$233+ Cheap flights from Panama to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Panama to South Carolina with Cheapflights
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Cheapest flights from Panama to South CarolinaExplore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Februari 3, 2026.
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Februari 3, 2026.
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/2710:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Rab 6/311:03 am
CHS
- PTY
1 stop9h 28m
United Airlines
Deal found 2/2![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/271:10 pm
PTY
- CHS
2 stops22h 06m
American Airlines
Sel 6/28:33 pm
CHS
- PTY
2 stops16h 37m
American Airlines
Deal found 2/1![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/271:10 pm
PTY
- CHS
2 stops19h 58m
American Airlines
Rab 6/36:10 pm
CHS
- PTY
2 stops19h 00m
American Airlines
Deal found 2/1![American Airlines logo]()
$412
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/281:10 pm
PTY
- CHS
1 stop9h 49m
American Airlines
Rab 6/37:43 pm
CHS
- PTY
1 stop17h 27m
American Airlines
Deal found 2/3![American Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/2710:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Sel 6/211:03 am
CHS
- PTY
1 stop9h 28m
United Airlines
Deal found 2/1![United Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sen 6/11:10 pm
PTY
- CHS
2 stops21h 27m
American Airlines
Sel 6/161:06 pm
CHS
- PTY
2 stops24h 04m
American Airlines
Deal found 2/1![American Airlines logo]()
$440
This Avianca Connect deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 4/85:55 pm
PTY
- CLT
2 stops17h 12m
Multiple Airlines
Rab 4/228:55 am
CLT
- PTY
2 stops17h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$451
This KAYAK deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/279:45 am
PTY
- CHS
1 stop13h 06m
Multiple Airlines
Rab 6/311:03 am
CHS
- PTY
1 stop9h 28m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$458
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 3/42:40 pm
PTY
- CHS
1 stop9h 19m
American Airlines
Rab 3/118:08 pm
CHS
- PTY
1 stop19h 12m
American Airlines
Deal found 2/2![American Airlines logo]()
$474
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/179:33 pm
PTY
- CLT
1 stop11h 14m
Multiple Airlines
Sel 3/317:00 am
CLT
- PTY
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$479
This Avianca Connect deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Min 5/103:05 am
PTY
- CLT
2 stops16h 24m
Multiple Airlines
Sen 5/186:00 am
CLT
- PTY
2 stops20h 05m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$483
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/1912:03 pm
PTY
- CLT
1 stop7h 14m
Multiple Airlines
Kam 3/261:20 pm
CLT
- PTY
1 stop7h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$497
Best flights from Panama to South CarolinaDiscover carefully curated flight deals from Panama to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated Februari 3, 2026.
Discover carefully curated flight deals from Panama to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated Februari 3, 2026.
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/2710:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Rab 6/311:03 am
CHS
- PTY
1 stop9h 28m
United Airlines
Deal found 2/1![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/271:10 pm
PTY
- CHS
1 stop28h 53m
American Airlines
Sel 6/26:10 pm
CHS
- PTY
2 stops19h 00m
American Airlines
Deal found 2/1![American Airlines logo]()
$408
This Avianca Connect deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 4/85:55 pm
PTY
- CLT
2 stops17h 12m
Multiple Airlines
Rab 4/228:55 am
CLT
- PTY
2 stops17h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$451
This KAYAK deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/510:00 am
PTY
- GSP
1 stop13h 59m
Avianca
Sab 3/146:23 am
GSP
- PTY
1 stop22h 47m
Avianca
Deal found 2/1![Avianca logo]()
$587
This KAYAK deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sab 3/78:55 am
PTY
- GSP
1 stop13h 03m
Copa Airlines
Sab 3/146:23 am
GSP
- PTY
1 stop22h 47m
Copa Airlines
Deal found 2/1![Copa Airlines logo]()
$608
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/192:28 pm
PTY
- CAE
1 stop8h 20m
Delta
Kam 3/266:50 am
CAE
- PTY
1 stop7h 13m
Delta
Deal found 2/2![Delta logo]()
$619
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sen 6/17:55 am
PTY
- CHS
1 stop13h 17m
United Airlines
Sel 6/167:00 am
CHS
- PTY
1 stop12h 37m
United Airlines
Deal found 2/1![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 5/271:10 pm
PTY
- CHS
1 stop28h 53m
American Airlines
Rab 6/31:06 pm
CHS
- PTY
2 stops24h 04m
American Airlines
Deal found 2/1![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/2810:00 am
PTY
- CHS
1 stop11h 12m
United Airlines
Rab 6/311:03 am
CHS
- PTY
1 stop9h 28m
United Airlines
Deal found 2/1![United Airlines logo]()
$399
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/179:33 pm
PTY
- CLT
1 stop11h 14m
Multiple Airlines
Sel 3/317:00 am
CLT
- PTY
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/1912:03 pm
PTY
- CLT
1 stop7h 14m
Multiple Airlines
Kam 3/261:20 pm
CLT
- PTY
1 stop7h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Jum 5/11:49 pm
PTY
- CLT
1 stop19h 11m
American Airlines
Jum 5/156:10 am
CLT
- PTY
1 stop7h 36m
American Airlines
Deal found 2/1![American Airlines logo]()
$523
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 4/303:30 pm
PTY
- CLT
1 stop18h 26m
United Airlines
Kam 5/146:35 am
CLT
- PTY
1 stop10h 37m
United Airlines
Deal found 2/1![United Airlines logo]()
$504
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/191:40 pm
PTY
- GSP
2 stops21h 35m
American Airlines
Min 3/296:22 pm
GSP
- PTY
2 stops21h 39m
American Airlines
Deal found 2/2![American Airlines logo]()
$549
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 4/87:55 am
PTY
- CLT
1 stop12h 46m
United Airlines
Rab 4/2211:09 am
CLT
- PTY
1 stop9h 22m
United Airlines
Deal found 2/1![United Airlines logo]()
$504
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/1912:03 pm
PTY
- GSP
1 stop7h 53m
Multiple Airlines
Min 3/299:46 pm
GSP
- PTY
1 stop23h 33m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$586
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/191:40 pm
PTY
- CAE
2 stops19h 57m
American Airlines
Kam 3/266:18 pm
CAE
- PTY
2 stops21h 02m
American Airlines
Deal found 2/2![American Airlines logo]()
$558
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 2/244:41 pm
PTY
- GSP
1 stop22h 55m
United Airlines
Sel 3/104:55 pm
GSP
- PTY
1 stop26h 43m
United Airlines
Deal found 2/1![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 2/242:40 pm
PTY
- GSP
2 stops19h 39m
American Airlines
Sel 3/107:37 pm
GSP
- PTY
2 stops19h 43m
American Airlines
Deal found 2/1![American Airlines logo]()
$571
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/312:28 pm
PTY
- CAE
1 stop8h 20m
Delta
Min 4/55:34 am
CAE
- PTY
1 stop8h 29m
Delta
Deal found 2/2![Delta logo]()
$884
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/287:55 am
PTY
- GSP
1 stop13h 16m
United Airlines
Sen 6/14:55 pm
GSP
- PTY
1 stop26h 42m
United Airlines
Deal found 1/31![United Airlines logo]()
$565
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/313:51 pm
PTY
- CAE
2 stops21h 23m
American Airlines
Min 4/56:00 am
CAE
- PTY
2 stops10h 01m
American Airlines
Deal found 2/2![American Airlines logo]()
$596
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/52:40 pm
PTY
- GSP
2 stops19h 35m
American Airlines
Sab 3/147:26 pm
GSP
- PTY
1 stop18h 14m
American Airlines
Deal found 2/1![American Airlines logo]()
$650
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/1912:03 pm
PTY
- CAE
1 stop28h 01m
Multiple Airlines
Kam 3/263:30 pm
CAE
- PTY
2 stops53h 50m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$1,215
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/286:02 pm
PTY
- CAE
2 stops19h 08m
United Airlines
Sen 6/110:18 am
CAE
- PTY
2 stops29h 04m
United Airlines
Deal found 1/31![United Airlines logo]()
$6,209
Last-minute flights from Panama to South CarolinaDiscover last-minute flight deals from Panama to South Carolina. Data last updated Februari 3, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to South Carolina. Data last updated Februari 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 2/113:20 pm
PTY
- CHS
1 stop8h 35m
Delta
Sen 2/167:30 am
CHS
- PTY
1 stop6h 20m
Delta
Deal found 2/1![Delta logo]()
$563
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 2/124:05 pm
PTY
- CHS
1 stop7h 54m
American Airlines
Min 3/18:25 pm
CHS
- PTY
2 stops18h 50m
American Airlines
Deal found 2/1![American Airlines logo]()
$562
This Avianca Connect deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Jum 2/132:55 pm
PTY
- CLT
2 stops21h 25m
Multiple Airlines
Sen 2/167:00 am
CLT
- PTY
2 stops17h 40m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$524
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 2/244:41 pm
PTY
- GSP
1 stop22h 55m
United Airlines
Sel 3/104:55 pm
GSP
- PTY
1 stop26h 43m
United Airlines
Deal found 2/1![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 2/242:40 pm
PTY
- GSP
2 stops19h 39m
American Airlines
Sel 3/107:37 pm
GSP
- PTY
2 stops19h 43m
American Airlines
Deal found 2/1![American Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 3/42:40 pm
PTY
- CHS
1 stop9h 19m
American Airlines
Rab 3/118:19 pm
CHS
- PTY
2 stops19h 01m
American Airlines
Deal found 2/1![American Airlines logo]()
$420
This Travelocity deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 3/411:25 am
PTY
- CHS
3 stops23h 32m
Multiple Airlines
Rab 3/1111:48 am
CHS
- PTY
2 stops32h 07m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$558
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sab 3/712:03 pm
PTY
- CLT
1 stop11h 53m
Multiple Airlines
Sab 3/141:20 pm
CLT
- PTY
1 stop7h 59m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$512
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/179:33 pm
PTY
- CLT
1 stop11h 14m
Multiple Airlines
Sel 3/317:00 am
CLT
- PTY
1 stop10h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$479
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/1912:03 pm
PTY
- CLT
1 stop7h 14m
Multiple Airlines
Kam 3/261:20 pm
CLT
- PTY
1 stop7h 59m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/191:40 pm
PTY
- GSP
2 stops21h 35m
American Airlines
Min 3/296:22 pm
GSP
- PTY
2 stops21h 39m
American Airlines
Deal found 2/2![American Airlines logo]()
$549
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/191:40 pm
PTY
- CAE
2 stops19h 57m
American Airlines
Kam 3/266:18 pm
CAE
- PTY
2 stops21h 02m
American Airlines
Deal found 2/2![American Airlines logo]()
$558
One-way flights from Panama to South CarolinaSearch for one-way flight options from Panama to South Carolina. Find affordable one-way fares based on user searches. Data last updated Februari 3, 2026.
Search for one-way flight options from Panama to South Carolina. Find affordable one-way fares based on user searches. Data last updated Februari 3, 2026.
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/212:20 pm
PTY
- CHS
1 stop7h 36m
Delta
Deal found 2/2![Delta logo]()
$233
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Rab 3/42:40 pm
PTY
- CHS
1 stop19h 46m
American Airlines
Deal found 2/2![American Airlines logo]()
$242
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Jum 4/243:30 pm
PTY
- CHS
1 stop29h 29m
United Airlines
Deal found 2/2![United Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sel 3/32:55 am
PTY
- CHS
3 stops29h 43m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$285
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 3/54:05 pm
PTY
- MYR
2 stops16h 35m
American Airlines
Deal found 2/2![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Min 5/102:20 pm
PTY
- GSP
1 stop8h 33m
Delta
Deal found 2/3![Delta logo]()
$322
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Min 5/107:55 am
PTY
- GSP
1 stop13h 19m
United Airlines
Deal found 2/2![United Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sab 2/215:50 pm
PTY
- CLT
2 stops38h 36m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$328
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sen 2/165:50 pm
PTY
- MYR
3 stops38h 23m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Jum 4/249:45 am
PTY
- CLT
1 stop10h 30m
United Airlines
Deal found 2/2![United Airlines logo]()
$332
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Kam 5/215:30 am
PTY
- CHS
3 stops16h 11m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Min 5/101:49 pm
PTY
- GSP
2 stops21h 30m
American Airlines
Deal found 2/3![American Airlines logo]()
$342
Find flight deals from Panama to South Carolina
Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated Februari 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $399 (United Airlines) |
One-way from | $233 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Februari 3, 2026.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.
Fly from
Panama
Fly to
South Carolina
Route
Depart
Return
Price
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Rab 5/27
10:00 am-10:12 pm
1 stop11h 12m
Charleston
Rab 6/3
11:03 am-7:31 pm
1 stop9h 28m
$399
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Sen 6/1
7:55 am-10:12 pm
1 stop13h 17m
Charleston
Sel 6/16
7:00 am-6:37 pm
1 stop12h 37m
$399
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Kam 5/28
10:00 am-10:12 pm
1 stop11h 12m
Charleston
Rab 6/3
11:03 am-7:31 pm
1 stop9h 28m
$399
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Rab 5/27
1:10 pm-7:03 pm
1 stop28h 53m
Charleston
Sel 6/2
6:10 pm-12:10 pm
2 stops19h 00m
$408
Panama CityCharleston
PTY - CHS
PTYCHS
Panama City Tocumen Intl
Rab 5/27
1:10 pm-7:03 pm
1 stop28h 53m
Charleston
Rab 6/3
1:06 pm-12:10 pm
2 stops24h 04m
$408
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Rab 4/8
5:55 pm-12:07 pm
2 stops17h 12m
Charlotte Douglas
Rab 4/22
8:55 am-1:05 am
2 stops17h 10m
$451
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Sel 3/17
9:33 pm-9:47 am
1 stop11h 14m
Charlotte Douglas
Sel 3/31
7:00 am-4:06 pm
1 stop10h 06m
$479
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Kam 3/19
12:03 pm-8:17 pm
1 stop7h 14m
Charlotte Douglas
Kam 3/26
1:20 pm-8:19 pm
1 stop7h 59m
$497
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Kam 4/30
3:30 pm-10:56 am
1 stop18h 26m
Charlotte Douglas
Kam 5/14
6:35 am-4:12 pm
1 stop10h 37m
$504
Panama CityCharlotte
PTY - CLT
PTYCLT
Panama City Tocumen Intl
Rab 4/8
7:55 am-9:41 pm
1 stop12h 46m
Charlotte Douglas
Rab 4/22
11:09 am-7:31 pm
1 stop9h 22m
$504
Showing 1-10 of 40 results
Best time to book a flight from Panama to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
PTY-CHS
PTY-CLT
PTY-GSP
PTY-CAE
PTY-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to South Carolina
PA0-USSC
PTY-CHS
PTY-CLT
PTY-GSP
PTY-CAE
What is the cheapest month to book a flight from Panama to South Carolina?
Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in July is currently the most expensive (average of $479). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.