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South Carolina

$62+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated September 11, 2025.

Round-trip from

$124
(Southwest)

One-way from

$62
(Southwest)

Popular in

March

Cheapest in

November

Average price

$346

Good round-trip deal

$389 or less
From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($29 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/286:40 pmSTL - CLT
Nonstop1h 50mSouthwest
Wed 10/292:00 pmCLT - STL
Nonstop2h 00mSouthwest
Deal found 9/11$124
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:40 pmSTL - CLT
Nonstop1h 50mSouthwest
Tue 10/146:10 pmCLT - STL
1 stop4h 40mSouthwest
Deal found 9/10$144
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/76:25 amSTL - CLT
Nonstop1h 55mAmerican Airlines
Tue 10/148:38 amCLT - STL
Nonstop1h 59mAmerican Airlines
Deal found 9/9$157
This Booking.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:22 pmSTL - CLT
1 stop15h 20mFrontier
Fri 11/146:07 pmCLT - STL
1 stop16h 00mFrontier
Deal found 9/10$170
This Frontier deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/47:55 pmSTL - CLT
1 stop19h 30mFrontier
Mon 10/65:20 pmCLT - STL
1 stop16h 47mFrontier
Deal found 9/11$180
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/18:17 amSTL - CLT
Nonstop1h 58mAmerican Airlines
Sat 10/41:36 pmCLT - STL
1 stop7h 56mAmerican Airlines
Deal found 9/10$182
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/158:30 amSTL - CLT
Nonstop1h 55mAmerican Airlines
Sat 11/1512:16 pmCLT - STL
Nonstop2h 01mAmerican Airlines
Deal found 9/9$187
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/121:30 pmMCI - CLT
1 stop6h 40mSouthwest
Sat 11/158:15 amCLT - MCI
1 stop6h 50mSouthwest
Deal found 9/10$200
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:05 pmMCI - SAV
1 stop7h 20mSouthwest
Wed 10/87:35 amSAV - MCI
1 stop4h 55mSouthwest
Deal found 9/11$201
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/211:32 amMCI - CLT
1 stop9h 21mAmerican Airlines
Tue 12/91:47 pmCLT - MCI
1 stop8h 42mAmerican Airlines
Deal found 9/10$207
This Southwest deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2012:00 pmMCI - CLT
1 stop4h 40mSouthwest
Tue 12/26:10 amCLT - MCI
1 stop6h 15mSouthwest
Deal found 9/8$214
This Cheapflightsfares deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/25:15 amMCI - CLT
1 stop6h 38mSpirit Airlines
Sat 10/41:53 pmCLT - MCI
1 stop10h 14mSpirit Airlines
Deal found 9/9$217

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 10/7

6:40 pm-9:30 pm

Nonstop1h 50m

Charlotte Douglas

Tue 10/14

6:10 pm-9:50 pm

1 stop4h 40m

$144

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 10/8

6:25 am-9:20 am

Nonstop1h 55m

Charlotte Douglas

Wed 10/15

11:01 am-12:06 pm

Nonstop2h 05m

$157

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 10/28

8:55 am-3:45 pm

2 stops5h 50m

Charlotte Douglas

Wed 10/29

8:05 am-5:45 pm

2 stops10h 40m

$180

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 10/8

9:10 am-4:40 pm

1 stop6h 30m

Charlotte Douglas

Wed 10/15

9:39 am-12:35 pm

1 stop3h 56m

$197

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 11/12

1:30 pm-9:10 pm

1 stop6h 40m

Charlotte Douglas

Sat 11/15

8:15 am-2:05 pm

1 stop6h 50m

$200

Kansas CitySavannah

MCI - SAV

MCISAV

Kansas City

Wed 10/1

12:05 pm-8:25 pm

1 stop7h 20m

Savannah/Hilton Head

Wed 10/8

7:35 am-11:30 am

1 stop4h 55m

$201

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 3/2

10:00 am-4:03 pm

1 stop5h 03m

Charlotte Douglas

Wed 3/4

5:30 am-10:50 am

1 stop6h 20m

$205

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Thu 11/20

12:00 pm-5:40 pm

1 stop4h 40m

Charlotte Douglas

Tue 12/2

6:10 am-11:25 am

1 stop6h 15m

$214

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Sat 10/18

3:59 pm-8:51 pm

1 stop3h 52m

Charleston

Mon 10/20

8:03 pm-11:41 pm

1 stop4h 38m

$217

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Fri 11/14

11:12 am-10:12 am

2 stops22h 00m

Charlotte Douglas

Sun 11/16

10:42 pm-10:17 am

2 stops12h 35m

$219

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 11, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,937 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,023 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Food

7.0

Overall

8.0

Comfort

8.0

Crew

8.6

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to South Carolina?

    There are many flights that can get you from Missouri to South Carolina in 1h 50m. Fly via Southwest, American Airlines, or Delta to get the fastest option. There are 574 mi between Missouri and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $62. Users have also found prices from $102 and $103 on Spirit Airlines and Delta, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$99Average$218FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$370FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$204Average$403FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$223Average$457FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$257Average$398FlexibilityNo cancel feeOn-time63%

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