$70+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 19 — Apr 261
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 20, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 20, 2026.
This Priceline deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/20![Frontier logo]()
$140
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:19 pm
STL
- CLT
1 stop21h 35m
Frontier
Wed 4/157:49 pm
CLT
- STL
1 stop24h 32m
Frontier
Deal found 3/20![Frontier logo]()
$151
This Expedia deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/54:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Sun 4/128:10 am
CLT
- STL
1 stop24h 41m
Frontier
Deal found 3/20![Frontier logo]()
$160
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/20![Frontier logo]()
$171
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/19![Frontier logo]()
$180
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/15![Frontier logo]()
$189
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Sun 4/267:50 am
CLT
- STL
1 stop16h 29m
Frontier
Deal found 3/20![Frontier logo]()
$192
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Thu 4/94:18 pm
CLT
- STL
1 stop8h 07m
Frontier
Deal found 3/19![Frontier logo]()
$195
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Sat 4/187:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/16![American Airlines logo]()
$197
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Fri 4/104:33 pm
CLT
- STL
1 stop8h 25m
Frontier
Deal found 3/19![Frontier logo]()
$201
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/15![Frontier logo]()
$205
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/612:40 pm
STL
- CHS
1 stop4h 55m
Southwest
Wed 5/133:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/18![Southwest logo]()
$227
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 20, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 20, 2026.
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/162:25 pm
STL
- CLT
1 stop5h 50m
Southwest
Wed 5/207:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 3/17![Southwest logo]()
$238
This United Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:30 am
STL
- CHS
2 stops7h 23m
United Airlines
Sat 4/185:00 pm
CHS
- STL
1 stop5h 13m
United Airlines
Deal found 3/19![United Airlines logo]()
$253
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/86:00 am
STL
- CLT
1 stop6h 41m
Delta
Sat 4/116:00 am
CLT
- STL
1 stop4h 46m
Delta
Deal found 3/19![Delta logo]()
$301
This American Airlines deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:49 am
SGF
- CLT
Nonstop2h 21m
American Airlines
Mon 6/89:23 am
CLT
- SGF
Nonstop2h 34m
American Airlines
Deal found 3/15![American Airlines logo]()
$460
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 4/188:00 am
CHS
- STL
1 stop7h 00m
Southwest
Deal found 3/19![Southwest logo]()
$238
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1212:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Sat 5/164:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/15![Southwest logo]()
$239
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:35 am
STL
- CHS
2 stops10h 05m
Southwest
Tue 5/197:15 pm
CHS
- STL
1 stop3h 45m
Southwest
Deal found 3/17![Southwest logo]()
$242
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:30 am
STL
- CHS
1 stop4h 47m
United Airlines
Wed 5/1310:15 am
CHS
- STL
2 stops11h 58m
United Airlines
Deal found 3/16![United Airlines logo]()
$312
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:15 am
STL
- CLT
1 stop6h 05m
Southwest
Wed 4/226:40 am
CLT
- STL
2 stops9h 10m
Southwest
Deal found 3/19![Southwest logo]()
$243
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
SGF
- SAV
1 stop4h 20m
Delta
Sat 9/197:00 am
SAV
- SGF
1 stop5h 01m
Delta
Deal found 3/17![Delta logo]()
$329
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/216:00 am
STL
- CLT
1 stop4h 05m
Delta
Sat 5/306:59 am
CLT
- STL
1 stop3h 40m
Delta
Deal found 3/18![Delta logo]()
$332
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:00 am
SGF
- SAV
2 stops11h 15m
United Airlines
Tue 4/285:04 pm
SAV
- SGF
1 stop6h 00m
United Airlines
Deal found 3/16![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/162:25 pm
STL
- CHS
1 stop3h 45m
Southwest
Tue 5/197:40 am
CHS
- STL
2 stops8h 35m
Southwest
Deal found 3/15![Southwest logo]()
$264
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:15 am
STL
- SAV
1 stop5h 34m
United Airlines
Fri 5/84:55 pm
SAV
- STL
1 stop5h 18m
United Airlines
Deal found 3/16![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/146:45 am
STL
- CLT
1 stop4h 18m
Delta
Sun 6/147:59 pm
CLT
- STL
1 stop4h 39m
Delta
Deal found 3/19![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:05 pm
MCI
- SAV
1 stop5h 10m
United Airlines
Wed 4/225:45 am
SAV
- MCI
2 stops9h 40m
United Airlines
Deal found 3/16![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/34:41 pm
STL
- MYR
1 stop6h 33m
Delta
Sun 5/107:55 pm
MYR
- STL
1 stop5h 04m
Delta
Deal found 3/18![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:45 pm
STL
- CHS
2 stops6h 05m
Southwest
Mon 5/117:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 3/16![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:45 am
STL
- SAV
1 stop6h 28m
United Airlines
Sat 5/912:18 pm
SAV
- STL
1 stop5h 21m
United Airlines
Deal found 3/18![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
STL
- MYR
1 stop6h 31m
Delta
Tue 4/76:54 pm
MYR
- STL
1 stop6h 04m
Delta
Deal found 3/18![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/110:30 am
STL
- CLT
2 stops10h 35m
Southwest
Wed 4/87:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 3/19![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/176:00 am
STL
- SAV
1 stop7h 16m
United Airlines
Mon 6/2211:30 am
SAV
- STL
1 stop5h 16m
United Airlines
Deal found 3/20![United Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:56 pm
SGF
- SAV
1 stop3h 47m
Delta
Sun 4/512:33 pm
SAV
- SGF
1 stop6h 38m
Delta
Deal found 3/16![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:45 pm
STL
- CLT
2 stops7h 55m
Southwest
Mon 6/87:10 am
CLT
- STL
2 stops12h 20m
Southwest
Deal found 3/19![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Tue 6/96:00 am
CLT
- STL
2 stops10h 46m
United Airlines
Deal found 3/16![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:52 pm
SGF
- SAV
1 stop3h 48m
Delta
Mon 5/1812:34 pm
SAV
- SGF
1 stop6h 32m
Delta
Deal found 3/19![Delta logo]()
$354
This Southwest deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/301:45 pm
STL
- CLT
1 stop7h 15m
Southwest
Sun 5/312:50 pm
CLT
- STL
Nonstop2h 05m
Southwest
Deal found 3/19![Southwest logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:15 am
SGF
- SAV
1 stop6h 12m
United Airlines
Mon 4/65:04 pm
SAV
- SGF
1 stop8h 32m
United Airlines
Deal found 3/18![United Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:20 am
STL
- SAV
1 stop6h 26m
Delta
Mon 6/2212:26 pm
SAV
- STL
1 stop4h 32m
Delta
Deal found 3/15![Delta logo]()
$367
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1610:15 am
STL
- CLT
2 stops7h 30m
Southwest
Sat 4/1810:55 am
CLT
- STL
2 stops8h 10m
Southwest
Deal found 3/17![Southwest logo]()
$314
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated March 20, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated March 20, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/19![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Fri 4/104:33 pm
CLT
- STL
1 stop8h 25m
Frontier
Deal found 3/19![Frontier logo]()
$201
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/44:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Thu 4/94:18 pm
CLT
- STL
1 stop8h 07m
Frontier
Deal found 3/19![Frontier logo]()
$195
This Frontier deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/54:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Thu 4/94:18 pm
CLT
- STL
1 stop8h 07m
Frontier
Deal found 3/19![Frontier logo]()
$160
This Frontier deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/15![Frontier logo]()
$205
This Cheapflightsfares deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:24 pm
MCI
- CLT
1 stop11h 14m
Spirit Airlines
Thu 4/92:47 pm
CLT
- MCI
1 stop10h 06m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$235
This American Airlines deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/117:00 am
STL
- CLT
Nonstop2h 02m
American Airlines
Sat 4/187:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/16![American Airlines logo]()
$197
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:19 pm
STL
- CLT
1 stop21h 35m
Frontier
Wed 4/157:49 pm
CLT
- STL
1 stop24h 32m
Frontier
Deal found 3/20![Frontier logo]()
$151
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/15![Frontier logo]()
$189
This Priceline deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/20![Frontier logo]()
$140
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/20![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Sun 4/267:50 am
CLT
- STL
1 stop16h 29m
Frontier
Deal found 3/20![Frontier logo]()
$192
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 20, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 20, 2026.
This Frontier deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 3/20![Frontier logo]()
$70
This Expedia deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 3/18![Frontier logo]()
$96
This Mytrip deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/14:54 pm
STL
- CLT
1 stop22h 52m
Frontier
Deal found 3/15![Frontier logo]()
$100
This CheapOair deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/17![Frontier logo]()
$102
This Delta deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
STL
- CLT
1 stop4h 05m
Delta
Deal found 3/17![Delta logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:24 pm
MCI
- CLT
1 stop19h 46m
Spirit Airlines
Deal found 3/16![Spirit Airlines logo]()
$109
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:35 am
STL
- CLT
2 stops8h 20m
Southwest
Deal found 3/20![Southwest logo]()
$114
This Priceline deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:47 am
STL
- CLT
1 stop8h 16m
Frontier
Deal found 3/20![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1711:19 am
MCI
- SAV
2 stops10h 29m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:53 am
MCI
- SAV
2 stops33h 55m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$119
This American Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/81:29 pm
STL
- CHS
1 stop7h 57m
American Airlines
Deal found 3/17![American Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1412:24 pm
MCI
- MYR
1 stop26h 19m
Multiple Airlines
Deal found 3/16![Multiple Airlines logo]()
$120
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated March 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $140 (Priceline) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | February |
Average price | $482 |
Good round-trip deal | $393 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 20, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 5/16
2:25 pm-9:15 pm
1 stop5h 50m
Charlotte Douglas
Wed 5/20
7:20 pm-10:00 pm
1 stop3h 40m
$238
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 4/14
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Sat 4/18
8:00 am-2:00 pm
1 stop7h 00m
$238
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/12
12:05 pm-3:00 pm
Nonstop1h 55m
Charleston
Sat 5/16
4:40 pm-6:00 pm
Nonstop2h 20m
$239
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/19
6:35 am-5:40 pm
2 stops10h 05m
Charleston
Tue 5/19
7:15 pm-10:00 pm
1 stop3h 45m
$242
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 4/16
11:15 am-6:20 pm
1 stop6h 05m
Charlotte Douglas
Wed 4/22
6:40 am-2:50 pm
2 stops9h 10m
$243
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 4/14
6:30 am-2:53 pm
2 stops7h 23m
Charleston
Sat 4/18
5:00 pm-9:13 pm
1 stop5h 13m
$253
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 5/16
2:25 pm-7:10 pm
1 stop3h 45m
Charleston
Tue 5/19
7:40 am-3:15 pm
2 stops8h 35m
$264
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 4/8
6:00 am-1:41 pm
1 stop6h 41m
Charlotte Douglas
Sat 4/11
6:00 am-9:46 am
1 stop4h 46m
$301
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 5/8
1:45 pm-8:50 pm
2 stops6h 05m
Charleston
Mon 5/11
7:55 pm-11:15 pm
1 stop4h 20m
$303
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 4/1
10:30 am-10:05 pm
2 stops10h 35m
Charlotte Douglas
Wed 4/8
7:20 pm-10:00 pm
1 stop3h 40m
$306
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
MCI-CLT
STL-CHS
MCI-SAV
MCI-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
MCI-CLT
STL-CHS
MCI-SAV
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 20, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 20, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on March 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$360 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$400 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$328 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$401 | FlexibilityNo cancel fee | On-time63% |