HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Charleston

$118+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Charleston with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or January, booked 90 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$267
(Mytrip)

One-way from

$118
(Kiwi.com)

Popular in

March

Cheapest in

September

Average price

$445
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
Search Deals
From Des Moines to Charleston
Search Deals
One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:07 pmDSM - CHS
1 stop4h 25mAmerican Airlines
Wed 12/316:00 amCHS - DSM
1 stop7h 54mAmerican Airlines
Deal found 11/12$313
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/238:19 pmDSM - CHS
2 stops11h 38mMultiple Airlines
Wed 11/267:00 amCHS - DSM
1 stop15h 09mMultiple Airlines
Deal found 11/12$316
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/22:16 pmDSM - CHS
1 stop6h 32mDelta
Thu 12/43:15 pmCHS - DSM
1 stop7h 00mDelta
Deal found 11/11$329
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:45 amDSM - CHS
1 stop8h 24mUnited Airlines
Thu 12/411:00 amCHS - DSM
2 stops11h 37mUnited Airlines
Deal found 11/11$334
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/169:03 pmDSM - CHS
2 stops34h 34mMultiple Airlines
Sun 11/236:13 pmCHS - DSM
1 stop19h 42mMultiple Airlines
Deal found 11/11$352
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:30 pmDSM - CHS
1 stop4h 28mDelta
Sat 12/2712:23 pmCHS - DSM
1 stop5h 52mDelta
Deal found 11/12$387
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/209:19 amDSM - CHS
1 stop11h 46mMultiple Airlines
Sun 11/309:12 amCHS - DSM
2 stops38h 51mMultiple Airlines
Deal found 11/12$390
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/278:58 amDSM - CHS
2 stops11h 53mAmerican Airlines
Mon 12/13:01 pmCHS - DSM
1 stop8h 52mAmerican Airlines
Deal found 11/12$395

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 1/29

4:30 pm-5:36 pm

2 stops24h 06m

Charleston

Sun 2/1

5:05 pm-9:21 pm

3 stops29h 16m

$290

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

6:54 am-2:18 pm

1 stop6h 24m

Charleston

Sat 1/24

9:00 am-12:17 pm

1 stop4h 17m

$315

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 11/23

8:19 pm-8:57 am

2 stops11h 38m

Charleston

Wed 11/26

7:00 am-9:09 pm

1 stop15h 09m

$316

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 3/10

10:15 am-6:02 pm

1 stop6h 47m

Charleston

Wed 3/11

6:30 am-10:23 am

1 stop4h 53m

$317

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 12/24

2:07 pm-7:32 pm

1 stop4h 25m

Charleston

Wed 12/31

6:42 am-2:52 pm

2 stops9h 10m

$318

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

1:16 pm-11:07 pm

2 stops8h 51m

Charleston

Sat 1/24

6:10 am-12:46 pm

2 stops7h 36m

$325

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 1/16

8:18 pm-8:33 am

2 stops35h 15m

Charleston

Fri 1/23

3:21 pm-5:08 pm

1 stop26h 47m

$327

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 1/23

7:39 am-4:39 pm

1 stop8h 00m

Charleston

Wed 1/28

10:18 am-3:45 pm

1 stop6h 27m

$328

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 2/8

4:30 pm-5:36 pm

2 stops24h 06m

$131

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 12/22

8:29 pm-3:28 pm

3 stops41h 59m

$175

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on November 7, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated November 13, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,007 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,017 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,007 reviews

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $315, Delta can have you in Charleston from Des Moines in 6h 24m. Des Moines and Charleston are separated by a distance of 956 mi.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $199. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $261 and $266, respectively. Delta is currently priced 48% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Santee
Walterboro
Isle of Palms
Mount Pleasant
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Charleston

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Charlotte flights
Omaha to Charlotte flights
Omaha to Charleston flights
Moline to Charlotte flights
Cedar Rapids to Charleston flights
Des Moines to Columbia flights
Omaha to Savannah flights
Cedar Rapids to Charlotte flights
Moline to Charleston flights
Des Moines to Savannah flights
Cedar Rapids to Savannah flights
Cedar Rapids to Greenville flights
Omaha to Myrtle Beach flights
Moline to Savannah flights
Moline to Myrtle Beach flights
Omaha to Columbia flights
Cedar Rapids to Columbia flights
Des Moines to Greenville flights
Moline to Greenville flights
Cedar Rapids to Myrtle Beach flights
Des Moines to Myrtle Beach flights
Omaha to Greenville flights
Moline to Columbia flights
Des Moines to Hilton Head Island flights
La Crosse to Greenville flights
Moline to Augusta flights
Moline to Hilton Head Island flights
Omaha to Hilton Head Island flights
Sioux City to Charleston flights
Dubuque to Savannah flights
Waterloo to Greenville flights
Sioux City to Charlotte flights
La Crosse to Charleston flights
La Crosse to Savannah flights
Waterloo to Charlotte flights
Cedar Rapids to Hilton Head Island flights
Waterloo to Myrtle Beach flights
Moline to Florence flights
La Crosse to Charlotte flights
Dubuque to Myrtle Beach flights
Omaha to Florence flights
Dubuque to Greenville flights
Dubuque to Charlotte flights
Cedar Rapids to Florence flights
Sioux City to Columbia flights

Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$364FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$261Average$374FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$426FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.