Panama

$159+ Cheap flights from South Carolina to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/4. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — PTY
Jan 22 — Jan 291
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Cheap flight deals from South Carolina to Panama

Discover tips and strategies to find the most affordable flight options for your journey from South Carolina (USSC) to Panama (PA0). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 17, 2025.

Round-trip from

$382
(Avianca Connect)

One-way from

$159
(United Airlines)
From South Carolina to Panama
One-way flight from South Carolina to Panama

Find flight deals from South Carolina to Panama

Cheapest flights from South Carolina to Panama
Explore the most affordable flight options available from South Carolina to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 17, 2025.

This Avianca Connect deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/126:40 amCLT - PTY
2 stops17h 40mMultiple Airlines
Thu 2/133:19 amPTY - CLT
2 stops16h 28mMultiple Airlines
Deal found 1/16$382
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/267:40 pmGSP - PTY
2 stops20h 10mAmerican Airlines
Tue 3/111:05 pmPTY - GSP
2 stops19h 51mAmerican Airlines
Deal found 1/15$388
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/257:00 amGSP - PTY
1 stop10h 07mUnited Airlines
Mon 3/103:40 pmPTY - GSP
1 stop30h 35mUnited Airlines
Deal found 1/15$392
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/196:16 pmCHS - PTY
2 stops21h 34mAmerican Airlines
Wed 2/262:30 pmPTY - CHS
2 stops20h 10mAmerican Airlines
Deal found 1/16$408
This Delta deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2112:30 pmCHS - PTY
1 stop7h 31mDelta
Wed 2/263:27 pmPTY - CHS
1 stop17h 56mDelta
Deal found 1/16$430
This United Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/186:50 amCHS - PTY
1 stop12h 48mUnited Airlines
Fri 2/284:40 pmPTY - CHS
1 stop23h 48mUnited Airlines
Deal found 1/16$432
This Kiwi.com deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/227:15 amCHS - PTY
1 stop13h 04mMultiple Airlines
Sun 2/2312:03 pmPTY - CHS
1 stop9h 16mMultiple Airlines
Deal found 1/16$436
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/257:00 amSAV - PTY
1 stop6h 15mAmerican Airlines
Tue 4/13:30 pmPTY - SAV
1 stop6h 54mAmerican Airlines
Deal found 1/16$437
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2410:25 pmCLT - PTY
1 stop17h 07mAmerican Airlines
Tue 4/13:30 pmPTY - CLT
1 stop7h 39mAmerican Airlines
Deal found 1/16$437
This American Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/126:12 pmMYR - PTY
2 stops19h 18mAmerican Airlines
Mon 5/191:50 pmPTY - MYR
2 stops20h 11mAmerican Airlines
Deal found 1/16$442
This United Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/76:45 amCLT - PTY
1 stop8h 29mUnited Airlines
Tue 5/2710:55 pmPTY - CLT
1 stop9h 51mUnited Airlines
Deal found 1/16$447
This United Airlines deal was found by Cheapflights users on 1/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1211:30 amMYR - PTY
1 stop9h 01mUnited Airlines
Mon 5/1910:55 pmPTY - MYR
1 stop10h 48mUnited Airlines
Deal found 1/16$491

Find flights from South Carolina to Panama within your budget

Customize your flight search to find flights from South Carolina to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 17, 2025.

Fly from

Any airport

Fly to

Any airport

Route

Depart

Return

Price

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Wed 2/12

6:40 am-12:20 am

2 stops17h 40m

Panama City Tocumen Intl

Thu 2/13

3:19 am-7:47 pm

2 stops16h 28m

$382

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Tue 4/1

7:00 am-6:37 pm

1 stop12h 37m

Panama City Tocumen Intl

Mon 4/7

10:55 pm-11:13 am

1 stop11h 18m

$383

GreenvillePanama City

GSP - PTY

GSPPTY

Greenville

Wed 2/26

7:40 pm-3:50 pm

2 stops20h 10m

Panama City Tocumen Intl

Tue 3/11

1:05 pm-9:56 am

2 stops19h 51m

$388

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Wed 2/19

6:16 pm-3:50 pm

2 stops21h 34m

Panama City Tocumen Intl

Wed 2/26

2:30 pm-10:40 am

2 stops20h 10m

$408

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Fri 2/21

12:30 pm-8:01 pm

1 stop7h 31m

Panama City Tocumen Intl

Wed 2/26

3:27 pm-9:23 am

1 stop17h 56m

$430

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Tue 2/18

6:50 am-7:38 pm

1 stop12h 48m

Panama City Tocumen Intl

Fri 2/28

4:40 pm-4:28 pm

1 stop23h 48m

$432

CharlestonPanama City

CHS - PTY

CHSPTY

Charleston

Sat 2/22

7:15 am-8:19 pm

1 stop13h 04m

Panama City Tocumen Intl

Sun 2/23

12:03 pm-9:19 pm

1 stop9h 16m

$436

SavannahPanama City

SAV - PTY

SAVPTY

Savannah/Hilton Head

Tue 3/25

7:00 am-12:15 pm

1 stop6h 15m

Panama City Tocumen Intl

Tue 4/1

3:30 pm-11:24 pm

1 stop6h 54m

$437

CharlottePanama City

CLT - PTY

CLTPTY

Charlotte Douglas

Mon 3/24

10:25 pm-2:32 pm

1 stop17h 07m

Panama City Tocumen Intl

Tue 4/1

3:30 pm-12:09 am

1 stop7h 39m

$437

Myrtle BeachPanama City

MYR - PTY

MYRPTY

Myrtle Beach Intl

Mon 5/12

6:12 pm-12:30 pm

2 stops19h 18m

Panama City Tocumen Intl

Mon 5/19

1:50 pm-11:01 am

2 stops20h 11m

$442

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/16

Showing 1-10 of 37 results
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Best time to book a flight from South Carolina to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Travel insights for flights from South Carolina to Panama

Get recent, data-driven insights about flights from South Carolina to Panama including ideal travel times, pricing trends, and more.

What is the cheapest month to book a flight from South Carolina to Panama?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Panama (average of $478). Flying from South Carolina to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to PA?

Find hourly flight availability from South Carolina to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 17, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Panama as you normally would.

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 17, 2025.
Read through reviews of airlines operating flights from South Carolina to Panama, such as Delta, American Airlines and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
8.0
Very good
8,511 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

8.0
Very good
8,511 reviews
8.0
Very good
8,511 reviews

Food

7.3

Comfort

8.0

Crew

8.6

Boarding

8.2

Overall

8.0

Entertainment

7.9

Reviews

1 / 10

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

7.4
Good
8,965 reviews
8.0
Very good
8,511 reviews