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South Carolina

$76+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated June 12, 2025.

Round-trip from

$157
(American Airlines)

One-way from

$76
(FlightHub)

Popular in

March

Cheapest in

August

Average price

$396

Good round-trip deal

$425 or less
From Missouri to South Carolina
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One-way flight from Missouri to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Price to beat on a round-trip flight from Missouri to South Carolina.
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/104:28 pmSTL - MYR
1 stop6h 34mAmerican Airlines
Tue 7/157:50 pmMYR - STL
1 stop5h 09mAmerican Airlines
Deal found 6/10$157
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/271:40 pmSTL - MYR
Nonstop1h 55mSouthwest
Thu 7/317:55 pmMYR - STL
1 stop4h 25mSouthwest
Deal found 6/10$167
This FlightHub deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/48:44 amSTL - MYR
1 stop7h 15mSpirit Airlines
Thu 9/1112:18 pmMYR - STL
1 stop20h 31mSpirit Airlines
Deal found 6/12$174
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1010:47 amSTL - CLT
1 stop5h 37mSpirit Airlines
Sun 7/136:29 pmCLT - STL
1 stop16h 23mSpirit Airlines
Deal found 6/10$183
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/217:25 amMCI - CLT
1 stop10h 35mSouthwest
Tue 8/265:25 pmCLT - MCI
1 stop5h 25mSouthwest
Deal found 6/11$186
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/277:11 pmSTL - MYR
1 stop3h 48mDelta
Thu 7/316:00 amMYR - STL
1 stop4h 41mDelta
Deal found 6/10$197
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:26 amSTL - CLT
Nonstop1h 58mAmerican Airlines
Thu 8/1410:55 pmCLT - STL
Nonstop2h 00mAmerican Airlines
Deal found 6/11$197
This FlightHub deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/188:44 amSTL - CHS
1 stop23h 49mSpirit Airlines
Sun 9/2110:28 amCHS - STL
1 stop22h 21mSpirit Airlines
Deal found 6/11$202
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/44:40 pmSTL - CLT
1 stop5h 20mSouthwest
Thu 8/77:50 pmCLT - STL
Nonstop2h 00mSouthwest
Deal found 6/10$207
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/3012:20 pmMCI - SAV
1 stop5h 45mSouthwest
Mon 11/35:30 pmSAV - MCI
1 stop7h 10mSouthwest
Deal found 6/12$217
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/76:00 amSTL - SAV
1 stop4h 37mAmerican Airlines
Mon 8/117:37 amSAV - STL
1 stop5h 58mAmerican Airlines
Deal found 6/10$217
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:00 amSTL - CLT
1 stop4h 01mDelta
Thu 8/149:53 amCLT - STL
1 stop5h 44mDelta
Deal found 6/10$217

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Thu 7/10

4:28 pm-12:02 am

1 stop6h 34m

Myrtle Beach Intl

Tue 7/15

7:50 pm-11:59 pm

1 stop5h 09m

$157

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Sun 7/27

1:40 pm-4:35 pm

Nonstop1h 55m

Myrtle Beach Intl

Thu 7/31

7:55 pm-11:20 pm

1 stop4h 25m

$167

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Thu 9/4

8:44 am-4:59 pm

1 stop7h 15m

Myrtle Beach Intl

Thu 9/11

12:18 pm-7:49 am

1 stop20h 31m

$174

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 7/10

10:47 am-5:24 pm

1 stop5h 37m

Charlotte Douglas

Sun 7/13

6:29 pm-9:52 am

1 stop16h 23m

$183

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Thu 8/21

7:25 am-7:00 pm

1 stop10h 35m

Charlotte Douglas

Tue 8/26

5:25 pm-9:50 pm

1 stop5h 25m

$186

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Sun 7/27

7:11 pm-11:59 pm

1 stop3h 48m

Myrtle Beach Intl

Thu 7/31

6:00 am-9:41 am

1 stop4h 41m

$197

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 8/12

6:26 am-9:24 am

Nonstop1h 58m

Charlotte Douglas

Thu 8/14

10:55 pm-11:55 pm

Nonstop2h 00m

$197

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 8/4

4:40 pm-11:00 pm

1 stop5h 20m

Charlotte Douglas

Thu 8/7

7:50 pm-8:50 pm

Nonstop2h 00m

$207

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 8/12

6:00 am-11:01 am

1 stop4h 01m

Charlotte Douglas

Thu 8/14

9:53 am-2:37 pm

1 stop5h 44m

$217

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Thu 8/7

6:00 am-11:37 am

1 stop4h 37m

Savannah/Hilton Head

Mon 8/11

7:37 am-12:35 pm

1 stop5h 58m

$217

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 12, 2025.
Read reviews from past customers who have flown Alaska Airlines, Southwest and Delta from Missouri to South Carolina. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
10,000 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,287 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,946 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,790 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Allegiant Air
7.3
Good
725 reviews
Alaska Airlines
8.0
Very good
10,000 reviews

Entertainment

7.1

Overall

8.0

Boarding

8.1

Food

7.1

Crew

8.5

Comfort

7.8

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Spirit Airlines. According to our data, you can fly for as low as $76. Users have also found prices from $79 and $84 on Southwest and American Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $217). Flying from Missouri to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$112Average$231FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$158Average$408FlexibilityNo cancel feeOn-time71%
DeltaCheapest$196Average$367FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$223Average$430FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$276Average$401FlexibilityNo cancel feeOn-time63%

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