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$126+ Cheap flights from South Carolina to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SFO
Jun 10 — Jun 171
Wed 6/10
Wed 6/17
1 adult, Economy
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Cheap flight deals from South Carolina to San Francisco

Cheapest flights from South Carolina to San Francisco
Explore the most affordable flight options available from South Carolina to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:25 am
CHS
-
SFO
1 stop7h 37m
Breeze Airways
Sun 9/612:47 pm
SFO
-
CHS
1 stop7h 00m
Breeze Airways
Deal found 5/9$267
This Breeze Airways deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:30 am
CHS
-
SFO
1 stop8h 07m
Breeze Airways
Wed 9/912:36 pm
SFO
-
CHS
1 stop7h 19m
Breeze Airways
Deal found 5/7$272
This Kiwi.com deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:10 am
CHS
-
SFO
1 stop7h 59m
Breeze Airways
Mon 12/711:54 am
SFO
-
CHS
1 stop6h 40m
Breeze Airways
Deal found 5/11$278
This Breeze Airways deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:10 am
CHS
-
SFO
1 stop7h 59m
Breeze Airways
Sun 11/1512:46 pm
SFO
-
CHS
1 stop6h 50m
Breeze Airways
Deal found 5/10$289
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/295:25 pm
CAE
-
SFO
1 stop8h 31m
United Airlines
Sat 9/511:30 pm
SFO
-
CAE
1 stop7h 40m
United Airlines
Deal found 5/6$291
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:30 am
CHS
-
SFO
1 stop8h 07m
Breeze Airways
Fri 5/2912:18 pm
SFO
-
CHS
1 stop6h 48m
Breeze Airways
Deal found 5/6$292
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:30 am
CHS
-
SFO
1 stop8h 07m
Breeze Airways
Sat 8/2912:22 pm
SFO
-
CHS
1 stop7h 27m
Breeze Airways
Deal found 5/7$297
This CheapOair deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:25 am
CHS
-
SFO
1 stop7h 37m
Breeze Airways
Mon 8/1712:18 pm
SFO
-
CHS
1 stop6h 48m
Breeze Airways
Deal found 5/9$299
This Breeze Airways deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am
CHS
-
SFO
1 stop8h 01m
Breeze Airways
Mon 12/711:54 am
SFO
-
CHS
1 stop6h 40m
Breeze Airways
Deal found 5/8$300
This Mytrip deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:14 pm
CLT
-
SFO
1 stop15h 47m
Frontier
Mon 6/812:52 pm
SFO
-
CLT
1 stop26h 27m
Frontier
Deal found 5/7$301
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:35 pm
CAE
-
SFO
1 stop8h 41m
United Airlines
Tue 9/2211:30 pm
SFO
-
CAE
1 stop7h 40m
United Airlines
Deal found 5/9$301
This Kiwi.com deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:30 am
CHS
-
SFO
1 stop8h 07m
Breeze Airways
Fri 8/2812:18 pm
SFO
-
CHS
1 stop6h 48m
Breeze Airways
Deal found 5/7$301

Find flight deals from South Carolina to San Francisco

Keep the following information in mind while searching for South Carolina to San Francisco flight deals. Data was last updated May 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$267
(Kiwi.com)

One-way from

$126
(Mytrip)

Popular in

November

Cheapest in

October

Average price

$555
Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.
Search Deals
From South Carolina to San Francisco
Search Deals
One-way flight from South Carolina to San Francisco
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ColumbiaSan Francisco

CAE - SFO

CAESFO

Columbia Metropolitan

Wed 8/5

6:08 pm-11:54 pm

1 stop8h 46m

San Francisco

Wed 8/19

10:10 pm-9:17 am

1 stop8h 07m

$301

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Thu 7/9

1:55 pm-7:55 pm

1 stop9h 00m

San Francisco

Sun 7/12

11:40 pm-11:25 am

1 stop8h 45m

$323

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Wed 8/5

5:06 pm-11:54 pm

1 stop9h 48m

San Francisco

Sun 8/9

11:50 pm-12:07 pm

1 stop9h 17m

$323

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Thu 5/28

7:59 pm-12:46 am

1 stop7h 47m

San Francisco

Mon 6/1

9:55 pm-9:38 am

1 stop8h 43m

$323

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Thu 7/30

7:06 am-2:17 pm

1 stop10h 11m

San Francisco

Fri 8/7

5:36 am-5:58 pm

1 stop9h 22m

$323

ColumbiaSan Francisco

CAE - SFO

CAESFO

Columbia Metropolitan

Fri 6/5

5:50 pm-12:46 am

1 stop9h 56m

San Francisco

Sat 7/11

10:45 pm-9:22 am

1 stop7h 37m

$329

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Wed 7/29

2:10 pm-10:15 pm

2 stops11h 05m

San Francisco

Mon 8/3

10:50 pm-12:50 pm

1 stop11h 00m

$334

ColumbiaSan Francisco

CAE - SFO

CAESFO

Columbia Metropolitan

Mon 5/25

5:40 am-10:10 am

1 stop7h 30m

San Francisco

Fri 5/29

1:45 pm-11:47 pm

1 stop7h 02m

$357

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Thu 7/23

5:00 pm-10:49 pm

1 stop8h 49m

San Francisco

Wed 7/29

10:59 pm-9:01 am

1 stop7h 02m

$371
Quickest round-trip

ColumbiaSan Francisco

CAE - SFO

CAESFO

Columbia Metropolitan

Sat 6/27

6:00 am-10:05 am

1 stop7h 05m

San Francisco

Wed 7/29

10:59 pm-9:22 am

1 stop7h 23m

$379

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/6

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Francisco

How far ahead should I book a flight from South Carolina to San Francisco?

Booking 76 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to San Francisco. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from South Carolina to San Francisco?

Currently, May is the cheapest month in which you can book a flight from South Carolina to San Francisco (average of $85). Flying from South Carolina to San Francisco in March is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Weekly flight availability from South Carolina to San Francisco

Explore weekly flight availability from South Carolina to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 11, 2026.

The most flights from USSC to SFO are scheduled on a Monday (1 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (1 on average).

How much does it cost to fly round-trip from South Carolina to San Francisco?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from South Carolina?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from South Carolina. San Francisco is conveniently located just 11.0 mi from San Francisco’s city center.

  • How long is the flight from South Carolina to San Francisco?

    Delta, Southwest, and United Airlines can get you from South Carolina to San Francisco in just under 8h 30m. Your travel time can differ by up to 30m. The distance between South Carolina and San Francisco is about 2306 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to San Francisco one-way?

    One-way options have recently been found by users for as low as $117 on Volaris. Other airlines that offer cheap prices include Aeromexico from $124 and Alaska Airlines from $133 one-way.

  • What are the most popular routes from South Carolina to San Francisco?

    The most popular route from South Carolina to San Francisco is Charlotte Douglas - San Francisco. You may also consider Charleston - San Francisco or Greenville - San Francisco.

  • Can I find deals for flights from South Carolina to San Francisco that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Francisco.

  • Can I find deals for business class flights from South Carolina to San Francisco?

    Yes. Cheapflights offers flight deals from South Carolina to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Francisco?

    Currently, May is the cheapest month in which you can book a flight from South Carolina to San Francisco (average of $85). Flying from South Carolina to San Francisco in March is currently the most expensive (average of $256). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Vacaville
Roseville
San Carlos
Redwood City
Sunnyvale
Turlock
Vallejo
San Lorenzo
Davis
Emeryville
Manteca
Elk Grove

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to San Francisco

Discover the top 6 airlines that operate flights from South Carolina to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$131Average$289FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$199Average$471FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$469FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$464FlexibilityNo cancel feeOn-time69%
JetBlueCheapest$276Average$278FlexibilityNo cancel feeOn-time62%
SouthwestCheapest$301Average$531FlexibilityNo cancel feeOn-time63%

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