$99+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — CHS
Jul 21 — Jul 281
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 21, 2026.
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Sat 8/229:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Deal found 6/18![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/12:30 pm
STL
- CHS
1 stop6h 20m
Southwest
Sat 8/86:45 am
CHS
- STL
Nonstop2h 00m
Southwest
Deal found 6/20![Southwest logo]()
$204
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:55 am
STL
- CLT
1 stop6h 40m
Southwest
Tue 7/211:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/16![Southwest logo]()
$207
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:34 am
STL
- CHS
1 stop3h 42m
American Airlines
Sat 8/157:56 pm
CHS
- STL
1 stop5h 02m
American Airlines
Deal found 6/20![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:40 pm
STL
- CHS
Nonstop2h 00m
Southwest
Thu 8/135:20 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 6/19![Southwest logo]()
$212
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Tue 7/141:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/18![Southwest logo]()
$213
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:15 am
STL
- CHS
2 stops9h 40m
Southwest
Wed 8/128:10 am
CHS
- STL
1 stop7h 40m
Southwest
Deal found 6/19![Southwest logo]()
$214
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:45 am
STL
- CLT
1 stop5h 35m
Southwest
Tue 9/112:35 pm
CLT
- STL
1 stop6h 20m
Southwest
Deal found 6/17![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/12:30 pm
STL
- CHS
1 stop6h 20m
Southwest
Thu 8/65:20 pm
CHS
- STL
Nonstop2h 05m
Southwest
Deal found 6/20![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:45 am
STL
- CHS
2 stops8h 00m
Southwest
Tue 9/81:25 pm
CHS
- STL
1 stop8h 45m
Southwest
Deal found 6/20![Southwest logo]()
$220
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:25 pm
STL
- CLT
Nonstop1h 50m
Southwest
Tue 11/36:20 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 6/17![Southwest logo]()
$221
This deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/86:00 am
STL
- CHS
1 stop4h 38m
Delta
Tue 9/156:40 am
CHS
- STL
1 stop5h 15m
Delta
Deal found 6/17![Delta logo]()
$227
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 21, 2026.
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Tue 7/283:10 pm
CLT
- STL
1 stop4h 10m
Southwest
Deal found 6/16![Southwest logo]()
$207
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
STL
- CLT
1 stop4h 26m
Delta
Wed 7/295:30 am
CLT
- STL
1 stop3h 49m
Delta
Deal found 6/20![Delta logo]()
$217
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/227:25 am
STL
- CLT
1 stop5h 31m
United Airlines
Tue 9/18:05 am
CLT
- STL
1 stop4h 57m
United Airlines
Deal found 6/17![United Airlines logo]()
$217
This CheapOair deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Mon 7/2010:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/20![Frontier logo]()
$279
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1012:24 pm
COU
- CHS
1 stop4h 43m
American Airlines
Sat 11/146:32 pm
CHS
- COU
1 stop5h 03m
American Airlines
Deal found 6/19![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:40 am
STL
- CLT
1 stop4h 30m
Southwest
Tue 8/411:10 am
CLT
- STL
1 stop6h 35m
Southwest
Deal found 6/19![Southwest logo]()
$217
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:00 pm
STL
- CLT
1 stop3h 50m
Southwest
Wed 8/56:50 am
CLT
- STL
2 stops8h 40m
Southwest
Deal found 6/16![Southwest logo]()
$222
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Tue 7/147:05 pm
CLT
- STL
1 stop4h 25m
Southwest
Deal found 6/18![Southwest logo]()
$222
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:51 am
STL
- CHS
1 stop4h 00m
Delta
Sun 11/157:59 pm
CHS
- STL
1 stop4h 40m
Delta
Deal found 6/19![Delta logo]()
$286
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
STL
- CHS
1 stop6h 13m
United Airlines
Wed 8/1910:19 am
CHS
- STL
2 stops12h 41m
United Airlines
Deal found 6/20![United Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/52:45 pm
STL
- CLT
1 stop5h 40m
Southwest
Wed 8/126:50 am
CLT
- STL
2 stops9h 00m
Southwest
Deal found 6/19![Southwest logo]()
$222
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:24 pm
COU
- CHS
1 stop4h 43m
American Airlines
Sat 11/146:32 pm
CHS
- COU
1 stop5h 03m
American Airlines
Deal found 6/21![American Airlines logo]()
$298
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Tue 7/2110:40 am
CLT
- STL
2 stops8h 45m
Southwest
Deal found 6/16![Southwest logo]()
$227
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/193:11 pm
COU
- CHS
1 stop5h 23m
United Airlines
Mon 8/242:54 pm
CHS
- COU
2 stops9h 01m
United Airlines
Deal found 6/17![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:00 am
STL
- SAV
1 stop4h 12m
Delta
Wed 7/87:07 pm
SAV
- STL
1 stop4h 08m
Delta
Deal found 6/18![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/294:25 pm
STL
- CLT
Nonstop1h 50m
Southwest
Tue 11/31:30 pm
CLT
- STL
2 stops6h 50m
Southwest
Deal found 6/17![Southwest logo]()
$236
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:25 pm
COU
- CHS
1 stop5h 23m
United Airlines
Thu 8/66:00 am
CHS
- COU
1 stop5h 13m
United Airlines
Deal found 6/16![United Airlines logo]()
$332
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:58 pm
STL
- SAV
1 stop3h 55m
Delta
Wed 7/291:57 pm
SAV
- STL
1 stop4h 56m
Delta
Deal found 6/17![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:25 pm
STL
- CHS
Nonstop2h 00m
Southwest
Wed 9/307:20 pm
CHS
- STL
1 stop3h 50m
Southwest
Deal found 6/17![Southwest logo]()
$236
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:25 am
MCI
- MYR
1 stop6h 42m
Delta
Wed 8/196:00 am
MYR
- MCI
1 stop6h 17m
Delta
Deal found 6/16![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:30 am
STL
- SAV
1 stop4h 34m
United Airlines
Sun 8/236:00 am
SAV
- STL
2 stops7h 02m
United Airlines
Deal found 6/20![United Airlines logo]()
$346
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Mon 8/107:40 am
CLT
- STL
1 stop4h 55m
Southwest
Deal found 6/16![Southwest logo]()
$255
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:58 pm
MCI
- MYR
1 stop6h 32m
Delta
Mon 8/177:02 pm
MYR
- MCI
1 stop5h 56m
Delta
Deal found 6/17![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- SAV
1 stop6h 04m
United Airlines
Wed 8/264:59 pm
SAV
- STL
1 stop6h 01m
United Airlines
Deal found 6/20![United Airlines logo]()
$379
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Tue 8/116:50 am
CLT
- STL
2 stops9h 00m
Southwest
Deal found 6/19![Southwest logo]()
$265
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:43 am
MCI
- MYR
1 stop6h 50m
Delta
Thu 8/1311:43 am
MYR
- MCI
1 stop5h 30m
Delta
Deal found 6/16![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
STL
- MYR
1 stop5h 53m
United Airlines
Wed 9/210:08 am
MYR
- STL
2 stops12h 52m
United Airlines
Deal found 6/17![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:15 am
STL
- CHS
2 stops7h 50m
Southwest
Sat 10/31:15 pm
CHS
- STL
2 stops9h 05m
Southwest
Deal found 6/18![Southwest logo]()
$265
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/65:43 am
MCI
- MYR
1 stop4h 04m
Delta
Mon 8/106:00 am
MYR
- MCI
1 stop4h 19m
Delta
Deal found 6/19![Delta logo]()
$378
This United Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:25 pm
COU
- CHS
1 stop5h 23m
United Airlines
Tue 7/213:34 pm
CHS
- COU
2 stops8h 59m
United Airlines
Deal found 6/17![United Airlines logo]()
$384
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated June 21, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated June 21, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Sun 7/1210:59 pm
CLT
- STL
1 stop26h 00m
Frontier
Deal found 6/16![Frontier logo]()
$247
This American Airlines deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/115:10 am
STL
- CLT
Nonstop1h 53m
American Airlines
Tue 7/147:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Deal found 6/18![American Airlines logo]()
$197
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Tue 7/141:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/18![Southwest logo]()
$213
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:55 am
STL
- CLT
1 stop6h 40m
Southwest
Tue 7/211:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/16![Southwest logo]()
$207
This CheapOair deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Wed 7/2210:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/20![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/185:48 pm
COU
- CHS
1 stop13h 50m
Multiple Airlines
Tue 7/213:13 pm
CHS
- COU
1 stop20h 41m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$252
This CheapOair deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/181:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Wed 7/2210:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/20![Frontier logo]()
$254
This CheapOair deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/201:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Wed 7/2910:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/20![Frontier logo]()
$259
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
STL
- CLT
1 stop4h 26m
Delta
Wed 7/295:30 am
CLT
- STL
1 stop3h 49m
Delta
Deal found 6/16![Delta logo]()
$217
This CheapOair deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Wed 7/2912:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Deal found 6/17![Frontier logo]()
$245
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:12 pm
STL
- CLT
Nonstop2h 03m
American Airlines
Wed 7/2910:56 pm
CLT
- STL
Nonstop2h 02m
American Airlines
Deal found 6/20![American Airlines logo]()
$246
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/252:35 pm
STL
- CHS
1 stop7h 34m
American Airlines
Sat 8/18:21 pm
CHS
- STL
1 stop4h 54m
American Airlines
Deal found 6/20![American Airlines logo]()
$254
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 21, 2026.
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/154:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/16![Southwest logo]()
$99
This Southwest deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/81:40 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/19![Southwest logo]()
$100
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:00 am
STL
- CHS
1 stop5h 00m
Delta
Deal found 6/19![Delta logo]()
$105
This Frontier deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/121:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/18![Frontier logo]()
$105
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/17![Southwest logo]()
$109
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/19:50 am
STL
- CHS
2 stops6h 45m
Southwest
Deal found 6/20![Southwest logo]()
$110
This Southwest deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:35 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/20![Southwest logo]()
$113
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:40 am
STL
- CLT
2 stops7h 55m
Southwest
Deal found 6/17![Southwest logo]()
$114
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/149:24 am
STL
- CHS
1 stop5h 29m
Delta
Deal found 6/16![Delta logo]()
$114
This Frontier deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:45 pm
MCI
- CLT
1 stop6h 34m
Frontier
Deal found 6/20![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/84:57 pm
STL
- SAV
2 stops24h 19m
Multiple Airlines
Deal found 6/19![Multiple Airlines logo]()
$118
This Delta deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:23 pm
STL
- CHS
1 stop5h 36m
Delta
Deal found 6/19![Delta logo]()
$118
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated June 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $197 (American Airlines) |
One-way from | $99 (Southwest) |
Popular in | April |
Cheapest in | February |
Average price | $435 |
Good round-trip deal | $350 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 7/22
4:50 pm-7:40 pm
Nonstop1h 50m
Charlotte Douglas
Tue 7/28
3:10 pm-6:20 pm
1 stop4h 10m
$207
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/25
6:00 am-11:26 am
1 stop4h 26m
Charlotte Douglas
Wed 7/29
5:30 am-8:19 am
1 stop3h 49m
$217
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 8/22
7:25 am-1:56 pm
1 stop5h 31m
Charlotte Douglas
Tue 9/1
8:05 am-12:02 pm
1 stop4h 57m
$217
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 7/29
5:40 am-11:10 am
1 stop4h 30m
Charlotte Douglas
Tue 8/4
11:10 am-4:45 pm
1 stop6h 35m
$217
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 8/1
4:00 pm-8:50 pm
1 stop3h 50m
Charlotte Douglas
Wed 8/5
6:50 am-2:30 pm
2 stops8h 40m
$222
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/11
9:30 am-10:10 pm
1 stop11h 40m
Charlotte Douglas
Tue 7/14
7:05 pm-10:30 pm
1 stop4h 25m
$222
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 8/5
2:45 pm-9:25 pm
1 stop5h 40m
Charlotte Douglas
Wed 8/12
6:50 am-2:50 pm
2 stops9h 00m
$222
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 7/14
5:40 am-2:35 pm
2 stops7h 55m
Charlotte Douglas
Tue 7/21
10:40 am-6:25 pm
2 stops8h 45m
$227
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 10/29
4:25 pm-7:15 pm
Nonstop1h 50m
Charlotte Douglas
Tue 11/3
1:30 pm-7:20 pm
2 stops6h 50m
$236
Quickest round-trip
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 9/26
1:25 pm-4:25 pm
Nonstop2h 00m
Charleston
Wed 9/30
7:20 pm-10:10 pm
1 stop3h 50m
$236
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
STL-CHS
COU-CHS
MCI-MYR
STL-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
STL-CHS
COU-CHS
MCI-MYR
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 21, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 21, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Entertainment
7.5
Overall
7.9
Comfort
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
6.0
GoodReza,Jun 2026
TPA - MDW
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on June 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 4 airlines flying from Missouri to South Carolina
Discover the top 4 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$150 | Average$375 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$192 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$377 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$440 | FlexibilityNo cancel fee | On-time63% |