$151+ Cheap flights from Des Moines to Charleston (DSM - CHS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jun 12 — Jun 191
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Charleston
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Cheapest flights from Des Moines to CharlestonExplore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
Explore the most affordable flight options available from Des Moines to Charleston. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 13, 2026.
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:55 am
DSM
- CHS
1 stop6h 46m
American Airlines
Tue 6/97:47 pm
CHS
- DSM
1 stop5h 03m
American Airlines
Deal found 5/12![American Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:06 pm
DSM
- CHS
1 stop14h 32m
Multiple Airlines
Fri 7/39:44 pm
CHS
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:20 am
DSM
- CHS
1 stop5h 01m
Delta
Sat 10/34:30 pm
CHS
- DSM
1 stop6h 56m
Delta
Deal found 5/13![Delta logo]()
$365
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:20 am
DSM
- CHS
2 stops11h 55m
Southwest
Wed 7/153:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Deal found 5/10![Southwest logo]()
$366
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:00 am
DSM
- CHS
2 stops8h 25m
American Airlines
Sat 10/36:35 pm
CHS
- DSM
1 stop6h 40m
American Airlines
Deal found 5/13![American Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:20 am
DSM
- CHS
2 stops11h 55m
Southwest
Tue 6/303:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Deal found 5/11![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:47 pm
DSM
- CHS
1 stop8h 02m
American Airlines
Sat 7/47:30 am
CHS
- DSM
1 stop6h 33m
American Airlines
Deal found 5/13![American Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:39 pm
DSM
- CHS
1 stop4h 57m
Delta
Mon 6/296:44 pm
CHS
- DSM
1 stop4h 47m
Delta
Deal found 5/11![Delta logo]()
$375
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:37 pm
DSM
- CHS
1 stop7h 28m
American Airlines
Thu 7/27:05 am
CHS
- DSM
1 stop6h 29m
American Airlines
Deal found 5/11![American Airlines logo]()
$377
Best flights from Des Moines to CharlestonDiscover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
Discover carefully curated flight deals from Des Moines to Charleston that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 13, 2026.
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/103:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Wed 6/176:10 am
CHS
- DSM
1 stop6h 20m
Southwest
Deal found 5/11![Southwest logo]()
$355
This United Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:00 am
DSM
- CHS
1 stop4h 27m
United Airlines
Wed 10/147:00 am
CHS
- DSM
2 stops8h 11m
United Airlines
Deal found 5/11![United Airlines logo]()
$360
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:45 am
DSM
- CHS
1 stop4h 40m
Delta
Sat 10/36:30 am
CHS
- DSM
1 stop4h 44m
Delta
Deal found 5/11![Delta logo]()
$365
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:45 pm
DSM
- CHS
1 stop4h 40m
Southwest
Wed 7/223:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Deal found 5/10![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:33 am
DSM
- CHS
1 stop9h 08m
Delta
Thu 6/185:10 am
CHS
- DSM
1 stop6h 33m
Delta
Deal found 5/10![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:35 pm
DSM
- CHS
1 stop4h 40m
Southwest
Sat 7/45:30 am
CHS
- DSM
1 stop7h 05m
Southwest
Deal found 5/12![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:41 pm
DSM
- CHS
1 stop4h 18m
Delta
Sat 6/611:47 am
CHS
- DSM
1 stop4h 57m
Delta
Deal found 5/8![Delta logo]()
$375
This Delta deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/172:15 pm
DSM
- CHS
1 stop6h 32m
Delta
Mon 9/215:30 am
CHS
- DSM
1 stop5h 44m
Delta
Deal found 5/9![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:35 am
DSM
- CHS
2 stops7h 35m
Southwest
Mon 10/193:15 pm
CHS
- DSM
2 stops9h 15m
Southwest
Deal found 5/12![Southwest logo]()
$376
Last-minute flights from Des Moines to CharlestonDiscover last-minute flight deals from Des Moines to Charleston. Data last updated May 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Charleston. Data last updated May 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:55 am
DSM
- CHS
1 stop6h 46m
American Airlines
Tue 6/97:47 pm
CHS
- DSM
1 stop5h 03m
American Airlines
Deal found 5/12![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/33:15 pm
DSM
- CHS
1 stop4h 50m
Southwest
Mon 6/84:45 pm
CHS
- DSM
2 stops7h 45m
Southwest
Deal found 5/10![Southwest logo]()
$370
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/222:25 pm
DSM
- CHS
1 stop6h 41m
Delta
Wed 7/15:10 am
CHS
- DSM
1 stop6h 35m
Delta
Deal found 5/11![Delta logo]()
$365
This Delta deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:39 pm
DSM
- CHS
1 stop4h 57m
Delta
Mon 6/296:44 pm
CHS
- DSM
1 stop4h 47m
Delta
Deal found 5/11![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:20 am
DSM
- CHS
2 stops11h 55m
Southwest
Tue 6/303:00 pm
CHS
- DSM
2 stops8h 45m
Southwest
Deal found 5/11![Southwest logo]()
$371
This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/251:37 pm
DSM
- CHS
1 stop7h 28m
American Airlines
Thu 7/28:21 pm
CHS
- DSM
1 stop4h 40m
American Airlines
Deal found 5/11![American Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:06 pm
DSM
- CHS
1 stop14h 32m
Multiple Airlines
Fri 7/39:44 pm
CHS
- DSM
1 stop24h 59m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$362
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:47 pm
DSM
- CHS
1 stop8h 02m
American Airlines
Sat 7/47:30 am
CHS
- DSM
1 stop6h 33m
American Airlines
Deal found 5/13![American Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/273:35 pm
DSM
- CHS
1 stop4h 40m
Southwest
Sat 7/411:00 am
CHS
- DSM
2 stops10h 15m
Southwest
Deal found 5/13![Southwest logo]()
$380
One-way flights from Des Moines to CharlestonSearch for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
Search for one-way flight options from Des Moines to Charleston. Find affordable one-way fares based on user searches. Data last updated May 13, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:59 pm
DSM
- CHS
2 stops51h 50m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- CHS
1 stop24h 34m
Multiple Airlines
Deal found 5/11![Multiple Airlines logo]()
$170
This American Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:00 am
DSM
- CHS
1 stop5h 33m
American Airlines
Deal found 5/9![American Airlines logo]()
$178
This United Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:00 am
DSM
- CHS
2 stops8h 50m
United Airlines
Deal found 5/13![United Airlines logo]()
$183
This Southwest deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:20 am
DSM
- CHS
2 stops11h 55m
Southwest
Deal found 5/9![Southwest logo]()
$189
This American Airlines deal was found by Cheapflights users on 5/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:12 am
DSM
- CHS
1 stop5h 17m
American Airlines
Deal found 5/13![American Airlines logo]()
$204
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/241:48 pm
DSM
- CHS
2 stops7h 18m
American Airlines
Deal found 5/8![American Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:41 pm
DSM
- CHS
3 stops38h 57m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$255
Find flight deals from Des Moines to Charleston
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Charleston (CHS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $355 (American Airlines) |
One-way from | $151 (Kiwi.com) |
Popular in | February |
Cheapest in | September |
Average price | $477 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Des Moines to Charleston that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 6/10
3:45 pm-9:25 pm
1 stop4h 40m
Charleston
Wed 6/17
6:10 am-11:30 am
1 stop6h 20m
$355
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 10/7
5:00 am-10:27 am
1 stop4h 27m
Charleston
Wed 10/14
7:00 am-2:11 pm
2 stops8h 11m
$360
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 7/14
3:45 pm-9:25 pm
1 stop4h 40m
Charleston
Wed 7/22
3:00 pm-10:45 pm
2 stops8h 45m
$360
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 9/30
5:45 am-11:25 am
1 stop4h 40m
Charleston
Sat 10/3
6:30 am-10:14 am
1 stop4h 44m
$365
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 6/15
7:33 am-5:41 pm
1 stop9h 08m
Charleston
Thu 6/18
5:10 am-10:43 am
1 stop6h 33m
$375
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Sat 6/27
3:35 pm-9:15 pm
1 stop4h 40m
Charleston
Sat 7/4
5:30 am-11:35 am
1 stop7h 05m
$375
Quickest round-trip
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 6/1
6:41 pm-11:59 pm
1 stop4h 18m
Charleston
Sat 6/6
11:47 am-3:44 pm
1 stop4h 57m
$375
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Thu 9/17
2:15 pm-9:47 pm
1 stop6h 32m
Charleston
Mon 9/21
5:30 am-10:14 am
1 stop5h 44m
$375
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 10/14
5:35 am-2:10 pm
2 stops7h 35m
Charleston
Mon 10/19
3:15 pm-11:30 pm
2 stops9h 15m
$376
Cheapest one-way
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Mon 7/20
4:40 pm-6:14 pm
1 stop24h 34m
$170
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Charleston
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Charleston in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Charleston flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Charleston flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Charleston flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Charleston flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Charleston flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Charleston
Have a flexible travel schedule? Discover the best time to fly to Charleston from Des Moines with our price prediction graph.
DSM-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Charleston
What is the cheapest month to book a flight from Des Moines to Charleston?
Currently, September is the cheapest month in which you can book a flight from Des Moines to Charleston (average of $280). Flying from Des Moines to Charleston in February is currently the most expensive (average of $508). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Charleston?
Reviews of airlines servicing Charleston
Get insights into the airlines that provide service to Charleston. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Charleston. Reviews last updated May 13, 2026.
See what other customers who have flown with Delta,United Airlines, andAmerican Airlines from Des Moines to Charleston have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Entertainment
7.8
Food
7.2
Overall
7.9
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Charleston. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Charleston?
Book flights to Charleston if you plan to visit one of these locationsNorth Charleston
Santee
Summerville
Walterboro
Isle of Palms
Mount Pleasant
Goose Creek
Edisto Beach
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Explore flights to Charleston departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
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Search flights from Des Moines to Charleston by cabin class
Find flights from Des Moines to Charleston, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Charleston flights
Browse other Des Moines and Charleston flight options. Last updated on May 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on May 13, 2026.
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Top 3 airlines flying from Des Moines to Charleston
Discover the top 3 airlines that operate flights from Des Moines to Charleston. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$392 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$242 | Average$365 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$398 | FlexibilityNo cancel fee | On-time69% |