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South Carolina

$55+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Frontier deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:30 pmSTL - CLT
1 stop5h 08mFrontier
Mon 12/89:20 pmCLT - STL
1 stop26h 13mFrontier
Deal found 11/6$124
This Booking.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/59:54 amSTL - CLT
1 stop10h 44mFrontier
Sat 12/68:52 amCLT - STL
1 stop14h 41mFrontier
Deal found 11/3$135
This Frontier deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:30 pmSTL - CLT
1 stop5h 08mFrontier
Sun 1/118:46 pmCLT - STL
1 stop12h 04mFrontier
Deal found 11/4$142
This Booking.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:30 pmSTL - CLT
1 stop15h 27mFrontier
Fri 12/1210:33 pmCLT - STL
1 stop25h 00mFrontier
Deal found 11/5$150
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:30 pmSTL - CLT
1 stop15h 27mFrontier
Tue 12/1610:45 amCLT - STL
1 stop12h 48mFrontier
Deal found 11/4$151
This Booking.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/264:13 pmSTL - CLT
1 stop16h 39mFrontier
Mon 12/12:47 pmCLT - STL
1 stop10h 10mFrontier
Deal found 11/4$153
This Booking.com deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:28 pmMCI - CLT
1 stop19h 49mFrontier
Mon 11/176:12 pmCLT - MCI
1 stop24h 07mFrontier
Deal found 11/3$162
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:30 pmSTL - CAE
1 stop22h 47mMultiple Airlines
Sun 1/1112:20 pmCAE - STL
1 stop11h 13mMultiple Airlines
Deal found 11/4$177
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:12 amSTL - CLT
Nonstop1h 57mAmerican Airlines
Sat 12/137:05 amCLT - STL
Nonstop2h 19mAmerican Airlines
Deal found 11/4$181
This Mytrip deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/196:00 amMCI - CLT
1 stop11h 54mMultiple Airlines
Sun 11/235:16 pmCLT - MCI
1 stop27h 17mMultiple Airlines
Deal found 11/4$183
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:15 pmSTL - CLT
Nonstop1h 45mSouthwest
Tue 12/166:10 amCLT - STL
1 stop5h 30mSouthwest
Deal found 11/4$191
This Mytrip deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3011:51 amSTL - CLT
1 stop7h 42mMultiple Airlines
Tue 1/138:41 pmCLT - STL
1 stop26h 56mMultiple Airlines
Deal found 11/5$194

Cheap flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$124
(Expedia)

One-way from

$55
(Priceline)

Popular in

November

Cheapest in

July

Average price

$451
Provider with most accurate pricing for Lambert-St Louis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Myrtle Beach Intl flights.
Search Deals
From Missouri to South Carolina
Search Deals
One-way flight from Missouri to South Carolina
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 1/28

5:11 pm-7:57 am

1 stop13h 46m

Charlotte Douglas

Fri 1/30

10:01 pm-10:33 pm

1 stop25h 32m

$135

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 12/10

3:30 pm-3:17 pm

1 stop22h 47m

Columbia Metropolitan

Sun 1/11

12:20 pm-10:33 pm

1 stop11h 13m

$177

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 12/3

5:45 pm-11:59 pm

1 stop5h 14m

Charlotte Douglas

Sun 12/7

6:30 am-10:39 am

1 stop5h 09m

$197

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 12/13

11:19 am-6:28 pm

1 stop6h 09m

Charlotte Douglas

Sun 12/14

6:33 am-10:45 am

1 stop5h 12m

$201

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 12/6

10:45 am-4:13 pm

1 stop4h 28m

Charlotte Douglas

Sat 12/13

2:12 pm-6:00 pm

1 stop4h 48m

$201

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Tue 3/31

6:00 am-11:20 am

1 stop4h 20m

Columbia Metropolitan

Sat 4/4

8:44 am-11:50 am

1 stop4h 06m

$211

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 12/30

7:05 am-10:07 am

Nonstop2h 02m

Charlotte Douglas

Tue 1/13

10:09 pm-11:12 pm

Nonstop2h 03m

$217

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 12/5

2:55 pm-5:40 pm

Nonstop1h 45m

Charlotte Douglas

Mon 12/8

6:20 pm-10:00 pm

1 stop4h 40m

$223

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 12/9

1:50 pm-8:50 pm

1 stop6h 00m

Charlotte Douglas

Wed 12/10

12:55 pm-2:05 pm

Nonstop2h 10m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 12/30

6:45 am-12:10 pm

1 stop4h 25m

Charlotte Douglas

Tue 1/13

8:25 am-9:35 am

Nonstop2h 10m

$227

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in March is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Missouri to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 6, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,240 reviews
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,004 reviews
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,003 reviews
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,042 reviews
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,114 reviews
Southwest
8.0
Very good
4,240 reviews

Comfort

8.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to South Carolina?

    There are many flights that can get you from Missouri to South Carolina in 5h 14m. Fly via Frontier, United Airlines, or Delta to get the fastest option. There are 806 mi between Missouri and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $69. Users have also found prices from $90 and $99 on Southwest and Spirit Airlines, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in March is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$84Average$220FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$372FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$204Average$408FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$237Average$399FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$248Average$318FlexibilityNo cancel feeOn-time69%

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