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South Carolina

$64+ Cheap flights from Missouri to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Missouri to South Carolina

Cheapest flights from Missouri to South Carolina
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 pmSTL - CHS
1 stop5h 45mAmerican Airlines
Wed 1/145:57 pmCHS - STL
1 stop5h 58mAmerican Airlines
Deal found 12/3$159
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:43 pmSTL - CLT
1 stop14h 39mFrontier
Sun 12/219:33 pmCLT - STL
1 stop13h 12mFrontier
Deal found 12/2$172
This Booking.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:43 pmSTL - CLT
1 stop20h 06mFrontier
Wed 12/1710:45 amCLT - STL
1 stop12h 48mFrontier
Deal found 12/3$174
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/159:54 amSTL - CLT
1 stop9h 31mFrontier
Tue 12/1610:45 amCLT - STL
1 stop12h 48mFrontier
Deal found 12/3$180
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/93:30 pmSTL - CLT
1 stop17h 20mFrontier
Thu 12/1110:33 pmCLT - STL
1 stop11h 26mFrontier
Deal found 12/2$192
This Mytrip deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:30 pmSTL - CLT
1 stop17h 20mFrontier
Fri 12/192:51 pmCLT - STL
1 stop5h 51mFrontier
Deal found 12/2$197
This Kiwi.com deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/206:15 pmMCI - CHS
1 stop26h 08mSpirit Airlines
Mon 12/2210:18 pmCHS - MCI
1 stop19h 52mSpirit Airlines
Deal found 12/2$207
This Priceline deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/143:30 pmSTL - CLT
1 stop5h 08mFrontier
Fri 12/192:51 pmCLT - STL
1 stop5h 51mFrontier
Deal found 12/3$212
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:30 pmSTL - CLT
1 stop27h 30mMultiple Airlines
Wed 12/1710:45 amCLT - STL
2 stops23h 55mMultiple Airlines
Deal found 12/3$213
This Southwest deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:20 pmSTL - CLT
1 stop4h 40mSouthwest
Tue 1/68:25 amCLT - STL
Nonstop2h 10mSouthwest
Deal found 12/2$216
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/163:30 pmSTL - CAE
2 stops39h 18mMultiple Airlines
Sun 1/1112:20 pmCAE - STL
1 stop20h 45mMultiple Airlines
Deal found 12/3$217
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:04 pmSTL - CLT
Nonstop1h 56mAmerican Airlines
Thu 12/259:00 amCLT - STL
Nonstop1h 59mAmerican Airlines
Deal found 12/2$217

Find flight deals from Missouri to South Carolina

Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$123
(American Airlines)

One-way from

$64
(Frontier)

Popular in

December

Cheapest in

July

Average price

$460
Provider with most accurate pricing for Lambert-St Louis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Myrtle Beach Intl flights.
Search Deals
From Missouri to South Carolina
Search Deals
One-way flight from Missouri to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($37 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

Fly from

Missouri

Fly to

South Carolina

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 1/24

8:13 am-11:11 am

Nonstop1h 58m

Charlotte Douglas

Sat 1/31

10:23 pm-11:26 pm

Nonstop2h 03m

$123

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Tue 2/24

6:00 am-11:37 am

1 stop4h 37m

Savannah/Hilton Head

Tue 3/3

6:25 am-12:31 pm

2 stops7h 06m

$164

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Wed 1/7

3:54 pm-11:16 pm

1 stop6h 22m

Savannah/Hilton Head

Tue 1/13

3:05 pm-9:51 pm

2 stops7h 46m

$164

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Tue 1/13

6:52 am-12:07 pm

1 stop4h 15m

Savannah/Hilton Head

Wed 1/21

3:05 pm-9:51 pm

2 stops7h 46m

$164

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Sun 2/1

8:41 pm-4:18 pm

1 stop18h 37m

Charlotte Douglas

Wed 2/4

7:43 pm-10:31 am

1 stop15h 48m

$173

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 1/24

10:19 am-4:05 pm

1 stop4h 46m

Charlotte Douglas

Sat 1/31

5:00 pm-8:43 pm

1 stop4h 43m

$177

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Sat 2/21

5:00 pm-9:31 pm

1 stop3h 31m

Savannah/Hilton Head

Sat 2/28

5:30 am-9:06 am

1 stop4h 36m

$181

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Thu 1/15

8:33 pm-6:42 pm

1 stop21h 09m

Charlotte Douglas

Wed 1/21

7:43 pm-10:31 am

1 stop15h 48m

$188

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 2/2

2:30 pm-5:15 pm

Nonstop1h 45m

Charlotte Douglas

Thu 2/5

5:05 pm-6:15 pm

Nonstop2h 10m

$194

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Tue 1/13

6:05 am-3:20 pm

2 stops8h 15m

Savannah/Hilton Head

Wed 1/21

11:15 am-7:00 pm

2 stops8h 45m

$196

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South Carolina

What is the cheapest month to book a flight from Missouri to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in March is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SC?

Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 38% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Missouri to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 4, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,250 reviews
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,011 reviews
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,066 reviews
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,047 reviews
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Spirit Airlines
6.3
Okay
8,157 reviews
Southwest
8.0
Very good
4,250 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Missouri to South Carolina flight route?

    The Missouri to South Carolina flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Missouri to South Carolina?

    There are many flights that can get you from Missouri to South Carolina in 1h 45m. Fly via American Airlines, Delta, or Southwest to get the fastest option. There are 574 mi between Missouri and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to South Carolina one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $83. Users have also found prices from $117 and $138 on Delta and Southwest, respectively.

  • Can I find deals for flights from Missouri to South Carolina that include hotel bookings?

    Yes. In addition to deals on Missouri to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South Carolina.

  • Can I find deals for business class flights from Missouri to South Carolina?

    Yes. Cheapflights offers flight deals from Missouri to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in March is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South Carolina

Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$84Average$217FlexibilityNo cancel feeOn-time65%
DeltaCheapest$150Average$373FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$204Average$410FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$237Average$399FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$248Average$318FlexibilityNo cancel feeOn-time69%

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