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$73+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$193
(Kiwi.com)

One-way from

$73
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$467
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($38 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This American Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:56 pmDSM - CAE
1 stop4h 37mAmerican Airlines
Thu 1/87:10 pmCAE - DSM
1 stop4h 58mAmerican Airlines
Deal found 11/23$249
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CLT
1 stop22h 16mMultiple Airlines
Wed 12/102:58 pmCLT - DSM
2 stops31h 38mMultiple Airlines
Deal found 11/23$256
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/74:21 pmDSM - CLT
2 stops43h 20mMultiple Airlines
Thu 12/112:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Deal found 11/23$259
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/72:56 pmDSM - CLT
1 stop17h 43mMultiple Airlines
Wed 12/102:58 pmCLT - DSM
2 stops31h 38mMultiple Airlines
Deal found 11/23$261
This American Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:05 pmDSM - CAE
1 stop6h 51mAmerican Airlines
Wed 12/176:49 amCAE - DSM
1 stop6h 34mAmerican Airlines
Deal found 11/25$264
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:31 amDSM - CLT
2 stops37h 28mMultiple Airlines
Thu 12/112:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Deal found 11/23$265
This Kiwi.com deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - CLT
1 stop22h 16mMultiple Airlines
Thu 12/112:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Deal found 11/24$269
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:56 pmDSM - CAE
1 stop4h 37mAmerican Airlines
Sun 1/47:59 pmCAE - DSM
1 stop5h 38mAmerican Airlines
Deal found 11/24$274
This Mytrip deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/114:21 pmDSM - CLT
2 stops20h 42mMultiple Airlines
Sun 12/147:00 amCLT - DSM
1 stop16h 21mMultiple Airlines
Deal found 11/25$276
This United Airlines deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:17 pmDSM - CAE
1 stop5h 50mUnited Airlines
Sun 12/145:24 pmCAE - DSM
1 stop5h 13mUnited Airlines
Deal found 11/25$279
This Kiwi.com deal was found by Cheapflights users on 11/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:25 pmDSM - CLT
2 stops23h 38mMultiple Airlines
Sun 12/142:58 pmCLT - DSM
1 stop8h 23mMultiple Airlines
Deal found 11/25$281
This American Airlines deal was found by Cheapflights users on 11/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/201:56 pmDSM - CAE
1 stop7h 02mAmerican Airlines
Sat 1/36:09 amCAE - DSM
1 stop6h 42mAmerican Airlines
Deal found 11/24$285

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 1/17

10:16 am-4:59 pm

1 stop5h 43m

Columbia Metropolitan

Wed 1/21

5:06 pm-10:29 pm

1 stop6h 23m

$249

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 12/20

1:56 pm-7:33 pm

1 stop4h 37m

Columbia Metropolitan

Thu 1/8

10:10 am-4:24 pm

2 stops7h 14m

$254

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Thu 1/8

4:00 pm-10:58 pm

1 stop5h 58m

Columbia Metropolitan

Thu 1/15

6:00 am-12:46 pm

1 stop7h 46m

$274

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Sat 12/20

1:56 pm-7:33 pm

1 stop4h 37m

Columbia Metropolitan

Sun 1/4

7:59 pm-12:37 am

1 stop5h 38m

$274

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Wed 12/10

3:17 pm-10:07 pm

1 stop5h 50m

Columbia Metropolitan

Sun 12/14

5:24 pm-9:37 pm

1 stop5h 13m

$279

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 2/21

12:25 pm-5:44 pm

1 stop4h 19m

Greenville

Wed 2/25

11:35 am-7:33 pm

1 stop8h 58m

$289

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Sat 2/21

11:30 am-8:00 pm

1 stop7h 30m

Savannah/Hilton Head

Sat 2/28

9:40 am-2:27 pm

1 stop5h 47m

$289

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Thu 1/8

7:34 am-5:32 pm

1 stop8h 58m

Savannah/Hilton Head

Thu 1/15

6:49 am-10:38 am

1 stop4h 49m

$289

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 1/13

4:25 pm-11:57 pm

1 stop6h 32m

Myrtle Beach Intl

Mon 1/19

7:19 pm-11:08 pm

1 stop4h 49m

$289

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Thu 1/8

1:16 pm-9:34 pm

1 stop7h 18m

Savannah/Hilton Head

Thu 1/15

7:34 am-12:46 pm

1 stop6h 12m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/24

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in November is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

Unlike in the morning, when flights are generally more expensive, you can save up to 20% on flights from Des Moines to South Carolina by exploring options for tickets in the afternoon.

What is the cheapest day to fly from Des Moines to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Des Moines to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Des Moines to South Carolina flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 26, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,254 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,999 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,046 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,038 reviews
Southwest
8.0
Very good
4,254 reviews

Comfort

8.0

Crew

8.6

Overall

8.0

Entertainment

7.5

Food

7.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • How long is the flight from Des Moines to South Carolina?

    Departing from Des Moines to South Carolina will take you 5h 43m. There are 861 mi between Des Moines and South Carolina. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Frontier. According to our data, you can fly for as low as $132. Users have also found prices from $185 and $190 on United Airlines and American Airlines, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Columbia Metropolitan or Des Moines - Charleston as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $166). Flying from Des Moines to South Carolina in November is currently the most expensive (average of $288). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$199Average$394FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$374FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$431FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%

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