:15 pm
1 stop7h 15m
$335
Quickest round-trip
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 10/6
2:15 pm-8:41 pm
1 stop5h 26m
Charleston
Thu 10/8
6:30 am-10:18 am
1 stop4h 48m
$336
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 11/7
11:04 am-4:51 pm
1 stop4h 47m
Charleston
Tue 11/10
5:55 pm-10:29 pm
1 stop5h 34m
$336
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 10/5
5:35 am-4:30 pm
1 stop9h 55m
Charleston
Fri 10/9
5:15 pm-10:35 pm
1 stop6h 20m
$387
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 9/1
6:00 am-1:58 pm
1 stop6h 58m
Charleston
Wed 9/2
11:40 am-5:28 pm
1 stop6h 48m
$397
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 7/20
6:37 pm-12:26 am
1 stop4h 49m
Charleston
Fri 7/24
7:20 am-1:34 pm
1 stop7h 14m
$407
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Fri 7/31
6:37 pm-12:26 am
1 stop4h 49m
Charleston
Mon 8/3
5:06 pm-10:37 pm
1 stop6h 31m
$407
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 7/20
4:40 pm-10:55 pm
1 stop5h 15m
Charleston
Fri 7/24
12:00 pm-10:25 pm
2 stops11h 25m
$412
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $280). Flying from Des Moines to Charleston in February is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated June 15, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Entertainment
7.8
Crew
8.5
Food
7.2
Comfort
7.8
Boarding
8.1
Overall
7.9
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Top 3 airlines flying from Des Moines to Charleston
Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$242 | Average$370 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$403 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$398 | FlexibilityNo cancel fee | On-time69% |