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$111+ Cheap flights from San Francisco (SFO) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — CHS
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from San Francisco to South Carolina

Cheapest flights from San Francisco to South Carolina
Explore the most affordable flight options available from San Francisco to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This Breeze Airways deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:36 pm
SFO
-
CHS
1 stop7h 19m
Breeze Airways
Sat 9/266:20 am
CHS
-
SFO
1 stop8h 31m
Breeze Airways
Deal found 3/15$259
This Breeze Airways deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2212:46 pm
SFO
-
CHS
1 stop6h 50m
Breeze Airways
Sat 9/266:20 am
CHS
-
SFO
1 stop8h 31m
Breeze Airways
Deal found 3/12$269
This United Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:00 am
SFO
-
CHS
1 stop8h 11m
United Airlines
Tue 5/51:19 pm
CHS
-
SFO
1 stop8h 19m
United Airlines
Deal found 3/13$271
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/215:25 am
SFO
-
CHS
1 stop12h 40m
Southwest
Tue 5/51:15 pm
CHS
-
SFO
2 stops11h 55m
Southwest
Deal found 3/12$282
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/285:00 am
SFO
-
CHS
1 stop8h 11m
United Airlines
Mon 5/46:53 pm
CHS
-
SFO
1 stop9h 57m
United Airlines
Deal found 3/12$287
This Expedia deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:36 pm
SFO
-
CHS
1 stop7h 19m
Multiple Airlines
Tue 9/156:14 pm
CHS
-
SFO
1 stop17h 59m
Multiple Airlines
Deal found 3/15$288
This Delta deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:30 pm
SFO
-
CHS
1 stop7h 21m
Delta
Tue 5/59:38 am
CHS
-
SFO
1 stop10h 19m
Delta
Deal found 3/13$291
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:15 pm
SFO
-
CHS
1 stop10h 45m
Southwest
Tue 5/51:15 pm
CHS
-
SFO
2 stops11h 55m
Southwest
Deal found 3/12$292
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:15 pm
SFO
-
CHS
1 stop10h 45m
Southwest
Sat 5/27:00 am
CHS
-
SFO
2 stops12h 20m
Southwest
Deal found 3/11$296
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:57 pm
SFO
-
CHS
1 stop7h 12m
Delta
Sat 5/304:55 pm
CHS
-
SFO
1 stop8h 43m
Delta
Deal found 3/11$297
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/189:15 pm
SFO
-
CHS
1 stop9h 55m
Southwest
Fri 5/15:50 pm
CHS
-
SFO
2 stops9h 20m
Southwest
Deal found 3/11$302
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:35 pm
SFO
-
CHS
1 stop8h 16m
Delta
Sat 5/303:10 pm
CHS
-
SFO
1 stop8h 32m
Delta
Deal found 3/11$303

Find flight deals from San Francisco to South Carolina

Keep the following information in mind while searching for San Francisco to South Carolina flight deals. Data was last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$271
(United Airlines)

One-way from

$111
(Breeze Airways)

Popular in

December

Cheapest in

February

Average price

$697
Provider with most accurate pricing for San Francisco-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Myrtle Beach Intl flights.
Search Deals
From San Francisco to South Carolina
Search Deals
One-way flight from San Francisco to South Carolina
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($34 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($24 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from San Francisco to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Sat 4/18

10:50 am-9:37 pm

1 stop7h 47m

Charleston

Fri 5/1

6:00 am-12:30 pm

1 stop9h 30m

$297

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Mon 8/10

10:38 pm-10:04 am

1 stop8h 26m

Charleston

Fri 8/14

6:43 pm-12:20 am

1 stop8h 37m

$303

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Fri 5/15

11:05 pm-10:13 am

1 stop8h 08m

Charleston

Tue 5/19

7:44 pm-1:16 am

1 stop8h 32m

$330

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Tue 4/28

9:30 pm-10:23 am

1 stop9h 53m

Charleston

Mon 5/4

7:44 pm-1:16 am

1 stop8h 32m

$334

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Tue 4/28

5:25 am-9:05 pm

1 stop12h 40m

Charleston

Mon 5/4

6:00 am-12:35 pm

2 stops9h 35m

$356

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Mon 4/13

12:45 am-1:55 pm

1 stop10h 10m

Charleston

Tue 4/21

6:00 am-5:13 pm

2 stops14h 13m

$376

San FranciscoCharleston

SFO - CHS

SFOCHS

San Francisco

Tue 4/14

9:30 pm-10:23 am

1 stop9h 53m

Charleston

Wed 4/15

5:00 pm-12:39 am

1 stop10h 39m

$391

San FranciscoGreenville

SFO - GSP

SFOGSP

San Francisco

Thu 4/23

6:00 am-4:28 pm

1 stop7h 28m

Greenville

Sat 4/25

7:30 am-2:55 pm

1 stop10h 25m

$399

San FranciscoMyrtle Beach

SFO - MYR

SFOMYR

San Francisco

Mon 4/27

9:15 pm-10:35 am

1 stop10h 20m

Myrtle Beach Intl

Thu 4/30

1:45 pm-10:25 pm

2 stops11h 40m

$400

San FranciscoMyrtle Beach

SFO - MYR

SFOMYR

San Francisco

Sat 5/2

5:40 am-6:15 pm

2 stops9h 35m

Myrtle Beach Intl

Sat 5/9

2:20 pm-8:45 pm

1 stop9h 25m

$402

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/12

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from San Francisco to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to South Carolina

What is the cheapest month to book a flight from San Francisco to South Carolina?

Currently, May is the cheapest month in which you can book a flight from San Francisco to South Carolina (average of $148). Flying from San Francisco to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to SC?

Find hourly flight availability from San Francisco to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 16, 2026.

Unlike in the morning, when flights are generally more expensive, you can save up to 68% on flights from San Francisco to South Carolina by exploring options for tickets at noon.

What is the cheapest day to fly from San Francisco to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from San Francisco to South Carolina. Price data was last updated on February 7, 2026.

Travelers seeking maximum savings on their San Francisco to South Carolina flight should consider departing on Saturday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 16, 2026.
Peruse reviews from past customers who have flown with Breeze Airways,Southwest, andDelta from San Francisco to South Carolina to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Breeze Airways
8.1
Very good
271 reviews
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Southwest
8.0
Very good
4,318 reviews
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
Delta
7.9
Good
8,294 reviews
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
United Airlines
7.4
Good
9,429 reviews
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.
American Airlines
7.1
Good
11,466 reviews
Breeze Airways
8.1
Very good
271 reviews

Food

6.6

Crew

8.7

Comfort

8.2

Overall

8.1

Boarding

8.3

Entertainment

6.6

Reviews

1 / 17
2.0
Mediocre

Justine,Jan 2026

RDU - MCO

1/10, I have never experienced the amount of delays, my flight was supposed to board at 8:34pm, we didn’t board until 3:35am from RDU. The staff got rude and very disrespectful when you asked what was going on it was like we didn’t board until something wrong or were pestering them for answers. I was 1 question 1 time, they were not communicating with us at all. So when our plane was now 6+ hrs delayed and nothing was being said to us .. yeah I think we have a right to ask a question. Everything took so long and was such a process; I have never experienced this before and I’m a frequent flyer, breeze makes spirit airlines look like a 100/10 airline.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Francisco to South Carolina?

    For a flight from San Francisco to South Carolina, you will be flying from San Francisco. San Francisco (SFO) is just 11.8 mi from the center of the city.

  • How long is the flight from San Francisco to South Carolina?

    A quick flight from San Francisco to South Carolina can take about 7h 28m. United Airlines provides one of the quickest options available for as low as $399. San Francisco and South Carolina are separated by a distance of 2227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from San Francisco to South Carolina one-way?

    One-way options have recently been found by users for as low as $89 on Breeze Airways. Other airlines that offer cheap prices include American Airlines from $125 and Alaska Airlines from $138 one-way.

  • What are the most popular routes from San Francisco to South Carolina?

    Most travelers choose San Francisco - Charlotte Douglas, San Francisco - Charleston or San Francisco - Savannah/Hilton Head when deciding on the best route from San Francisco to South Carolina.

  • Can I find deals for flights from San Francisco to South Carolina that include hotel bookings?

    Yes. In addition to deals on San Francisco to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to South Carolina.

  • Can I find deals for business class flights from San Francisco to South Carolina?

    Yes. Cheapflights offers flight deals from San Francisco to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to South Carolina (average of $148). Flying from San Francisco to South Carolina in March is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Francisco to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from San Francisco to South Carolina

Discover the top 6 airlines that operate flights from San Francisco to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$167Average$277FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$219Average$450FlexibilityNo cancel feeOn-time71%
JetBlueCheapest$234Average$362FlexibilityNo cancel feeOn-time62%
DeltaCheapest$256Average$467FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$262Average$478FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$293Average$495FlexibilityNo cancel feeOn-time63%

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