$346+ Cheap flights from Panama to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — CHS
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Panama to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Panama to South CarolinaExplore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Panama to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/910:00 am -
1 stop13h 00m
Sun 11/225:37 pm -
2 stops26h 25m
Deal found 9/12![United Airlines logo]()
$604
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:55 pm -
2 stops16h 48m
Sat 11/217:20 am -
2 stops18h 50m
Deal found 9/14![Multiple Airlines logo]()
$612
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:00 am -
1 stop13h 00m
Mon 11/165:37 pm -
2 stops21h 08m
Deal found 9/13![United Airlines logo]()
$618
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:00 am -
1 stop11h 41m
Wed 11/183:30 pm -
2 stops28h 32m
Deal found 9/15![United Airlines logo]()
$626
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:55 am -
1 stop13h 04m
Sat 11/213:29 pm -
2 stops28h 09m
Deal found 9/14![United Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2310:00 am -
2 stops28h 50m
Sat 1/28:07 am -
2 stops21h 03m
Deal found 9/16![United Airlines logo]()
$658
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:23 pm -
1 stop7h 32m
Mon 10/199:40 pm -
1 stop11h 26m
Deal found 9/13![Multiple Airlines logo]()
$669
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:29 pm -
1 stop8h 28m
Mon 11/305:30 am -
1 stop8h 32m
Deal found 9/15![Delta logo]()
$671
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/512:23 pm -
1 stop7h 51m
Mon 10/129:40 pm -
1 stop11h 26m
Deal found 9/14![Multiple Airlines logo]()
$681
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:45 am -
2 stops27h 41m
Tue 10/2010:23 am -
2 stops10h 08m
Deal found 9/15![United Airlines logo]()
$684
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:34 pm -
1 stop8h 18m
Sun 11/297:21 am -
1 stop7h 13m
Deal found 9/13![American Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/154:41 pm -
1 stop29h 18m
Sat 11/216:00 am -
1 stop14h 02m
Deal found 9/14![United Airlines logo]()
$690
Best flights from Panama to South CarolinaDiscover carefully curated flight deals from Panama to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Panama to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:41 pm -
2 stops24h 15m
Sun 11/225:37 pm -
2 stops26h 25m
Deal found 9/12![United Airlines logo]()
$604
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/253:34 pm -
1 stop8h 18m
Sun 11/297:21 am -
1 stop7h 13m
Deal found 9/13![American Airlines logo]()
$685
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:24 pm -
1 stop8h 23m
Sun 12/137:00 am -
1 stop7h 03m
Deal found 9/12![Delta logo]()
$824
This BusinessClass deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:45 am -
1 stop24h 30m
Tue 10/2012:02 pm -
1 stop8h 29m
Deal found 9/15![Copa Airlines logo]()
$1,087
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:00 am -
1 stop13h 00m
Mon 11/165:37 pm -
2 stops21h 08m
Deal found 9/12![United Airlines logo]()
$618
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:00 am -
1 stop30h 52m
Wed 11/186:40 am -
1 stop12h 58m
Deal found 9/15![United Airlines logo]()
$626
This Ovago deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/143:13 pm -
2 stops20h 17m
Fri 12/185:00 am -
2 stops8h 51m
Deal found 9/16![GOL logo]()
$1,521
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/410:00 am -
2 stops23h 59m
Tue 2/98:15 am -
2 stops11h 47m
Deal found 9/13![United Airlines logo]()
$639
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/214:41 pm -
2 stops24h 15m
Mon 1/256:15 am -
2 stops13h 47m
Deal found 9/12![United Airlines logo]()
$639
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/178:55 am -
1 stop13h 04m
Sat 11/213:35 pm -
1 stop28h 27m
Deal found 9/14![United Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2311:55 pm -
1 stop22h 04m
Sat 1/26:20 am -
1 stop10h 52m
Deal found 9/14![United Airlines logo]()
$658
This WestJet deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WestJet is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/299:00 am -
2 stops31h 17m
Thu 11/512:00 pm -
2 stops44h 05m
Deal found 9/14![WestJet logo]()
$2,206
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/288:55 am -
1 stop15h 04m
Sun 1/36:20 am -
1 stop10h 52m
Deal found 9/12![United Airlines logo]()
$658
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/173:29 pm -
1 stop8h 19m
Tue 1/57:00 am -
1 stop6h 55m
Deal found 9/16![Delta logo]()
$1,326
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:45 am -
2 stops27h 41m
Tue 10/2010:23 am -
2 stops10h 08m
Deal found 9/15![United Airlines logo]()
$684
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:41 pm -
2 stops25h 25m
Thu 11/57:00 pm -
2 stops25h 02m
Deal found 9/16![United Airlines logo]()
$715
This KAYAK deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1410:00 am -
1 stop25h 45m
Fri 12/1810:36 am -
2 stops18h 34m
Deal found 9/16![Copa Airlines logo]()
$1,678
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/209:45 am -
1 stop13h 14m
Fri 10/237:00 am -
1 stop12h 37m
Deal found 9/13![United Airlines logo]()
$727
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/710:00 am -
2 stops22h 46m
Sun 12/132:29 pm -
2 stops29h 33m
Deal found 9/12![United Airlines logo]()
$1,070
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/172:51 pm -
3 stops17h 41m
Tue 1/55:04 am -
2 stops10h 29m
Deal found 9/16![American Airlines logo]()
$3,107
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/610:00 am -
1 stop31h 11m
Mon 11/95:54 pm -
1 stop26h 08m
Deal found 9/15![United Airlines logo]()
$1,272
Last-minute flights from Panama to South CarolinaDiscover last-minute flight deals from Panama to South Carolina. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Panama to South Carolina. Data last updated September 17, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:23 pm -
1 stop8h 36m
Tue 10/136:45 am -
1 stop7h 14m
Deal found 9/12![Delta logo]()
$767
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/512:23 pm -
1 stop7h 51m
Mon 10/129:40 pm -
1 stop11h 26m
Deal found 9/14![Multiple Airlines logo]()
$681
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/69:45 am -
2 stops23h 23m
Thu 10/226:00 am -
2 stops14h 31m
Deal found 9/16![United Airlines logo]()
$735
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/82:02 pm -
2 stops15h 25m
Thu 10/227:09 am -
1 stop6h 53m
Deal found 9/13![American Airlines logo]()
$748
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1212:23 pm -
1 stop7h 32m
Mon 10/199:40 pm -
1 stop11h 26m
Deal found 9/13![Multiple Airlines logo]()
$743
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/139:45 am -
2 stops27h 41m
Tue 10/2010:23 am -
2 stops10h 08m
Deal found 9/15![United Airlines logo]()
$684
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:23 pm -
1 stop7h 32m
Mon 10/199:40 pm -
1 stop11h 26m
Deal found 9/13![Multiple Airlines logo]()
$669
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/209:45 am -
1 stop13h 14m
Fri 10/237:00 am -
1 stop12h 37m
Deal found 9/13![United Airlines logo]()
$727
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:55 am -
1 stop25h 54m
Tue 11/36:40 am -
1 stop8h 05m
Deal found 9/12![United Airlines logo]()
$696
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/272:02 pm -
2 stops15h 25m
Tue 11/310:41 pm -
2 stops15h 32m
Deal found 9/12![American Airlines logo]()
$710
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/292:02 pm -
1 stop28h 36m
Thu 11/58:12 pm -
1 stop18h 01m
Deal found 9/16![American Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:41 pm -
2 stops20h 49m
Thu 11/52:51 pm -
2 stops23h 54m
Deal found 9/16![United Airlines logo]()
$729
One-way flights from Panama to South CarolinaSearch for one-way flight options from Panama to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Panama to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:00 am -
2 stops24h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1710:00 am -
1 stop31h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/210:00 am -
1 stop13h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![United Airlines logo]()
$346
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:13 pm -
2 stops20h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![American Airlines logo]()
$355
This Expedia deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:50 pm -
2 stops17h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/304:41 pm -
1 stop29h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$378
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:33 pm -
3 stops24h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/124:41 pm -
2 stops28h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![United Airlines logo]()
$424
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:33 pm -
2 stops14h 55m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$426
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:00 am -
2 stops22h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$443
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:45 am -
2 stops13h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$450
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:48 pm -
3 stops19h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$456
Find flight deals from Panama to South Carolina
Keep the following information in mind while searching for Panama to South Carolina flight deals. Data was last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $604 (United Airlines) |
One-way from | $346 (United Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Panama to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Panama to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Panama CityCharlotte
PTY Panama City Tocumen Intl - CLT Charlotte Douglas
PTYCLT
Panama City Tocumen Intl
Mon 11/16
10:00 am-12:39 pm
1 stop26h 39m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$346
Panama CityMyrtle Beach
PTY Panama City Tocumen Intl - MYR Myrtle Beach Intl
PTYMYR
Panama City Tocumen Intl
Tue 11/17
10:00 am-5:11 pm
1 stop31h 11m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$346
Panama CityGreenville
PTY Panama City Tocumen Intl - GSP Greenville
PTYGSP
Panama City Tocumen Intl
Wed 12/2
8:55 am-8:59 pm
2 stops12h 04m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$346
Panama CityMyrtle Beach
PTY Panama City Tocumen Intl - MYR Myrtle Beach Intl
PTYMYR
Panama City Tocumen Intl
Tue 11/17
3:13 pm-11:32 am
2 stops20h 19m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$355
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Tue 10/6
3:50 pm-10:19 am
2 stops17h 29m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$358
Panama CityCharlotte
PTY Panama City Tocumen Intl - CLT Charlotte Douglas
PTYCLT
Panama City Tocumen Intl
Sat 1/30
4:41 pm-9:52 pm
1 stop29h 11m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$378
Panama CityCharlotte
PTY Panama City Tocumen Intl - CLT Charlotte Douglas
PTYCLT
Panama City Tocumen Intl
Sun 1/31
4:41 pm-9:52 pm
1 stop29h 11m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$378
Panama CityCharlotte
PTY Panama City Tocumen Intl - CLT Charlotte Douglas
PTYCLT
Panama City Tocumen Intl
Sat 2/6
10:00 am-9:44 am
2 stops23h 44m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$384
Panama CityCharleston
PTY Panama City Tocumen Intl - CHS Charleston
PTYCHS
Panama City Tocumen Intl
Mon 10/5
9:33 pm-10:36 pm
3 stops24h 03m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$421
Panama CityGreenville
PTY Panama City Tocumen Intl - GSP Greenville
PTYGSP
Panama City Tocumen Intl
Tue 1/12
4:41 pm-8:46 pm
2 stops28h 05m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$424
Showing 1-10 of 43 resultsSorted by cheapest first
Best time to book a flight from Panama to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Panama with our price prediction graph.
PTY-GSP
PTY-CHS
PTY-CLT
PTY-CAE
PTY-AGS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Panama to South Carolina
PA0-USSC
PTY-GSP
PTY-CHS
PTY-CLT
PTY-CAE
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2026.
Read through reviews of airlines operating flights from Panama to South Carolina, such as American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Entertainment
6.8
Boarding
7.4
Comfort
7.2
Overall
7.1
Food
6.4
Reviews
1 / 20
2.0
MediocreSherif,Aug 2026
YYZ - ORD
Crew
7.9
Entertainment
6.8
Boarding
7.4
Comfort
7.2
Overall
7.1
Food
6.4
Reviews
1 / 20
2.0
MediocreSherif,Aug 2026
YYZ - ORD
Related info for your journey
Find useful and relevant information for your journey from Panama to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Panama to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Panama to South Carolina by cabin class
Find flights from Panama to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Panama and South Carolina flights
Browse other Panama and South Carolina flight options. Last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Panama after your stay in South Carolina
Panama to South Carolina flights
Consider these flights traveling from Panama to South Carolina.
Top airline flying from Panama to South Carolina
Discover the top airline that operate flights from Panama to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$431 | Average$642 | FlexibilityNo cancel fee | On-time71% |