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South Carolina

$93+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Jan 26 — Feb 21
Mon 1/26
Mon 2/2
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 27, 2025.

This American Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:28 pmDSM - CLT
1 stop6h 10mAmerican Airlines
Sat 1/311:42 amCLT - DSM
Nonstop2h 32mAmerican Airlines
Deal found 12/25$431
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:55 pmDSM - CLT
1 stop4h 42mDelta
Sat 1/36:20 amCLT - DSM
1 stop6h 08mDelta
Deal found 12/25$441
This American Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:07 pmDSM - CLT
Nonstop2h 23mAmerican Airlines
Sat 1/311:42 amCLT - DSM
Nonstop2h 32mAmerican Airlines
Deal found 12/27$469
This United Airlines deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:35 amDSM - CLT
1 stop5h 03mUnited Airlines
Sat 1/36:20 amCLT - DSM
2 stops11h 05mUnited Airlines
Deal found 12/25$484
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:30 pmDSM - CLT
1 stop4h 16mDelta
Sat 1/36:20 amCLT - DSM
1 stop6h 08mDelta
Deal found 12/26$489
This American Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:25 pmDSM - CLT
1 stop4h 45mAmerican Airlines
Fri 1/210:46 pmCLT - DSM
Nonstop2h 51mAmerican Airlines
Deal found 12/27$532
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:35 amDSM - CLT
1 stop4h 18mDelta
Sat 1/37:05 amCLT - DSM
1 stop4h 33mDelta
Deal found 12/26$555
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/303:14 pmDSM - CLT
2 stops7h 45mUnited Airlines
Sat 1/36:20 amCLT - DSM
1 stop5h 30mUnited Airlines
Deal found 12/26$564
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:35 amDSM - CHS
1 stop7h 21mDelta
Fri 1/29:23 amCHS - DSM
1 stop5h 15mDelta
Deal found 12/26$677
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:25 pmDSM - CHS
2 stops7h 46mAmerican Airlines
Fri 1/212:25 pmCHS - DSM
1 stop7h 02mAmerican Airlines
Deal found 12/26$682
This Kiwi.com deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:35 amDSM - MYR
1 stop16h 24mMultiple Airlines
Wed 12/316:00 amMYR - DSM
1 stop8h 54mMultiple Airlines
Deal found 12/25$737
This American Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/301:34 pmDSM - CHS
2 stops7h 37mAmerican Airlines
Thu 1/112:51 pmCHS - DSM
2 stops6h 31mAmerican Airlines
Deal found 12/26$747

Find flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated December 27, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$229
(Kiwi.com)

One-way from

$93
(Trip.com)

Popular in

June

Cheapest in

August

Average price

$373
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Des Moines to South Carolina
Search Deals
One-way flight from Des Moines to South Carolina
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($38 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 1/17

5:58 pm-4:19 pm

1 stop21h 21m

Greenville

Thu 1/29

4:55 pm-9:21 pm

1 stop29h 26m

$252

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 1/25

2:58 pm-8:58 am

1 stop17h 00m

Greenville

Sun 2/1

4:55 pm-9:21 pm

1 stop29h 26m

$260

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 2/10

7:43 am-4:58 pm

1 stop8h 15m

Columbia Metropolitan

Tue 2/17

6:00 am-1:09 pm

1 stop8h 09m

$269

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Tue 2/10

5:35 am-11:58 am

1 stop5h 23m

Columbia Metropolitan

Tue 2/17

3:09 pm-8:49 pm

2 stops6h 40m

$274

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 1/14

7:43 am-4:58 pm

1 stop8h 15m

Columbia Metropolitan

Sat 1/17

6:08 am-3:15 pm

2 stops10h 07m

$279

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 1/10

4:00 pm-10:58 pm

1 stop5h 58m

Columbia Metropolitan

Wed 1/14

6:00 am-12:46 pm

1 stop7h 46m

$279

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

10:14 am-6:19 pm

1 stop7h 05m

Charleston

Sat 1/24

6:30 am-12:15 pm

1 stop6h 45m

$293

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 2/18

5:15 pm-11:57 pm

1 stop5h 42m

Savannah/Hilton Head

Sat 2/21

8:15 am-12:14 pm

1 stop4h 59m

$293

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Mon 2/9

7:43 am-4:58 pm

1 stop8h 15m

Columbia Metropolitan

Mon 2/16

6:00 am-1:09 pm

1 stop8h 09m

$294

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/18

1:55 pm-9:43 pm

1 stop6h 48m

Charleston

Sat 1/24

6:10 am-12:46 pm

2 stops7h 36m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/27

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 27, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Des Moines to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to South Carolina. Price data was last updated on March 30, 2025.

Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 27, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,256 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,256 reviews
Southwest
8.0
Very good
4,256 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,019 reviews
Southwest
8.0
Very good
4,256 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,113 reviews
Southwest
8.0
Very good
4,256 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,073 reviews
Southwest
8.0
Very good
4,256 reviews

Crew

8.6

Boarding

8.1

Entertainment

7.5

Overall

8.0

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • How long is the flight from Des Moines to South Carolina?

    Departing from Des Moines to South Carolina will take you 5h 01m. There are 945 mi between Des Moines and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Moline to Tampa flights
Cedar Rapids to Miami flights
Omaha to Los Angeles flights
Omaha to Tampa flights
Des Moines to Orlando Sanford Intl flights
Cedar Rapids to Dallas/Fort Worth flights
Des Moines to Atlanta flights
Des Moines to Newark flights
Omaha to Fort Lauderdale flights
Omaha to Dulles Intl flights
Omaha to San Francisco flights
Des Moines to Charlotte flights
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Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$386FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$383FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$437FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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