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South Carolina

$252+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
May 19 — May 261
Tue 5/19
Tue 5/26
1 adult, Economy
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Cheap flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.

This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:21 pm
PTY
-
CLT
1 stop8h 36m
Delta
Mon 9/145:30 am
CLT
-
PTY
1 stop8h 26m
Delta
Deal found 4/17$465
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:40 pm
PTY
-
CLT
1 stop6h 51m
American Airlines
Mon 9/1410:25 pm
CLT
-
PTY
1 stop16h 45m
American Airlines
Deal found 4/18$474
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:33 pm
PTY
-
CLT
1 stop13h 10m
Multiple Airlines
Fri 5/812:48 pm
CLT
-
PTY
1 stop7h 32m
Multiple Airlines
Deal found 4/17$477
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/153:40 pm
PTY
-
CLT
1 stop14h 28m
American Airlines
Sat 9/267:05 am
CLT
-
PTY
1 stop8h 05m
American Airlines
Deal found 4/14$496
This Delta deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:15 pm
PTY
-
CHS
1 stop8h 44m
Delta
Tue 6/165:10 am
CHS
-
PTY
1 stop8h 59m
Delta
Deal found 4/18$496
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/13:40 pm
PTY
-
GSP
2 stops22h 11m
American Airlines
Sun 10/48:40 pm
GSP
-
PTY
2 stops18h 20m
American Airlines
Deal found 4/14$500
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:40 pm
PTY
-
CHS
1 stop6h 25m
American Airlines
Sun 9/277:39 am
CHS
-
PTY
1 stop7h 31m
American Airlines
Deal found 4/15$514
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:15 pm
PTY
-
CHS
1 stop7h 41m
Delta
Wed 6/35:15 am
CHS
-
PTY
1 stop8h 35m
Delta
Deal found 4/15$517
This Mytrip deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:55 pm
PTY
-
CLT
3 stops27h 06m
Multiple Airlines
Sun 5/36:30 am
CLT
-
PTY
2 stops29h 00m
Multiple Airlines
Deal found 4/14$525
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:14 pm
PTY
-
CHS
1 stop9h 45m
American Airlines
Wed 6/36:42 pm
CHS
-
PTY
2 stops18h 32m
American Airlines
Deal found 4/15$530
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/213:30 pm
PTY
-
CHS
2 stops21h 25m
United Airlines
Tue 8/256:43 pm
CHS
-
PTY
2 stops20h 31m
United Airlines
Deal found 4/16$549
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:30 pm
PTY
-
CHS
1 stop29h 29m
United Airlines
Sat 5/236:00 am
CHS
-
PTY
2 stops23h 04m
United Airlines
Deal found 4/16$555

Find flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated April 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$465
(Delta)

One-way from

$252
(Mytrip)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
Search Deals
From Panama to South Carolina
Search Deals
One-way flight from Panama to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

2:21 pm-11:57 pm

1 stop8h 36m

Charlotte Douglas

Mon 9/14

5:30 am-12:56 pm

1 stop8h 26m

$465

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 9/15

3:40 pm-7:08 am

1 stop14h 28m

Charlotte Douglas

Sat 9/26

7:05 am-2:10 pm

1 stop8h 05m

$496

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Mon 6/1

2:15 pm-11:59 pm

1 stop8h 44m

Charleston

Tue 6/16

5:10 am-1:09 pm

1 stop8h 59m

$496

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Wed 5/27

2:15 pm-11:59 pm

1 stop8h 44m

Charleston

Wed 6/3

5:15 am-12:50 pm

1 stop8h 35m

$517

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Thu 9/24

3:40 pm-11:05 pm

1 stop6h 25m

Charleston

Sun 9/27

8:43 pm-2:10 pm

2 stops18h 27m

$518

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Fri 5/1

5:55 pm-10:01 pm

3 stops27h 06m

Charlotte Douglas

Sun 5/3

6:30 am-10:30 am

2 stops29h 00m

$525

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 8/21

3:30 pm-1:55 pm

2 stops21h 25m

Charleston

Tue 8/25

6:43 pm-2:14 pm

2 stops20h 31m

$549

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Sat 5/16

3:30 pm-12:17 pm

2 stops19h 47m

Charleston

Sat 5/23

7:47 pm-7:31 pm

2 stops24h 44m

$555

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 5/13

2:15 pm-11:43 pm

1 stop8h 28m

Greenville

Tue 5/19

5:40 am-12:50 pm

1 stop8h 10m

$561

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Tue 5/19

1:49 pm-6:26 am

2 stops15h 37m

Charlotte Douglas

Tue 5/26

4:40 pm-12:14 pm

1 stop20h 34m

$579

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/17

Showing 1-10 of 49 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Panama to South Carolina?

    Airlines like Delta, American Airlines, and United Airlines fly from Panama to South Carolina in about 8h 36m. The time it takes to get you to your destination can typically vary by up to 9h 02m. Panama and South Carolina are separated by a distance of 1808 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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