
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $225 (CheapOair) |
One-way from | $100 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $354 |
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Tue 2/24
7:45 am-4:55 pm
1 stop8h 10m
Columbia Metropolitan
Sat 2/28
7:00 am-11:56 am
1 stop5h 56m
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Sat 3/28
5:20 pm-11:48 pm
1 stop5h 28m
Columbia Metropolitan
Sat 4/4
5:34 am-10:48 am
1 stop6h 14m
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 2/25
7:45 am-4:55 pm
1 stop8h 10m
Columbia Metropolitan
Sat 2/28
7:00 am-11:56 am
1 stop5h 56m
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sun 3/22
3:59 pm-5:33 pm
1 stop24h 34m
Myrtle Beach Intl
Wed 3/25
6:28 pm-1:29 pm
1 stop20h 01m
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 3/9
4:20 pm-10:25 pm
1 stop5h 05m
Charlotte Douglas
Mon 3/16
8:00 am-12:10 pm
1 stop5h 10m
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 3/24
7:15 am-4:08 pm
1 stop7h 53m
Charleston
Tue 3/31
8:00 am-12:29 pm
1 stop5h 29m
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 3/10
2:04 pm-8:00 pm
1 stop4h 56m
Savannah/Hilton Head
Tue 3/17
10:00 am-2:22 pm
1 stop5h 22m
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 3/18
5:20 pm-12:04 am
1 stop5h 44m
Myrtle Beach Intl
Wed 3/25
6:00 am-4:54 pm
2 stops11h 54m
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 3/17
5:20 pm-12:04 am
1 stop5h 44m
Myrtle Beach Intl
Wed 3/25
6:00 am-4:54 pm
2 stops11h 54m
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 4/28
3:21 pm-9:08 pm
1 stop4h 47m
Savannah/Hilton Head
Sat 5/2
6:00 am-2:24 pm
2 stops9h 24m
Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Unlike in the morning, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.
Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Boarding
Crew
Overall
Food
Entertainment
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Overall
Food
Entertainment
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Overall
Food
Entertainment
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Overall
Food
Entertainment
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
Boarding
Crew
Overall
Food
Entertainment
Comfort
Reviews
Thomas,Dec 2025
SEA - DEN
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$408 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% |