$66+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Feb 28 — Mar 71
1 adult, Economy
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$131
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/213:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Wed 2/252:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/27![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 1/28![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/273:49 pm
STL
- CLT
1 stop15h 44m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 1/28![Frontier logo]()
$150
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Thu 3/510:46 pm
CLT
- STL
1 stop9h 16m
Frontier
Deal found 1/28![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:49 pm
STL
- CLT
1 stop15h 09m
Multiple Airlines
Tue 2/245:49 pm
CLT
- STL
1 stop29h 38m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:22 pm
STL
- CLT
2 stops21h 55m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:51 pm
STL
- CLT
2 stops16h 52m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/28![Frontier logo]()
$161
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:17 pm
STL
- CLT
2 stops22h 00m
Multiple Airlines
Tue 3/32:46 pm
CLT
- STL
1 stop8h 41m
Multiple Airlines
Deal found 1/28![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:51 pm
STL
- CLT
2 stops16h 52m
Frontier
Mon 3/210:42 pm
CLT
- STL
1 stop24h 45m
Frontier
Deal found 1/27![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:24 pm
MCI
- CLT
1 stop14h 34m
Multiple Airlines
Wed 3/41:24 pm
CLT
- MCI
1 stop22h 06m
Multiple Airlines
Deal found 1/27![Multiple Airlines logo]()
$177
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated January 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $125 (Kiwi.com) |
One-way from | $66 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $415 |
Good round-trip deal | $360 or less |
Good one-way deal | $216 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Missouri
Fly to
South Carolina
Route
Depart
Return
Price
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Mon 3/9
11:26 am-8:26 am
1 stop20h 00m
Charlotte Douglas
Thu 3/12
1:24 pm-10:23 am
1 stop21h 59m
$187
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Wed 2/25
4:24 pm-10:17 am
1 stop16h 53m
Charlotte Douglas
Wed 3/4
1:24 pm-10:30 am
1 stop22h 06m
$187
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 3/2
3:49 pm-8:38 am
1 stop15h 49m
Charleston
Tue 3/3
5:00 pm-6:51 am
2 stops14h 51m
$188
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Sat 5/16
12:12 pm-12:40 am
1 stop11h 28m
Charlotte Douglas
Sat 5/23
6:00 am-11:07 am
1 stop6h 07m
$201
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Thu 3/5
11:26 am-8:26 am
1 stop20h 00m
Charlotte Douglas
Sun 3/8
7:13 pm-10:30 am
1 stop16h 17m
$207
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Fri 2/27
11:26 am-11:56 pm
1 stop11h 30m
Charlotte Douglas
Sun 3/1
9:52 pm-9:53 am
2 stops13h 01m
$212
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Mon 4/20
12:12 pm-9:42 am
1 stop20h 30m
Myrtle Beach Intl
Fri 4/24
7:51 pm-11:07 am
1 stop16h 16m
$226
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Wed 2/18
4:39 pm-9:34 am
2 stops15h 55m
Charlotte Douglas
Sun 2/22
3:07 pm-3:29 pm
1 stop25h 22m
$229
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 2/25
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Wed 3/4
8:25 am-9:35 am
Nonstop2h 10m
$231
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 2/24
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Tue 3/3
8:25 am-9:35 am
Nonstop2h 10m
$231
Showing 1-10 of 60 results
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated January 29, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$84 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$368 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$409 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$397 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$268 | Average$318 | FlexibilityNo cancel fee | On-time69% |