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South Carolina

$94+ Cheap flights from Mississippi to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — CHS
Apr 16 — Apr 231
Thu 4/16
Thu 4/23
1 adult, Economy
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Cheap flight deals from Mississippi to South Carolina

Cheapest flights from Mississippi to South Carolina
Explore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 17, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:52 pm
MEM
-
CHS
1 stop4h 07m
Multiple Airlines
Mon 5/43:21 pm
CHS
-
MEM
1 stop25h 19m
Multiple Airlines
Deal found 3/14$197
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:49 pm
MEM
-
SAV
1 stop22h 02m
Multiple Airlines
Wed 8/512:19 pm
SAV
-
MEM
1 stop20h 25m
Multiple Airlines
Deal found 3/13$208
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/304:37 pm
MEM
-
CLT
1 stop20h 40m
Multiple Airlines
Wed 4/19:00 pm
CLT
-
MEM
1 stop23h 40m
Multiple Airlines
Deal found 3/16$208
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:00 pm
MEM
-
CAE
1 stop25h 00m
Allegiant Air
Thu 4/23:29 pm
CAE
-
MEM
1 stop16h 41m
Allegiant Air
Deal found 3/13$212
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:14 am
MEM
-
CLT
1 stop22h 03m
Spirit Airlines
Tue 4/2111:17 am
CLT
-
MEM
1 stop5h 23m
Spirit Airlines
Deal found 3/15$214
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/302:52 pm
MEM
-
CHS
1 stop4h 07m
Breeze Airways
Thu 5/78:20 pm
CHS
-
MEM
1 stop23h 03m
Breeze Airways
Deal found 3/16$219
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:03 pm
MEM
-
CHS
1 stop13h 34m
Multiple Airlines
Wed 6/108:56 pm
CHS
-
MEM
1 stop23h 53m
Multiple Airlines
Deal found 3/17$224
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:03 pm
MEM
-
CHS
1 stop16h 47m
Multiple Airlines
Wed 6/108:56 pm
CHS
-
MEM
1 stop23h 53m
Multiple Airlines
Deal found 3/17$229
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/293:00 pm
MEM
-
CLT
1 stop16h 21m
Multiple Airlines
Wed 4/19:00 pm
CLT
-
MEM
1 stop23h 40m
Multiple Airlines
Deal found 3/16$234
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:45 pm
MEM
-
CLT
1 stop13h 25m
Multiple Airlines
Thu 5/79:54 pm
CLT
-
MEM
1 stop20h 55m
Multiple Airlines
Deal found 3/16$235
This Kiwi.com deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/272:19 pm
MEM
-
CLT
1 stop17h 41m
Multiple Airlines
Wed 4/19:00 pm
CLT
-
MEM
1 stop23h 40m
Multiple Airlines
Deal found 3/16$242
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:33 pm
MEM
-
CHS
1 stop16h 55m
Multiple Airlines
Wed 6/108:56 pm
CHS
-
MEM
1 stop23h 53m
Multiple Airlines
Deal found 3/17$243

Find flight deals from Mississippi to South Carolina

Keep the following information in mind while searching for Mississippi to South Carolina flight deals. Data was last updated March 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$192
(Kiwi.com)

One-way from

$94
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Myrtle Beach Intl flights.
Search Deals
From Mississippi to South Carolina
Search Deals
One-way flight from Mississippi to South Carolina
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Mississippi to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisGreenville

MEM - GSP

MEMGSP

Memphis

Wed 4/29

3:25 pm-9:40 pm

1 stop5h 15m

Greenville

Wed 5/6

1:55 pm-9:45 pm

2 stops8h 50m

$300

MemphisMyrtle Beach

MEM - MYR

MEMMYR

Memphis

Sat 4/25

7:30 am-2:17 pm

1 stop5h 47m

Myrtle Beach Intl

Tue 4/28

3:15 pm-10:04 pm

1 stop7h 49m

$310

MemphisMyrtle Beach

MEM - MYR

MEMMYR

Memphis

Sat 4/25

7:50 am-12:10 pm

1 stop3h 20m

Myrtle Beach Intl

Tue 4/28

2:10 pm-10:50 pm

2 stops9h 40m

$315

MemphisSavannah

MEM - SAV

MEMSAV

Memphis

Sat 5/9

2:45 pm-6:55 pm

1 stop3h 10m

Savannah/Hilton Head

Wed 5/13

7:05 pm-9:45 pm

1 stop3h 40m

$317

MemphisCharleston

MEM - CHS

MEMCHS

Memphis

Wed 4/15

4:09 pm-11:59 pm

1 stop6h 50m

Charleston

Wed 4/22

5:00 pm-10:04 pm

1 stop6h 04m

$319

MemphisCharleston

MEM - CHS

MEMCHS

Memphis

Wed 4/15

8:10 am-12:25 pm

1 stop3h 15m

Charleston

Wed 4/22

6:40 am-9:05 am

1 stop3h 25m

$319

MemphisGreenville

MEM - GSP

MEMGSP

Memphis

Fri 4/24

7:26 pm-11:56 pm

1 stop3h 30m

Greenville

Tue 4/28

8:50 am-11:12 am

1 stop3h 22m

$335

MemphisGreenville

MEM - GSP

MEMGSP

Memphis

Wed 5/6

11:10 am-4:59 pm

1 stop4h 49m

Greenville

Sat 5/9

6:36 am-10:54 am

1 stop5h 18m

$357

MemphisMyrtle Beach

MEM - MYR

MEMMYR

Memphis

Wed 5/27

5:15 am-3:25 pm

2 stops9h 10m

Myrtle Beach Intl

Mon 6/1

3:45 pm-11:00 pm

1 stop8h 15m

$358

MemphisSavannah

MEM - SAV

MEMSAV

Memphis

Fri 5/8

7:45 am-5:45 pm

2 stops9h 00m

Savannah/Hilton Head

Wed 5/13

6:40 am-12:45 pm

2 stops7h 05m

$362

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/17

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Mississippi to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South Carolina

What is the cheapest month to book a flight from Mississippi to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Mississippi to South Carolina (average of $191). Flying from Mississippi to South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 17, 2026.
See what other customers who have flown with Delta and American Airlines from Mississippi to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,288 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,288 reviews
Delta
7.9
Good
8,288 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,468 reviews
Delta
7.9
Good
8,288 reviews

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Comfort

7.9

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to South Carolina?

    Departing from Mississippi to South Carolina will take you 4h 37m. The distance between Mississippi and South Carolina is about 543 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to South Carolina that include hotel bookings?

    Yes. In addition to deals on Mississippi to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South Carolina.

  • Can I find deals for business class flights from Mississippi to South Carolina?

    Yes. Cheapflights offers flight deals from Mississippi to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to South Carolina (average of $191). Flying from Mississippi to South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to South Carolina

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Top 2 airlines flying from Mississippi to South Carolina

Discover the top 2 airlines that operate flights from Mississippi to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$191Average$327FlexibilityNo cancel feeOn-time71%
DeltaCheapest$193Average$415FlexibilityNo cancel feeOn-timeN/A

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