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$157+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or May, booked 87 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$274
(Kiwi.com)

One-way from

$157
(American Airlines)

Popular in

November

Cheapest in

September

Average price

$296
From Des Moines to Charleston
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One-way flight from Des Moines to Charleston
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Highest demand for flights based on searches. 14% potential increase in price ($68 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/510:55 amDSM - CHS
1 stop20h 42mMultiple Airlines
Tue 11/112:59 pmCHS - DSM
1 stop20h 06mMultiple Airlines
Deal found 9/15$274
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:19 pmDSM - CHS
2 stops8h 06mAmerican Airlines
Tue 11/116:00 amCHS - DSM
1 stop7h 24mAmerican Airlines
Deal found 9/15$302
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2510:00 amDSM - CHS
1 stop8h 11mDelta
Tue 10/289:46 amCHS - DSM
1 stop5h 49mDelta
Deal found 9/15$305
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amDSM - CHS
2 stops8h 40mAmerican Airlines
Tue 10/2810:21 amCHS - DSM
1 stop7h 41mAmerican Airlines
Deal found 9/15$310
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/315:15 pmDSM - CHS
1 stop5h 44mDelta
Fri 11/76:40 amCHS - DSM
1 stop4h 25mDelta
Deal found 9/16$336
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:56 pmDSM - CHS
1 stop4h 52mAmerican Airlines
Fri 11/76:40 pmCHS - DSM
1 stop6h 10mAmerican Airlines
Deal found 9/16$337
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2612:54 pmDSM - CHS
1 stop7h 54mAmerican Airlines
Fri 11/285:10 amCHS - DSM
2 stops8h 26mAmerican Airlines
Deal found 9/16$341
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - CHS
1 stop18h 49mMultiple Airlines
Sun 12/145:40 pmCHS - DSM
2 stops16h 01mMultiple Airlines
Deal found 9/15$346
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:40 amDSM - CHS
1 stop7h 05mMultiple Airlines
Sun 11/165:40 pmCHS - DSM
2 stops20h 07mMultiple Airlines
Deal found 9/16$347

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/25

10:00 am-7:11 pm

1 stop8h 11m

Charleston

Tue 10/28

9:46 am-2:35 pm

1 stop5h 49m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/25

1:55 pm-9:18 pm

1 stop6h 23m

Charleston

Tue 10/28

3:30 pm-9:13 pm

1 stop6h 43m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 10/22

7:20 am-5:02 pm

1 stop8h 42m

Charleston

Sat 10/25

6:00 am-10:05 am

1 stop5h 05m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/18

7:30 am-1:12 pm

1 stop4h 42m

Charleston

Wed 10/22

7:45 pm-12:02 am

1 stop5h 17m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/11

5:15 pm-11:59 pm

1 stop5h 44m

Charleston

Tue 10/14

7:05 pm-10:30 pm

1 stop4h 25m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/18

5:47 am-11:49 am

1 stop5h 02m

Charleston

Wed 10/22

9:30 am-1:28 pm

1 stop4h 58m

$305

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/11

5:00 am-1:23 pm

2 stops7h 23m

Charleston

Tue 10/14

7:41 pm-11:08 pm

1 stop4h 27m

$310

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 12/22

8:45 am-4:17 pm

1 stop6h 32m

$157

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 9/30

6:30 pm-11:48 pm

1 stop4h 18m

$224

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 10/1

3:05 pm-10:15 pm

1 stop6h 10m

$224

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 14 results
1
2

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on September 12, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Comfort

7.9

Crew

8.5

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $305, Delta can have you in Charleston from Des Moines in 6h 23m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $237. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $262 and $286, respectively. Delta is currently priced 39% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Des Moines to Charleston one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $157. However, be on the lookout for offers from Delta and United Airlines, as they are both options that can get you from Des Moines to Charleston for a low price.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $217). Flying from Des Moines to Charleston in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Mount Pleasant
Isle of Palms
Santee
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$375FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$262Average$371FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$286Average$462FlexibilityNo cancel feeOn-time69%

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