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$155+ Cheap flights from Des Moines to Charleston (DSM - CHS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Find cheap flights from Des Moines to Charleston with Cheapflights

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Cheapflights Tip: The best prices from Des Moines to Charleston are usually found in September or May, booked 87 days in advance, depart on a Monday or Friday and return on a Wednesday

Cheap flight deals from Des Moines to Charleston

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$235
(Kiwi.com)

One-way from

$155
(Kiwi.com)

Popular in

November

Cheapest in

September

Average price

$365
Provider with most accurate pricing for Des Moines-Charleston flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Charleston flights.
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From Des Moines to Charleston
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One-way flight from Des Moines to Charleston
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($87 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to Charleston

Cheapest flights from Des Moines to Charleston
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CHS
1 stop7h 26mMultiple Airlines
Fri 11/149:02 amCHS - DSM
1 stop6h 53mMultiple Airlines
Deal found 10/29$235
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:50 amDSM - CHS
1 stop10h 52mMultiple Airlines
Sat 11/223:09 pmCHS - DSM
2 stops31h 05mMultiple Airlines
Deal found 10/27$329
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:15 amDSM - CHS
1 stop7h 03mUnited Airlines
Tue 12/306:05 amCHS - DSM
1 stop5h 45mUnited Airlines
Deal found 10/27$341
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:40 amDSM - CHS
1 stop7h 26mMultiple Airlines
Fri 11/217:05 amCHS - DSM
2 stops39h 43mMultiple Airlines
Deal found 10/27$342
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:50 amDSM - CHS
1 stop6h 26mDelta
Fri 12/193:15 pmCHS - DSM
1 stop7h 00mDelta
Deal found 10/28$350
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2211:30 amDSM - CHS
1 stop6h 30mAmerican Airlines
Fri 11/286:00 amCHS - DSM
1 stop7h 24mAmerican Airlines
Deal found 10/27$352
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:57 pmDSM - CHS
2 stops7h 09mAmerican Airlines
Fri 12/196:00 amCHS - DSM
1 stop7h 48mAmerican Airlines
Deal found 10/28$355
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:45 amDSM - CHS
2 stops9h 55mSouthwest
Sun 12/211:55 pmCHS - DSM
2 stops10h 15mSouthwest
Deal found 10/26$360
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:40 amDSM - CHS
1 stop22h 16mMultiple Airlines
Sun 11/97:05 amCHS - DSM
2 stops31h 42mMultiple Airlines
Deal found 10/27$366

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.

Fly from

Des Moines

Fly to

Charleston

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Mon 11/10

8:40 am-5:06 pm

1 stop7h 26m

Charleston

Fri 11/14

9:02 am-2:55 pm

1 stop6h 53m

$235

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

6:54 am-2:18 pm

1 stop6h 24m

Charleston

Sat 1/24

6:30 am-12:17 pm

1 stop6h 47m

$289

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

6:00 am-4:56 pm

2 stops9h 56m

Charleston

Sat 1/24

12:31 pm-4:24 pm

1 stop4h 53m

$294

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 12/18

5:34 am-11:45 am

1 stop5h 11m

Charleston

Sun 12/21

6:35 am-10:38 am

1 stop5h 03m

$350

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 12/16

6:50 am-2:16 pm

1 stop6h 26m

Charleston

Fri 12/19

3:15 pm-9:15 pm

1 stop7h 00m

$350

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Thu 12/18

5:45 am-4:40 pm

2 stops9h 55m

Charleston

Sun 12/21

4:30 pm-11:10 pm

1 stop7h 40m

$355

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 12/16

12:57 pm-9:06 pm

2 stops7h 09m

Charleston

Fri 12/19

6:00 am-12:48 pm

1 stop7h 48m

$355

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 11/22

3:32 pm-12:13 am

2 stops7h 41m

Charleston

Fri 11/28

6:00 am-12:24 pm

1 stop7h 24m

$357

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 11/14

8:40 am-7:56 am

1 stop22h 16m

Charleston

Fri 11/21

2:39 pm-9:09 pm

1 stop7h 30m

$371

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 11/7

8:40 am-7:56 am

1 stop22h 16m

Charleston

Sun 11/9

2:59 pm-10:35 am

1 stop20h 36m

$373

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Charleston

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Charleston

Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Charleston

How far ahead should I book a flight from Des Moines to Charleston?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Charleston. Price data was last updated on October 24, 2025.

The price you pay for your flight from Des Moines to Charleston may vary depending on when you book. For the best chance of a lower fare, look to book 86 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Charleston?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Charleston

Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated October 29, 2025.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,992 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,992 reviews
Delta
7.9
Good
7,992 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,999 reviews
Delta
7.9
Good
7,992 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,992 reviews

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Charleston?

    For as low as $289, Delta can have you in Charleston from Des Moines in 6h 24m. Des Moines and Charleston are separated by a distance of 956 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Des Moines to Charleston round-trip?

    Flying on Delta is currently your cheapest option to Charleston, with prices starting at $199. Additional round-trip tickets that might be worth considering are offered by American Airlines and United Airlines, with the lowest prices starting at $261 and $266, respectively. Delta is currently priced 49% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Charleston that include hotel bookings?

    Yes. In addition to deals on Des Moines to Charleston flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Charleston?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Charleston.

  • Can I find deals for business class flights from Des Moines to Charleston?

    Yes. Cheapflights offers flight deals from Des Moines to Charleston by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Charleston?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $166). Flying from Des Moines to Charleston in February is currently the most expensive (average of $287). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
North Charleston
Summerville
Walterboro
Isle of Palms
Santee
Mount Pleasant
Edisto Beach

Browse thousands of different options on Cheapflights for your next trip

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Charleston

Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$371FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$261Average$373FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$426FlexibilityNo cancel feeOn-time69%

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