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$125+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 15 — May 221
Fri 5/15
Fri 5/22
1 adult, Economy
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Cheap flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 15, 2026.

This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/21:37 pm
DSM
-
CHS
1 stop5h 13m
American Airlines
Tue 6/98:25 am
CHS
-
DSM
1 stop5h 55m
American Airlines
Deal found 4/14$335
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/211:00 am
DSM
-
CHS
1 stop28h 25m
Multiple Airlines
Sat 5/93:44 pm
CHS
-
DSM
2 stops24h 31m
Multiple Airlines
Deal found 4/10$337
This Southwest deal was found by Cheapflights users on 4/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:55 am
DSM
-
CHS
2 stops10h 40m
Southwest
Tue 5/121:15 pm
CHS
-
DSM
2 stops9h 00m
Southwest
Deal found 4/12$345
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
DSM
-
CHS
1 stop4h 51m
United Airlines
Sat 5/165:08 pm
CHS
-
DSM
1 stop5h 17m
United Airlines
Deal found 4/13$346
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
DSM
-
CHS
1 stop6h 45m
American Airlines
Sat 5/236:45 am
CHS
-
DSM
1 stop7h 07m
American Airlines
Deal found 4/10$355
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/212:03 pm
DSM
-
CHS
1 stop5h 37m
American Airlines
Sat 5/96:01 am
CHS
-
DSM
1 stop8h 19m
American Airlines
Deal found 4/10$357
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/33:52 pm
DSM
-
CHS
1 stop16h 45m
Multiple Airlines
Sun 8/166:00 am
CHS
-
DSM
2 stops18h 19m
Multiple Airlines
Deal found 4/14$368
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/124:40 pm
DSM
-
CHS
1 stop5h 10m
Southwest
Wed 6/177:00 am
CHS
-
DSM
1 stop5h 30m
Southwest
Deal found 4/10$371
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
-
CHS
2 stops10h 25m
Southwest
Sat 5/98:00 am
CHS
-
DSM
2 stops13h 55m
Southwest
Deal found 4/10$373

Find flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 15, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$335
(American Airlines)

One-way from

$125
(Kiwi.com)

Popular in

February

Cheapest in

September

Average price

$380
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
Search Deals
From Des Moines to Charleston
Search Deals
One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/5

3:15 pm-9:05 pm

1 stop4h 50m

Charleston

Tue 5/12

7:15 am-11:25 am

1 stop5h 10m

$335

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/12

10:02 am-6:59 pm

2 stops7h 57m

Charleston

Sat 5/16

5:07 pm-10:45 pm

1 stop6h 38m

$351

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 6/12

5:10 am-11:25 am

1 stop5h 15m

Charleston

Wed 6/17

7:00 am-11:30 am

1 stop5h 30m

$371

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 5/2

6:40 am-6:05 pm

2 stops10h 25m

Charleston

Sat 5/9

8:00 am-8:55 pm

2 stops13h 55m

$373

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/12

6:55 am-6:35 pm

2 stops10h 40m

Charleston

Sat 5/16

7:35 am-8:55 pm

2 stops14h 20m

$375

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 6/12

11:28 am-5:18 pm

1 stop4h 50m

Charleston

Wed 6/17

5:10 am-10:43 am

1 stop6h 33m

$388

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 6/1

5:25 am-12:35 pm

2 stops6h 10m

Charleston

Sat 6/6

5:30 am-2:50 pm

2 stops10h 20m

$401

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 7/13

5:10 am-11:25 am

1 stop5h 15m

Charleston

Sat 7/18

6:15 pm-10:50 pm

1 stop5h 35m

$407

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 5/25

4:20 pm-9:55 pm

1 stop4h 35m

Charleston

Mon 6/1

2:15 pm-11:05 pm

2 stops9h 50m

$412

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 5/19

11:40 am-7:39 pm

1 stop6h 59m

Charleston

Wed 5/20

5:08 pm-11:24 pm

1 stop7h 16m

$415

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/11

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on April 10, 2026.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 70 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $204). Flying from Des Moines to Charleston in March is currently the most expensive (average of $353). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Charleston?

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated April 15, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,404 reviews

Boarding

8.1

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,404 reviews
Delta
7.9
Good
8,404 reviews

Boarding

8.1

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,589 reviews
Delta
7.9
Good
8,404 reviews

Boarding

8.1

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,580 reviews
Delta
7.9
Good
8,404 reviews

Boarding

8.1

Entertainment

7.8

Crew

8.5

Overall

7.9

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $335, Southwest can have you in Charleston from Des Moines in 4h 50m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $237. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $242 and $266, respectively. Delta is currently priced 40% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $204). Flying from Des Moines to Charleston in March is currently the most expensive (average of $353). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$387FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$242Average$353FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$398FlexibilityNo cancel feeOn-time69%

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