$119+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This CheapOair deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop6h 30m
Sun 9/207:54 pm -
1 stop24h 39m
Deal found 8/20![Frontier logo]()
$260
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:58 pm -
2 stops28h 57m
Wed 9/235:37 pm -
1 stop27h 20m
Deal found 8/18![Multiple Airlines logo]()
$266
This CheapOair deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/111:29 am -
1 stop6h 30m
Sun 10/47:54 pm -
1 stop24h 39m
Deal found 8/20![Frontier logo]()
$270
This CheapOair deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop6h 30m
Thu 9/247:54 pm -
1 stop24h 39m
Deal found 8/20![Frontier logo]()
$279
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/17![Frontier logo]()
$283
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:45 am -
1 stop4h 27m
Sat 10/36:09 pm -
1 stop5h 17m
Deal found 8/18![Delta logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am -
2 stops26h 34m
Thu 10/89:32 am -
1 stop6h 10m
Deal found 8/17![Multiple Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:03 pm -
1 stop5h 20m
Sun 10/185:59 pm -
1 stop5h 34m
Deal found 8/20![Delta logo]()
$319
This CheapOair deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1311:29 am -
1 stop6h 30m
Sun 9/207:54 pm -
1 stop24h 39m
Deal found 8/16![Frontier logo]()
$321
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 36m
Sat 10/37:18 am -
1 stop7h 41m
Deal found 8/17![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:30 pm -
1 stop4h 29m
Tue 9/296:32 am -
1 stop6h 32m
Deal found 8/17![American Airlines logo]()
$325
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:09 am -
1 stop4h 14m
Wed 11/115:03 pm -
1 stop7h 21m
Deal found 8/17![American Airlines logo]()
$325
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:35 am -
1 stop4h 08m
Sun 10/185:59 pm -
1 stop5h 34m
Deal found 8/19![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/119:55 am -
1 stop6h 45m
Sat 11/144:57 pm -
1 stop6h 53m
Deal found 8/17![United Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:40 pm -
1 stop5h 35m
Sat 9/123:25 pm -
1 stop5h 05m
Deal found 8/18![Southwest logo]()
$337
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/254:13 pm -
1 stop5h 14m
Tue 9/86:46 pm -
1 stop5h 58m
Deal found 8/21![American Airlines logo]()
$359
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/74:07 pm -
1 stop4h 37m
Tue 11/103:23 pm -
1 stop6h 50m
Deal found 8/20![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:23 pm -
2 stops9h 36m
Mon 9/216:30 am -
1 stop5h 01m
Deal found 8/16![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:25 pm -
1 stop4h 10m
Mon 11/166:50 pm -
1 stop4h 10m
Deal found 8/20![Southwest logo]()
$337
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:39 am -
1 stop6h 45m
Thu 10/155:30 am -
1 stop6h 12m
Deal found 8/17![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:30 am -
1 stop8h 40m
Sat 11/149:50 am -
2 stops8h 43m
Deal found 8/17![United Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:44 pm -
1 stop7h 15m
Sun 9/138:41 pm -
1 stop4h 11m
Deal found 8/16![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:10 am -
2 stops11h 55m
Wed 9/2312:35 pm -
2 stops10h 25m
Deal found 8/18![Southwest logo]()
$353
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:54 pm -
1 stop4h 01m
Thu 9/246:45 am -
1 stop5h 01m
Deal found 8/18![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:05 am -
2 stops10h 06m
Thu 11/1211:27 am -
2 stops11h 33m
Deal found 8/20![United Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/2310:35 am -
2 stops7h 24m
Tue 9/291:11 pm -
1 stop5h 15m
Deal found 8/21![American Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/241:20 pm -
1 stop4h 45m
Fri 10/306:50 am -
2 stops7h 30m
Deal found 8/18![Southwest logo]()
$356
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:10 pm -
1 stop6h 45m
Thu 9/176:45 am -
1 stop5h 01m
Deal found 8/19![Delta logo]()
$325
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:05 am -
2 stops10h 06m
Wed 11/1111:27 am -
2 stops11h 58m
Deal found 8/18![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:10 pm -
2 stops13h 40m
Fri 10/306:40 am -
1 stop5h 30m
Deal found 8/20![Southwest logo]()
$358
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:45 am -
1 stop6h 36m
Sun 12/205:30 am -
1 stop5h 48m
Deal found 8/21![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:40 am -
1 stop10h 55m
Fri 9/253:20 pm -
2 stops7h 55m
Deal found 8/20![Southwest logo]()
$376
This United Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/2811:30 am -
2 stops10h 55m
Sun 1/314:59 pm -
1 stop5h 18m
Deal found 8/21![United Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:15 pm -
1 stop5h 20m
Wed 1/1310:55 am -
1 stop6h 32m
Deal found 8/19![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:25 am -
2 stops12h 30m
Wed 11/113:25 pm -
2 stops7h 35m
Deal found 8/19![Southwest logo]()
$378
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/98:00 am -
2 stops10h 07m
Sat 9/126:25 am -
1 stop5h 11m
Deal found 8/16![United Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:22 am -
1 stop5h 16m
Tue 11/1012:25 pm -
2 stops21h 25m
Deal found 8/21![American Airlines logo]()
$528
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:05 am -
2 stops7h 23m
Fri 11/273:29 pm -
1 stop7h 56m
Deal found 8/18![United Airlines logo]()
$383
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:10 am -
2 stops8h 55m
Wed 9/232:25 pm -
2 stops8h 35m
Deal found 8/17![Southwest logo]()
$391
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/127:06 am -
1 stop6h 15m
Mon 11/1612:25 pm -
2 stops21h 25m
Deal found 8/18![American Airlines logo]()
$528
This Delta deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/511:28 am -
1 stop7h 22m
Tue 9/86:26 pm -
1 stop5h 00m
Deal found 8/21![Delta logo]()
$411
This Southwest deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:25 am -
2 stops12h 25m
Thu 11/51:15 pm -
2 stops10h 45m
Deal found 8/17![Southwest logo]()
$393
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated August 21, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am -
1 stop7h 17m
Fri 9/113:24 pm -
1 stop7h 04m
Deal found 8/16![United Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/111:30 pm -
1 stop4h 15m
Mon 9/147:19 pm -
1 stop5h 22m
Deal found 8/17![American Airlines logo]()
$325
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/124:10 pm -
1 stop6h 45m
Thu 9/176:45 am -
1 stop5h 01m
Deal found 8/18![Delta logo]()
$325
This CheapOair deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1311:29 am -
1 stop6h 30m
Sun 9/207:54 pm -
1 stop24h 39m
Deal found 8/16![Frontier logo]()
$321
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:23 pm -
2 stops9h 36m
Mon 9/216:30 am -
1 stop5h 01m
Deal found 8/16![United Airlines logo]()
$330
This CheapOair deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop6h 30m
Sun 9/207:54 pm -
1 stop24h 39m
Deal found 8/20![Frontier logo]()
$260
This CheapOair deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop6h 30m
Thu 9/247:54 pm -
1 stop24h 39m
Deal found 8/20![Frontier logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/201:58 pm -
2 stops28h 57m
Wed 9/235:37 pm -
1 stop27h 20m
Deal found 8/18![Multiple Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:30 pm -
1 stop4h 29m
Tue 9/296:32 am -
1 stop6h 32m
Deal found 8/17![American Airlines logo]()
$325
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2411:29 am -
1 stop6h 30m
Sun 9/277:54 pm -
1 stop24h 39m
Deal found 8/17![Frontier logo]()
$283
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:45 am -
1 stop4h 27m
Sat 10/36:09 pm -
1 stop5h 17m
Deal found 8/18![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:30 pm -
1 stop6h 36m
Sat 10/37:18 am -
1 stop7h 41m
Deal found 8/17![American Airlines logo]()
$325
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
This Frontier deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:29 am -
1 stop6h 30m
Deal found 8/17![Frontier logo]()
$119
This CheapOair deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop18h 37m
Deal found 8/17![Frontier logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:25 am -
2 stops25h 12m
Deal found 8/19![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:45 am -
2 stops24h 52m
Deal found 8/19![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
2 stops34h 12m
Deal found 8/17![Multiple Airlines logo]()
$142
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/149:31 pm -
2 stops34h 04m
Deal found 8/17![Multiple Airlines logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:58 pm -
2 stops28h 57m
Deal found 8/17![Multiple Airlines logo]()
$149
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:35 pm -
1 stop6h 59m
Deal found 8/20![United Airlines logo]()
$163
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:15 am -
1 stop7h 18m
Deal found 8/18![United Airlines logo]()
$163
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:11 pm -
1 stop6h 44m
Deal found 8/20![Delta logo]()
$163
This United Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/128:00 am -
2 stops9h 06m
Deal found 8/18![United Airlines logo]()
$168
This United Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:23 pm -
2 stops8h 59m
Deal found 8/20![United Airlines logo]()
$168
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated August 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $260 (CheapOair) |
One-way from | $119 (Frontier) |
Popular in | July |
Cheapest in | January |
Average price | $391 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesColumbia
DSM Des Moines - CAE Columbia Metropolitan
DSMCAE
Des Moines
Thu 10/15
5:35 am-10:43 am
1 stop4h 08m
Columbia Metropolitan
Sun 10/18
5:59 pm-10:33 pm
1 stop5h 34m
$319
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Wed 11/11
9:55 am-5:40 pm
1 stop6h 45m
Savannah/Hilton Head
Sat 11/14
4:57 pm-10:50 pm
1 stop6h 53m
$325
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Sat 11/7
4:07 pm-9:44 pm
1 stop4h 37m
Charleston
Tue 11/10
3:23 pm-9:13 pm
1 stop6h 50m
$325
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Sat 10/10
5:39 am-1:24 pm
1 stop6h 45m
Savannah/Hilton Head
Thu 10/15
5:30 am-10:42 am
1 stop6h 12m
$325
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Mon 9/21
6:54 pm-11:55 pm
1 stop4h 01m
Savannah/Hilton Head
Thu 9/24
6:45 am-10:46 am
1 stop5h 01m
$325
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Sat 9/12
4:10 pm-11:55 pm
1 stop6h 45m
Savannah/Hilton Head
Thu 9/17
6:45 am-10:46 am
1 stop5h 01m
$325
Des MoinesCharleston
DSM Des Moines - CHS Charleston
DSMCHS
Des Moines
Tue 9/15
1:23 pm-11:59 pm
2 stops9h 36m
Charleston
Mon 9/21
6:30 am-10:31 am
1 stop5h 01m
$330
Des MoinesSavannah
DSM Des Moines - SAV Savannah/Hilton Head
DSMSAV
Des Moines
Tue 11/10
5:30 am-3:10 pm
1 stop8h 40m
Savannah/Hilton Head
Sat 11/14
9:50 am-5:33 pm
2 stops8h 43m
$330
Des MoinesCharlotte
DSM Des Moines - CLT Charlotte Douglas
DSMCLT
Des Moines
Wed 9/9
2:40 pm-9:15 pm
1 stop5h 35m
Charlotte Douglas
Sat 9/12
3:25 pm-7:30 pm
1 stop5h 05m
$337
Quickest round-trip
Des MoinesCharlotte
DSM Des Moines - CLT Charlotte Douglas
DSMCLT
Des Moines
Thu 11/12
4:25 pm-9:35 pm
1 stop4h 10m
Charlotte Douglas
Mon 11/16
6:50 pm-10:00 pm
1 stop4h 10m
$337
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-CAE
DSM-SAV
DSM-CLT
DSM-CHS
DSM-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-CAE
DSM-SAV
DSM-CLT
DSM-CHS
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, September is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $366). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $473). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to South Carolina?
Airfare is below average for this route at the moment.
Des Moines to South Carolina flights typically cost between $336 and $508 in September.The cheapest round-trip price found within the last 5 days was $325 on American Airlines (Sep 30-Oct 3).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated August 21, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Boarding
8.1
Entertainment
7.5
Overall
8.0
Crew
8.6
Food
7.0
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on August 21, 2026.
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Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$158 | Average$425 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$266 | Average$463 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$281 | Average$425 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$344 | Average$412 | FlexibilityNo cancel fee | On-time63% |