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South Carolina

$292+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Sep 1 — Sep 81
Tue 9/1
Tue 9/8
1 adult, Economy
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Cheap flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2026.

This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/219:45 am
PTY
-
CLT
2 stops13h 14m
United Airlines
Thu 10/16:00 am
CLT
-
PTY
2 stops14h 31m
United Airlines
Deal found 7/31$572
This Copa Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:41 pm
PTY
-
CLT
1 stop14h 03m
Copa Airlines
Fri 10/166:00 am
CLT
-
PTY
1 stop8h 31m
Copa Airlines
Deal found 7/29$581
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/43:24 pm
PTY
-
CHS
1 stop8h 35m
Delta
Mon 11/95:20 am
CHS
-
PTY
1 stop8h 45m
Delta
Deal found 7/31$583
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/267:55 am
PTY
-
CHS
1 stop13h 04m
United Airlines
Wed 10/287:00 am
CHS
-
PTY
1 stop13h 02m
United Airlines
Deal found 8/2$592
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1312:21 pm
PTY
-
CLT
2 stops30h 34m
Multiple Airlines
Fri 11/133:31 pm
CLT
-
PTY
1 stop16h 18m
Multiple Airlines
Deal found 7/30$598
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/199:45 am
PTY
-
CLT
1 stop9h 59m
United Airlines
Wed 10/710:25 am
CLT
-
PTY
2 stops10h 06m
United Airlines
Deal found 7/31$604
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:30 pm
PTY
-
GSP
1 stop6h 47m
Delta
Fri 11/275:30 am
GSP
-
PTY
1 stop8h 35m
Delta
Deal found 8/1$604
This United Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:41 pm
PTY
-
CHS
2 stops17h 46m
United Airlines
Mon 1/44:55 pm
CHS
-
PTY
2 stops24h 17m
United Airlines
Deal found 7/30$604
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:21 pm
PTY
-
CLT
2 stops49h 07m
Multiple Airlines
Fri 11/133:31 pm
CLT
-
PTY
1 stop16h 18m
Multiple Airlines
Deal found 7/30$605
This Expedia deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:50 pm
PTY
-
CHS
2 stops17h 18m
Multiple Airlines
Tue 8/1810:58 am
CHS
-
PTY
2 stops24h 32m
Multiple Airlines
Deal found 8/1$607
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:36 pm
PTY
-
CLT
2 stops25h 38m
Multiple Airlines
Fri 11/133:31 pm
CLT
-
PTY
1 stop16h 18m
Multiple Airlines
Deal found 7/30$608
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1312:21 pm
PTY
-
CLT
2 stops30h 34m
Multiple Airlines
Sun 11/153:31 pm
CLT
-
PTY
1 stop16h 18m
Multiple Airlines
Deal found 7/30$609

Find flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated August 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$572
(United Airlines)

One-way from

$292
(Kiwi.com)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama to South Carolina
Search Deals
One-way flight from Panama to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 11/4

4:41 pm-2:06 pm

2 stops21h 25m

Charleston

Mon 11/9

7:00 am-8:02 pm

1 stop13h 02m

$583

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 10/26

7:55 am-9:59 pm

1 stop13h 04m

Charleston

Wed 10/28

7:00 am-7:02 pm

1 stop13h 02m

$592
Quickest round-trip

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 11/23

3:30 pm-10:17 pm

1 stop6h 47m

Greenville

Fri 11/27

5:30 am-2:05 pm

1 stop8h 35m

$604

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 9/21

9:45 am-11:59 pm

2 stops13h 14m

Charlotte Douglas

Sun 10/4

11:00 am-7:31 pm

1 stop9h 31m

$604

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Mon 11/23

10:00 am-9:51 am

2 stops23h 51m

Greenville

Fri 11/27

7:43 pm-7:38 pm

2 stops23h 55m

$604

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 9/25

3:50 pm-10:17 am

2 stops17h 27m

Charleston

Sun 12/6

7:40 am-6:55 pm

2 stops35h 15m

$607

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 11/4

3:13 pm-10:37 am

2 stops19h 24m

Charleston

Mon 11/9

6:02 pm-2:13 pm

2 stops20h 11m

$609

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Wed 9/16

2:23 pm-11:59 pm

1 stop8h 36m

Charlotte Douglas

Wed 9/30

5:30 am-12:58 pm

1 stop8h 28m

$627

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 11/4

11:25 am-9:59 am

3 stops22h 34m

Charleston

Mon 11/9

8:25 pm-6:55 pm

2 stops22h 30m

$627

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:43 pm

1 stop9h 27m

Charleston

Sun 12/6

6:00 am-1:48 pm

1 stop7h 48m

$632

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 50 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $376). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 2, 2026.
Read through reviews of airlines operating flights from Panama to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,845 reviews

Food

6.4

Boarding

7.5

Comfort

7.2

Crew

7.9

Entertainment

6.8

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,845 reviews
American Airlines
7.1
Good
11,845 reviews

Food

6.4

Boarding

7.5

Comfort

7.2

Crew

7.9

Entertainment

6.8

Overall

7.1

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Carolina?

    Airlines like Delta, United Airlines, and American Airlines fly from Panama to South Carolina in about 8h 35m. The time it takes to get you to your destination can typically vary by up to 15h 27m. Panama and South Carolina are separated by a distance of 1645 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $376). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$577FlexibilityNo cancel feeOn-time71%

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