$82+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
May 18 — May 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Mon 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 4/13![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Sat 5/25:51 pm
CLT
- MCI
1 stop20h 39m
Frontier
Deal found 4/14![Frontier logo]()
$212
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:34 pm
MCI
- CLT
1 stop26h 44m
Frontier
Tue 5/267:14 pm
CLT
- MCI
1 stop19h 35m
Frontier
Deal found 4/13![Frontier logo]()
$216
This CheapOair deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:34 pm
MCI
- CLT
1 stop26h 44m
Frontier
Wed 6/1010:14 pm
CLT
- MCI
1 stop15h 46m
Frontier
Deal found 4/16![Frontier logo]()
$217
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:37 pm
MCI
- CLT
1 stop21h 41m
Multiple Airlines
Tue 5/57:58 pm
CLT
- MCI
1 stop14h 31m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$219
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:05 am
STL
- CHS
1 stop5h 58m
Delta
Wed 5/275:15 am
CHS
- STL
1 stop5h 29m
Delta
Deal found 4/14![Delta logo]()
$227
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:35 am
MCI
- CLT
1 stop7h 17m
Spirit Airlines
Sun 5/177:57 pm
CLT
- MCI
1 stop14h 32m
Spirit Airlines
Deal found 4/13![Spirit Airlines logo]()
$238
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 pm
STL
- CHS
1 stop3h 54m
Delta
Tue 6/29:26 am
CHS
- STL
1 stop3h 54m
Delta
Deal found 4/16![Delta logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:53 am
MCI
- CLT
2 stops20h 17m
Multiple Airlines
Sun 5/37:55 am
CLT
- MCI
1 stop26h 34m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$243
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 5/187:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 4/16![Southwest logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:19 pm
STL
- MYR
1 stop15h 46m
Multiple Airlines
Mon 5/119:39 pm
MYR
- STL
2 stops36h 16m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$246
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:20 pm
STL
- CHS
1 stop5h 39m
Delta
Sat 6/66:03 pm
CHS
- STL
1 stop6h 56m
Delta
Deal found 4/16![Delta logo]()
$249
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:45 pm
STL
- CLT
2 stops6h 55m
Southwest
Fri 5/298:30 pm
CLT
- STL
1 stop3h 45m
Southwest
Deal found 4/16![Southwest logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:35 am
MCI
- MYR
1 stop21h 30m
Multiple Airlines
Sun 5/173:53 pm
MYR
- MCI
1 stop18h 36m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$283
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:41 pm
STL
- CLT
1 stop5h 58m
United Airlines
Wed 6/246:00 am
CLT
- STL
2 stops7h 11m
United Airlines
Deal found 4/13![United Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/79:15 am
STL
- CLT
1 stop5h 54m
Delta
Sun 5/107:46 pm
CLT
- STL
1 stop5h 13m
Delta
Deal found 4/13![Delta logo]()
$304
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:00 am
SGF
- CLT
Nonstop2h 20m
American Airlines
Fri 5/224:13 pm
CLT
- SGF
Nonstop2h 29m
American Airlines
Deal found 4/15![American Airlines logo]()
$485
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:30 pm
STL
- CLT
1 stop6h 10m
Southwest
Sun 5/1012:50 pm
CLT
- STL
Nonstop2h 05m
Southwest
Deal found 4/13![Southwest logo]()
$280
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:45 am
STL
- CLT
2 stops12h 24m
United Airlines
Tue 5/195:28 pm
CLT
- STL
1 stop4h 45m
United Airlines
Deal found 4/15![United Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/83:40 pm
STL
- CLT
Nonstop1h 50m
Southwest
Fri 6/124:40 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 4/14![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:07 pm
STL
- CLT
1 stop5h 52m
Delta
Sun 7/55:30 am
CLT
- STL
1 stop3h 46m
Delta
Deal found 4/17![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Wed 5/206:00 am
CHS
- STL
2 stops7h 47m
United Airlines
Deal found 4/17![United Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:05 pm
STL
- SAV
1 stop3h 35m
Delta
Tue 5/266:53 pm
SAV
- STL
1 stop6h 06m
Delta
Deal found 4/17![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:40 am
STL
- CLT
1 stop4h 15m
Southwest
Wed 6/171:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 4/17![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:30 am
STL
- CHS
1 stop6h 21m
United Airlines
Wed 5/611:15 am
CHS
- STL
2 stops10h 58m
United Airlines
Deal found 4/13![United Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:24 pm
STL
- SAV
1 stop5h 30m
Delta
Wed 6/175:19 pm
SAV
- STL
1 stop7h 04m
Delta
Deal found 4/15![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/219:55 am
STL
- CLT
2 stops7h 25m
Southwest
Tue 5/267:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 4/16![Southwest logo]()
$316
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:41 pm
STL
- CLT
1 stop6h 04m
United Airlines
Tue 6/96:00 am
CLT
- STL
2 stops10h 46m
United Airlines
Deal found 4/16![United Airlines logo]()
$323
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/133:26 pm
SGF
- CLT
1 stop16h 22m
Multiple Airlines
Thu 7/168:34 pm
CLT
- SGF
1 stop13h 56m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$441
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:03 pm
STL
- CHS
1 stop6h 38m
Delta
Fri 5/85:15 am
CHS
- STL
1 stop3h 55m
Delta
Deal found 4/15![Delta logo]()
$332
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1112:40 pm
STL
- SAV
1 stop6h 50m
Southwest
Wed 6/171:25 pm
SAV
- STL
Nonstop2h 05m
Southwest
Deal found 4/13![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
STL
- MYR
1 stop6h 48m
United Airlines
Thu 5/143:14 pm
MYR
- STL
1 stop6h 59m
United Airlines
Deal found 4/13![United Airlines logo]()
$328
This Delta deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/13:45 pm
STL
- MYR
1 stop5h 05m
Delta
Tue 7/711:27 am
MYR
- STL
1 stop6h 52m
Delta
Deal found 4/13![Delta logo]()
$333
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:15 am
STL
- SAV
2 stops8h 45m
Southwest
Sat 5/1611:35 am
SAV
- STL
1 stop5h 50m
Southwest
Deal found 4/14![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/173:40 pm
STL
- CHS
1 stop6h 39m
Delta
Wed 7/225:10 am
CHS
- STL
1 stop4h 09m
Delta
Deal found 4/17![Delta logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:00 am
SGF
- SAV
1 stop7h 11m
United Airlines
Wed 9/29:50 am
SAV
- SGF
2 stops9h 51m
United Airlines
Deal found 4/13![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/103:40 pm
STL
- CHS
1 stop4h 09m
Delta
Wed 7/156:24 pm
CHS
- STL
1 stop4h 48m
Delta
Deal found 4/14![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 5/187:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 4/13![Southwest logo]()
$350
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:30 am
STL
- CHS
1 stop6h 25m
United Airlines
Tue 5/56:00 am
CHS
- STL
1 stop5h 28m
United Airlines
Deal found 4/13![United Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:00 am
STL
- SAV
1 stop4h 30m
Delta
Fri 5/85:18 pm
SAV
- STL
1 stop7h 03m
Delta
Deal found 4/15![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:40 am
STL
- SAV
2 stops9h 00m
Southwest
Fri 9/255:00 pm
SAV
- STL
2 stops7h 05m
Southwest
Deal found 4/13![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:00 am
STL
- SAV
2 stops7h 43m
United Airlines
Sat 8/158:00 am
SAV
- STL
1 stop5h 13m
United Airlines
Deal found 4/17![United Airlines logo]()
$374
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated April 18, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated April 18, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Sat 5/25:51 pm
CLT
- MCI
1 stop20h 39m
Frontier
Deal found 4/14![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:53 am
MCI
- CLT
2 stops20h 17m
Multiple Airlines
Sun 5/37:55 am
CLT
- MCI
1 stop26h 34m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$243
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Mon 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 4/13![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:37 pm
MCI
- CLT
1 stop21h 41m
Multiple Airlines
Tue 5/57:58 pm
CLT
- MCI
1 stop14h 31m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:37 pm
MCI
- CLT
1 stop27h 25m
Spirit Airlines
Wed 5/66:49 pm
CLT
- MCI
1 stop15h 40m
Spirit Airlines
Deal found 4/16![Spirit Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:19 pm
STL
- MYR
1 stop15h 46m
Multiple Airlines
Mon 5/119:39 pm
MYR
- STL
2 stops36h 16m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$246
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:35 am
MCI
- CLT
1 stop7h 17m
Spirit Airlines
Sun 5/177:57 pm
CLT
- MCI
1 stop14h 32m
Spirit Airlines
Deal found 4/13![Spirit Airlines logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CHS
1 stop15h 29m
Multiple Airlines
Mon 5/183:23 pm
CHS
- STL
1 stop9h 58m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$256
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/165:20 pm
STL
- CHS
Nonstop1h 55m
Southwest
Mon 5/187:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 4/16![Southwest logo]()
$244
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:05 am
STL
- CHS
1 stop5h 58m
Delta
Wed 5/275:15 am
CHS
- STL
1 stop5h 29m
Delta
Deal found 4/14![Delta logo]()
$227
This CheapOair deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/232:34 pm
MCI
- CLT
1 stop26h 44m
Frontier
Tue 5/267:14 pm
CLT
- MCI
1 stop19h 35m
Frontier
Deal found 4/13![Frontier logo]()
$216
This Delta deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:05 pm
STL
- CHS
1 stop3h 54m
Delta
Tue 6/29:26 am
CHS
- STL
1 stop3h 54m
Delta
Deal found 4/16![Delta logo]()
$238
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
This CheapOair deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 4/14![Frontier logo]()
$82
This Priceline deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:51 pm
STL
- CLT
1 stop11h 08m
Frontier
Deal found 4/16![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:30 pm
STL
- CLT
1 stop11h 29m
Frontier
Deal found 4/15![Frontier logo]()
$91
This Cheapflightsfares deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1610:35 am
MCI
- CLT
1 stop7h 17m
Spirit Airlines
Deal found 4/17![Spirit Airlines logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:17 pm
STL
- CLT
1 stop23h 23m
Frontier
Deal found 4/13![Frontier logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:33 pm
STL
- CLT
2 stops18h 38m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$98
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 4/17![Southwest logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:33 pm
STL
- CLT
2 stops18h 38m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:16 pm
MCI
- CLT
2 stops22h 32m
Frontier
Deal found 4/17![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/114:19 pm
STL
- CHS
1 stop16h 39m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:24 pm
MCI
- CHS
2 stops24h 36m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:13 pm
STL
- CLT
2 stops23h 35m
Frontier
Deal found 4/14![Frontier logo]()
$102
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated April 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (CheapOair) |
One-way from | $82 (CheapOair) |
Popular in | April |
Cheapest in | February |
Average price | $497 |
Good round-trip deal | $315 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 5/27
1:45 pm-9:40 pm
2 stops6h 55m
Charlotte Douglas
Fri 5/29
8:30 pm-11:15 pm
1 stop3h 45m
$262
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 5/6
2:30 pm-9:40 pm
1 stop6h 10m
Charlotte Douglas
Sun 5/10
12:50 pm-1:55 pm
Nonstop2h 05m
$280
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Thu 5/14
10:35 am-9:05 am
1 stop21h 30m
Myrtle Beach Intl
Sun 5/17
3:53 pm-9:29 am
1 stop18h 36m
$283
Quickest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 6/8
3:40 pm-6:30 pm
Nonstop1h 50m
Charlotte Douglas
Fri 6/12
4:40 pm-5:50 pm
Nonstop2h 10m
$284
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 6/17
5:41 pm-12:39 am
1 stop5h 58m
Charlotte Douglas
Wed 6/24
6:00 am-12:11 pm
2 stops7h 11m
$302
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 5/12
7:45 am-9:09 pm
2 stops12h 24m
Charlotte Douglas
Tue 5/19
5:28 pm-9:13 pm
1 stop4h 45m
$302
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 5/7
9:15 am-4:09 pm
1 stop5h 54m
Charlotte Douglas
Sun 5/10
7:46 pm-11:59 pm
1 stop5h 13m
$304
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 6/15
5:40 am-10:55 am
1 stop4h 15m
Charlotte Douglas
Wed 6/17
1:25 pm-2:25 pm
Nonstop2h 00m
$309
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/19
7:45 am-1:51 pm
1 stop5h 06m
Charleston
Wed 5/20
6:00 am-12:47 pm
2 stops7h 47m
$312
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/5
6:30 am-1:51 pm
1 stop6h 21m
Charleston
Wed 5/6
11:15 am-9:13 pm
2 stops10h 58m
$312
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
STL-CHS
STL-MYR
MCI-SAV
MCI-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
STL-CHS
STL-MYR
MCI-SAV
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 18, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 18, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Overall
8.0
Comfort
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top destinations
Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on April 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$364 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$403 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$176 | Average$222 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$406 | FlexibilityNo cancel fee | On-time63% |