South Carolina

$270+ Cheap flights from Panama to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Jul 9 — Jul 161
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Cheap flight deals from Panama to South Carolina

Cheapest flights from Panama to South Carolina
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:30 am
PTY
-
CLT
2 stops10h 42m
Multiple Airlines
Fri 7/316:48 pm
CLT
-
PTY
1 stop14h 18m
Multiple Airlines
Deal found 6/4$495
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:55 pm
PTY
-
CLT
2 stops22h 17m
Multiple Airlines
Tue 8/46:48 pm
CLT
-
PTY
1 stop14h 42m
Multiple Airlines
Deal found 6/8$521
This Delta deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:21 pm
PTY
-
CLT
1 stop8h 36m
Delta
Mon 9/145:30 am
CLT
-
PTY
1 stop8h 26m
Delta
Deal found 6/4$551
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:25 am
PTY
-
CLT
2 stops15h 42m
Multiple Airlines
Mon 8/36:48 pm
CLT
-
PTY
1 stop14h 18m
Multiple Airlines
Deal found 6/5$558
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:16 pm
PTY
-
CLT
1 stop6h 58m
American Airlines
Mon 9/141:30 pm
CLT
-
PTY
1 stop23h 54m
American Airlines
Deal found 6/6$570
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:30 pm
PTY
-
CLT
1 stop17h 10m
Delta
Mon 11/306:45 am
CLT
-
PTY
1 stop7h 20m
Delta
Deal found 6/8$583
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:24 pm
PTY
-
CHS
1 stop9h 02m
Delta
Tue 7/285:10 am
CHS
-
PTY
1 stop8h 55m
Delta
Deal found 6/7$591
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/252:27 pm
PTY
-
CLT
1 stop28h 47m
Delta
Mon 8/37:54 pm
CLT
-
PTY
1 stop18h 01m
Delta
Deal found 6/5$594
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:14 pm
PTY
-
CHS
2 stops21h 26m
American Airlines
Tue 7/286:00 am
CHS
-
PTY
1 stop7h 14m
American Airlines
Deal found 6/7$594
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:16 pm
PTY
-
GSP
2 stops20h 47m
American Airlines
Sun 10/46:23 pm
GSP
-
PTY
2 stops20h 37m
American Airlines
Deal found 6/5$597
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/263:35 pm
PTY
-
CLT
1 stop18h 01m
American Airlines
Thu 11/58:19 pm
CLT
-
PTY
1 stop17h 17m
American Airlines
Deal found 6/7$602
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:55 pm
PTY
-
CHS
1 stop8h 56m
United Airlines
Tue 7/2811:13 am
CHS
-
PTY
1 stop17h 51m
United Airlines
Deal found 6/4$609

Find flight deals from Panama to South Carolina

Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated June 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$495
(Kiwi.com)

One-way from

$270
(Trip.com)
Provider with most accurate pricing for Panama City Tocumen Intl-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Panama City Tocumen Intl-Myrtle Beach Intl flights.
From Panama to South Carolina
One-way flight from Panama to South Carolina

Cheapflights Fare Finder

 
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Thu 9/10

2:21 pm-11:57 pm

1 stop8h 36m

Charlotte Douglas

Mon 9/14

5:30 am-12:56 pm

1 stop8h 26m

$551

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 7/24

2:24 pm-12:26 am

1 stop9h 02m

Charleston

Tue 7/28

5:10 am-1:05 pm

1 stop8h 55m

$591

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 9/30

1:16 pm-11:03 am

2 stops20h 47m

Greenville

Sun 10/4

6:23 pm-2:00 pm

2 stops20h 37m

$597

Panama CityCharleston

PTY - CHS

PTYCHS

Panama City Tocumen Intl

Fri 7/24

10:55 pm-8:51 am

1 stop8h 56m

Charleston

Tue 7/28

11:13 am-4:04 am

1 stop17h 51m

$609
Quickest round-trip

Panama CityAugusta

PTY - AGS

PTYAGS

Panama City Tocumen Intl

Wed 11/11

3:30 pm-11:55 pm

1 stop8h 25m

Augusta Bush Field

Sat 11/14

7:00 am-2:05 pm

1 stop7h 05m

$630

Panama CityAugusta

PTY - AGS

PTYAGS

Panama City Tocumen Intl

Wed 11/11

2:43 pm-12:53 pm

2 stops22h 10m

Augusta Bush Field

Sat 11/14

6:12 pm-1:36 pm

2 stops19h 24m

$654

Panama CityCharlotte

PTY - CLT

PTYCLT

Panama City Tocumen Intl

Mon 11/23

3:30 pm-11:53 pm

1 stop8h 23m

Charlotte Douglas

Tue 12/1

5:30 am-2:05 pm

1 stop8h 35m

$657

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Wed 7/15

1:14 pm-12:14 pm

2 stops22h 00m

Greenville

Wed 9/2

1:37 pm-12:39 pm

2 stops24h 02m

$659

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sun 6/28

1:15 pm-11:59 pm

1 stop9h 44m

Greenville

Sat 9/26

5:14 pm-12:16 pm

2 stops20h 02m

$689

Panama CityGreenville

PTY - GSP

PTYGSP

Panama City Tocumen Intl

Sat 8/29

10:55 pm-10:35 am

1 stop10h 40m

Greenville

Tue 9/1

11:25 am-7:31 pm

1 stop9h 06m

$705

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/7

Showing 1-10 of 54 resultsSorted by cheapest first
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Best time to book a flight from Panama to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama to South Carolina

What is the cheapest month to book a flight from Panama to South Carolina?

Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 9, 2026.
Read through reviews of airlines operating flights from Panama to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Overall

7.1

Food

6.4

Crew

7.9

Reviews

1 / 20
10.0
Excellent

Beatriz,May 2026

HEL - DFW

Very modern and confortable plane. Dinner was delicious. Whole crew were polite and perfect.

Entertainment

6.9

Boarding

7.5

Comfort

7.2

Overall

7.1

Food

6.4

Crew

7.9

Reviews

1 / 20
10.0
Excellent

Beatriz,May 2026

HEL - DFW

Very modern and confortable plane. Dinner was delicious. Whole crew were polite and perfect.

Related info for your journey

Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Panama to South Carolina?

    Airlines like Delta, American Airlines, and United Airlines fly from Panama to South Carolina in about 8h 36m. The time it takes to get you to your destination can typically vary by up to 12h 11m. Panama and South Carolina are separated by a distance of 1808 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Panama to South Carolina that include hotel bookings?

    Yes. In addition to deals on Panama to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama to South Carolina.

  • Can I find deals for business class flights from Panama to South Carolina?

    Yes. Cheapflights offers flight deals from Panama to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama to South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Panama to South Carolina (average of $148). Flying from Panama to South Carolina in March is currently the most expensive (average of $715). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Panama to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Panama to South Carolina

Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$397Average$577FlexibilityNo cancel feeOn-time71%

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