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$136+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Apr 16 — Apr 231
Thu 4/16
Thu 4/23
1 adult, Economy
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Cheap flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:53 pm
DSM
-
CHS
1 stop13h 42m
Multiple Airlines
Sat 5/93:44 pm
CHS
-
DSM
2 stops23h 02m
Multiple Airlines
Deal found 3/14$332
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:21 pm
DSM
-
CHS
1 stop5h 04m
United Airlines
Sat 4/188:00 am
CHS
-
DSM
1 stop5h 29m
United Airlines
Deal found 3/12$337
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:15 pm
DSM
-
CHS
1 stop4h 50m
Southwest
Sat 4/258:00 am
CHS
-
DSM
1 stop4h 30m
Southwest
Deal found 3/17$346
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:00 am
DSM
-
CHS
2 stops8h 14m
American Airlines
Wed 4/85:00 am
CHS
-
DSM
2 stops7h 30m
American Airlines
Deal found 3/12$347
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/113:21 pm
DSM
-
CHS
1 stop5h 04m
United Airlines
Sat 4/189:28 am
CHS
-
DSM
1 stop6h 00m
United Airlines
Deal found 3/12$355
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
DSM
-
CHS
1 stop4h 49m
American Airlines
Sat 4/252:09 pm
CHS
-
DSM
1 stop8h 45m
American Airlines
Deal found 3/13$357
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:15 pm
DSM
-
CHS
1 stop4h 50m
Southwest
Sat 5/308:00 am
CHS
-
DSM
1 stop4h 30m
Southwest
Deal found 3/12$363

Find flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$332
(Kiwi.com)

One-way from

$136
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$596
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
Search Deals
From Des Moines to Charleston
Search Deals
One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 4/14

3:21 pm-9:25 pm

1 stop5h 04m

Charleston

Sat 4/18

8:00 am-12:29 pm

1 stop5h 29m

$337
Quickest round-trip

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 4/14

3:15 pm-9:05 pm

1 stop4h 50m

Charleston

Sat 4/18

8:00 am-11:30 am

1 stop4h 30m

$337

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 6/3

5:30 am-3:00 pm

2 stops8h 30m

Charleston

Wed 6/10

7:00 am-11:30 am

1 stop5h 30m

$380

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 9/13

5:40 am-11:30 am

1 stop4h 50m

Charleston

Sat 9/19

7:35 am-11:30 am

1 stop4h 55m

$407

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/1

4:20 pm-9:55 pm

1 stop4h 35m

Charleston

Fri 5/8

7:40 am-11:45 am

1 stop5h 05m

$407

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 4/5

5:25 am-4:35 pm

2 stops10h 10m

Charleston

Wed 4/8

7:15 am-11:25 am

1 stop5h 10m

$416

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 4/20

1:10 pm-11:59 pm

2 stops9h 49m

Charleston

Wed 4/22

6:00 am-12:29 pm

2 stops7h 29m

$417

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 7/16

1:05 pm-9:48 pm

1 stop7h 43m

Charleston

Sun 7/19

6:00 am-10:22 am

1 stop5h 22m

$427

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 4/11

6:40 am-7:10 pm

2 stops11h 30m

Charleston

Sat 4/18

8:00 am-8:55 pm

2 stops13h 55m

$431
Cheapest one-way

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 4/6

7:40 pm-9:35 am

1 stop12h 55m

$153

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/13

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on March 13, 2026.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated March 17, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,431 reviews
Delta
7.9
Good
8,288 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,468 reviews
Delta
7.9
Good
8,288 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Boarding

8.1

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $337, United Airlines can have you in Charleston from Des Moines in 4h 50m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $148. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $242 and $266, respectively. Delta is currently priced 61% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Santee
Walterboro
Summerville
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$148Average$324FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$242Average$355FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$398FlexibilityNo cancel feeOn-time69%

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