HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$102+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated September 11, 2025.

Round-trip from

$218
(Kiwi.com)

One-way from

$102
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$348
From Des Moines to South Carolina
Search Deals
One-way flight from Des Moines to South Carolina
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($28 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:48 pmDSM - CHS
1 stop7h 01mAmerican Airlines
Tue 10/286:30 amCHS - DSM
1 stop5h 15mAmerican Airlines
Deal found 9/10$219
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/73:48 pmDSM - MYR
1 stop5h 48mAmerican Airlines
Tue 10/214:47 pmMYR - DSM
1 stop7h 29mAmerican Airlines
Deal found 9/10$219
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:38 pmDSM - SAV
1 stop4h 25mAmerican Airlines
Sat 10/117:38 amSAV - DSM
1 stop6h 00mAmerican Airlines
Deal found 9/10$219
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:25 amDSM - CLT
1 stop29h 43mMultiple Airlines
Wed 10/110:46 amCLT - DSM
1 stop24h 05mMultiple Airlines
Deal found 9/9$219
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2512:52 pmDSM - CHS
2 stops9h 50mUnited Airlines
Tue 10/284:11 pmCHS - DSM
1 stop8h 33mUnited Airlines
Deal found 9/10$224
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/712:49 pmDSM - MYR
2 stops9h 05mAmerican Airlines
Tue 10/147:26 pmMYR - DSM
1 stop5h 33mAmerican Airlines
Deal found 9/9$224
This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:07 amDSM - CLT
1 stop9h 55mAmerican Airlines
Sat 10/188:45 pmCLT - DSM
Nonstop2h 43mAmerican Airlines
Deal found 9/9$225
This Southwest deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:45 pmDSM - CLT
1 stop3h 45mSouthwest
Wed 11/56:10 amCLT - DSM
2 stops6h 15mSouthwest
Deal found 9/9$227
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:25 amDSM - CHS
2 stops11h 10mSouthwest
Tue 10/281:50 pmCHS - DSM
2 stops9h 00mSouthwest
Deal found 9/10$228
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:25 amDSM - CLT
2 stops11h 15mSouthwest
Wed 11/56:10 amCLT - DSM
2 stops6h 15mSouthwest
Deal found 9/11$236
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/257:25 amDSM - CLT
1 stop12h 20mSouthwest
Wed 10/292:00 pmCLT - DSM
1 stop8h 50mSouthwest
Deal found 9/11$237
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/189:19 amDSM - CLT
1 stop21h 41mMultiple Airlines
Fri 10/318:52 amCLT - DSM
1 stop6h 58mMultiple Airlines
Deal found 9/9$240

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/25

6:07 am-1:10 pm

1 stop6h 03m

Charleston

Tue 10/28

6:30 am-10:45 am

1 stop5h 15m

$219

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Wed 10/22

3:48 pm-11:49 pm

1 stop7h 01m

Charleston

Sat 10/25

7:30 am-11:25 am

1 stop4h 55m

$219

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/18

3:53 pm-9:56 pm

1 stop5h 03m

Charleston

Wed 10/22

6:35 am-12:19 pm

1 stop6h 44m

$219

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 10/7

5:42 pm-10:54 pm

1 stop4h 12m

Myrtle Beach Intl

Tue 10/14

4:47 pm-11:16 pm

1 stop7h 29m

$219

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 10/7

6:07 am-11:56 am

1 stop4h 49m

Myrtle Beach Intl

Tue 10/21

12:18 pm-5:02 pm

1 stop5h 44m

$219

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Wed 10/1

5:38 pm-11:03 pm

1 stop4h 25m

Savannah/Hilton Head

Sat 10/11

7:38 am-12:38 pm

1 stop6h 00m

$219

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/25

12:52 pm-11:42 pm

2 stops9h 50m

Charleston

Tue 10/28

4:11 pm-11:44 pm

1 stop8h 33m

$224

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/11

1:48 pm-9:39 pm

2 stops6h 51m

Charleston

Tue 10/14

7:45 pm-12:02 am

1 stop5h 17m

$224

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 10/22

4:45 pm-9:30 pm

1 stop3h 45m

Charlotte Douglas

Wed 11/5

12:55 pm-9:35 pm

1 stop9h 40m

$227

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sat 10/25

7:25 am-7:35 pm

2 stops11h 10m

Charleston

Tue 10/28

1:50 pm-9:50 pm

2 stops9h 00m

$228

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 59 results
1
2
3
...
6

Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 11, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,960 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,937 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,248 reviews

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Crew

8.6

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • How long is the flight from Des Moines to South Carolina?

    Departing from Des Moines to South Carolina will take you 3h 45m. There are 813 mi between Des Moines and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for American Airlines. According to our data, you can fly for as low as $110. Users have also found prices from $111 and $115 on Southwest and United Airlines, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Seattle flights
Omaha to Las Vegas flights
Omaha to LaGuardia flights
Omaha to Denver flights
Cedar Rapids to Denver flights
Des Moines to Denver flights
Des Moines to LaGuardia flights
Omaha to Dallas/Fort Worth flights
Omaha to John F Kennedy Intl flights
Cedar Rapids to Dallas/Fort Worth flights
Cedar Rapids to Orlando flights
Omaha to Orlando flights
Des Moines to Las Vegas flights
Des Moines to Dallas/Fort Worth flights
Des Moines to Sky Harbor Intl flights
Omaha to Los Angeles flights
Omaha to O'Hare Intl flights
Des Moines to John F Kennedy Intl flights
Cedar Rapids to Sky Harbor Intl flights
Des Moines to Orlando flights
Omaha to Sky Harbor Intl flights
Omaha to Hobby flights
Omaha to Newark flights
Cedar Rapids to John F Kennedy Intl flights
Des Moines to Hobby flights
Omaha to Miami flights
Moline to Denver flights
Omaha to Atlanta flights
Des Moines to Los Angeles flights
Cedar Rapids to Reagan-National flights
Moline to Orlando flights
Cedar Rapids to Las Vegas flights
Des Moines to Miami flights
Omaha to George Bush Intcntl flights
Omaha to Nashville flights
Des Moines to Reagan-National flights
Des Moines to Charlotte flights
Cedar Rapids to Los Angeles flights
Des Moines to O'Hare Intl flights
Omaha to San Francisco flights
Cedar Rapids to LaGuardia flights
Des Moines to Atlanta flights
Cedar Rapids to Newark flights
Des Moines to George Bush Intcntl flights
Cedar Rapids to Hobby flights
Des Moines to Seattle flights
Omaha to Philadelphia flights
Omaha to Dulles Intl flights
Omaha to Boston flights
Des Moines to Dulles Intl flights

Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$237Average$388FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$379FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$286Average$495FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.