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Central America

$130+ Cheap flights from Missouri to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SJO
Dec 17 — Dec 241
Wed 12/17
Wed 12/24
1 adult, Economy
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Find flight deals from Missouri to Central America

Cheapest flights from Missouri to Central America
Explore the most affordable flight options available from Missouri to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 17, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:47 pmSTL - SJO
1 stop21h 38mSpirit Airlines
Wed 12/171:31 pmSJO - STL
1 stop21h 25mSpirit Airlines
Deal found 11/16$305
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:05 amSTL - SJO
1 stop15h 15mDelta
Thu 12/182:31 pmSJO - STL
1 stop17h 53mDelta
Deal found 11/16$318
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/121:35 pmSTL - SJO
1 stop8h 25mUnited Airlines
Tue 12/1611:28 pmSJO - STL
2 stops14h 57mUnited Airlines
Deal found 11/16$322
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:15 amSTL - SJO
1 stop14h 24mUnited Airlines
Thu 12/182:20 pmSJO - STL
1 stop7h 35mUnited Airlines
Deal found 11/16$333
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:47 pmSTL - SJO
2 stops20h 55mMultiple Airlines
Mon 12/1512:39 pmSJO - STL
1 stop9h 54mMultiple Airlines
Deal found 11/16$337
This Kiwi.com deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:30 pmSTL - SJO
1 stop20h 12mMultiple Airlines
Wed 12/171:31 pmSJO - STL
1 stop21h 25mMultiple Airlines
Deal found 11/16$339
This KAYAK deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:01 pmMCI - SJO
1 stop17h 24mSpirit Airlines
Fri 12/121:31 pmSJO - MCI
1 stop28h 25mSpirit Airlines
Deal found 11/15$340
This KAYAK deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/57:01 pmMCI - SAL
1 stop18h 37mSpirit Airlines
Fri 12/123:52 pmSAL - MCI
1 stop26h 04mSpirit Airlines
Deal found 11/15$344
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:00 amSTL - SJO
1 stop7h 05mDelta
Fri 12/57:00 amSJO - STL
1 stop9h 06mDelta
Deal found 11/17$348
This Mytrip deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:01 pmMCI - SJO
2 stops20h 19mMultiple Airlines
Fri 12/1212:39 pmSJO - MCI
1 stop10h 36mMultiple Airlines
Deal found 11/15$349
This Delta deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amSTL - BZE
1 stop8h 47mDelta
Tue 1/271:40 pmBZE - STL
1 stop9h 57mDelta
Deal found 11/16$349
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/247:00 amSTL - SJO
1 stop16h 12mAmerican Airlines
Tue 12/21:11 pmSJO - STL
2 stops9h 56mAmerican Airlines
Deal found 11/16$352

Cheap flight deals from Missouri to Central America

Keep the following information in mind while searching for Missouri to Central America flight deals. Data was last updated November 17, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$281
(Kiwi.com)

One-way from

$130
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$597
Provider with most accurate pricing for Lambert-St Louis-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-San Salvador El Salvador Intl flights.
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From Missouri to Central America
Search Deals
One-way flight from Missouri to Central America
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($111 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
Use the filters below to find and compare flights from Missouri to Central America that are best for you.

Fly from

Missouri

Fly to

Central America

Route

Depart

Return

Price

St. LouisGuatemala City

STL - GUA

STLGUA

Lambert-St Louis

Sun 1/11

5:11 pm-11:20 am

1 stop18h 09m

Guatemala City La Aurora

Thu 1/15

12:15 pm-10:34 pm

1 stop10h 19m

$281

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Thu 2/5

9:59 am-10:15 pm

1 stop12h 16m

San José Juan Santamaria Intl

Mon 2/9

7:00 am-5:50 pm

1 stop10h 50m

$318

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Fri 12/12

1:35 pm-10:00 pm

1 stop8h 25m

San José Juan Santamaria Intl

Tue 12/16

2:20 pm-9:58 pm

1 stop7h 38m

$318

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Mon 2/2

9:59 am-10:15 pm

1 stop12h 16m

San José Juan Santamaria Intl

Mon 2/9

7:00 am-8:37 pm

1 stop13h 37m

$318

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Fri 1/30

3:45 pm-10:15 pm

1 stop6h 30m

San José Juan Santamaria Intl

Sat 2/7

3:54 pm-11:40 pm

1 stop7h 46m

$318

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Mon 1/26

9:59 am-10:15 pm

1 stop12h 16m

San José Juan Santamaria Intl

Sun 2/1

7:00 am-8:37 pm

1 stop13h 37m

$318

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Tue 1/27

6:00 am-7:30 pm

1 stop13h 30m

San José Juan Santamaria Intl

Tue 2/3

1:45 pm-9:25 pm

1 stop7h 40m

$319

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Wed 2/4

10:07 am-6:16 pm

1 stop8h 09m

San José Juan Santamaria Intl

Wed 2/11

8:45 am-10:58 pm

2 stops14h 13m

$322

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Mon 3/9

6:00 am-12:50 pm

1 stop7h 50m

Liberia

Tue 3/17

2:05 pm-11:40 pm

1 stop8h 35m

$343

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Wed 3/11

6:00 am-12:50 pm

1 stop7h 50m

Liberia

Tue 3/17

1:15 pm-11:40 pm

1 stop9h 25m

$343

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/14

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Central America

What is the cheapest month to book a flight from Missouri to Central America?

Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in January is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to CA?

Find hourly flight availability from Missouri to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 17, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Central America at noon. If you’re flexible enough to do this you can expect to save up to 24% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Missouri to Central America?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Central America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Central America flight should consider departing on Wednesday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Central America?

    For as low as $354, Delta can have you in Central America from Missouri in 5h 59m. The distance between Missouri and Central America is about 1470 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Central America one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $134. United Airlines flights start at $134 while deals on Spirit Airlines start at $143 one-way.

  • Can I find deals for flights from Missouri to Central America that include hotel bookings?

    Yes. In addition to deals on Missouri to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Central America.

  • Can I find deals for business class flights from Missouri to Central America?

    Yes. Cheapflights offers flight deals from Missouri to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Central America?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in January is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Missouri to Central America

Discover the top 5 airlines that operate flights from Missouri to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$552FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$263Average$399FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$287Average$614FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$337Average$624FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$366Average$622FlexibilityNo cancel feeOn-time63%

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