HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$240+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/204:41 pmPTY - CLT
1 stop29h 01mUnited Airlines
Thu 2/266:33 amCLT - PTY
1 stop10h 34mUnited Airlines
Deal found 12/16$469
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:55 amPTY - CLT
1 stop12h 47mUnited Airlines
Sat 2/286:33 amCLT - PTY
1 stop13h 05mUnited Airlines
Deal found 12/17$490
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/298:00 amPTY - CLT
1 stop11h 10mDelta
Mon 1/55:25 amCLT - PTY
1 stop8h 30mDelta
Deal found 12/17$501
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/164:43 pmPTY - CLT
1 stop15h 08mAmerican Airlines
Fri 1/96:30 amCLT - PTY
1 stop6h 57mAmerican Airlines
Deal found 12/16$508
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/244:41 pmPTY - CLT
1 stop29h 01mUnited Airlines
Sat 1/36:22 amCLT - PTY
1 stop13h 16mUnited Airlines
Deal found 12/16$511
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:25 amPTY - CLT
1 stop8h 13mMultiple Airlines
Thu 1/110:34 amCLT - PTY
2 stops14h 26mMultiple Airlines
Deal found 12/17$520
This Delta deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:00 amPTY - CLT
1 stop11h 10mDelta
Thu 1/85:25 amCLT - PTY
1 stop8h 30mDelta
Deal found 12/17$522
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:55 pmPTY - CLT
1 stop7h 04mAmerican Airlines
Sat 1/37:11 amCLT - PTY
1 stop6h 42mAmerican Airlines
Deal found 12/16$533
This American Airlines deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:53 pmPTY - CLT
2 stops17h 28mAmerican Airlines
Sat 1/36:20 amCLT - PTY
1 stop7h 33mAmerican Airlines
Deal found 12/18$535
This Delta deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:22 pmPTY - CHS
1 stop8h 36mDelta
Wed 12/316:00 amCHS - PTY
1 stop14h 00mDelta
Deal found 12/15$540
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:53 pmPTY - CHS
2 stops21h 13mAmerican Airlines
Wed 12/319:27 amCHS - PTY
1 stop6h 27mAmerican Airlines
Deal found 12/15$554
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/152:50 pmPTY - CHS
1 stop9h 56mAmerican Airlines
Mon 12/298:08 pmCHS - PTY
2 stops19h 46mAmerican Airlines
Deal found 12/15$575

Find flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$361
(Kiwi.com)

One-way from

$240
(United Airlines)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama to South Carolina
Search Deals
One-way flight from Panama to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Panama

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 1/15

9:33 pm-8:18 am

1 stop10h 45m

Charlotte Douglas

Mon 1/19

9:13 am-8:37 pm

1 stop11h 24m

$361

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 2/5

4:41 pm-4:17 pm

1 stop23h 36m

Charleston

Tue 2/17

5:07 pm-5:07 pm

1 stop24h 00m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/3

4:41 pm-9:54 pm

1 stop29h 13m

Charleston

Tue 2/17

5:07 pm-5:07 pm

1 stop24h 00m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/10

8:55 am-9:57 pm

1 stop13h 02m

Charleston

Mon 2/23

5:07 pm-2:45 pm

1 stop21h 38m

$377

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 5/29

1:50 pm-10:59 am

2 stops20h 09m

Charleston

Mon 6/1

4:22 pm-12:25 pm

2 stops21h 03m

$397

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/10

2:27 pm-2:25 pm

2 stops23h 58m

Charleston

Mon 2/23

8:10 pm-1:50 pm

1 stop17h 40m

$398

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 1/22

4:41 pm-9:57 pm

1 stop29h 16m

Charleston

Mon 1/26

11:00 am-8:02 pm

1 stop9h 02m

$401

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 2/5

2:27 pm-1:39 pm

2 stops23h 12m

Charleston

Tue 2/17

6:00 am-1:50 pm

1 stop7h 50m

$454

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Tue 2/3

2:27 pm-1:34 pm

2 stops23h 07m

Charleston

Tue 2/17

6:00 am-1:50 pm

1 stop7h 50m

$454

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 2/10

8:55 am-3:42 pm

1 stop30h 47m

Charlotte Douglas

Mon 2/23

11:07 am-8:02 pm

1 stop8h 55m

$481

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 57 results
1
2
3
...
6

Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in April is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SC?

Find hourly flight availability from Panama to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 35% on flights from Panama to South Carolina by exploring options for tickets at noon.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Panama to South Carolina, such as Delta. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Boarding

8.1

Entertainment

7.9

Crew

8.5

Overall

7.9

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Carolina?

    Airlines like United Airlines, American Airlines, and Delta fly from Panama to South Carolina in about 11h 10m. The time it takes to get you to your destination can typically vary by up to 12h 26m. Panama and South Carolina are separated by a distance of 1808 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in April is currently the most expensive (average of $601). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
San José to John F Kennedy Intl flights
San José to Newark flights
San José to Orlando flights
San José to Miami flights
Guatemala City to Los Angeles flights
Guatemala City to John F Kennedy Intl flights
San José to Fort Lauderdale flights
San Salvador to Los Angeles flights
Panama City to John F Kennedy Intl flights
San José to Los Angeles flights
San José to LaGuardia flights
Guatemala City to Miami flights
Panama City to Newark flights
Guatemala City to Newark flights
Panama City to Miami flights
Panama City to Orlando flights
San Salvador to Miami flights
Guatemala City to Fort Lauderdale flights
Guatemala City to Orlando flights
San José to Hobby flights
Guatemala City to LaGuardia flights
San Pedro Sula to John F Kennedy Intl flights
San Salvador to Hobby flights
San José to Las Vegas flights
San Salvador to John F Kennedy Intl flights
San Salvador to Dulles Intl flights
Panama City to LaGuardia flights
San Salvador to George Bush Intcntl flights
San Pedro Sula to Hobby flights
San José to Atlanta flights
San José to George Bush Intcntl flights
Guatemala City to Hobby flights
San Pedro Sula to George Bush Intcntl flights
San José to Denver flights
San Pedro Sula to Miami flights
Guatemala City to George Bush Intcntl flights
San José to Dallas/Fort Worth flights
San Salvador to Newark flights
San José to O'Hare Intl flights
Guatemala City to Atlanta flights
Managua to Miami flights
San José to Dulles Intl flights
San Salvador to Dallas/Fort Worth flights
Guatemala City to O'Hare Intl flights
San José to San Francisco flights
Guatemala City to Dallas/Fort Worth flights
Guatemala City to Las Vegas flights
San Pedro Sula to Fort Lauderdale flights
Guatemala City to Ontario flights
San Pedro Sula to Newark flights

Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$205Average$603FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.