$82+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
may. 11 — may. 181
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 11, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on abril 11, 2026.
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
lun. 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 4/10![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
vie. 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 4/6![Frontier logo]()
$171
This Frontier deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/319:06 pm
STL
- CLT
1 stop8h 53m
Frontier
mar. 6/97:58 pm
CLT
- STL
1 stop5h 11m
Frontier
Deal found 4/11![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/229:06 pm
STL
- CLT
1 stop8h 53m
Frontier
mar. 5/268:55 am
CLT
- STL
1 stop10h 11m
Frontier
Deal found 4/10![Frontier logo]()
$185
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/244:59 pm
STL
- CLT
1 stop22h 36m
Frontier
dom. 4/267:50 am
CLT
- STL
1 stop16h 29m
Frontier
Deal found 4/10![Frontier logo]()
$191
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/136:00 am
STL
- CHS
1 stop7h 47m
Delta
mar. 5/196:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
sáb. 5/25:51 pm
CLT
- MCI
1 stop20h 39m
Frontier
Deal found 4/10![Frontier logo]()
$212
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/84:19 pm
STL
- CLT
1 stop18h 15m
Frontier
sáb. 6/1312:29 pm
CLT
- STL
1 stop12h 40m
Frontier
Deal found 4/10![Frontier logo]()
$216
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/3010:35 am
STL
- CHS
2 stops7h 35m
Southwest
sáb. 6/67:15 pm
CHS
- STL
1 stop5h 15m
Southwest
Deal found 4/7![Southwest logo]()
$216
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/136:35 am
STL
- CHS
1 stop6h 00m
Southwest
mar. 5/197:15 pm
CHS
- STL
1 stop3h 45m
Southwest
Deal found 4/10![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/1212:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
lun. 5/182:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/7![Southwest logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/16:01 pm
MCI
- CLT
1 stop21h 34m
Multiple Airlines
dom. 5/312:16 pm
CLT
- MCI
1 stop22h 13m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$231
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 11, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated abril 11, 2026.
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/15:20 pm
STL
- CHS
1 stop4h 36m
Delta
sáb. 6/66:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/210:15 am
STL
- CHS
2 stops8h 45m
Southwest
mar. 6/93:00 pm
CHS
- STL
2 stops9h 10m
Southwest
Deal found 4/10![Southwest logo]()
$237
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/261:13 pm
STL
- CHS
1 stop7h 35m
United Airlines
mar. 6/3011:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Deal found 4/6![United Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/152:11 pm
MCI
- CLT
Nonstop2h 27m
American Airlines
lun. 5/184:30 pm
CLT
- MCI
1 stop6h 51m
American Airlines
Deal found 4/10![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/61:45 pm
STL
- CLT
1 stop6h 10m
Southwest
mié. 5/136:25 pm
CLT
- STL
1 stop4h 45m
Southwest
Deal found 4/10![Southwest logo]()
$259
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/21:03 pm
STL
- CHS
1 stop6h 38m
Delta
vie. 5/84:55 pm
CHS
- STL
1 stop5h 43m
Delta
Deal found 4/6![Delta logo]()
$284
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/174:00 pm
STL
- CLT
1 stop4h 10m
Southwest
lun. 6/224:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 4/6![Southwest logo]()
$260
This United Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/57:45 am
STL
- CHS
1 stop5h 06m
United Airlines
mié. 5/65:08 pm
CHS
- STL
1 stop5h 05m
United Airlines
Deal found 4/7![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/28:45 am
STL
- CLT
1 stop5h 15m
Southwest
dom. 5/312:50 pm
CLT
- STL
Nonstop2h 05m
Southwest
Deal found 4/6![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/15:41 pm
STL
- CLT
1 stop6h 04m
United Airlines
mar. 6/910:27 am
CLT
- STL
2 stops11h 49m
United Airlines
Deal found 4/9![United Airlines logo]()
$323
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/109:40 am
STL
- CLT
2 stops7h 00m
Southwest
vie. 6/127:05 pm
CLT
- STL
1 stop4h 45m
Southwest
Deal found 4/6![Southwest logo]()
$275
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/286:50 pm
STL
- MYR
1 stop4h 24m
Delta
lun. 5/43:49 pm
MYR
- STL
1 stop6h 30m
Delta
Deal found 4/9![Delta logo]()
$333
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/610:25 am
STL
- SAV
1 stop6h 24m
United Airlines
jue. 5/75:45 am
SAV
- STL
1 stop5h 43m
United Airlines
Deal found 4/6![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/512:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
vie. 5/82:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/8![Southwest logo]()
$277
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/29:31 am
STL
- SAV
1 stop3h 51m
Delta
sáb. 5/96:36 am
SAV
- STL
1 stop6h 18m
Delta
Deal found 4/10![Delta logo]()
$337
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/277:16 am
COU
- CLT
Nonstop2h 14m
American Airlines
mar. 7/79:28 pm
CLT
- COU
Nonstop2h 12m
American Airlines
Deal found 4/10![American Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/67:05 pm
STL
- SAV
1 stop3h 35m
Delta
sáb. 6/136:00 am
SAV
- STL
1 stop4h 08m
Delta
Deal found 4/9![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/93:22 pm
MCI
- SAV
2 stops7h 37m
United Airlines
sáb. 5/166:00 am
SAV
- MCI
1 stop6h 25m
United Airlines
Deal found 4/10![United Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/11:45 pm
STL
- CLT
2 stops7h 55m
Southwest
lun. 5/44:20 pm
CLT
- STL
2 stops7h 25m
Southwest
Deal found 4/6![Southwest logo]()
$285
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/225:20 pm
STL
- SAV
1 stop4h 09m
Delta
mar. 5/265:30 am
SAV
- STL
1 stop3h 48m
Delta
Deal found 4/6![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 4/227:45 am
STL
- MYR
1 stop5h 32m
United Airlines
vie. 4/243:15 pm
MYR
- STL
1 stop6h 58m
United Airlines
Deal found 4/8![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/105:40 am
STL
- CLT
1 stop4h 30m
Southwest
sáb. 9/58:25 am
CLT
- STL
2 stops10h 45m
Southwest
Deal found 4/9![Southwest logo]()
$288
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/312:58 pm
SGF
- CLT
Nonstop2h 12m
American Airlines
dom. 9/64:27 pm
CLT
- SGF
Nonstop2h 18m
American Airlines
Deal found 4/11![American Airlines logo]()
$485
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 6/197:08 am
STL
- SAV
1 stop6h 40m
Delta
lun. 6/227:05 pm
SAV
- STL
1 stop5h 51m
Delta
Deal found 4/9![Delta logo]()
$341
This United Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/306:00 am
STL
- SAV
2 stops7h 43m
United Airlines
vie. 6/58:00 am
SAV
- STL
1 stop5h 11m
United Airlines
Deal found 4/8![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/175:40 am
STL
- CLT
2 stops7h 55m
Southwest
sáb. 8/298:25 am
CLT
- STL
2 stops6h 00m
Southwest
Deal found 4/7![Southwest logo]()
$293
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/147:01 pm
STL
- SAV
1 stop3h 39m
Delta
mar. 5/195:05 pm
SAV
- STL
1 stop5h 33m
Delta
Deal found 4/7![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/109:40 am
STL
- CLT
2 stops7h 00m
Southwest
sáb. 9/128:25 am
CLT
- STL
2 stops6h 10m
Southwest
Deal found 4/9![Southwest logo]()
$293
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/35:00 am
COU
- CLT
1 stop7h 50m
United Airlines
sáb. 6/66:15 am
CLT
- COU
1 stop5h 33m
United Airlines
Deal found 4/6![United Airlines logo]()
$380
This Delta deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/102:10 pm
MCI
- CLT
1 stop6h 45m
Delta
dom. 6/148:01 am
CLT
- MCI
1 stop5h 14m
Delta
Deal found 4/10![Delta logo]()
$355
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated abril 11, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated abril 11, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
vie. 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 4/6![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/244:59 pm
STL
- CLT
1 stop22h 36m
Frontier
dom. 4/267:50 am
CLT
- STL
1 stop16h 29m
Frontier
Deal found 4/10![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
sáb. 5/25:51 pm
CLT
- MCI
1 stop20h 39m
Frontier
Deal found 4/10![Frontier logo]()
$212
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
lun. 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 4/10![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/16:01 pm
MCI
- CLT
1 stop21h 34m
Multiple Airlines
dom. 5/312:16 pm
CLT
- MCI
1 stop22h 13m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$231
This Kiwi.com deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/94:19 pm
STL
- CHS
1 stop15h 19m
Multiple Airlines
sáb. 5/163:44 pm
CHS
- STL
1 stop9h 37m
Multiple Airlines
Deal found 4/9![Multiple Airlines logo]()
$233
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/1212:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
lun. 5/182:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 4/7![Southwest logo]()
$228
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/136:00 am
STL
- CHS
1 stop7h 47m
Delta
mar. 5/196:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/7![Delta logo]()
$211
This Southwest deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/136:35 am
STL
- CHS
1 stop6h 00m
Southwest
mar. 5/197:15 pm
CHS
- STL
1 stop3h 45m
Southwest
Deal found 4/10![Southwest logo]()
$227
This Frontier deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/229:06 pm
STL
- CLT
1 stop8h 53m
Frontier
mar. 5/268:55 am
CLT
- STL
1 stop10h 11m
Frontier
Deal found 4/10![Frontier logo]()
$185
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/3010:35 am
STL
- CHS
2 stops7h 35m
Southwest
sáb. 6/67:15 pm
CHS
- STL
1 stop5h 15m
Southwest
Deal found 4/7![Southwest logo]()
$216
This Frontier deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 5/319:06 pm
STL
- CLT
1 stop8h 53m
Frontier
mar. 6/97:58 pm
CLT
- STL
1 stop5h 11m
Frontier
Deal found 4/11![Frontier logo]()
$180
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated abril 11, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated abril 11, 2026.
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 4/10![Frontier logo]()
$82
This Priceline deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 6/66:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 4/6![Frontier logo]()
$90
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 5/84:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 4/10![Frontier logo]()
$91
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 5/74:19 pm
STL
- CLT
1 stop23h 24m
Frontier
Deal found 4/10![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 6/84:19 pm
STL
- CLT
1 stop18h 15m
Frontier
Deal found 4/10![Frontier logo]()
$94
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/106:58 pm
STL
- CLT
1 stop11h 17m
Frontier
Deal found 4/8![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 6/101:45 pm
MCI
- CLT
1 stop6h 39m
Frontier
Deal found 4/8![Frontier logo]()
$95
This Expedia deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 4/7![Frontier logo]()
$96
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 5/137:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Deal found 4/7![American Airlines logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 6/96:31 pm
STL
- CLT
2 stops22h 17m
Frontier
Deal found 4/10![Frontier logo]()
$101
This Expedia deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 7/81:45 pm
MCI
- CLT
1 stop27h 34m
Frontier
Deal found 4/8![Frontier logo]()
$101
This CheapOair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 4/10![Frontier logo]()
$102
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated abril 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $151 (CheapOair) |
One-way from | $82 (CheapOair) |
Popular in | April |
Cheapest in | February |
Average price | $497 |
Good round-trip deal | $315 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 11, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
lun. 6/1
5:20 pm-10:56 pm
1 stop4h 36m
Charleston
sáb. 6/6
6:03 pm-11:59 pm
1 stop6h 56m
$211
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
mar. 6/2
10:15 am-8:00 pm
2 stops8h 45m
Charleston
mar. 6/9
3:00 pm-11:10 pm
2 stops9h 10m
$237
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
mié. 5/6
1:45 pm-8:55 pm
1 stop6h 10m
Charlotte Douglas
mié. 5/13
6:25 pm-10:10 pm
1 stop4h 45m
$259
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
mié. 6/17
4:00 pm-9:10 pm
1 stop4h 10m
Charlotte Douglas
lun. 6/22
4:40 pm-5:50 pm
Nonstop2h 10m
$260
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
sáb. 5/2
8:45 am-3:00 pm
1 stop5h 15m
Charlotte Douglas
dom. 5/3
12:50 pm-1:55 pm
Nonstop2h 05m
$273
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
mié. 6/10
9:40 am-5:40 pm
2 stops7h 00m
Charlotte Douglas
vie. 6/12
7:05 pm-10:50 pm
1 stop4h 45m
$275
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
mar. 5/5
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
vie. 5/8
2:15 pm-3:30 pm
Nonstop2h 15m
$277
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
sáb. 5/2
1:03 pm-8:41 pm
1 stop6h 38m
Charleston
vie. 5/8
4:55 pm-9:38 pm
1 stop5h 43m
$284
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
vie. 5/1
1:45 pm-10:40 pm
2 stops7h 55m
Charlotte Douglas
lun. 5/4
4:20 pm-10:45 pm
2 stops7h 25m
$285
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
vie. 6/26
1:13 pm-9:48 pm
1 stop7h 35m
Charleston
mar. 6/30
11:31 am-3:46 pm
1 stop5h 15m
$287
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
MCI-CLT
STL-CLT
STL-CHS
STL-MYR
MCI-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
MCI-CLT
STL-CLT
STL-CHS
STL-MYR
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated abril 11, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Missouri to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated abril 11, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Crew
8.6
Overall
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on abril 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated abril 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$363 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$404 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$406 | FlexibilityNo cancel fee | On-time63% |