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South Carolina

$226+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Aug 6 — Aug 131
Wed 8/6
Wed 8/13
1 adult, Economy
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Cheap flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated August 1, 2025.

Round-trip from

$397
(American Airlines)

One-way from

$226
(American Airlines)
From Panama to South Carolina
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One-way flight from Panama to South Carolina
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Find flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2025.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/283:30 pmPTY - CHS
2 stops17h 48mAmerican Airlines
Mon 9/17:50 pmCHS - PTY
1 stop19h 40mAmerican Airlines
Deal found 7/30$397
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1710:00 amPTY - CHS
1 stop29h 44mUnited Airlines
Sat 11/16:30 amCHS - PTY
1 stop13h 08mUnited Airlines
Deal found 7/31$415
This Avianca Connect deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/45:25 pmPTY - CLT
2 stops17h 58mMultiple Airlines
Mon 9/86:00 amCLT - PTY
2 stops16h 10mMultiple Airlines
Deal found 7/30$438
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/34:41 pmPTY - CLT
1 stop18h 10mUnited Airlines
Tue 1/134:45 pmCLT - PTY
1 stop22h 00mUnited Airlines
Deal found 7/29$481
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/173:17 pmPTY - CLT
1 stop19h 46mDelta
Wed 12/35:30 amCLT - PTY
1 stop8h 22mDelta
Deal found 7/31$492
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/313:15 pmPTY - CAE
2 stops22h 22mAmerican Airlines
Wed 11/57:15 pmCAE - PTY
2 stops18h 21mAmerican Airlines
Deal found 7/30$495
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/163:15 pmPTY - CLT
1 stop21h 32mAmerican Airlines
Thu 10/236:50 pmCLT - PTY
1 stop20h 10mAmerican Airlines
Deal found 7/30$500
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/53:31 pmPTY - GSP
1 stop7h 25mAmerican Airlines
Wed 1/145:38 amGSP - PTY
1 stop7h 32mAmerican Airlines
Deal found 7/29$501
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/262:10 pmPTY - CAE
1 stop8h 27mDelta
Tue 9/306:47 amCAE - PTY
1 stop7h 08mDelta
Deal found 7/30$512
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/127:55 amPTY - GSP
1 stop13h 05mUnited Airlines
Sat 9/67:00 amGSP - PTY
1 stop12h 37mUnited Airlines
Deal found 7/31$576
This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1711:00 amPTY - CHS
2 stops31h 46mMultiple Airlines
Sat 11/18:44 pmCHS - PTY
3 stops21h 11mMultiple Airlines
Deal found 7/30$659
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/133:20 amPTY - CAE
2 stops16h 22mMultiple Airlines
Sat 8/305:51 pmCAE - PTY
1 stop27h 28mMultiple Airlines
Deal found 7/29$680

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2025.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Panama

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 8/28

3:30 pm-10:18 am

2 stops17h 48m

Charleston

Mon 9/1

7:50 pm-2:30 pm

1 stop19h 40m

$397

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 10/17

10:00 am-4:44 pm

1 stop29h 44m

Charleston

Sat 11/1

6:30 am-6:38 pm

1 stop13h 08m

$415

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/4

5:25 pm-12:23 pm

2 stops17h 58m

Charlotte Douglas

Mon 9/8

6:00 am-9:10 pm

2 stops16h 10m

$438

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 12/3

4:41 pm-10:51 am

1 stop18h 10m

Charlotte Douglas

Tue 1/13

4:45 pm-2:45 pm

1 stop22h 00m

$481

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 11/17

3:17 pm-11:03 am

1 stop19h 46m

Charlotte Douglas

Sun 11/30

8:25 am-1:52 pm

1 stop29h 27m

$492

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 10/16

3:15 pm-1:47 pm

1 stop21h 32m

Charlotte Douglas

Thu 10/23

6:50 pm-2:00 pm

1 stop20h 10m

$500

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Fri 9/5

3:31 pm-11:56 pm

1 stop7h 25m

Greenville

Wed 1/14

5:38 am-1:10 pm

1 stop7h 32m

$501

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Fri 9/26

2:10 pm-11:37 pm

1 stop8h 27m

Columbia Metropolitan

Tue 9/30

6:47 am-12:55 pm

1 stop7h 08m

$512

Panama CityColumbia

PTY - CAE

PTYCAE

Panama City Tocumen Intl

Mon 9/8

3:31 pm-10:08 am

2 stops17h 37m

Columbia Metropolitan

Thu 9/11

7:41 pm-2:31 pm

2 stops19h 50m

$559

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Tue 8/12

7:55 am-10:00 pm

1 stop13h 05m

Greenville

Sat 9/6

7:00 am-6:37 pm

1 stop12h 37m

$576

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 21 results
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest time of day to fly from PA to SC?

Find hourly flight availability from Panama to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 1, 2025.
Read through reviews of airlines operating flights from Panama to South Carolina, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Michael,Jul 2025

AMS - ATL

Overall it was great experience, with the exception of snack food. The food offered in two main meals was just fine but for the mid-flight snack, the only option was a large cookie, too sweet and high sugar content. Snacks at the back of the plane were also mainly sweets. There was one nice baked cheddar option but it quickly ran out.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$423Average$501FlexibilityNo cancel feeOn-time71%

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