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South Carolina

$70+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated August 14, 2025.

Round-trip from

$139
(American Airlines)

One-way from

$70
(American Airlines)

Popular in

March

Cheapest in

November

Average price

$356

Good round-trip deal

$207 or less
From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Highest demand for flights based on searches. 6% potential increase in price ($27 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/24:05 pmMCI - CLT
Nonstop2h 19mAmerican Airlines
Tue 12/91:00 pmCLT - MCI
Nonstop2h 27mAmerican Airlines
Deal found 8/12$139
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/812:40 pmMCI - CLT
Nonstop2h 18mAmerican Airlines
Mon 10/134:19 pmCLT - MCI
Nonstop2h 26mAmerican Airlines
Deal found 8/12$156
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/107:55 pmSTL - CLT
1 stop19h 30mFrontier
Sun 9/218:51 pmCLT - STL
1 stop17h 11mFrontier
Deal found 8/14$165
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/253:50 pmMCI - CLT
Nonstop2h 23mAmerican Airlines
Mon 9/2910:38 amCLT - MCI
Nonstop2h 31mAmerican Airlines
Deal found 8/12$173
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:00 amSTL - CHS
1 stop6h 11mAmerican Airlines
Sun 9/145:00 amCHS - STL
1 stop4h 05mAmerican Airlines
Deal found 8/11$173
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/141:30 pmMCI - CLT
1 stop4h 30mSouthwest
Tue 11/185:10 pmCLT - MCI
1 stop6h 20mSouthwest
Deal found 8/12$175
This Priceline deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/212:02 pmSTL - CLT
1 stop5h 44mFrontier
Mon 8/259:42 amCLT - STL
1 stop5h 39mFrontier
Deal found 8/13$176
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/67:01 amSTL - CHS
2 stops8h 35mAmerican Airlines
Fri 9/194:22 pmCHS - STL
1 stop5h 48mAmerican Airlines
Deal found 8/12$178
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/107:55 pmSTL - CLT
1 stop19h 30mFrontier
Mon 9/155:20 pmCLT - STL
1 stop16h 46mFrontier
Deal found 8/14$181
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:55 pmSTL - CLT
1 stop19h 48mFrontier
Sun 10/58:51 pmCLT - STL
1 stop24h 46mFrontier
Deal found 8/14$187
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/276:10 amSTL - CHS
1 stop4h 20mAmerican Airlines
Sat 10/47:28 pmCHS - STL
1 stop4h 39mAmerican Airlines
Deal found 8/14$187
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/131:45 pmSTL - CLT
Nonstop1h 50mSouthwest
Wed 9/175:25 pmCLT - STL
Nonstop2h 05mSouthwest
Deal found 8/12$189

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Tue 12/2

6:36 pm-9:55 pm

Nonstop2h 19m

Charlotte Douglas

Tue 12/9

1:00 pm-2:27 pm

Nonstop2h 27m

$139

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 9/10

8:00 am-11:27 am

Nonstop2h 27m

Charlotte Douglas

Wed 9/17

10:38 am-12:09 pm

Nonstop2h 31m

$139

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 10/8

6:14 am-9:35 am

Nonstop2h 21m

Charlotte Douglas

Mon 10/13

10:40 pm-12:09 am

Nonstop2h 29m

$156

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Tue 10/7

12:49 pm-4:07 pm

Nonstop2h 18m

Charlotte Douglas

Mon 10/13

10:40 pm-12:09 am

Nonstop2h 29m

$156

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 10/29

6:14 am-9:35 am

Nonstop2h 21m

Charlotte Douglas

Sun 11/2

10:27 pm-12:02 am

Nonstop2h 35m

$156

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 9/11

10:49 am-11:22 am

1 stop23h 33m

Charlotte Douglas

Thu 9/18

5:20 pm-9:06 am

1 stop16h 46m

$165

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 9/10

7:55 pm-4:25 pm

1 stop19h 30m

Charlotte Douglas

Sun 9/21

8:51 pm-1:02 pm

1 stop17h 11m

$165

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 9/19

1:57 pm-1:01 pm

1 stop22h 04m

Charlotte Douglas

Sun 9/21

5:20 pm-9:06 am

1 stop16h 46m

$165

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 9/13

7:55 pm-4:25 pm

1 stop19h 30m

Charlotte Douglas

Sun 9/14

8:51 pm-1:02 pm

1 stop17h 11m

$165

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Wed 9/10

6:00 am-1:11 pm

1 stop6h 11m

Charleston

Sun 9/14

5:00 am-8:05 am

1 stop4h 05m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 14, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Spirit Airlines
6.3
Okay
8,045 reviews
Southwest
8.0
Very good
4,244 reviews

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Overall

8.0

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $70. Users have also found prices from $79 and $84 on Southwest and Frontier, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$99Average$252FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$375FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$199Average$411FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$446FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$237Average$398FlexibilityNo cancel feeOn-time63%

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