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South Carolina

$100+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Nov 13 — Nov 201
Thu 11/13
Thu 11/20
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated October 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$205
(Kiwi.com)

One-way from

$100
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$406
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - CLT
2 stops25h 16mFrontier
Thu 11/136:07 pmCLT - DSM
1 stop20h 42mFrontier
Deal found 10/11$205
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - CLT
2 stops25h 16mMultiple Airlines
Fri 11/145:45 amCLT - DSM
1 stop10h 10mMultiple Airlines
Deal found 10/11$214
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CLT
1 stop12h 28mMultiple Airlines
Thu 11/135:40 pmCLT - DSM
1 stop22h 15mMultiple Airlines
Deal found 10/14$219
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:40 amDSM - CLT
1 stop8h 45mMultiple Airlines
Wed 11/128:04 pmCLT - DSM
2 stops18h 52mMultiple Airlines
Deal found 10/11$227
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/510:55 amDSM - CLT
1 stop21h 07mMultiple Airlines
Tue 11/119:05 pmCLT - DSM
1 stop14h 00mMultiple Airlines
Deal found 10/12$228
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:30 amDSM - CHS
1 stop8h 43mMultiple Airlines
Wed 10/297:55 pmCHS - DSM
2 stops40h 20mMultiple Airlines
Deal found 10/13$231
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/910:50 amDSM - CLT
1 stop21h 12mMultiple Airlines
Wed 11/128:04 pmCLT - DSM
2 stops18h 52mMultiple Airlines
Deal found 10/11$243
This Kiwi.com deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:35 amDSM - CLT
1 stop28h 29mMultiple Airlines
Thu 12/1112:59 pmCLT - DSM
1 stop24h 56mMultiple Airlines
Deal found 10/13$244
This Kiwi.com deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/910:50 amDSM - CLT
1 stop21h 12mMultiple Airlines
Thu 11/136:07 pmCLT - DSM
1 stop20h 42mMultiple Airlines
Deal found 10/11$248
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:07 amDSM - CAE
1 stop7h 08mAmerican Airlines
Sun 11/28:00 pmCAE - DSM
1 stop5h 21mAmerican Airlines
Deal found 10/12$254
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/317:06 amDSM - CAE
1 stop7h 27mAmerican Airlines
Sat 11/13:02 pmCAE - DSM
1 stop7h 11mAmerican Airlines
Deal found 10/13$259
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:00 amDSM - CHS
1 stop6h 12mAmerican Airlines
Thu 12/47:15 amCHS - DSM
1 stop5h 27mAmerican Airlines
Deal found 10/13$282

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 11/10

2:32 pm-4:48 pm

2 stops25h 16m

Charlotte Douglas

Thu 11/13

5:40 pm-2:55 pm

1 stop22h 15m

$226

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 10/31

7:06 am-3:33 pm

1 stop7h 27m

Columbia Metropolitan

Sun 11/2

8:00 pm-12:21 am

1 stop5h 21m

$254

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 10/31

7:06 am-3:33 pm

1 stop7h 27m

Columbia Metropolitan

Sat 11/1

3:02 pm-9:13 pm

1 stop7h 11m

$259

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 10/31

3:15 pm-10:06 pm

1 stop5h 51m

Greenville

Tue 11/4

11:48 am-7:20 pm

1 stop8h 32m

$282

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

7:25 am-5:23 pm

1 stop8h 58m

Charleston

Sat 1/24

10:00 am-3:48 pm

1 stop6h 48m

$284

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 10/30

5:00 am-3:04 pm

2 stops9h 04m

Columbia Metropolitan

Sun 11/2

8:00 pm-12:21 am

1 stop5h 21m

$284

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Thu 11/27

6:17 am-4:17 pm

2 stops9h 00m

Savannah/Hilton Head

Thu 12/4

12:30 pm-5:47 pm

1 stop6h 17m

$287

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 1/6

4:30 pm-11:26 pm

1 stop5h 56m

Greenville

Sat 1/17

8:42 am-4:24 pm

2 stops8h 42m

$287

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

1:16 pm-9:53 pm

1 stop7h 37m

Charleston

Sat 1/24

6:10 am-12:46 pm

2 stops7h 36m

$289

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 11/27

6:00 am-1:59 pm

2 stops6h 59m

Myrtle Beach Intl

Thu 12/4

6:00 am-12:23 pm

2 stops7h 23m

$291

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/12

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 14, 2025.

Unlike in the evening, when flights are generally more expensive, you can save up to 22% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Des Moines to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Des Moines to South Carolina?

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 14, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,975 reviews
Southwest
8.0
Very good
4,238 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,976 reviews
Southwest
8.0
Very good
4,238 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,042 reviews
Southwest
8.0
Very good
4,238 reviews

Comfort

8.0

Food

7.0

Boarding

8.1

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • How long is the flight from Des Moines to South Carolina?

    Departing from Des Moines to South Carolina will take you 5h 51m. There are 771 mi between Des Moines and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $107. Users have also found prices from $126 and $154 on Delta and Allegiant Air, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Columbia Metropolitan as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$396FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$376FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$431FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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