$95+ Cheap flights from Des Moines (DSM) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Des Moines to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to South Carolina
Keep the following information in mind while searching for Des Moines to South Carolina flight deals. Data was last updated June 12, 2025.
Round-trip from | $199 (Mytrip) |
|---|---|
One-way from | $95 (Mytrip) |
Popular in | June |
Cheapest in | September |
Average price | $481 |
Find flight deals from Des Moines to South Carolina
Cheapest flights from Des Moines to South CarolinaExplore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
Explore the most affordable flight options available from Des Moines to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Thu 7/17
6:32 pm-2:02 pm
1 stop18h 30m
Charlotte Douglas
Thu 7/24
11:40 am-2:45 pm
1 stop28h 05m
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Thu 9/25
2:14 pm-10:20 pm
1 stop7h 06m
Charlotte Douglas
Thu 10/2
8:25 am-1:28 pm
1 stop6h 03m
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Mon 7/21
8:35 am-8:03 pm
1 stop10h 28m
Myrtle Beach Intl
Fri 7/25
8:34 am-2:45 pm
1 stop7h 11m
Des MoinesCharlotte
DSM - CLT
DSMCLT
Des Moines
Sun 9/21
8:41 pm-4:32 pm
1 stop18h 51m
Charlotte Douglas
Sun 9/28
5:34 pm-7:56 pm
1 stop27h 22m
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 7/30
5:30 am-10:15 am
1 stop3h 45m
Columbia Metropolitan
Mon 8/4
7:11 pm-10:33 pm
1 stop4h 22m
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Wed 7/30
5:00 am-2:06 pm
2 stops8h 06m
Columbia Metropolitan
Mon 8/4
6:04 pm-11:01 pm
1 stop5h 57m
Des MoinesSavannah
DSM - SAV
DSMSAV
Des Moines
Sat 6/28
1:13 pm-5:56 pm
2 stops27h 43m
Savannah/Hilton Head
Thu 7/3
8:15 am-12:46 pm
1 stop29h 31m
Des MoinesCharleston
DSM - CHS
DSMCHS
Des Moines
Wed 9/10
6:00 am-3:17 pm
1 stop8h 17m
Charleston
Wed 9/24
5:37 pm-11:07 pm
1 stop6h 30m
Des MoinesColumbia
DSM - CAE
DSMCAE
Des Moines
Sat 7/26
1:13 pm-9:00 pm
2 stops30h 47m
Columbia Metropolitan
Sat 8/2
4:37 pm-10:38 pm
2 stops31h 01m
Des MoinesGreenville
DSM - GSP
DSMGSP
Des Moines
Thu 7/10
7:54 pm-2:59 pm
1 stop18h 05m
Greenville
Sun 7/13
10:06 pm-4:14 pm
1 stop19h 08m
Best time to book a flight from Des Moines to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Des Moines with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to South Carolina
What is the cheapest month to book a flight from Des Moines to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Des Moines to South Carolina (average of $217). Flying from Des Moines to South Carolina in March is currently the most expensive (average of $335). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SC?
Find hourly flight availability from Des Moines to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to South Carolina as you normally would.
Rainfall in South Carolina by month
Plan your trip to South Carolina by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in South Carolina ranges from 3.0 - 6.5 inches per month. July is typically the wettest month, when rainfall can reach 6.5 in. November is typically the driest time to visit South Carolina when rainfall is around 3.0 in.
Temperature in South Carolina by month
Plan your trip to South Carolina by taking into account the average temperature totals by month.
If weather is an important factor for your trip to South Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 44.6 F).
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 12, 2025.
Get a feel of what it's like to fly with Southwest, Delta and United Airlines from Des Moines to South Carolina by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Boarding
Comfort
Entertainment
Overall
Food
Crew
Reviews
John,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to South Carolina
Discover the top 4 airlines that operate flights from Des Moines to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$486 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$392 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$258 | Average$379 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$376 | Average$447 | FlexibilityNo cancel fee | On-time63% |