$100+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Mar 13 — Mar 201
1 adult, Economy
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Find cheap flights from Des Moines to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/92:32 pm
CLT
- DSM
1 stop20h 33m
Frontier
Deal found 2/11![Frontier logo]()
$225
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/132:32 pm
CLT
- DSM
1 stop28h 29m
Frontier
Deal found 2/11![Frontier logo]()
$227
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Sun 4/197:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 2/11![Frontier logo]()
$247
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:45 am
DSM
- CAE
1 stop8h 10m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/8![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/171:23 pm
DSM
- MYR
1 stop27h 10m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/223:59 pm
DSM
- MYR
1 stop24h 34m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
DSM
- CAE
2 stops6h 42m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/8![American Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
DSM
- CLT
1 stop5h 05m
Southwest
Mon 3/168:00 am
CLT
- DSM
1 stop5h 10m
Southwest
Deal found 2/7![Southwest logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:17 pm
DSM
- MYR
2 stops21h 16m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$296
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- CLT
1 stop22h 21m
Frontier
Sun 3/87:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/11![Frontier logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- CLT
1 stop21h 27m
Multiple Airlines
Fri 4/310:49 pm
CLT
- DSM
2 stops39h 57m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$304
This CheapOair deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:32 pm
DSM
- CLT
1 stop22h 25m
Frontier
Sun 2/155:13 pm
CLT
- DSM
1 stop26h 19m
Frontier
Deal found 2/8![Frontier logo]()
$306
Best flights from Des Moines to South CarolinaDiscover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
Discover carefully curated flight deals from Des Moines to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 11, 2026.
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:45 am
DSM
- CAE
1 stop8h 10m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/8![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:20 pm
DSM
- CAE
1 stop5h 28m
Delta
Sat 4/45:34 am
CAE
- DSM
1 stop6h 14m
Delta
Deal found 2/11![Delta logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/223:59 pm
DSM
- MYR
1 stop24h 34m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$283
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
DSM
- CLT
1 stop5h 05m
Southwest
Mon 3/168:00 am
CLT
- DSM
1 stop5h 10m
Southwest
Deal found 2/7![Southwest logo]()
$292
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:15 am
DSM
- CHS
1 stop7h 53m
United Airlines
Tue 3/318:00 am
CHS
- DSM
1 stop5h 29m
United Airlines
Deal found 2/9![United Airlines logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:45 am
DSM
- CAE
1 stop8h 10m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/9![American Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:04 pm
DSM
- SAV
1 stop4h 56m
United Airlines
Tue 3/1710:00 am
SAV
- DSM
1 stop5h 22m
United Airlines
Deal found 2/10![United Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Wed 3/256:00 am
MYR
- DSM
2 stops11h 54m
Delta
Deal found 2/10![Delta logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/266:00 am
DSM
- CLT
1 stop7h 17m
Multiple Airlines
Thu 4/29:15 am
CLT
- DSM
1 stop14h 36m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/255:35 am
DSM
- CLT
2 stops8h 35m
Southwest
Fri 5/17:00 pm
CLT
- DSM
1 stop5h 05m
Southwest
Deal found 2/8![Southwest logo]()
$333
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Wed 3/256:00 am
MYR
- DSM
2 stops11h 54m
Delta
Deal found 2/10![Delta logo]()
$322
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:21 pm
DSM
- SAV
1 stop4h 47m
United Airlines
Sat 5/26:00 am
SAV
- DSM
2 stops9h 24m
United Airlines
Deal found 2/8![United Airlines logo]()
$322
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:15 am
DSM
- SAV
1 stop7h 06m
American Airlines
Mon 3/95:20 pm
SAV
- DSM
1 stop6h 14m
American Airlines
Deal found 2/10![American Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- CLT
1 stop4h 30m
Southwest
Sat 4/256:10 am
CLT
- DSM
2 stops8h 20m
Southwest
Deal found 2/8![Southwest logo]()
$333
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/19:00 am
DSM
- CHS
2 stops31h 40m
Multiple Airlines
Fri 3/63:21 pm
CHS
- DSM
1 stop19h 04m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/233:28 pm
DSM
- CHS
1 stop4h 29m
United Airlines
Wed 3/253:55 pm
CHS
- DSM
1 stop8h 47m
United Airlines
Deal found 2/9![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Thu 3/261:01 pm
MYR
- DSM
1 stop4h 53m
Delta
Deal found 2/10![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Sat 5/166:10 am
CLT
- DSM
2 stops8h 20m
Southwest
Deal found 2/8![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:38 pm
DSM
- GSP
2 stops7h 10m
American Airlines
Mon 3/98:17 pm
GSP
- DSM
1 stop4h 23m
American Airlines
Deal found 2/8![American Airlines logo]()
$346
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/278:04 am
DSM
- MYR
1 stop5h 13m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 06m
United Airlines
Deal found 2/9![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Thu 3/2610:23 am
MYR
- DSM
1 stop7h 10m
Delta
Deal found 2/10![Delta logo]()
$329
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:30 am
DSM
- MYR
2 stops12h 05m
Southwest
Tue 3/243:40 pm
MYR
- DSM
2 stops7h 25m
Southwest
Deal found 2/8![Southwest logo]()
$345
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:00 pm
DSM
- MYR
1 stop5h 45m
American Airlines
Tue 3/245:38 pm
MYR
- DSM
1 stop7h 04m
American Airlines
Deal found 2/8![American Airlines logo]()
$352
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/42:59 pm
DSM
- SAV
1 stop5h 56m
United Airlines
Mon 3/910:00 am
SAV
- DSM
1 stop5h 24m
United Airlines
Deal found 2/9![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/265:35 am
DSM
- CAE
1 stop4h 58m
Delta
Thu 4/25:34 am
CAE
- DSM
1 stop6h 14m
Delta
Deal found 2/9![Delta logo]()
$334
This Southwest deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:15 pm
DSM
- CLT
1 stop4h 40m
Southwest
Sat 4/118:10 am
CLT
- DSM
1 stop4h 20m
Southwest
Deal found 2/10![Southwest logo]()
$349
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/107:45 am
DSM
- CHS
1 stop7h 33m
American Airlines
Wed 3/185:10 am
CHS
- DSM
2 stops8h 55m
American Airlines
Deal found 2/8![American Airlines logo]()
$353
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/72:04 pm
DSM
- SAV
1 stop6h 09m
United Airlines
Wed 3/1110:00 am
SAV
- DSM
1 stop5h 24m
United Airlines
Deal found 2/9![United Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/710:28 am
DSM
- GSP
1 stop6h 01m
Delta
Sat 4/116:40 am
GSP
- DSM
1 stop5h 08m
Delta
Deal found 2/10![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:20 pm
DSM
- CLT
1 stop5h 05m
Southwest
Tue 3/315:50 pm
CLT
- DSM
1 stop5h 15m
Southwest
Deal found 2/11![Southwest logo]()
$349
Last-minute flights from Des Moines to South CarolinaDiscover last-minute flight deals from Des Moines to South Carolina. Data last updated February 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to South Carolina. Data last updated February 11, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/127:32 pm
DSM
- CLT
1 stop22h 25m
Frontier
Sun 2/155:13 pm
CLT
- DSM
1 stop26h 19m
Frontier
Deal found 2/8![Frontier logo]()
$306
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:00 am
DSM
- CAE
2 stops6h 42m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/8![American Airlines logo]()
$284
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:45 am
DSM
- CAE
1 stop8h 10m
American Airlines
Sat 2/287:00 am
CAE
- DSM
1 stop5h 56m
American Airlines
Deal found 2/8![American Airlines logo]()
$279
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- CLT
1 stop22h 21m
Frontier
Sun 3/87:43 pm
CLT
- DSM
1 stop24h 33m
Frontier
Deal found 2/11![Frontier logo]()
$300
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Mon 3/92:32 pm
CLT
- DSM
1 stop20h 33m
Frontier
Deal found 2/11![Frontier logo]()
$225
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
DSM
- CLT
1 stop5h 05m
Southwest
Mon 3/168:00 am
CLT
- DSM
1 stop5h 10m
Southwest
Deal found 2/7![Southwest logo]()
$292
This CheapOair deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1011:00 am
DSM
- CLT
1 stop20h 03m
Frontier
Fri 3/132:32 pm
CLT
- DSM
1 stop28h 29m
Frontier
Deal found 2/11![Frontier logo]()
$227
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/105:35 am
DSM
- CHS
1 stop4h 49m
Delta
Wed 3/185:27 am
CHS
- DSM
1 stop6h 21m
Delta
Deal found 2/8![Delta logo]()
$317
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:17 pm
DSM
- MYR
2 stops21h 16m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/171:23 pm
DSM
- MYR
1 stop27h 10m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/223:59 pm
DSM
- MYR
1 stop24h 34m
Multiple Airlines
Wed 3/256:28 pm
MYR
- DSM
1 stop20h 01m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:21 pm
DSM
- CLT
1 stop21h 27m
Multiple Airlines
Fri 4/310:49 pm
CLT
- DSM
2 stops39h 57m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$304
One-way flights from Des Moines to South CarolinaSearch for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
Search for one-way flight options from Des Moines to South Carolina. Find affordable one-way fares based on user searches. Data last updated February 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:14 pm
DSM
- CLT
1 stop21h 40m
Frontier
Deal found 2/11![Frontier logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- CLT
1 stop21h 07m
Frontier
Deal found 2/7![Frontier logo]()
$103
This Trip.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Deal found 2/8![Frontier logo]()
$110
This CheapOair deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
- CLT
1 stop22h 21m
Frontier
Deal found 2/10![Frontier logo]()
$111
This CheapOair deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- CLT
1 stop21h 27m
Frontier
Deal found 2/10![Frontier logo]()
$113
This Frontier deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:56 pm
DSM
- CLT
1 stop12h 02m
Frontier
Deal found 2/11![Frontier logo]()
$121
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:20 pm
DSM
- CLT
1 stop27h 34m
Frontier
Deal found 2/8![Frontier logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:00 am
DSM
- CLT
1 stop27h 14m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/122:51 pm
DSM
- CLT
2 stops40h 30m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$134
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/57:00 am
DSM
- MYR
1 stop12h 48m
Multiple Airlines
Deal found 2/8![Multiple Airlines logo]()
$137
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:00 am
DSM
- CLT
2 stops48h 26m
Multiple Airlines
Deal found 2/7![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- CLT
2 stops34h 42m
Frontier
Deal found 2/7![Frontier logo]()
$141
Find flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated February 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $225 (CheapOair) |
One-way from | $100 (Kiwi.com) |
Popular in | June |
Cheapest in | January |
Average price | $354 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Des Moines
Fly to
South Carolina
Route
Depart
Return
Price
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Tue 2/24
7:45 am-4:55 pm
1 stop8h 10m
Columbia Metropolitan
Sat 2/28
7:00 am-11:56 am
1 stop5h 56m
$279
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Sat 3/28
5:20 pm-11:48 pm
1 stop5h 28m
Columbia Metropolitan
Sat 4/4
5:34 am-10:48 am
1 stop6h 14m
$279
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 2/25
7:45 am-4:55 pm
1 stop8h 10m
Columbia Metropolitan
Sat 2/28
7:00 am-11:56 am
1 stop5h 56m
$279
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sun 3/22
3:59 pm-5:33 pm
1 stop24h 34m
Myrtle Beach Intl
Wed 3/25
6:28 pm-1:29 pm
1 stop20h 01m
$283
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Mon 3/9
4:20 pm-10:25 pm
1 stop5h 05m
Charlotte Douglas
Mon 3/16
8:00 am-12:10 pm
1 stop5h 10m
$292
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Tue 3/24
7:15 am-4:08 pm
1 stop7h 53m
Charleston
Tue 3/31
8:00 am-12:29 pm
1 stop5h 29m
$317
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 3/10
2:04 pm-8:00 pm
1 stop4h 56m
Savannah/Hilton Head
Tue 3/17
10:00 am-2:22 pm
1 stop5h 22m
$317
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Wed 3/18
5:20 pm-12:04 am
1 stop5h 44m
Myrtle Beach Intl
Wed 3/25
6:00 am-4:54 pm
2 stops11h 54m
$322
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 3/17
5:20 pm-12:04 am
1 stop5h 44m
Myrtle Beach Intl
Wed 3/25
6:00 am-4:54 pm
2 stops11h 54m
$322
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Tue 4/28
3:21 pm-9:08 pm
1 stop4h 47m
Savannah/Hilton Head
Sat 5/2
6:00 am-2:24 pm
2 stops9h 24m
$322
Showing 1-10 of 60 results
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
DSM-CLT
DSM-MYR
DSM-CAE
DSM-CHS
DSM-SAV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
DSM-USSC
DSM-CLT
DSM-MYR
DSM-CAE
DSM-CHS
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in February is currently the most expensive (average of $273). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SC?
Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 11, 2026.
Unlike in the morning, when flights are generally more expensive, you can save up to 36% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.
What is the cheapest day to fly from Des Moines to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from Des Moines to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated February 11, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Overall
8.0
Food
7.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and South Carolina flights
Browse other Des Moines and South Carolina flight options. Last updated on February 11, 2026.
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Des Moines to South Carolina flights
Consider these flights traveling from Des Moines to South Carolina.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$166 | Average$388 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$377 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$408 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% |