$95+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Sep 18 — Sep 251
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 19, 2026.
This Frontier deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:39 pm -
1 stop22h 42m
Mon 9/149:32 am -
1 stop8h 02m
Deal found 8/18![Frontier logo]()
$177
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:19 pm -
1 stop14h 16m
Thu 10/19:40 pm -
1 stop19h 54m
Deal found 8/17![Frontier logo]()
$186
This Trip.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:19 pm -
1 stop14h 16m
Mon 10/59:32 am -
1 stop8h 02m
Deal found 8/14![Frontier logo]()
$190
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:00 am -
Nonstop1h 57m
Sat 10/1710:55 pm -
Nonstop2h 04m
Deal found 8/17![American Airlines logo]()
$197
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:21 am -
Nonstop1h 54m
Tue 9/228:35 am -
Nonstop1h 54m
Deal found 8/16![American Airlines logo]()
$198
This Expedia deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:34 pm -
1 stop19h 04m
Sun 11/1510:02 pm -
1 stop22h 37m
Deal found 8/14![Frontier logo]()
$205
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:35 pm -
Nonstop1h 45m
Tue 10/61:15 pm -
1 stop7h 40m
Deal found 8/19![Southwest logo]()
$207
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:00 pm -
1 stop4h 56m
Thu 9/106:44 am -
1 stop6h 13m
Deal found 8/17![United Airlines logo]()
$212
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:39 pm -
1 stop12h 56m
Sun 9/279:40 pm -
1 stop19h 54m
Deal found 8/17![Frontier logo]()
$215
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/510:25 am -
1 stop4h 45m
Sat 11/76:00 am -
1 stop4h 42m
Deal found 8/18![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:40 pm -
Nonstop2h 00m
Sat 9/266:45 am -
Nonstop2h 00m
Deal found 8/17![Southwest logo]()
$217
This CheapOair deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:10 pm -
1 stop21h 49m
Fri 10/27:54 pm -
1 stop24h 23m
Deal found 8/18![Frontier logo]()
$218
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 19, 2026.
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:40 pm -
1 stop5h 41m
Mon 9/147:39 pm -
1 stop5h 03m
Deal found 8/15![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:40 pm -
Nonstop2h 00m
Sat 9/266:45 am -
Nonstop2h 00m
Deal found 8/16![Southwest logo]()
$217
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:00 am -
2 stops8h 00m
Thu 9/106:44 am -
1 stop4h 28m
Deal found 8/17![United Airlines logo]()
$262
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:34 pm -
2 stops7h 13m
Fri 10/235:00 am -
1 stop5h 34m
Deal found 8/14![American Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:43 pm -
2 stops24h 53m
Sun 10/2510:05 pm -
1 stop11h 21m
Deal found 8/18![Multiple Airlines logo]()
$390
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/195:35 pm -
1 stop5h 24m
Sat 10/247:02 am -
1 stop3h 40m
Deal found 8/18![Delta logo]()
$227
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:05 am -
2 stops9h 25m
Mon 10/265:35 am -
1 stop6h 25m
Deal found 8/14![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:40 pm -
1 stop4h 40m
Wed 9/166:45 am -
2 stops9h 05m
Deal found 8/14![Southwest logo]()
$232
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:54 pm -
1 stop4h 05m
Tue 10/66:30 am -
1 stop5h 21m
Deal found 8/19![Delta logo]()
$246
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/202:25 pm -
1 stop5h 40m
Fri 10/2310:40 am -
Nonstop1h 55m
Deal found 8/18![Southwest logo]()
$236
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:00 am -
2 stops8h 22m
Mon 11/26:00 am -
2 stops7h 10m
Deal found 8/17![United Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/511:20 am -
2 stops9h 06m
Fri 9/117:25 pm -
1 stop4h 34m
Deal found 8/19![American Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:05 am -
1 stop5h 25m
Thu 9/177:39 pm -
1 stop5h 03m
Deal found 8/16![Delta logo]()
$268
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:30 am -
1 stop4h 25m
Fri 9/186:30 pm -
1 stop4h 40m
Deal found 8/16![Southwest logo]()
$246
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:15 am -
1 stop6h 43m
Sun 9/136:30 am -
1 stop5h 09m
Deal found 8/15![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/301:00 pm -
1 stop7h 40m
Mon 11/28:55 pm -
1 stop4h 00m
Deal found 8/17![Southwest logo]()
$246
This American Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am -
1 stop4h 24m
Sat 8/295:00 pm -
1 stop8h 10m
Deal found 8/19![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:04 am -
1 stop6h 57m
Tue 11/107:01 pm -
1 stop5h 54m
Deal found 8/18![Delta logo]()
$292
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:53 am -
1 stop7h 47m
Tue 9/1511:37 am -
1 stop5h 01m
Deal found 8/18![United Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1710:05 am -
2 stops8h 35m
Tue 10/201:55 pm -
2 stops7h 05m
Deal found 8/15![Southwest logo]()
$256
This United Airlines deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:59 pm -
1 stop5h 41m
Fri 9/112:54 pm -
2 stops9h 44m
Deal found 8/19![United Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:18 pm -
1 stop5h 12m
Thu 8/2711:43 am -
1 stop5h 30m
Deal found 8/15![Delta logo]()
$303
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:18 pm -
1 stop5h 12m
Sat 8/296:00 am -
1 stop5h 15m
Deal found 8/15![Delta logo]()
$303
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:14 pm -
1 stop5h 05m
Thu 9/102:10 pm -
2 stops10h 49m
Deal found 8/16![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:35 pm -
Nonstop1h 45m
Sun 10/1110:40 am -
Nonstop1h 55m
Deal found 8/15![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:08 pm -
2 stops9h 24m
Sat 9/193:55 pm -
1 stop6h 52m
Deal found 8/16![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:40 am -
1 stop8h 05m
Sat 9/266:30 am -
2 stops10h 00m
Deal found 8/14![Southwest logo]()
$286
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:59 pm -
1 stop5h 56m
Sat 9/198:05 am -
1 stop5h 27m
Deal found 8/18![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
2 stops11h 52m
Fri 9/1110:08 am -
2 stops10h 24m
Deal found 8/16![United Airlines logo]()
$340
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1112:15 pm -
2 stops8h 40m
Mon 9/147:20 pm -
1 stop3h 50m
Deal found 8/18![Southwest logo]()
$295
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated August 19, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated August 19, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/93:45 pm -
1 stop4h 30m
Thu 9/1011:50 am -
Nonstop1h 55m
Deal found 8/17![Southwest logo]()
$207
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:00 pm -
1 stop4h 56m
Thu 9/106:44 am -
1 stop6h 13m
Deal found 8/17![United Airlines logo]()
$212
This Frontier deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:39 pm -
1 stop22h 42m
Mon 9/149:32 am -
1 stop8h 02m
Deal found 8/18![Frontier logo]()
$177
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:21 am -
Nonstop1h 54m
Tue 9/154:34 pm -
Nonstop1h 56m
Deal found 8/16![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:35 pm -
Nonstop2h 00m
Tue 9/157:35 am -
1 stop4h 45m
Deal found 8/16![Southwest logo]()
$222
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:21 am -
Nonstop1h 54m
Tue 9/228:35 am -
Nonstop1h 54m
Deal found 8/16![American Airlines logo]()
$198
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:05 am -
1 stop5h 06m
Tue 9/222:25 pm -
1 stop6h 33m
Deal found 8/19![Delta logo]()
$217
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:45 pm -
1 stop3h 45m
Tue 9/221:30 pm -
2 stops6h 30m
Deal found 8/16![Southwest logo]()
$222
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:19 pm -
1 stop14h 16m
Thu 10/19:40 pm -
1 stop19h 54m
Deal found 8/17![Frontier logo]()
$186
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:40 pm -
Nonstop2h 00m
Sat 9/266:45 am -
Nonstop2h 00m
Deal found 8/14![Southwest logo]()
$217
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/246:39 pm -
1 stop12h 56m
Sun 9/279:40 pm -
1 stop19h 54m
Deal found 8/17![Frontier logo]()
$215
This CheapOair deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/308:10 pm -
1 stop21h 49m
Fri 10/27:54 pm -
1 stop24h 23m
Deal found 8/18![Frontier logo]()
$218
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 19, 2026.
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:19 pm -
1 stop14h 16m
Deal found 8/17![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/142:29 pm -
2 stops17h 09m
Deal found 8/15![Multiple Airlines logo]()
$95
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/194:30 pm -
1 stop21h 44m
Deal found 8/17![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:29 pm -
2 stops41h 06m
Deal found 8/19![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1610:35 am -
2 stops21h 03m
Deal found 8/15![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:35 am -
2 stops44h 05m
Deal found 8/14![Frontier logo]()
$107
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:05 am -
1 stop5h 25m
Deal found 8/19![Delta logo]()
$109
This Frontier deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/1411:20 am -
1 stop6h 39m
Deal found 8/14![Frontier logo]()
$109
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:35 pm -
Nonstop2h 00m
Deal found 8/15![Southwest logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:29 pm -
2 stops22h 39m
Deal found 8/17![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:35 pm -
2 stops37h 03m
Deal found 8/14![Multiple Airlines logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:35 pm -
2 stops37h 12m
Deal found 8/14![Frontier logo]()
$113
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated August 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $177 (Frontier) |
One-way from | $95 (CheapOair) |
Popular in | November |
Cheapest in | October |
Average price | $411 |
Good round-trip deal | $469 or less |
Good one-way deal | $444 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Thu 9/10
1:40 pm-8:21 pm
1 stop5h 41m
Charlotte Douglas
Mon 9/14
7:39 pm-11:42 pm
1 stop5h 03m
$217
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 9/19
1:40 pm-4:40 pm
Nonstop2h 00m
Charleston
Sat 9/26
6:45 am-7:45 am
Nonstop2h 00m
$217
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Mon 10/19
5:35 pm-11:59 pm
1 stop5h 24m
Charleston
Sat 10/24
7:02 am-9:42 am
1 stop3h 40m
$227
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 10/24
6:05 am-4:30 pm
2 stops9h 25m
Charleston
Mon 10/26
5:35 am-11:00 am
1 stop6h 25m
$232
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Wed 9/9
1:40 pm-7:20 pm
1 stop4h 40m
Charleston
Wed 9/16
6:45 am-2:50 pm
2 stops9h 05m
$232
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Tue 10/20
2:25 pm-9:05 pm
1 stop5h 40m
Charlotte Douglas
Fri 10/23
10:40 am-11:35 am
Nonstop1h 55m
$236
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Fri 10/2
6:54 pm-11:59 pm
1 stop4h 05m
Charleston
Tue 10/6
6:30 am-10:51 am
1 stop5h 21m
$246
St. LouisCharlotte
STL Lambert-St Louis - CLT Charlotte Douglas
STLCLT
Lambert-St Louis
Tue 9/15
6:30 am-11:55 am
1 stop4h 25m
Charlotte Douglas
Fri 9/18
6:30 pm-10:10 pm
1 stop4h 40m
$246
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Fri 10/30
1:00 pm-9:40 pm
1 stop7h 40m
Charleston
Mon 11/2
8:55 pm-11:55 pm
1 stop4h 00m
$246
St. LouisCharleston
STL Lambert-St Louis - CHS Charleston
STLCHS
Lambert-St Louis
Sat 10/17
10:05 am-7:40 pm
2 stops8h 35m
Charleston
Tue 10/20
1:55 pm-8:00 pm
2 stops7h 05m
$256
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
STL-CHS
MCI-MYR
MCI-CHS
COU-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
STL-CHS
MCI-MYR
MCI-CHS
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, October is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $351). Flying from Missouri to South Carolina in April is currently the most expensive (average of $468). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 19, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
Airfare is below average for this route at the moment.
Missouri to South Carolina flights typically cost between $256 and $543 in September.The cheapest round-trip price found within the last 5 days was $217 on Southwest (Sep 19-Sep 26).
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 50 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 19, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Entertainment
7.5
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on August 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 4 airlines flying from Missouri to South Carolina
Discover the top 4 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$195 | Average$435 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$384 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$385 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$261 | Average$454 | FlexibilityNo cancel fee | On-time63% |