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South Carolina

$256+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated September 15, 2025.

Round-trip from

$404
(United Airlines)

One-way from

$256
(Avianca Connect)
From Panama to South Carolina
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One-way flight from Panama to South Carolina
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Find flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/293:30 pmPTY - CLT
1 stop23h 23mUnited Airlines
Wed 10/14:50 pmCLT - PTY
1 stop26h 47mUnited Airlines
Deal found 9/14$404
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:41 pmPTY - CLT
1 stop18h 10mUnited Airlines
Tue 11/1811:34 amCLT - PTY
1 stop27h 11mUnited Airlines
Deal found 9/15$408
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:15 pmPTY - CLT
1 stop15h 05mAmerican Airlines
Wed 10/227:07 amCLT - PTY
1 stop7h 56mAmerican Airlines
Deal found 9/15$413
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/183:15 pmPTY - CHS
1 stop7h 44mAmerican Airlines
Tue 11/189:22 amCHS - PTY
1 stop28h 27mAmerican Airlines
Deal found 9/15$413
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/23:31 pmPTY - CLT
1 stop14h 54mAmerican Airlines
Mon 10/610:25 pmCLT - PTY
1 stop16h 38mAmerican Airlines
Deal found 9/13$422
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2010:25 amPTY - CLT
1 stop7h 09mMultiple Airlines
Fri 11/1410:42 pmCLT - PTY
1 stop9h 48mMultiple Airlines
Deal found 9/14$423
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/283:30 pmPTY - CLT
1 stop29h 29mUnited Airlines
Thu 10/211:46 amCLT - PTY
1 stop7h 51mUnited Airlines
Deal found 9/14$425
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/223:15 pmPTY - CLT
2 stops14h 11mAmerican Airlines
Wed 10/297:20 pmCLT - PTY
1 stop19h 43mAmerican Airlines
Deal found 9/14$427
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/279:33 pmPTY - CLT
1 stop9h 38mMultiple Airlines
Fri 10/247:24 pmCLT - PTY
1 stop13h 47mMultiple Airlines
Deal found 9/13$433
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/273:30 pmPTY - CLT
1 stop18h 21mUnited Airlines
Tue 10/217:00 amCLT - PTY
1 stop12h 37mUnited Airlines
Deal found 9/13$434
This Avianca Connect deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/265:25 pmPTY - CLT
2 stops18h 20mMultiple Airlines
Thu 10/235:45 amCLT - PTY
2 stops16h 25mMultiple Airlines
Deal found 9/13$435
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/273:31 pmPTY - CLT
2 stops13h 56mAmerican Airlines
Thu 10/210:25 pmCLT - PTY
1 stop17h 06mAmerican Airlines
Deal found 9/13$439

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Panama

Fly to

South Carolina

Route

Depart

Return

Price

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 9/29

3:30 pm-3:53 pm

1 stop23h 23m

Charlotte Douglas

Wed 10/22

11:46 am-6:37 pm

1 stop7h 51m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 9/30

10:00 am-9:59 pm

1 stop10h 59m

Charlotte Douglas

Thu 10/23

7:00 am-6:37 pm

1 stop12h 37m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 10/9

3:30 pm-9:59 pm

1 stop29h 29m

Charlotte Douglas

Thu 10/16

7:00 am-6:37 pm

1 stop12h 37m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 9/29

3:30 pm-10:51 am

1 stop18h 21m

Charlotte Douglas

Thu 10/23

7:00 am-6:37 pm

1 stop12h 37m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 9/29

3:30 pm-10:51 am

1 stop18h 21m

Charlotte Douglas

Tue 10/21

7:00 am-6:37 pm

1 stop12h 37m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 10/22

3:30 pm-9:59 pm

1 stop29h 29m

Charlotte Douglas

Wed 10/29

6:45 am-1:45 pm

1 stop8h 00m

$404

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 10/16

3:30 pm-9:59 pm

1 stop29h 29m

Charlotte Douglas

Thu 10/23

7:00 am-6:37 pm

1 stop12h 37m

$404

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 10/18

3:15 pm-11:59 pm

1 stop7h 44m

Charleston

Tue 11/18

9:22 am-1:49 pm

1 stop28h 27m

$413

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 10/17

3:30 pm-4:44 pm

1 stop24h 14m

Charleston

Sat 11/1

6:30 am-6:38 pm

1 stop13h 08m

$474

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 10/30

3:15 pm-11:35 am

2 stops19h 20m

Charleston

Thu 11/6

6:40 pm-1:49 pm

2 stops19h 09m

$531

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 34 results
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PA to SC?

Find hourly flight availability from Panama to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Panama to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Overall

7.2

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Crew

8.0

Comfort

7.2

Food

6.4

Entertainment

6.9

Overall

7.2

Boarding

7.5

Reviews

1 / 20
2.0
Mediocre

Nordia,Sep 2025

KIN - MIA

We were to land in Miami sometime after 3pm but couldn’t due to bad weather, we flew around for 2 hrs until we had to land in Forth Myers to refuel, we had to sit another 2 hrs at Forth Myers until given the clearance to refuel, we were hungry, thirsty and frustrated at that point. All the had on the flight to offer was a small plastic glass of water and a pack of biscoff, I requested a cup of tea and was told none was there. We were basically at another airport and not one of the staff could consider that the passengers might be hungry or thirsty being on a plane for around 8 hrs, which you weren’t prepared for, at least find some hot water on board.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Carolina?

    Airlines like United Airlines, American Airlines, and Delta fly from Panama to South Carolina in about 7h 44m. The time it takes to get you to your destination can typically vary by up to 15h 39m. Panama and South Carolina are separated by a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Panama to South Carolina one-way?

    $311 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $320 and $357, respectively.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Panama to South Carolina (average of $217). Flying from Panama to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Panama to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$546FlexibilityNo cancel feeOn-time71%

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