$78+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 5 — Apr 121
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/3![Frontier logo]()
$160
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/4![Frontier logo]()
$171
This Priceline deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/3![Frontier logo]()
$181
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/4![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:51 pm
STL
- CLT
1 stop19h 04m
Frontier
Mon 3/309:28 pm
CLT
- STL
1 stop26h 51m
Frontier
Deal found 3/4![Frontier logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:32 am
STL
- CLT
2 stops12h 06m
Multiple Airlines
Mon 3/232:32 pm
CLT
- STL
1 stop9h 47m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$201
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Multiple Airlines
Tue 4/2111:17 am
CLT
- STL
2 stops20h 33m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$202
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Multiple Airlines
Tue 5/55:30 pm
CLT
- MCI
1 stop24h 36m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$203
This CheapOair deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:19 pm
STL
- CLT
1 stop21h 35m
Frontier
Sun 4/121:46 pm
CLT
- STL
1 stop19h 05m
Frontier
Deal found 3/3![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop15h 19m
Multiple Airlines
Wed 4/295:30 pm
CLT
- STL
2 stops17h 56m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$210
This CheapOair deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:24 pm
MCI
- CLT
1 stop11h 14m
Spirit Airlines
Wed 3/253:55 pm
CLT
- MCI
1 stop8h 58m
Spirit Airlines
Deal found 3/2![Spirit Airlines logo]()
$210
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:13 am
MCI
- CLT
2 stops28h 22m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/2![Frontier logo]()
$212
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 6, 2026.
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2911:35 am
STL
- CLT
2 stops8h 20m
Southwest
Tue 5/51:45 pm
CLT
- STL
2 stops9h 15m
Southwest
Deal found 3/1![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1410:20 am
STL
- SAV
1 stop6h 35m
United Airlines
Thu 7/163:14 pm
SAV
- STL
1 stop7h 02m
United Airlines
Deal found 3/4![United Airlines logo]()
$267
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/229:00 am
STL
- CHS
1 stop7h 19m
Delta
Thu 6/255:30 am
CHS
- STL
1 stop3h 37m
Delta
Deal found 3/1![Delta logo]()
$281
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:21 pm
STL
- GSP
1 stop4h 42m
American Airlines
Sat 4/255:20 am
GSP
- STL
1 stop4h 10m
American Airlines
Deal found 3/4![American Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:51 pm
STL
- GSP
1 stop25h 47m
Multiple Airlines
Mon 3/306:45 pm
GSP
- STL
2 stops16h 47m
Multiple Airlines
Deal found 3/1![Multiple Airlines logo]()
$360
This Cheapflightsfares deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:45 am
MCI
- CLT
1 stop8h 15m
Spirit Airlines
Tue 3/243:55 pm
CLT
- MCI
1 stop8h 58m
Spirit Airlines
Deal found 3/6![Spirit Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:30 pm
STL
- CLT
1 stop6h 10m
Southwest
Tue 6/91:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 3/5![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:45 am
STL
- SAV
1 stop5h 00m
United Airlines
Wed 5/69:50 am
SAV
- STL
2 stops7h 49m
United Airlines
Deal found 3/1![United Airlines logo]()
$268
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:04 pm
STL
- SAV
1 stop6h 21m
Delta
Tue 4/73:13 pm
SAV
- STL
1 stop3h 40m
Delta
Deal found 3/1![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Wed 5/137:15 am
CHS
- STL
1 stop5h 15m
Southwest
Deal found 3/2![Southwest logo]()
$274
This United Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
MCI
- CLT
1 stop6h 42m
United Airlines
Sat 5/166:15 am
CLT
- MCI
1 stop5h 18m
United Airlines
Deal found 3/2![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/251:25 pm
MCI
- SAV
1 stop6h 18m
Delta
Sat 3/286:59 am
SAV
- MCI
1 stop6h 21m
Delta
Deal found 3/1![Delta logo]()
$290
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2611:41 am
STL
- GSP
1 stop5h 32m
American Airlines
Mon 3/308:17 pm
GSP
- STL
1 stop4h 27m
American Airlines
Deal found 3/1![American Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/104:40 pm
STL
- CLT
1 stop4h 20m
Southwest
Wed 4/227:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 3/2![Southwest logo]()
$276
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:21 pm
MCI
- SAV
2 stops7h 38m
United Airlines
Sat 4/182:25 pm
SAV
- MCI
1 stop6h 23m
United Airlines
Deal found 3/1![United Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:15 am
STL
- CLT
1 stop4h 35m
Delta
Sat 5/305:35 am
CLT
- STL
1 stop5h 04m
Delta
Deal found 3/5![Delta logo]()
$298
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
MCI
- SAV
1 stop7h 32m
American Airlines
Tue 4/213:03 pm
SAV
- MCI
1 stop8h 46m
American Airlines
Deal found 3/6![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/161:45 pm
STL
- CLT
1 stop7h 15m
Southwest
Sun 4/1912:50 pm
CLT
- STL
Nonstop2h 05m
Southwest
Deal found 3/1![Southwest logo]()
$279
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/319:10 am
STL
- SAV
2 stops9h 09m
United Airlines
Tue 4/75:04 pm
SAV
- STL
1 stop5h 09m
United Airlines
Deal found 3/1![United Airlines logo]()
$305
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:05 pm
STL
- SAV
1 stop3h 59m
Delta
Sun 6/147:50 pm
SAV
- STL
1 stop4h 48m
Delta
Deal found 3/3![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:10 pm
STL
- SAV
1 stop4h 40m
Southwest
Thu 7/163:55 pm
SAV
- STL
1 stop4h 15m
Southwest
Deal found 3/1![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:55 pm
STL
- MYR
1 stop4h 02m
American Airlines
Tue 4/1410:33 am
MYR
- STL
2 stops7h 08m
American Airlines
Deal found 3/6![American Airlines logo]()
$356
This United Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:10 am
STL
- CLT
1 stop7h 14m
United Airlines
Sun 4/266:00 am
CLT
- STL
2 stops7h 22m
United Airlines
Deal found 3/1![United Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/193:42 pm
STL
- SAV
1 stop5h 56m
Delta
Mon 6/225:30 am
SAV
- STL
1 stop3h 37m
Delta
Deal found 3/4![Delta logo]()
$307
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:10 pm
STL
- CHS
Nonstop1h 55m
Southwest
Wed 4/17:45 pm
CHS
- STL
1 stop3h 55m
Southwest
Deal found 3/3![Southwest logo]()
$288
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/21:03 pm
STL
- SAV
1 stop4h 51m
Delta
Fri 5/85:30 am
SAV
- STL
1 stop3h 40m
Delta
Deal found 3/3![Delta logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:41 pm
STL
- CLT
1 stop6h 04m
United Airlines
Mon 5/258:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Deal found 3/3![United Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/201:45 pm
STL
- CLT
2 stops7h 55m
Southwest
Mon 4/274:20 pm
CLT
- STL
2 stops7h 25m
Southwest
Deal found 3/6![Southwest logo]()
$294
This Delta deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/25:00 pm
STL
- SAV
1 stop5h 59m
Delta
Sat 5/95:29 pm
SAV
- STL
1 stop5h 00m
Delta
Deal found 3/2![Delta logo]()
$307
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:56 pm
MCI
- CLT
1 stop4h 49m
United Airlines
Sun 5/248:05 am
CLT
- MCI
1 stop7h 15m
United Airlines
Deal found 3/3![United Airlines logo]()
$335
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated March 6, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated March 6, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1811:32 am
STL
- CLT
2 stops12h 06m
Multiple Airlines
Mon 3/232:32 pm
CLT
- STL
1 stop9h 47m
Multiple Airlines
Deal found 3/2![Multiple Airlines logo]()
$201
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/244:51 pm
STL
- CLT
1 stop19h 04m
Frontier
Mon 3/309:28 pm
CLT
- STL
1 stop26h 51m
Frontier
Deal found 3/4![Frontier logo]()
$200
This CheapOair deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2412:24 pm
MCI
- CLT
1 stop11h 14m
Spirit Airlines
Wed 3/253:55 pm
CLT
- MCI
1 stop8h 58m
Spirit Airlines
Deal found 3/2![Spirit Airlines logo]()
$210
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/54:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/137:45 pm
CLT
- STL
1 stop28h 34m
Frontier
Deal found 3/6![Frontier logo]()
$195
This CheapOair deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:19 pm
STL
- CLT
1 stop21h 35m
Frontier
Sun 4/121:46 pm
CLT
- STL
1 stop19h 05m
Frontier
Deal found 3/3![Frontier logo]()
$206
This Priceline deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/3![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:59 pm
STL
- CLT
1 stop15h 19m
Multiple Airlines
Wed 4/295:30 pm
CLT
- STL
2 stops17h 56m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$210
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/3![Frontier logo]()
$160
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Mon 4/208:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/4![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:06 pm
STL
- CLT
1 stop19h 50m
Multiple Airlines
Tue 4/2111:17 am
CLT
- STL
2 stops20h 33m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$202
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:06 pm
STL
- CLT
1 stop19h 50m
Frontier
Mon 4/278:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/4![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2711:13 am
MCI
- CLT
2 stops28h 22m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/2![Frontier logo]()
$212
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 3/2![Frontier logo]()
$78
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:15 pm
MCI
- CLT
1 stop27h 39m
Frontier
Deal found 3/3![Frontier logo]()
$80
This Travelocity deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:24 pm
MCI
- CHS
1 stop8h 49m
Spirit Airlines
Deal found 3/1![Spirit Airlines logo]()
$83
This Expedia deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:06 pm
STL
- CLT
1 stop20h 29m
Frontier
Deal found 3/4![Frontier logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:17 pm
STL
- CLT
1 stop21h 37m
Frontier
Deal found 3/2![Frontier logo]()
$89
This Spirit deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:45 am
MCI
- CLT
1 stop8h 15m
Spirit Airlines
Deal found 3/2![Spirit Airlines logo]()
$89
This CheapOair deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:12 pm
STL
- CLT
1 stop19h 40m
Frontier
Deal found 3/3![Frontier logo]()
$92
This CheapOair deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Deal found 3/4![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- CLT
1 stop25h 03m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$94
This Expedia deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:24 pm
MCI
- CHS
1 stop8h 49m
Spirit Airlines
Deal found 3/2![Spirit Airlines logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Deal found 3/3![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3111:27 am
STL
- CLT
2 stops26h 00m
Frontier
Deal found 3/3![Frontier logo]()
$98
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated March 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $160 (Frontier) |
One-way from | $78 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $476 |
Good round-trip deal | $392 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 4/29
11:35 am-8:55 pm
2 stops8h 20m
Charlotte Douglas
Tue 5/5
1:45 pm-10:00 pm
2 stops9h 15m
$265
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 6/2
2:30 pm-9:40 pm
1 stop6h 10m
Charlotte Douglas
Tue 6/9
1:25 pm-2:25 pm
Nonstop2h 00m
$265
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 7/14
10:20 am-5:55 pm
1 stop6h 35m
Savannah/Hilton Head
Thu 7/16
3:14 pm-9:16 pm
1 stop7h 02m
$267
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Sat 5/2
8:45 am-2:45 pm
1 stop5h 00m
Savannah/Hilton Head
Wed 5/6
9:50 am-4:39 pm
2 stops7h 49m
$268
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 5/8
4:00 pm-9:30 pm
1 stop4h 30m
Charleston
Wed 5/13
7:15 am-11:30 am
1 stop5h 15m
$274
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 4/10
4:40 pm-10:00 pm
1 stop4h 20m
Charlotte Douglas
Wed 4/22
7:20 pm-10:00 pm
1 stop3h 40m
$276
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 4/16
1:45 pm-10:00 pm
1 stop7h 15m
Charlotte Douglas
Sun 4/19
12:50 pm-1:55 pm
Nonstop2h 05m
$279
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 6/22
9:00 am-5:19 pm
1 stop7h 19m
Charleston
Thu 6/25
5:30 am-8:07 am
1 stop3h 37m
$281
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 3/31
12:04 pm-7:25 pm
1 stop6h 21m
Savannah/Hilton Head
Tue 4/7
3:13 pm-5:53 pm
1 stop3h 40m
$287
St. LouisSavannah
STL - SAV
STLSAV
Lambert-St Louis
Tue 7/14
3:10 pm-8:50 pm
1 stop4h 40m
Savannah/Hilton Head
Thu 7/16
3:55 pm-7:10 pm
1 stop4h 15m
$287
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
MCI-CLT
STL-SAV
STL-CLT
MCI-CHS
STL-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
MCI-CLT
STL-SAV
STL-CLT
MCI-CHS
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 6, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 64% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 6, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on March 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$359 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$405 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$402 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$268 | Average$318 | FlexibilityNo cancel fee | On-time69% |