$89+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Mar 24 — Mar 311
1 adult, Economy
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Find cheap flights from Des Moines to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- CLT
1 stop21h 31m
Frontier
Thu 5/77:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 2/19![Frontier logo]()
$171
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Thu 3/267:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$226
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- CLT
1 stop20h 43m
Frontier
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/20![Frontier logo]()
$235
This CheapOair deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/21![Frontier logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:55 am
DSM
- CLT
2 stops45h 08m
Multiple Airlines
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$245
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Sun 4/196:18 pm
CLT
- DSM
1 stop19h 51m
Frontier
Deal found 2/20![Frontier logo]()
$247
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:59 pm
DSM
- CLT
1 stop12h 04m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/19![Frontier logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- MYR
1 stop24h 30m
Multiple Airlines
Wed 4/13:29 pm
MYR
- DSM
1 stop23h 17m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$253
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/99:28 pm
CLT
- DSM
1 stop13h 37m
Frontier
Deal found 2/20![Frontier logo]()
$261
This Trip.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:59 pm
DSM
- MYR
1 stop15h 45m
Multiple Airlines
Sun 3/1512:05 pm
MYR
- DSM
1 stop23h 00m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$276
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:32 pm
DSM
- CLT
2 stops34h 31m
Multiple Airlines
Thu 3/121:20 pm
CLT
- DSM
1 stop7h 54m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$265
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/221:10 pm
DSM
- SAV
1 stop5h 05m
United Airlines
Sat 4/254:19 pm
SAV
- DSM
1 stop8h 23m
United Airlines
Deal found 2/19![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:09 am
DSM
- MYR
2 stops10h 15m
American Airlines
Wed 5/134:09 pm
MYR
- DSM
1 stop7h 09m
American Airlines
Deal found 2/18![American Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:10 am
DSM
- SAV
2 stops10h 21m
Delta
Sat 4/255:35 am
SAV
- DSM
1 stop6h 30m
Delta
Deal found 2/20![Delta logo]()
$322
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Tue 4/147:35 am
CLT
- DSM
1 stop4h 50m
Southwest
Deal found 2/20![Southwest logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Thu 3/267:48 pm
CLT
- DSM
2 stops24h 28m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$282
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/257:45 am
DSM
- CAE
1 stop8h 10m
American Airlines
Sat 3/289:04 am
CAE
- DSM
1 stop5h 03m
American Airlines
Deal found 2/18![American Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:30 am
DSM
- GSP
1 stop6h 26m
Delta
Tue 3/315:40 am
GSP
- DSM
1 stop6h 08m
Delta
Deal found 2/21![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:20 am
DSM
- CHS
1 stop5h 05m
United Airlines
Wed 4/226:00 am
CHS
- DSM
2 stops9h 25m
United Airlines
Deal found 2/21![United Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:30 am
DSM
- MYR
1 stop24h 30m
Multiple Airlines
Tue 3/2412:05 pm
MYR
- DSM
2 stops32h 11m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/73:58 pm
DSM
- CAE
1 stop6h 52m
American Airlines
Wed 3/119:04 am
CAE
- DSM
1 stop5h 03m
American Airlines
Deal found 2/20![American Airlines logo]()
$331
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:10 am
DSM
- MYR
2 stops7h 56m
Delta
Thu 4/236:00 am
MYR
- DSM
1 stop6h 05m
Delta
Deal found 2/19![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/28:00 am
DSM
- CAE
1 stop4h 41m
United Airlines
Wed 5/66:30 am
CAE
- DSM
1 stop5h 07m
United Airlines
Deal found 2/20![United Airlines logo]()
$339
This Trip.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:59 pm
DSM
- MYR
1 stop15h 45m
Multiple Airlines
Sun 3/156:28 pm
MYR
- DSM
2 stops16h 37m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/203:35 pm
DSM
- CHS
1 stop4h 40m
Southwest
Fri 6/268:00 am
CHS
- DSM
1 stop4h 30m
Southwest
Deal found 2/20![Southwest logo]()
$387
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
DSM
- HHH
1 stop6h 22m
American Airlines
Mon 4/136:39 pm
HHH
- DSM
1 stop4h 39m
American Airlines
Deal found 2/22![American Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:44 pm
DSM
- GSP
1 stop6h 29m
Delta
Thu 5/710:09 am
GSP
- DSM
1 stop4h 38m
Delta
Deal found 2/18![Delta logo]()
$341
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/13:40 pm
DSM
- CLT
1 stop4h 25m
Southwest
Sun 4/57:50 am
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 2/18![Southwest logo]()
$396
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:23 am
DSM
- MYR
1 stop24h 27m
Multiple Airlines
Tue 5/197:51 pm
MYR
- DSM
2 stops43h 25m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$336
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/21:10 pm
DSM
- CHS
2 stops9h 49m
United Airlines
Sun 4/56:00 am
CHS
- DSM
2 stops7h 29m
United Airlines
Deal found 2/19![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:09 am
DSM
- GSP
1 stop7h 37m
American Airlines
Thu 5/78:16 pm
GSP
- DSM
1 stop4h 33m
American Airlines
Deal found 2/19![American Airlines logo]()
$341
This Delta deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/206:41 pm
DSM
- MYR
1 stop4h 16m
Delta
Sat 5/236:00 am
MYR
- DSM
1 stop6h 03m
Delta
Deal found 2/20![Delta logo]()
$352
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/51:30 pm
DSM
- CHS
1 stop6h 10m
Southwest
Mon 6/88:00 am
CHS
- DSM
1 stop4h 30m
Southwest
Deal found 2/18![Southwest logo]()
$397
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/21:10 pm
DSM
- SAV
2 stops9h 49m
United Airlines
Sun 4/55:40 am
SAV
- DSM
2 stops9h 45m
United Airlines
Deal found 2/19![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/511:17 am
DSM
- CHS
1 stop6h 11m
American Airlines
Wed 4/87:07 am
CHS
- DSM
1 stop7h 39m
American Airlines
Deal found 2/18![American Airlines logo]()
$352
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:41 pm
DSM
- MYR
1 stop4h 16m
Delta
Tue 5/194:05 pm
MYR
- DSM
1 stop7h 27m
Delta
Deal found 2/18![Delta logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:21 pm
DSM
- CLT
1 stop21h 27m
Multiple Airlines
Fri 3/139:28 pm
CLT
- DSM
1 stop13h 33m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$362
This Southwest deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Sun 5/34:50 pm
CLT
- DSM
1 stop6h 30m
Southwest
Deal found 2/18![Southwest logo]()
$400
This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/163:01 pm
DSM
- CHS
1 stop6h 14m
United Airlines
Sun 7/196:00 am
CHS
- DSM
1 stop5h 22m
United Airlines
Deal found 2/21![United Airlines logo]()
$387
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated February 22, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated February 22, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/99:28 pm
CLT
- DSM
1 stop13h 37m
Frontier
Deal found 2/20![Frontier logo]()
$261
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:59 pm
DSM
- CLT
1 stop12h 04m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/19![Frontier logo]()
$251
This Trip.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:59 pm
DSM
- MYR
1 stop15h 45m
Multiple Airlines
Sun 3/1512:05 pm
MYR
- DSM
1 stop23h 00m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$276
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/811:00 am
DSM
- CLT
1 stop19h 58m
Frontier
Mon 3/169:28 pm
CLT
- DSM
1 stop13h 17m
Frontier
Deal found 2/19![Frontier logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:32 pm
DSM
- CLT
2 stops34h 31m
Multiple Airlines
Thu 3/121:20 pm
CLT
- DSM
1 stop7h 54m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$265
This CheapOair deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/137:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/18![Frontier logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Thu 3/267:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$226
This CheapOair deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:55 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/21![Frontier logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:30 am
DSM
- MYR
1 stop24h 30m
Multiple Airlines
Wed 4/13:29 pm
MYR
- DSM
1 stop23h 17m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$253
This CheapOair deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- CLT
1 stop20h 43m
Frontier
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/20![Frontier logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:55 am
DSM
- CLT
2 stops45h 08m
Multiple Airlines
Fri 3/277:43 pm
CLT
- DSM
1 stop24h 33m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$245
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
This Trip.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/202:04 pm
DSM
- CLT
1 stop27h 50m
Frontier
Deal found 2/21![Frontier logo]()
$89
This CheapOair deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- CLT
1 stop25h 15m
Frontier
Deal found 2/19![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/198:30 am
DSM
- CLT
1 stop22h 28m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$94
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/241:23 pm
DSM
- CLT
1 stop23h 54m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$116
This Expedia deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:15 am
DSM
- CLT
1 stop26h 35m
Frontier
Deal found 2/21![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/214:41 pm
DSM
- CLT
1 stop16h 51m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/223:59 pm
DSM
- CLT
1 stop15h 22m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/198:30 am
DSM
- CLT
1 stop24h 47m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:55 am
DSM
- CLT
2 stops45h 08m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/156:44 pm
DSM
- MYR
1 stop13h 57m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Deal found 2/19![Frontier logo]()
$133
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2510:04 am
DSM
- SAV
1 stop5h 26m
American Airlines
Deal found 2/20![American Airlines logo]()
$159
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated February 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $171 (CheapOair) |
One-way from | $89 (Trip.com) |
Popular in | November |
Cheapest in | January |
Average price | $354 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Des Moines
Fly to
South Carolina
Route
Depart
Return
Price
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Tue 3/10
11:00 am-8:03 am
1 stop20h 03m
Charlotte Douglas
Fri 3/13
7:43 pm-7:16 pm
1 stop24h 33m
$206
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 3/9
8:32 pm-8:03 am
2 stops34h 31m
Charlotte Douglas
Thu 3/12
1:20 pm-8:14 pm
1 stop7h 54m
$265
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Sun 3/22
8:30 am-7:58 am
1 stop22h 28m
Charlotte Douglas
Thu 3/26
7:48 pm-7:16 pm
2 stops24h 28m
$282
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Thu 3/19
8:30 am-10:00 am
1 stop24h 30m
Myrtle Beach Intl
Tue 3/24
12:05 pm-7:16 pm
2 stops32h 11m
$309
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Wed 4/22
1:10 pm-7:15 pm
1 stop5h 05m
Savannah/Hilton Head
Sat 4/25
4:19 pm-11:42 pm
1 stop8h 23m
$317
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sat 3/7
5:59 pm-10:44 am
1 stop15h 45m
Myrtle Beach Intl
Sun 3/15
6:28 pm-10:05 am
2 stops16h 37m
$317
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 5/6
11:09 am-10:24 pm
2 stops10h 15m
Myrtle Beach Intl
Wed 5/13
4:09 pm-10:18 pm
1 stop7h 09m
$322
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Wed 4/22
6:10 am-5:31 pm
2 stops10h 21m
Savannah/Hilton Head
Sat 4/25
5:35 am-11:05 am
1 stop6h 30m
$322
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 3/25
7:45 am-4:55 pm
1 stop8h 10m
Columbia Metropolitan
Sat 3/28
9:04 am-1:07 pm
1 stop5h 03m
$326
Des MoinesGreenville
DSM - GSP
DSMGSP
Des Moines
Thu 3/26
7:30 am-2:56 pm
1 stop6h 26m
Greenville
Tue 3/31
5:40 am-10:48 am
1 stop6h 08m
$329
Showing 1-10 of 60 results
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-CLT
DSM-SAV
DSM-MYR
DSM-CAE
DSM-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-CLT
DSM-SAV
DSM-MYR
DSM-CAE
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SC?
Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 22, 2026.
Unlike in the morning, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.
What is the cheapest day to fly from Des Moines to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Des Moines to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 22, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on February 22, 2026.
Popular flight searches
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Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$369 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$398 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% |