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South Carolina

$60+ Cheap flights from Mississippi to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — CHS
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Mississippi to South Carolina

Cheapest flights from Mississippi to South Carolina
Explore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This Expedia deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:07 pmMEM - CLT
1 stop14h 15mFrontier
Thu 1/112:17 pmCLT - MEM
1 stop7h 55mFrontier
Deal found 12/14$238
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:05 amMEM - GSP
1 stop6h 09mAmerican Airlines
Sat 1/36:20 pmGSP - MEM
1 stop6h 36mAmerican Airlines
Deal found 12/13$298
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:27 pmMEM - SAV
1 stop18h 30mMultiple Airlines
Mon 1/51:23 pmSAV - MEM
2 stops54h 59mMultiple Airlines
Deal found 12/14$323
This Expedia deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:07 pmMEM - CLT
1 stop14h 15mMultiple Airlines
Thu 1/19:00 amCLT - MEM
2 stops11h 22mMultiple Airlines
Deal found 12/14$336
This Kiwi.com deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:11 pmMEM - CHS
2 stops25h 12mMultiple Airlines
Mon 12/2910:18 pmCHS - MEM
1 stop22h 24mMultiple Airlines
Deal found 12/14$340
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:27 pmMEM - CLT
1 stop23h 06mMultiple Airlines
Sun 1/49:33 pmCLT - MEM
1 stop22h 49mMultiple Airlines
Deal found 12/13$344
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:17 pmMEM - CLT
1 stop16h 39mMultiple Airlines
Thu 1/12:22 pmCLT - MEM
1 stop6h 00mMultiple Airlines
Deal found 12/15$346
This American Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:42 pmMEM - SAV
1 stop4h 57mAmerican Airlines
Thu 1/16:01 pmSAV - MEM
1 stop6h 55mAmerican Airlines
Deal found 12/12$351
This Delta deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:00 amMEM - MYR
1 stop3h 26mDelta
Tue 12/306:59 pmMYR - MEM
1 stop5h 12mDelta
Deal found 12/14$351
This United Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:29 pmMEM - CHS
1 stop5h 28mUnited Airlines
Sun 12/285:00 pmCHS - MEM
1 stop5h 46mUnited Airlines
Deal found 12/14$351
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:11 amBTR - CLT
Nonstop2h 14mAmerican Airlines
Thu 12/254:30 pmCLT - BTR
Nonstop2h 18mAmerican Airlines
Deal found 12/15$359
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/287:50 pmGPT - CLT
1 stop24h 08mMultiple Airlines
Thu 1/12:22 pmCLT - GPT
1 stop5h 48mMultiple Airlines
Deal found 12/13$366

Find flight deals from Mississippi to South Carolina

Keep the following information in mind while searching for Mississippi to South Carolina flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$183
(Kiwi.com)

One-way from

$60
(Breeze Airways)
Provider with most accurate pricing for Jackson-Evers Intl-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Myrtle Beach Intl flights.
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From Mississippi to South Carolina
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One-way flight from Mississippi to South Carolina
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Mississippi to South Carolina that are best for you.

Fly from

Mississippi

Fly to

South Carolina

Route

Depart

Return

Price

MemphisCharlotte

MEM - CLT

MEMCLT

Memphis

Fri 1/23

11:44 am-9:55 am

1 stop21h 11m

Charlotte Douglas

Sun 1/25

6:00 am-7:28 pm

1 stop14h 28m

$194

MemphisCharlotte

MEM - CLT

MEMCLT

Memphis

Fri 1/16

11:44 am-11:28 am

2 stops22h 44m

Charlotte Douglas

Sun 1/18

6:43 pm-1:04 pm

1 stop19h 21m

$203

MemphisCharlotte

MEM - CLT

MEMCLT

Memphis

Tue 1/13

11:44 am-4:07 pm

1 stop27h 23m

Charlotte Douglas

Fri 1/16

1:24 pm-10:49 am

2 stops22h 25m

$210

GulfportSavannah

GPT - SAV

GPTSAV

Gulfport Biloxi Regional

Fri 1/9

10:21 am-5:20 pm

1 stop5h 59m

Savannah/Hilton Head

Sun 1/11

5:30 am-9:33 am

1 stop5h 03m

$215

MemphisCharleston

MEM - CHS

MEMCHS

Memphis

Sat 1/10

11:44 am-8:38 am

1 stop19h 54m

Charleston

Sat 1/17

6:35 pm-4:52 pm

2 stops23h 17m

$220

GulfportCharlotte

GPT - CLT

GPTCLT

Gulfport Biloxi Regional

Mon 2/2

6:54 pm-1:58 pm

2 stops18h 04m

Charlotte Douglas

Thu 2/5

11:12 am-6:40 pm

1 stop8h 28m

$235

MemphisCharlotte

MEM - CLT

MEMCLT

Memphis

Sat 2/14

11:14 am-10:17 am

1 stop22h 03m

Charlotte Douglas

Sat 2/21

4:49 pm-10:19 am

1 stop18h 30m

$246

MemphisCharleston

MEM - CHS

MEMCHS

Memphis

Sun 1/4

8:08 pm-9:23 pm

1 stop24h 15m

Charleston

Wed 1/7

2:15 pm-9:50 am

2 stops20h 35m

$251

MemphisGreenville

MEM - GSP

MEMGSP

Memphis

Wed 2/4

8:00 am-4:52 pm

1 stop7h 52m

Greenville

Tue 2/10

10:51 am-5:26 pm

1 stop7h 35m

$257

MemphisCharleston

MEM - CHS

MEMCHS

Memphis

Sat 1/10

11:44 am-4:10 pm

3 stops27h 26m

Charleston

Sat 1/17

6:35 pm-10:49 am

2 stops17h 14m

$258

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/13

Showing 1-10 of 60 results
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Best time to book a flight from Mississippi to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South Carolina

What is the cheapest month to book a flight from Mississippi to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Mississippi to South Carolina (average of $191). Flying from Mississippi to South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to SC?

Find hourly flight availability from Mississippi to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Mississippi to South Carolina in the evening. If you’re flexible enough to do this you can expect to save up to 26% on your trip compared to booking a flight in the morning.

How much does it cost to fly round-trip from Mississippi to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 15, 2025.
See what other customers who have flown with Delta and American Airlines from Mississippi to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Food

7.3

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,008 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Food

7.3

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,051 reviews
Delta
7.9
Good
8,008 reviews

Boarding

8.1

Food

7.3

Comfort

7.9

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to South Carolina?

    Departing from Mississippi to South Carolina will take you 5h 59m. The distance between Mississippi and South Carolina is about 479 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to South Carolina that include hotel bookings?

    Yes. In addition to deals on Mississippi to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South Carolina.

  • Can I find deals for business class flights from Mississippi to South Carolina?

    Yes. Cheapflights offers flight deals from Mississippi to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to South Carolina (average of $191). Flying from Mississippi to South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to South Carolina

Discover the top 2 airlines that operate flights from Mississippi to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$191Average$405FlexibilityNo cancel feeOn-time71%
DeltaCheapest$193Average$405FlexibilityNo cancel feeOn-timeN/A

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