$67+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South Carolina
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:49 pm
STL
- CLT
1 stop15h 09m
Multiple Airlines
Sat 2/285:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Mon 3/99:28 pm
CLT
- STL
1 stop26h 51m
Frontier
Deal found 2/2![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/1![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Multiple Airlines
Thu 3/55:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Frontier
Wed 3/111:59 pm
CLT
- STL
1 stop10h 20m
Frontier
Deal found 2/1![Frontier logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:51 pm
STL
- CLT
1 stop14h 12m
Frontier
Tue 3/177:48 pm
CLT
- STL
1 stop12h 49m
Frontier
Deal found 2/1![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
- CLT
2 stops26h 34m
Multiple Airlines
Tue 3/101:59 pm
CLT
- STL
1 stop10h 20m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:17 pm
STL
- CLT
2 stops22h 00m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/31![Frontier logo]()
$160
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/1![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop17h 28m
Multiple Airlines
Thu 3/55:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$163
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/911:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Thu 3/121:20 pm
CLT
- MCI
1 stop23h 09m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$166
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:26 am
MCI
- CLT
1 stop20h 00m
Spirit Airlines
Thu 2/267:13 pm
CLT
- MCI
1 stop16h 17m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$168
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/911:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Thu 3/121:20 pm
CLT
- MCI
1 stop23h 09m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:12 pm
STL
- CLT
1 stop21h 16m
Frontier
Sun 3/87:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/1![Frontier logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CHS
1 stop15h 49m
Multiple Airlines
Thu 3/55:00 pm
CHS
- STL
2 stops19h 49m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$182
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:30 pm
STL
- CLT
Nonstop1h 45m
Southwest
Wed 3/45:50 pm
CLT
- STL
1 stop4h 10m
Southwest
Deal found 1/31![Southwest logo]()
$201
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:51 pm
STL
- CLT
Nonstop1h 58m
American Airlines
Tue 3/243:52 pm
CLT
- STL
Nonstop2h 09m
American Airlines
Deal found 2/1![American Airlines logo]()
$213
This United Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:00 am
STL
- CLT
1 stop5h 46m
United Airlines
Wed 3/47:01 am
CLT
- STL
2 stops10h 01m
United Airlines
Deal found 1/31![United Airlines logo]()
$216
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:03 am
STL
- SAV
1 stop4h 59m
Delta
Fri 3/137:59 pm
SAV
- STL
1 stop4h 59m
Delta
Deal found 2/1![Delta logo]()
$237
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/112:24 pm
MCI
- MYR
1 stop28h 09m
Spirit Airlines
Tue 4/76:28 pm
MYR
- MCI
1 stop18h 01m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Sat 2/218:44 pm
CLT
- STL
2 stops35h 07m
Frontier
Deal found 2/2![Frontier logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/2210:14 am
MCI
- CLT
2 stops49h 06m
Multiple Airlines
Wed 2/251:24 pm
CLT
- MCI
1 stop22h 06m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$202
This Cheapflightsfares deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/1612:12 pm
MCI
- CLT
1 stop11h 28m
Spirit Airlines
Sat 5/236:00 am
CLT
- MCI
1 stop6h 07m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$208
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:35 am
STL
- CLT
2 stops8h 10m
Southwest
Tue 4/287:20 pm
CLT
- STL
1 stop3h 40m
Southwest
Deal found 1/31![Southwest logo]()
$234
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 pm
STL
- SAV
1 stop4h 09m
Delta
Sun 5/37:59 pm
SAV
- STL
1 stop4h 35m
Delta
Deal found 2/1![Delta logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:12 pm
STL
- CLT
1 stop21h 16m
Frontier
Thu 3/127:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/2![Frontier logo]()
$216
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:40 am
STL
- SAV
2 stops10h 33m
United Airlines
Tue 3/314:59 pm
SAV
- STL
1 stop5h 09m
United Airlines
Deal found 2/2![United Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- CAE
1 stop29h 48m
Multiple Airlines
Mon 3/27:04 pm
CAE
- MCI
2 stops21h 25m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$223
This Delta deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/21:30 pm
STL
- SAV
1 stop4h 17m
Delta
Sun 7/57:50 pm
SAV
- STL
1 stop4h 48m
Delta
Deal found 1/31![Delta logo]()
$237
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:24 pm
MCI
- MYR
1 stop28h 09m
Spirit Airlines
Fri 4/177:51 pm
MYR
- MCI
1 stop16h 16m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$219
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2512:38 pm
MCI
- CAE
1 stop7h 46m
American Airlines
Sun 3/17:45 pm
CAE
- MCI
1 stop5h 30m
American Airlines
Deal found 2/2![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:40 am
STL
- CLT
1 stop7h 30m
Southwest
Mon 4/67:20 pm
CLT
- STL
1 stop5h 10m
Southwest
Deal found 2/1![Southwest logo]()
$257
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/49:55 am
STL
- CLT
2 stops10h 14m
United Airlines
Sat 3/78:00 am
CLT
- STL
1 stop14h 41m
United Airlines
Deal found 2/1![United Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:01 pm
STL
- SAV
1 stop5h 56m
Delta
Sat 3/145:33 am
SAV
- STL
1 stop4h 29m
Delta
Deal found 2/2![Delta logo]()
$237
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:22 pm
MCI
- CAE
1 stop6h 30m
American Airlines
Mon 3/28:11 pm
CAE
- MCI
1 stop4h 48m
American Airlines
Deal found 2/1![American Airlines logo]()
$269
This CheapOair deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/511:26 am
MCI
- MYR
1 stop19h 47m
Spirit Airlines
Mon 3/99:09 am
MYR
- MCI
2 stops31h 20m
Spirit Airlines
Deal found 1/31![Spirit Airlines logo]()
$234
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:25 am
STL
- CLT
2 stops6h 46m
United Airlines
Sat 3/148:00 am
CLT
- STL
1 stop14h 42m
United Airlines
Deal found 2/1![United Airlines logo]()
$259
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:59 pm
STL
- SAV
1 stop3h 57m
Delta
Sun 4/55:33 am
SAV
- STL
1 stop4h 14m
Delta
Deal found 2/1![Delta logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2611:26 am
MCI
- CLT
1 stop11h 30m
Multiple Airlines
Sun 3/19:21 am
CLT
- MCI
2 stops25h 32m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$265
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/264:22 pm
MCI
- CAE
1 stop6h 30m
American Airlines
Sun 3/17:45 pm
CAE
- MCI
1 stop5h 30m
American Airlines
Deal found 2/1![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:05 pm
STL
- CHS
Nonstop1h 55m
Southwest
Thu 5/72:15 pm
CHS
- STL
Nonstop2h 15m
Southwest
Deal found 2/2![Southwest logo]()
$276
This Mytrip deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2711:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Sun 3/89:21 am
CLT
- MCI
3 stops31h 08m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$236
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated February 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:49 pm
STL
- CLT
1 stop15h 09m
Multiple Airlines
Sat 2/285:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/253:49 pm
STL
- CLT
1 stop15h 09m
Frontier
Sat 2/285:54 pm
CLT
- STL
2 stops37h 57m
Frontier
Deal found 2/2![Frontier logo]()
$160
This CheapOair deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:51 pm
STL
- CLT
1 stop22h 27m
Frontier
Wed 3/42:46 pm
CLT
- STL
1 stop8h 41m
Frontier
Deal found 1/31![Frontier logo]()
$165
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Frontier
Tue 3/101:59 pm
CLT
- STL
1 stop10h 20m
Frontier
Deal found 2/1![Frontier logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/1![Frontier logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop17h 28m
Multiple Airlines
Thu 3/55:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Mon 3/99:28 pm
CLT
- STL
1 stop26h 51m
Frontier
Deal found 2/2![Frontier logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Fri 3/67:43 pm
CLT
- STL
1 stop15h 06m
Frontier
Deal found 2/1![Frontier logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Multiple Airlines
Thu 3/55:49 pm
CLT
- STL
1 stop7h 10m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
- CLT
2 stops26h 34m
Multiple Airlines
Tue 3/101:59 pm
CLT
- STL
1 stop10h 20m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:51 pm
STL
- CLT
1 stop14h 12m
Frontier
Tue 3/177:48 pm
CLT
- STL
1 stop12h 49m
Frontier
Deal found 2/1![Frontier logo]()
$154
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/911:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Thu 3/121:20 pm
CLT
- MCI
1 stop23h 09m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$166
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/23:49 pm
STL
- CLT
1 stop21h 02m
Frontier
Deal found 2/1![Frontier logo]()
$67
This Priceline deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- CHS
1 stop8h 49m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$73
This Cheapflightsfares deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/911:26 am
MCI
- CLT
1 stop11h 30m
Spirit Airlines
Deal found 2/3![Spirit Airlines logo]()
$73
This Cheapflightsfares deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3112:24 pm
MCI
- CLT
1 stop11h 14m
Spirit Airlines
Deal found 2/1![Spirit Airlines logo]()
$74
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:49 pm
STL
- CLT
1 stop15h 54m
Frontier
Deal found 2/2![Frontier logo]()
$76
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/288:41 pm
MCI
- CLT
1 stop18h 37m
Frontier
Deal found 2/1![Frontier logo]()
$76
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/13:49 pm
STL
- CLT
1 stop14h 00m
Frontier
Deal found 2/2![Frontier logo]()
$79
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/283:05 pm
STL
- CLT
Nonstop1h 45m
Southwest
Deal found 2/1![Southwest logo]()
$80
This Trip.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
- MYR
2 stops34h 51m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
- CLT
2 stops26h 34m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3012:24 pm
MCI
- CLT
1 stop24h 53m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:26 am
MCI
- MYR
1 stop19h 47m
Spirit Airlines
Deal found 2/2![Spirit Airlines logo]()
$87
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $137 (Kiwi.com) |
One-way from | $67 (Kiwi.com) |
Popular in | March |
Cheapest in | February |
Average price | $195 |
Good round-trip deal | $360 or less |
Good one-way deal | $216 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Missouri
Fly to
South Carolina
Route
Depart
Return
Price
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Mon 3/9
11:26 am-11:56 pm
1 stop11h 30m
Charlotte Douglas
Thu 3/12
1:20 pm-11:29 am
1 stop23h 09m
$166
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Wed 4/1
12:24 pm-5:33 pm
1 stop28h 09m
Myrtle Beach Intl
Tue 4/7
6:28 pm-11:29 am
1 stop18h 01m
$180
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Fri 3/6
8:12 pm-6:28 pm
1 stop21h 16m
Charlotte Douglas
Sun 3/8
7:43 pm-9:49 am
1 stop15h 06m
$181
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Mon 3/2
3:49 pm-8:38 am
1 stop15h 49m
Charleston
Thu 3/5
5:00 pm-11:49 am
2 stops19h 49m
$182
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 2/17
3:49 pm-7:58 am
1 stop15h 09m
Charlotte Douglas
Sat 2/21
8:44 pm-6:51 am
2 stops35h 07m
$199
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 2/25
2:30 pm-5:15 pm
Nonstop1h 45m
Charlotte Douglas
Wed 3/4
5:50 pm-9:00 pm
1 stop4h 10m
$201
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Sun 2/22
10:14 am-12:20 pm
2 stops49h 06m
Charlotte Douglas
Wed 2/25
1:24 pm-10:30 am
1 stop22h 06m
$202
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Sat 5/16
12:12 pm-12:40 am
1 stop11h 28m
Charlotte Douglas
Sat 5/23
6:00 am-11:07 am
1 stop6h 07m
$208
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 3/17
5:51 pm-8:49 pm
Nonstop1h 58m
Charlotte Douglas
Tue 3/24
3:52 pm-5:01 pm
Nonstop2h 09m
$213
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 2/25
7:00 am-1:46 pm
1 stop5h 46m
Charlotte Douglas
Wed 3/4
7:01 am-4:02 pm
2 stops10h 01m
$216
Showing 1-10 of 60 results
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
MCI-CLT
STL-CLT
STL-CHS
STL-SAV
MCI-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
MCI-CLT
STL-CLT
STL-CHS
STL-SAV
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $84). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 3, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 3, 2026.
See what other customers who have flown with Southwest, Delta, and United Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Crew
8.6
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$84 | Average$206 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$367 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$195 | Average$408 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$237 | Average$397 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$268 | Average$318 | FlexibilityNo cancel fee | On-time69% |