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South Carolina

$96+ Cheap flights from Des Moines (DSM) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — CHS
May 4 — May 111
Sun 5/4
Sun 5/11
1 adult, Economy
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Cheap flight deals from Des Moines to South Carolina

Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated April 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$267
(Mytrip)

One-way from

$96
(Mytrip)

Popular in

December

Cheapest in

September

Average price

$316
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
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From Des Moines to South Carolina
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One-way flight from Des Moines to South Carolina
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Highest demand for flights based on searches. 8% potential increase in price ($36 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in April 2025
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Find flight deals from Des Moines to South Carolina

Cheapest flights from Des Moines to South Carolina
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 29, 2025.

This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/227:15 pmDSM - CLT
1 stop19h 22mMultiple Airlines
Mon 5/266:34 pmCLT - DSM
1 stop22h 02mMultiple Airlines
Deal found 4/29$267
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/302:15 pmDSM - CHS
1 stop5h 33mAmerican Airlines
Tue 10/78:00 pmCHS - DSM
1 stop4h 45mAmerican Airlines
Deal found 4/29$271
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/26:30 pmDSM - MYR
1 stop4h 09mDelta
Tue 9/92:15 pmMYR - DSM
1 stop4h 24mDelta
Deal found 4/28$271
This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/71:15 pmDSM - MYR
2 stops28h 15mMultiple Airlines
Wed 6/116:00 amMYR - DSM
1 stop8h 33mMultiple Airlines
Deal found 4/29$275
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/3010:17 amDSM - CHS
1 stop6h 43mDelta
Tue 6/34:59 pmCHS - DSM
1 stop6h 31mDelta
Deal found 4/28$284
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/47:00 amDSM - CLT
Nonstop2h 21mAmerican Airlines
Fri 7/41:01 pmCLT - DSM
1 stop5h 09mAmerican Airlines
Deal found 4/28$284
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2412:48 pmDSM - MYR
2 stops8h 43mAmerican Airlines
Sat 5/315:45 pmMYR - DSM
1 stop4h 53mAmerican Airlines
Deal found 4/28$289
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/217:30 pmDSM - CLT
1 stop20h 02mFrontier
Sun 5/255:27 pmCLT - DSM
1 stop27h 08mFrontier
Deal found 4/29$291
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/110:59 amDSM - CLT
1 stop4h 26mDelta
Sat 7/56:01 pmCLT - DSM
1 stop6h 02mDelta
Deal found 4/28$307
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/35:35 amDSM - SAV
1 stop7h 07mDelta
Fri 6/612:58 pmSAV - DSM
1 stop7h 08mDelta
Deal found 4/28$311
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/77:00 amDSM - CLT
1 stop7h 15mSouthwest
Tue 8/125:25 pmCLT - DSM
1 stop5h 55mSouthwest
Deal found 4/28$316
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/35:40 amDSM - SAV
2 stops10h 30mSouthwest
Fri 6/63:55 pmSAV - DSM
2 stops8h 55mSouthwest
Deal found 4/28$321

Cheapflights Fare Finder

Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.

Fly from

Des Moines

Fly to

South Carolina

Route

Depart

Return

Price

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 5/22

7:15 pm-3:37 pm

1 stop19h 22m

Charlotte Douglas

Mon 5/26

6:34 pm-3:36 pm

1 stop22h 02m

$267

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Tue 9/30

2:15 pm-8:48 pm

1 stop5h 33m

Charleston

Tue 10/7

8:00 pm-11:45 pm

1 stop4h 45m

$271

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 6/7

1:15 pm-6:30 pm

2 stops28h 15m

Myrtle Beach Intl

Wed 6/11

6:00 am-1:33 pm

1 stop8h 33m

$275

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Fri 5/30

10:17 am-6:00 pm

1 stop6h 43m

Charleston

Tue 6/3

4:59 pm-10:30 pm

1 stop6h 31m

$284

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 5/24

6:30 am-11:52 am

1 stop4h 22m

Myrtle Beach Intl

Sat 5/31

6:00 am-10:41 am

1 stop5h 41m

$284

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Fri 7/4

7:00 am-10:21 am

Nonstop2h 21m

Charlotte Douglas

Fri 7/4

1:01 pm-5:10 pm

1 stop5h 09m

$284

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 5/24

12:48 pm-10:31 pm

2 stops8h 43m

Myrtle Beach Intl

Sat 5/31

5:45 pm-9:38 pm

1 stop4h 53m

$289

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Wed 5/21

7:30 pm-4:32 pm

1 stop20h 02m

Charlotte Douglas

Sun 5/25

5:27 pm-7:35 pm

1 stop27h 08m

$291

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 7/1

5:45 am-11:08 am

1 stop4h 23m

Charlotte Douglas

Fri 7/4

6:00 am-9:38 am

1 stop4h 38m

$307

Des MoinesSavannah

DSM - SAV

DSMSAV

Des Moines

Tue 6/3

5:35 am-1:42 pm

1 stop7h 07m

Savannah/Hilton Head

Fri 6/6

12:58 pm-7:06 pm

1 stop7h 08m

$311

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Showing 1-10 of 44 results
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Best time to book a flight from Des Moines to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to South Carolina

What is the cheapest month to book a flight from Des Moines to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SC?

Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 29, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.

Rainfall in South Carolina by month

Plan your trip to South Carolina by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.

Temperature in South Carolina by month

Plan your trip to South Carolina by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 29, 2025.
Get a feel of what it's like to fly with Alaska Airlines, Southwest and Delta from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Alaska Airlines
8.0
Very good
9,961 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Southwest
8.0
Very good
4,295 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Delta
8.0
Very good
7,936 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
United Airlines
7.4
Good
8,696 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.
Allegiant Air
7.3
Good
734 reviews
Alaska Airlines
8.0
Very good
9,961 reviews

Crew

8.5

Entertainment

7.1

Boarding

8.2

Comfort

7.9

Food

7.1

Overall

8.0

Reviews

1 / 20
10.0
Excellent

James,Apr 2025

LAX - SFO

Good flight except the uncontrollable cold air from the ceiling.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to South Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to South Carolina.

  • What are the cheapest airlines to fly from Des Moines to South Carolina one-way?

    For one-way options, check prices for Delta. According to our data, you can fly for as low as $136. Users have also found prices from $141 and $159 on American Airlines and Southwest, respectively.

  • What are the most popular routes from Des Moines to South Carolina?

    When deciding which route to take from Des Moines to South Carolina consider Des Moines - Charlotte Douglas, Des Moines - Charleston or Des Moines - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from Des Moines to South Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to South Carolina.

  • Can I find deals for business class flights from Des Moines to South Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to South Carolina

Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$471FlexibilityNo cancel feeOn-time69%
DeltaCheapest$248Average$383FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$258Average$393FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$376Average$447FlexibilityNo cancel feeOn-time63%

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