$82+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
May 1 — May 81
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Fri 5/16:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/30![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/31![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/31![Frontier logo]()
$171
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:41 am
STL
- CLT
1 stop14h 55m
Frontier
Sun 4/128:10 am
CLT
- STL
1 stop24h 41m
Frontier
Deal found 3/27![Frontier logo]()
$180
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Fri 4/176:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/30![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Sun 5/107:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 3/31![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Mon 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 3/30![Frontier logo]()
$192
This American Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:30 am
STL
- CLT
Nonstop2h 00m
American Airlines
Tue 6/97:35 am
CLT
- STL
Nonstop1h 58m
American Airlines
Deal found 3/31![American Airlines logo]()
$197
This Expedia deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:59 pm
STL
- CLT
1 stop15h 38m
Frontier
Tue 4/145:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/30![Frontier logo]()
$201
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:30 pm
STL
- CLT
1 stop6h 10m
Southwest
Tue 6/91:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 3/31![Southwest logo]()
$207
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:58 pm
STL
- CLT
1 stop11h 17m
Frontier
Sun 6/147:14 pm
CLT
- STL
1 stop25h 09m
Frontier
Deal found 3/31![Frontier logo]()
$210
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:08 pm
STL
- CLT
1 stop21h 06m
Frontier
Mon 5/251:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/27![Frontier logo]()
$211
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 1, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 1, 2026.
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:30 pm
STL
- CLT
1 stop6h 10m
Southwest
Tue 6/97:50 am
CLT
- STL
2 stops8h 00m
Southwest
Deal found 3/31![Southwest logo]()
$222
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:15 am
STL
- CHS
1 stop4h 58m
United Airlines
Tue 4/215:00 pm
CHS
- STL
1 stop5h 13m
United Airlines
Deal found 3/29![United Airlines logo]()
$298
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/261:02 pm
STL
- CHS
1 stop6h 39m
Delta
Mon 5/47:44 pm
CHS
- STL
1 stop4h 52m
Delta
Deal found 3/30![Delta logo]()
$326
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2812:27 pm
STL
- MYR
2 stops8h 29m
American Airlines
Mon 5/45:00 am
MYR
- STL
1 stop4h 30m
American Airlines
Deal found 4/1![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:35 am
STL
- CHS
1 stop6h 00m
Southwest
Thu 4/302:45 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/29![Southwest logo]()
$249
This Southwest deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/104:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Sun 6/149:20 pm
CLT
- STL
1 stop3h 35m
Southwest
Deal found 3/31![Southwest logo]()
$260
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:45 am
STL
- CHS
1 stop5h 06m
United Airlines
Wed 5/65:08 pm
CHS
- STL
1 stop6h 37m
United Airlines
Deal found 3/31![United Airlines logo]()
$312
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:01 pm
STL
- CHS
1 stop3h 58m
Delta
Sat 6/65:15 am
CHS
- STL
1 stop4h 04m
Delta
Deal found 3/31![Delta logo]()
$326
This Southwest deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:50 am
STL
- CHS
1 stop6h 10m
Southwest
Tue 4/213:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/29![Southwest logo]()
$288
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:28 pm
STL
- CLT
1 stop6h 17m
United Airlines
Wed 5/66:25 pm
CLT
- STL
1 stop6h 32m
United Airlines
Deal found 3/31![United Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/163:06 pm
MCI
- CLT
1 stop4h 12m
Delta
Sat 5/235:35 am
CLT
- MCI
1 stop4h 44m
Delta
Deal found 3/27![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/103:43 pm
STL
- CAE
1 stop5h 02m
American Airlines
Tue 4/1412:28 pm
CAE
- STL
1 stop8h 02m
American Airlines
Deal found 3/28![American Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:10 pm
STL
- CHS
1 stop7h 00m
Southwest
Wed 6/37:40 am
CHS
- STL
2 stops8h 30m
Southwest
Deal found 3/30![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/62:59 pm
MCI
- SAV
1 stop6h 00m
United Airlines
Sat 5/98:08 am
SAV
- MCI
1 stop7h 18m
United Airlines
Deal found 3/29![United Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:24 pm
STL
- MYR
1 stop5h 35m
Delta
Sun 6/147:54 pm
MYR
- STL
1 stop5h 02m
Delta
Deal found 3/31![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:45 pm
STL
- CHS
2 stops6h 05m
Southwest
Mon 6/17:55 pm
CHS
- STL
1 stop4h 20m
Southwest
Deal found 3/28![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:00 pm
MCI
- SAV
1 stop5h 59m
United Airlines
Sat 4/255:45 am
SAV
- MCI
2 stops7h 39m
United Airlines
Deal found 3/27![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/63:49 pm
STL
- CAE
1 stop7h 03m
American Airlines
Sat 4/112:43 pm
CAE
- STL
1 stop4h 06m
American Airlines
Deal found 4/1![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/64:41 pm
STL
- MYR
1 stop6h 33m
Delta
Fri 5/811:32 am
MYR
- STL
1 stop6h 44m
Delta
Deal found 3/27![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:45 pm
STL
- CHS
2 stops6h 05m
Southwest
Mon 5/115:45 pm
CHS
- STL
1 stop5h 55m
Southwest
Deal found 3/30![Southwest logo]()
$303
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Tue 6/910:27 am
CLT
- STL
2 stops11h 49m
United Airlines
Deal found 3/30![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 pm
STL
- MYR
1 stop4h 24m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/28![Delta logo]()
$351
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:30 am
STL
- CHS
1 stop4h 47m
United Airlines
Tue 5/1910:15 am
CHS
- STL
2 stops11h 58m
United Airlines
Deal found 3/29![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:15 pm
STL
- MYR
1 stop5h 43m
Delta
Fri 6/57:55 pm
MYR
- STL
1 stop5h 04m
Delta
Deal found 3/30![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/141:45 pm
STL
- CLT
1 stop6h 10m
Southwest
Tue 5/126:20 pm
CLT
- STL
1 stop4h 50m
Southwest
Deal found 3/28![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/302:21 pm
SGF
- CLT
1 stop6h 45m
American Airlines
Sun 5/315:45 am
CLT
- SGF
1 stop5h 45m
American Airlines
Deal found 4/1![American Airlines logo]()
$500
This United Airlines deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/247:45 am
STL
- MYR
1 stop5h 32m
United Airlines
Tue 4/283:15 pm
MYR
- STL
1 stop6h 58m
United Airlines
Deal found 3/29![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:21 am
STL
- MYR
1 stop7h 09m
Delta
Tue 6/27:55 pm
MYR
- STL
1 stop5h 04m
Delta
Deal found 3/28![Delta logo]()
$351
This Southwest deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/275:40 am
STL
- CHS
2 stops5h 55m
Southwest
Mon 5/46:00 am
CHS
- STL
2 stops7h 50m
Southwest
Deal found 3/30![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
STL
- CAE
1 stop6h 02m
Delta
Sun 6/215:35 am
CAE
- STL
1 stop3h 41m
Delta
Deal found 3/28![Delta logo]()
$357
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated April 1, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated April 1, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:41 am
STL
- CLT
1 stop14h 55m
Frontier
Sun 4/128:10 am
CLT
- STL
1 stop24h 41m
Frontier
Deal found 3/27![Frontier logo]()
$180
This Expedia deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/124:59 pm
STL
- CLT
1 stop15h 38m
Frontier
Tue 4/145:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/30![Frontier logo]()
$201
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Fri 4/176:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/30![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/174:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/31![Frontier logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Wed 4/228:09 pm
CLT
- STL
2 stops15h 21m
Frontier
Deal found 3/29![Frontier logo]()
$213
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Fri 5/16:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/30![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/31![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Mon 5/46:18 pm
CLT
- MCI
1 stop20h 31m
Frontier
Deal found 3/30![Frontier logo]()
$192
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Thu 5/75:20 pm
CLT
- MCI
1 stop21h 29m
Frontier
Deal found 4/1![Frontier logo]()
$212
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Mon 5/411:33 am
CLT
- STL
1 stop12h 46m
Frontier
Deal found 3/27![Frontier logo]()
$212
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Sun 5/107:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 3/31![Frontier logo]()
$192
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:08 pm
STL
- CLT
1 stop21h 06m
Frontier
Mon 5/251:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/27![Frontier logo]()
$211
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 1, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 1, 2026.
This CheapOair deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/284:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/28![Frontier logo]()
$82
This Frontier deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:51 pm
STL
- CLT
1 stop11h 34m
Frontier
Deal found 3/30![Frontier logo]()
$90
This Frontier deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:21 pm
STL
- CLT
1 stop9h 04m
Frontier
Deal found 3/28![Frontier logo]()
$95
This Expedia deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/30![Frontier logo]()
$96
This Trip.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Deal found 3/28![Frontier logo]()
$99
This Expedia deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:10 pm
STL
- CLT
1 stop19h 07m
Frontier
Deal found 3/31![Frontier logo]()
$101
This CheapOair deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/31![Frontier logo]()
$102
This CheapOair deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Deal found 4/1![Frontier logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- CLT
2 stops17h 13m
Multiple Airlines
Deal found 3/31![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/298:23 pm
STL
- CLT
2 stops16h 21m
Frontier
Deal found 3/31![Frontier logo]()
$108
This Delta deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
STL
- CLT
1 stop4h 05m
Delta
Deal found 3/31![Delta logo]()
$109
This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/306:00 am
STL
- CLT
2 stops7h 12m
United Airlines
Deal found 3/31![United Airlines logo]()
$114
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated April 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $151 (CheapOair) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | February |
Average price | $361 |
Good round-trip deal | $326 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Tue 6/2
2:30 pm-9:40 pm
1 stop6h 10m
Charlotte Douglas
Tue 6/9
7:50 am-2:50 pm
2 stops8h 00m
$222
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 4/22
6:35 am-1:35 pm
1 stop6h 00m
Charleston
Thu 4/30
2:45 pm-4:05 pm
Nonstop2h 20m
$249
Quickest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 6/10
4:50 pm-7:40 pm
Nonstop1h 50m
Charlotte Douglas
Sun 6/14
9:20 pm-11:55 pm
1 stop3h 35m
$260
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 4/18
8:50 am-4:00 pm
1 stop6h 10m
Charleston
Tue 4/21
3:40 pm-5:00 pm
Nonstop2h 20m
$288
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sun 5/31
2:10 pm-10:10 pm
1 stop7h 00m
Charleston
Wed 6/3
7:40 am-3:10 pm
2 stops8h 30m
$292
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Sat 4/18
11:15 am-5:13 pm
1 stop4h 58m
Charleston
Tue 4/21
5:00 pm-9:13 pm
1 stop5h 13m
$298
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 5/29
1:45 pm-8:50 pm
2 stops6h 05m
Charleston
Mon 6/1
7:55 pm-11:15 pm
1 stop4h 20m
$303
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 5/8
1:45 pm-8:50 pm
2 stops6h 05m
Charleston
Mon 5/11
5:45 pm-10:40 pm
1 stop5h 55m
$303
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/5
7:45 am-1:51 pm
1 stop5h 06m
Charleston
Wed 5/6
5:08 pm-10:45 pm
1 stop6h 37m
$312
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 5/4
5:28 pm-12:45 am
1 stop6h 17m
Charlotte Douglas
Wed 5/6
6:25 pm-11:57 pm
1 stop6h 32m
$318
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
MCI-CLT
STL-CHS
STL-MYR
STL-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
MCI-CLT
STL-CHS
STL-MYR
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 65% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Missouri to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 1, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Crew
8.6
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on April 1, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$361 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$403 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$404 | FlexibilityNo cancel fee | On-time63% |