$70+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — CHS
Apr 27 — May 41
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South Carolina with Cheapflights
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.
This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/23![Frontier logo]()
$140
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Fri 5/16:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/27![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/84:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Sun 5/107:58 pm
CLT
- STL
1 stop5h 23m
Frontier
Deal found 3/25![Frontier logo]()
$171
This Expedia deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Fri 4/104:33 pm
CLT
- STL
1 stop8h 25m
Frontier
Deal found 3/23![Frontier logo]()
$180
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:55 pm
STL
- CLT
Nonstop2h 00m
American Airlines
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/25![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:53 pm
STL
- CLT
Nonstop1h 57m
American Airlines
Sat 5/167:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/25![American Airlines logo]()
$190
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Wed 4/298:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/26![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/25![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:06 pm
STL
- CLT
1 stop20h 29m
Frontier
Sun 4/1910:07 am
CLT
- STL
1 stop14h 12m
Frontier
Deal found 3/26![Frontier logo]()
$192
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:47 am
STL
- CLT
1 stop8h 16m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/24![Frontier logo]()
$195
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/25![Frontier logo]()
$201
This Priceline deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/23![Frontier logo]()
$205
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 28, 2026.
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:08 pm
STL
- CLT
1 stop21h 06m
Frontier
Mon 5/251:00 pm
CLT
- STL
1 stop12h 21m
Frontier
Deal found 3/27![Frontier logo]()
$211
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:10 am
STL
- CLT
2 stops8h 00m
Southwest
Sat 4/257:05 am
CLT
- STL
2 stops7h 30m
Southwest
Deal found 3/26![Southwest logo]()
$219
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/287:25 am
STL
- MYR
1 stop4h 32m
Delta
Mon 5/47:03 pm
MYR
- STL
1 stop5h 33m
Delta
Deal found 3/27![Delta logo]()
$272
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:17 am
MCI
- CHS
1 stop5h 00m
United Airlines
Tue 5/191:19 pm
CHS
- MCI
1 stop5h 01m
United Airlines
Deal found 3/23![United Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:59 pm
STL
- MYR
1 stop16h 01m
Multiple Airlines
Sun 5/39:50 pm
MYR
- STL
2 stops44h 46m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$340
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/65:49 am
SGF
- CLT
Nonstop2h 21m
American Airlines
Mon 6/84:13 pm
CLT
- SGF
Nonstop2h 29m
American Airlines
Deal found 3/27![American Airlines logo]()
$460
This Southwest deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/122:30 pm
STL
- CHS
1 stop4h 30m
Southwest
Tue 5/193:40 pm
CHS
- STL
Nonstop2h 20m
Southwest
Deal found 3/27![Southwest logo]()
$249
This Delta deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:27 pm
STL
- CLT
1 stop5h 47m
Delta
Sat 5/305:35 am
CLT
- STL
1 stop5h 04m
Delta
Deal found 3/27![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/273:20 pm
MCI
- CLT
1 stop5h 40m
Southwest
Wed 4/297:20 pm
CLT
- MCI
1 stop4h 20m
Southwest
Deal found 3/25![Southwest logo]()
$258
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/192:59 pm
MCI
- SAV
1 stop6h 00m
United Airlines
Tue 5/2612:10 pm
SAV
- MCI
1 stop7h 53m
United Airlines
Deal found 3/24![United Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:00 pm
STL
- CHS
1 stop4h 30m
Southwest
Tue 4/286:40 am
CHS
- STL
2 stops7h 20m
Southwest
Deal found 3/26![Southwest logo]()
$265
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/126:30 am
STL
- MYR
1 stop6h 47m
United Airlines
Wed 4/153:15 pm
MYR
- STL
1 stop6h 58m
United Airlines
Deal found 3/24![United Airlines logo]()
$294
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:13 pm
MCI
- SAV
1 stop5h 27m
Delta
Wed 6/35:30 am
SAV
- MCI
1 stop4h 59m
Delta
Deal found 3/26![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/151:15 pm
STL
- MYR
1 stop6h 15m
Southwest
Sat 4/187:10 am
MYR
- STL
1 stop10h 15m
Southwest
Deal found 3/26![Southwest logo]()
$267
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/47:25 am
STL
- CAE
1 stop4h 49m
Delta
Tue 5/125:38 am
CAE
- STL
1 stop3h 32m
Delta
Deal found 3/24![Delta logo]()
$314
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:55 am
MCI
- SAV
2 stops7h 05m
Southwest
Tue 5/267:05 pm
SAV
- MCI
1 stop4h 35m
Southwest
Deal found 3/24![Southwest logo]()
$268
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:45 am
STL
- CHS
1 stop5h 10m
United Airlines
Wed 4/2211:22 am
CHS
- STL
2 stops11h 30m
United Airlines
Deal found 3/25![United Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/223:26 pm
SGF
- CLT
1 stop19h 51m
Multiple Airlines
Thu 6/259:10 pm
CLT
- SGF
1 stop13h 24m
Multiple Airlines
Deal found 3/27![Multiple Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:01 pm
STL
- CAE
1 stop3h 43m
Delta
Wed 5/135:38 am
CAE
- STL
1 stop3h 32m
Delta
Deal found 3/24![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/17:09 pm
STL
- CLT
1 stop4h 36m
United Airlines
Sat 5/25:28 pm
CLT
- STL
1 stop4h 45m
United Airlines
Deal found 3/23![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/11:45 pm
STL
- SAV
2 stops6h 30m
Southwest
Fri 6/57:20 am
SAV
- STL
1 stop4h 30m
Southwest
Deal found 3/23![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2110:49 am
STL
- SAV
1 stop4h 19m
Delta
Tue 5/265:30 am
SAV
- STL
1 stop3h 48m
Delta
Deal found 3/25![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:43 pm
SGF
- CLT
1 stop5h 10m
American Airlines
Wed 6/179:23 am
CLT
- SGF
Nonstop2h 34m
American Airlines
Deal found 3/27![American Airlines logo]()
$490
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:45 am
STL
- MYR
1 stop5h 33m
United Airlines
Tue 5/123:14 pm
MYR
- STL
1 stop6h 59m
United Airlines
Deal found 3/23![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:40 pm
MCI
- CLT
1 stop5h 00m
Southwest
Fri 6/127:05 pm
CLT
- MCI
1 stop5h 10m
Southwest
Deal found 3/24![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:06 pm
MCI
- SAV
1 stop6h 23m
Delta
Wed 6/35:30 am
SAV
- MCI
1 stop6h 46m
Delta
Deal found 3/26![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/27:45 am
STL
- SAV
2 stops10h 41m
United Airlines
Sat 5/95:45 am
SAV
- STL
2 stops8h 02m
United Airlines
Deal found 3/26![United Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/101:40 pm
MCI
- CLT
1 stop5h 00m
Southwest
Sat 6/136:35 am
CLT
- MCI
1 stop4h 05m
Southwest
Deal found 3/24![Southwest logo]()
$299
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/115:24 pm
STL
- SAV
1 stop5h 37m
Delta
Sun 6/145:39 am
SAV
- STL
1 stop3h 37m
Delta
Deal found 3/25![Delta logo]()
$338
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/210:25 am
STL
- CHS
2 stops12h 34m
United Airlines
Fri 5/85:08 pm
CHS
- STL
1 stop5h 05m
United Airlines
Deal found 3/26![United Airlines logo]()
$368
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated March 28, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated March 28, 2026 and is based on user searches.
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:47 am
STL
- CLT
1 stop8h 16m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/24![Frontier logo]()
$195
This Priceline deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/34:54 pm
STL
- CLT
1 stop6h 42m
Frontier
Tue 4/74:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/23![Frontier logo]()
$205
This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/64:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Thu 4/91:46 pm
CLT
- STL
1 stop10h 39m
Frontier
Deal found 3/23![Frontier logo]()
$180
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/94:59 pm
STL
- CLT
1 stop6h 37m
Frontier
Mon 4/134:33 pm
CLT
- STL
1 stop7h 52m
Frontier
Deal found 3/25![Frontier logo]()
$201
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/168:06 pm
STL
- CLT
1 stop20h 29m
Frontier
Sun 4/1910:07 am
CLT
- STL
1 stop14h 12m
Frontier
Deal found 3/26![Frontier logo]()
$192
This Frontier deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:39 am
STL
- CLT
1 stop6h 34m
Frontier
Tue 4/215:30 pm
CLT
- STL
1 stop6h 49m
Frontier
Deal found 3/23![Frontier logo]()
$140
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/204:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Mon 4/2710:22 am
CLT
- STL
1 stop13h 57m
Frontier
Deal found 3/23![Frontier logo]()
$171
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:55 pm
STL
- CLT
Nonstop2h 00m
American Airlines
Wed 4/297:26 am
CLT
- STL
Nonstop2h 04m
American Airlines
Deal found 3/25![American Airlines logo]()
$189
This CheapOair deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Fri 5/16:30 pm
CLT
- STL
1 stop26h 02m
Frontier
Deal found 3/27![Frontier logo]()
$151
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Fri 5/16:30 pm
CLT
- MCI
1 stop20h 36m
Frontier
Deal found 3/25![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/274:59 pm
STL
- CLT
1 stop22h 36m
Frontier
Wed 4/298:09 pm
CLT
- STL
1 stop28h 10m
Frontier
Deal found 3/26![Frontier logo]()
$191
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/296:00 am
STL
- CLT
1 stop6h 43m
Delta
Tue 5/58:10 am
CLT
- STL
1 stop4h 46m
Delta
Deal found 3/26![Delta logo]()
$209
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 28, 2026.
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/248:39 am
STL
- CLT
1 stop6h 34m
Frontier
Deal found 3/27![Frontier logo]()
$70
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/264:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/27![Frontier logo]()
$76
This CheapOair deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/224:59 pm
STL
- CLT
1 stop23h 46m
Frontier
Deal found 3/23![Frontier logo]()
$82
This CheapOair deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/162:15 pm
MCI
- CLT
1 stop26h 20m
Frontier
Deal found 3/26![Frontier logo]()
$82
This Frontier deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:51 pm
STL
- CLT
1 stop11h 34m
Frontier
Deal found 3/25![Frontier logo]()
$90
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/239:21 pm
STL
- CLT
1 stop9h 04m
Frontier
Deal found 3/24![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/241:45 pm
MCI
- CLT
1 stop6h 39m
Frontier
Deal found 3/27![Frontier logo]()
$95
This Expedia deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:59 pm
STL
- CLT
1 stop15h 28m
Frontier
Deal found 3/27![Frontier logo]()
$96
This Trip.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/74:59 pm
STL
- CLT
1 stop22h 50m
Frontier
Deal found 3/23![Frontier logo]()
$99
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:19 pm
STL
- CLT
1 stop18h 46m
Frontier
Deal found 3/25![Frontier logo]()
$102
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:15 pm
MCI
- CLT
1 stop25h 41m
Frontier
Deal found 3/25![Frontier logo]()
$102
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:55 pm
STL
- CLT
1 stop4h 00m
Southwest
Deal found 3/25![Southwest logo]()
$105
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated March 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $140 (Frontier) |
One-way from | $70 (Frontier) |
Popular in | March |
Cheapest in | February |
Average price | $482 |
Good round-trip deal | $372 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 5/23
8:08 pm-6:14 pm
1 stop21h 06m
Charlotte Douglas
Mon 5/25
1:00 pm-12:21 am
1 stop12h 21m
$211
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 4/18
6:10 am-3:10 pm
2 stops8h 00m
Charlotte Douglas
Sat 4/25
7:05 am-1:35 pm
2 stops7h 30m
$219
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Tue 5/12
2:30 pm-8:00 pm
1 stop4h 30m
Charleston
Tue 5/19
3:40 pm-5:00 pm
Nonstop2h 20m
$249
Kansas CityCharlotte
MCI - CLT
MCICLT
Kansas City
Mon 4/27
3:20 pm-10:00 pm
1 stop5h 40m
Charlotte Douglas
Wed 4/29
7:20 pm-10:40 pm
1 stop4h 20m
$258
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Fri 4/24
4:00 pm-9:30 pm
1 stop4h 30m
Charleston
Tue 4/28
6:40 am-1:00 pm
2 stops7h 20m
$265
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Wed 4/15
1:15 pm-8:30 pm
1 stop6h 15m
Myrtle Beach Intl
Sat 4/18
7:10 am-4:25 pm
1 stop10h 15m
$267
Kansas CitySavannah
MCI - SAV
MCISAV
Kansas City
Tue 5/19
11:55 am-8:00 pm
2 stops7h 05m
Savannah/Hilton Head
Tue 5/26
7:05 pm-10:40 pm
1 stop4h 35m
$268
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Tue 4/28
7:25 am-12:57 pm
1 stop4h 32m
Myrtle Beach Intl
Mon 5/4
7:03 pm-11:36 pm
1 stop5h 33m
$272
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Thu 5/21
1:27 pm-8:14 pm
1 stop5h 47m
Charlotte Douglas
Sat 5/30
5:35 am-9:39 am
1 stop5h 04m
$279
Kansas CityCharleston
MCI - CHS
MCICHS
Kansas City
Wed 5/13
6:17 am-12:17 pm
1 stop5h 00m
Charleston
Tue 5/19
1:19 pm-5:20 pm
1 stop5h 01m
$281
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
MCI-CLT
STL-CHS
STL-SAV
STL-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
MCI-CLT
STL-CHS
STL-SAV
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in December is currently the most expensive (average of $257). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 28, 2026.
A simple way to save on the total cost of your ticket is to fly from Missouri to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 64% on your trip compared to booking a flight at noon.
What is the cheapest day to fly from Missouri to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Missouri to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Missouri to South Carolina flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Thursday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from Missouri to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 28, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Crew
8.6
Overall
8.0
Entertainment
7.5
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on March 28, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 5 airlines flying from Missouri to South Carolina
Discover the top 5 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$99 | Average$207 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$99 | Average$362 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$172 | Average$404 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$328 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$401 | FlexibilityNo cancel fee | On-time63% |