$135+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Sep 12 — Sep 191
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Charleston with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Charleston
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Best
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Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 13, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 13, 2026.
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 36m
Sat 10/37:18 am -
1 stop7h 41m
Deal found 8/11![American Airlines logo]()
$269
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:24 am -
2 stops7h 26m
Wed 9/166:30 am -
1 stop5h 01m
Deal found 8/10![United Airlines logo]()
$274
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:00 am -
2 stops10h 25m
Sat 11/79:45 am -
2 stops10h 55m
Deal found 8/11![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:00 am -
2 stops9h 25m
Sat 11/149:45 am -
2 stops10h 55m
Deal found 8/10![Southwest logo]()
$281
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:22 am -
1 stop5h 52m
Sat 10/108:08 pm -
1 stop4h 50m
Deal found 8/13![American Airlines logo]()
$293
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:03 pm -
1 stop4h 55m
Tue 11/36:00 am -
1 stop5h 42m
Deal found 8/13![Delta logo]()
$297
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:21 pm -
1 stop7h 13m
Mon 9/76:30 am -
1 stop4h 56m
Deal found 8/10![United Airlines logo]()
$299
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:12 pm -
1 stop5h 21m
Fri 10/97:16 am -
1 stop7h 14m
Deal found 8/10![American Airlines logo]()
$306
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:00 am -
2 stops9h 48m
Fri 9/184:58 pm -
1 stop5h 30m
Deal found 8/12![United Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/91:24 pm -
1 stop7h 09m
Mon 10/126:30 am -
1 stop5h 01m
Deal found 8/11![United Airlines logo]()
$330
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 13, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 13, 2026.
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:00 am -
1 stop4h 58m
Fri 9/184:58 pm -
1 stop5h 30m
Deal found 8/12![United Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:30 am -
1 stop5h 17m
Thu 11/267:05 am -
1 stop4h 38m
Deal found 8/8![Delta logo]()
$371
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop6h 36m
Mon 11/1612:16 pm -
1 stop7h 38m
Deal found 8/8![American Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
2 stops8h 30m
Mon 11/166:35 am -
2 stops8h 40m
Deal found 8/8![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/68:00 am -
1 stop4h 58m
Thu 1/74:00 pm -
1 stop8h 39m
Deal found 8/12![United Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:30 am -
2 stops11h 24m
Tue 11/107:00 am -
2 stops11h 23m
Deal found 8/11![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
2 stops9h 25m
Sun 11/155:30 am -
2 stops8h 40m
Deal found 8/8![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:20 am -
2 stops10h 40m
Mon 10/262:35 pm -
2 stops9h 20m
Deal found 8/10![Southwest logo]()
$427
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:24 am -
2 stops7h 26m
Sun 9/136:30 am -
1 stop5h 01m
Deal found 8/11![United Airlines logo]()
$452
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated August 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated August 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop6h 26m
Wed 9/27:50 pm -
1 stop5h 30m
Deal found 8/10![American Airlines logo]()
$281
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:21 pm -
1 stop7h 13m
Mon 9/76:30 am -
1 stop4h 56m
Deal found 8/10![United Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:24 am -
2 stops7h 26m
Wed 9/166:30 am -
1 stop5h 01m
Deal found 8/10![United Airlines logo]()
$274
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:44 pm -
1 stop7h 15m
Sun 9/138:41 pm -
1 stop4h 11m
Deal found 8/11![American Airlines logo]()
$343
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:00 am -
1 stop4h 58m
Fri 9/184:58 pm -
1 stop5h 30m
Deal found 8/12![United Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:13 pm -
1 stop6h 55m
Mon 9/217:24 pm -
1 stop5h 17m
Deal found 8/11![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 36m
Sat 10/37:18 am -
1 stop7h 41m
Deal found 8/11![American Airlines logo]()
$269
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated August 13, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated August 13, 2026.
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm -
1 stop5h 05m
Deal found 8/12![Southwest logo]()
$135
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:29 pm -
1 stop7h 30m
Deal found 8/11![American Airlines logo]()
$136
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/84:11 pm -
1 stop4h 24m
Deal found 8/11![Delta logo]()
$141
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:22 pm -
2 stops7h 49m
Deal found 8/11![United Airlines logo]()
$146
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:22 am -
2 stops11h 37m
Deal found 8/11![United Airlines logo]()
$164
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:32 am -
1 stop7h 08m
Deal found 8/11![United Airlines logo]()
$175
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am -
2 stops7h 50m
Deal found 8/11![United Airlines logo]()
$186
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:03 am -
1 stop4h 35m
Deal found 8/8![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:10 am -
2 stops11h 10m
Deal found 8/8![Southwest logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:29 am -
3 stops32h 27m
Deal found 8/11![Multiple Airlines logo]()
$215
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (American Airlines) |
One-way from | $135 (Southwest) |
Popular in | February |
Cheapest in | January |
Average price | $410 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 9/12
8:00 am-1:58 pm
1 stop4h 58m
Charleston
Fri 9/18
4:58 pm-9:28 pm
1 stop5h 30m
$306
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 1/6
8:00 am-1:58 pm
1 stop4h 58m
Charleston
Thu 1/7
4:00 pm-11:39 pm
1 stop8h 39m
$349
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 11/7
5:30 am-5:54 pm
2 stops11h 24m
Charleston
Tue 11/10
7:00 am-5:23 pm
2 stops11h 23m
$359
Quickest round-trip
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Mon 11/23
5:30 am-11:47 am
1 stop5h 17m
Charleston
Thu 11/26
7:05 am-10:43 am
1 stop4h 38m
$371
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/11
6:00 am-1:36 pm
1 stop6h 36m
Charleston
Mon 11/16
12:16 pm-6:54 pm
1 stop7h 38m
$417
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/11
7:00 am-4:30 pm
2 stops8h 30m
Charleston
Mon 11/16
6:35 am-2:15 pm
2 stops8h 40m
$427
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Wed 11/11
7:00 am-5:25 pm
2 stops9h 25m
Charleston
Sun 11/15
5:30 am-1:10 pm
2 stops8h 40m
$427
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Fri 10/23
6:20 am-6:00 pm
2 stops10h 40m
Charleston
Mon 10/26
2:35 pm-10:55 pm
2 stops9h 20m
$427
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Thu 9/10
6:24 am-2:50 pm
2 stops7h 26m
Charleston
Sun 9/13
6:30 am-10:31 am
1 stop5h 01m
$452
Cheapest one-way
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 9/26
12:10 pm-6:15 pm
1 stop5h 05m
$135
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $312). Flying from Des Moines to Charleston in February is currently the most expensive (average of $608). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Airfare is below average for this route at the moment.
Des Moines to Charleston flights typically cost between $387 and $438 in September.The cheapest round-trip price found within the last 5 days was $269 on American Airlines (Sep 30-Oct 3).
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated August 13, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Crew
8.5
Boarding
8.1
Overall
7.8
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Mount Pleasant
Goose Creek
Edisto Beach
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Des Moines to Charleston
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Other flights to Charleston
Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 13, 2026.
Complete your trip
Complete your trip to Charleston by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Charleston flights
Browse other Des Moines and Charleston flight options. Last updated on August 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Des Moines to Charleston
Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$266 | Average$406 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$281 | Average$450 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$442 | FlexibilityNo cancel fee | On-timeN/A |