$97+ Cheap flights from Missouri to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Nov 18 — Nov 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am -
1 stop5h 24m
Fri 11/612:17 pm -
1 stop7h 00m
Deal found 10/14![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:30 am -
1 stop5h 55m
Wed 11/1811:00 am -
2 stops7h 25m
Deal found 10/14![Southwest logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/114:49 pm -
1 stop15h 39m
Thu 1/77:18 pm -
1 stop15h 58m
Deal found 10/14![Multiple Airlines logo]()
$264
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:06 am -
1 stop5h 50m
Wed 11/181:52 pm -
1 stop6h 00m
Deal found 10/14![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:26 pm -
1 stop15h 12m
Tue 12/83:00 pm -
2 stops21h 17m
Deal found 10/17![Multiple Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:45 pm -
1 stop4h 50m
Wed 11/183:25 pm -
2 stops8h 05m
Deal found 10/14![Southwest logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:49 pm -
1 stop16h 06m
Sat 12/125:58 pm -
1 stop24h 35m
Deal found 10/17![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:49 pm -
2 stops18h 42m
Thu 12/1710:15 pm -
1 stop20h 43m
Deal found 10/17![Multiple Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:15 am -
2 stops8h 50m
Thu 12/101:30 pm -
2 stops6h 55m
Deal found 10/14![Southwest logo]()
$298
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/74:49 pm -
1 stop16h 06m
Sun 12/138:10 pm -
1 stop20h 49m
Deal found 10/17![Multiple Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/234:50 pm -
2 stops6h 25m
Wed 12/307:55 pm -
1 stop5h 20m
Deal found 10/18![Southwest logo]()
$303
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2412:40 pm -
1 stop6h 25m
Thu 12/315:15 pm -
1 stop6h 00m
Deal found 10/18![Southwest logo]()
$311
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:55 am -
1 stop4h 35m
Thu 12/108:00 am -
1 stop5h 40m
Deal found 10/14![Southwest logo]()
$227
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:40 am -
1 stop4h 33m
Sun 12/67:00 am -
1 stop6h 15m
Deal found 10/14![Delta logo]()
$321
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/258:00 am -
1 stop4h 39m
Fri 1/14:11 pm -
1 stop6h 27m
Deal found 10/16![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:55 pm -
1 stop6h 04m
Thu 11/266:30 am -
1 stop8h 37m
Deal found 10/19![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:45 pm -
1 stop4h 50m
Wed 11/183:25 pm -
2 stops8h 05m
Deal found 10/14![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/137:00 am -
2 stops8h 20m
Tue 1/191:25 pm -
2 stops9h 20m
Deal found 10/18![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/75:26 pm -
1 stop3h 59m
Sun 1/106:00 am -
1 stop4h 35m
Deal found 10/14![Delta logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:28 am -
1 stop4h 37m
Wed 11/412:25 pm -
1 stop6h 04m
Deal found 10/14![American Airlines logo]()
$354
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/63:19 pm -
1 stop4h 44m
Tue 2/95:29 pm -
1 stop5h 17m
Deal found 10/14![United Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/85:40 am -
1 stop6h 51m
Wed 11/186:00 am -
1 stop4h 27m
Deal found 10/14![Delta logo]()
$343
This Southwest deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2510:30 am -
1 stop5h 55m
Wed 12/309:15 pm -
1 stop4h 00m
Deal found 10/16![Southwest logo]()
$320
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:00 am -
1 stop4h 36m
Mon 11/235:47 pm -
1 stop7h 11m
Deal found 10/15![American Airlines logo]()
$359
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
2 stops7h 28m
Thu 11/123:29 pm -
1 stop5h 14m
Deal found 10/14![United Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/510:55 am -
2 stops8h 10m
Sat 1/96:35 am -
2 stops10h 00m
Deal found 10/18![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/25:14 am -
1 stop7h 02m
Tue 3/97:00 am -
1 stop4h 49m
Deal found 10/18![American Airlines logo]()
$365
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:25 pm -
1 stop4h 36m
Mon 11/3010:32 am -
1 stop5h 17m
Deal found 10/14![Delta logo]()
$388
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
2 stops7h 40m
Fri 11/67:55 pm -
1 stop5h 15m
Deal found 10/14![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:00 am -
1 stop6h 19m
Wed 11/47:00 am -
2 stops8h 33m
Deal found 10/16![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/611:33 am -
1 stop6h 35m
Sat 11/710:16 am -
1 stop5h 21m
Deal found 10/14![United Airlines logo]()
$398
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:45 am -
2 stops6h 10m
Thu 12/107:05 pm -
1 stop3h 50m
Deal found 10/14![Southwest logo]()
$352
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/58:10 am -
1 stop5h 54m
Fri 12/116:59 pm -
1 stop5h 57m
Deal found 10/15![Delta logo]()
$429
This American Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/175:50 am -
1 stop5h 51m
Sat 12/193:40 pm -
1 stop5h 33m
Deal found 10/18![American Airlines logo]()
$432
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:00 am -
2 stops12h 08m
Sat 11/215:37 pm -
1 stop5h 03m
Deal found 10/15![United Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/111:20 pm -
1 stop5h 40m
Sat 12/1210:35 am -
2 stops10h 00m
Deal found 10/15![Southwest logo]()
$352
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:47 am -
1 stop3h 43m
Wed 11/412:23 pm -
2 stops9h 28m
Deal found 10/15![Delta logo]()
$435
This American Airlines deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:05 pm -
2 stops9h 54m
Thu 11/127:00 am -
1 stop5h 35m
Deal found 10/17![American Airlines logo]()
$445
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:30 am -
1 stop5h 16m
Sat 1/96:00 am -
1 stop5h 47m
Deal found 10/14![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/712:40 pm -
1 stop4h 45m
Wed 12/93:25 pm -
2 stops7h 30m
Deal found 10/14![Southwest logo]()
$352
This Delta deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:10 am -
1 stop5h 19m
Fri 12/45:35 am -
1 stop4h 54m
Deal found 10/14![Delta logo]()
$441
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:20 pm -
2 stops8h 00m
Mon 12/2110:35 am -
1 stop5h 05m
Deal found 10/15![Southwest logo]()
$354
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated October 19, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am -
1 stop5h 24m
Fri 11/612:17 pm -
1 stop7h 00m
Deal found 10/14![American Airlines logo]()
$227
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/410:55 am -
2 stops7h 40m
Fri 11/67:55 pm -
1 stop5h 15m
Deal found 10/14![Southwest logo]()
$323
This deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am -
1 stop5h 21m
Fri 11/63:29 pm -
1 stop4h 54m
Deal found 10/14![United Airlines logo]()
$327
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:06 am -
1 stop5h 50m
Wed 11/181:52 pm -
1 stop6h 00m
Deal found 10/14![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/71:45 pm -
1 stop4h 50m
Wed 11/183:25 pm -
2 stops8h 05m
Deal found 10/14![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/710:47 am -
1 stop5h 37m
Sun 11/225:20 am -
1 stop4h 40m
Deal found 10/15![Delta logo]()
$320
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:26 pm -
1 stop4h 51m
Thu 11/127:00 am -
1 stop5h 35m
Deal found 10/16![American Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:26 pm -
1 stop15h 12m
Wed 11/183:42 pm -
2 stops27h 57m
Deal found 10/16![Multiple Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:26 am -
1 stop6h 58m
Wed 11/1812:17 pm -
1 stop5h 26m
Deal found 10/16![American Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1110:30 am -
1 stop5h 55m
Wed 11/1811:00 am -
2 stops7h 25m
Deal found 10/14![Southwest logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/164:26 pm -
1 stop15h 12m
Tue 12/83:00 pm -
2 stops21h 17m
Deal found 10/17![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:05 pm -
1 stop13h 33m
Thu 12/36:45 am -
2 stops29h 32m
Deal found 10/18![Multiple Airlines logo]()
$316
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1412:02 pm -
2 stops19h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:34 pm -
2 stops37h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$108
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/91:00 pm -
1 stop5h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![United Airlines logo]()
$109
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am -
1 stop5h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![American Airlines logo]()
$114
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:00 am -
2 stops8h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![United Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1111:06 am -
1 stop30h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Multiple Airlines logo]()
$124
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:44 am -
1 stop6h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![American Airlines logo]()
$130
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:55 pm -
1 stop6h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Southwest logo]()
$135
This United Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:31 am -
2 stops8h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![United Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/235:01 pm -
1 stop14h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![Allegiant Air logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:13 pm -
1 stop13h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Multiple Airlines logo]()
$139
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:00 am -
2 stops9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Southwest logo]()
$140
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (American Airlines) |
One-way from | $97 (Kiwi.com) |
Popular in | April |
Cheapest in | February |
Average price | $412 |
Good round-trip deal | $246 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 12/12
2:33 pm-7:22 pm
1 stop3h 49m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 12/15
10:06 am-4:27 pm
1 stop5h 21m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Fri 12/11
2:33 pm-10:02 pm
1 stop6h 29m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$114
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 11/23
5:00 am-2:28 pm
2 stops8h 28m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$119
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Fri 11/13
5:50 pm-11:00 pm
1 stop4h 10m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$130
Kansas CityMyrtle Beach
MCI Kansas City - MYR Myrtle Beach Intl
MCIMYR
Kansas City
Wed 11/11
3:00 pm-10:29 pm
1 stop6h 29m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Kansas CityMyrtle Beach
MCI Kansas City - MYR Myrtle Beach Intl
MCIMYR
Kansas City
Fri 11/13
3:50 pm-10:05 pm
1 stop5h 15m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Kansas CityMyrtle Beach
MCI Kansas City - MYR Myrtle Beach Intl
MCIMYR
Kansas City
Fri 11/6
12:55 pm-8:20 pm
1 stop6h 25m
Myrtle Beach Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$135
Kansas CityGreenville
MCI Kansas City - GSP Greenville
MCIGSP
Kansas City
Mon 11/23
5:01 pm-8:14 am
1 stop14h 13m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$139
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Tue 12/1
6:13 pm-8:38 am
1 stop13h 25m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$139
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CHS
MCI-CHS
MCI-GSP
MCI-MYR
STL-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CHS
MCI-CHS
MCI-GSP
MCI-MYR
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $358). Flying from Missouri to South Carolina in April is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 19, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
Airfare is below average for this route at the moment.
Missouri to South Carolina flights typically cost between $307 and $529 in November.The cheapest round-trip price found within the last 5 days was $227 on American Airlines (Nov 4-Nov 6).
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 41 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 19, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Boarding
8.1
Overall
7.9
Entertainment
7.5
Food
7.0
Comfort
8.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on October 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 4 airlines flying from Missouri to South Carolina
Discover the top 4 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$195 | Average$441 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$400 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$383 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$245 | Average$439 | FlexibilityNo cancel fee | On-time63% |