HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$520+ Cheap flights from Roanoke (ROA) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — BOG
Mar 1 — Mar 81
Sun 3/1
Sun 3/8
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Roanoke to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Roanoke to South America

Cheapest flights from Roanoke to South America
Explore the most affordable flight options available from Roanoke to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 30, 2026.

This American Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:04 pm
ROA
-
GYE
2 stops20h 26m
American Airlines
Tue 2/173:30 pm
GYE
-
ROA
2 stops20h 04m
American Airlines
Deal found 1/29$637
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/138:00 pm
ROA
-
GYE
2 stops18h 30m
American Airlines
Wed 2/183:30 pm
GYE
-
ROA
2 stops19h 07m
American Airlines
Deal found 1/28$652
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:42 pm
ROA
-
UIO
2 stops30h 43m
United Airlines
Thu 5/712:35 am
UIO
-
ROA
2 stops32h 41m
United Airlines
Deal found 1/28$726
This LATAM Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:08 am
ROA
-
UIO
2 stops18h 35m
LATAM Airlines
Thu 5/712:59 am
UIO
-
ROA
1 stop12h 43m
LATAM Airlines
Deal found 1/27$758
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:50 pm
ROA
-
SCL
2 stops59h 00m
United Airlines
Thu 3/269:45 pm
SCL
-
ROA
2 stops36h 58m
United Airlines
Deal found 1/29$877
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:50 pm
ROA
-
SCL
2 stops35h 00m
United Airlines
Thu 3/269:45 pm
SCL
-
ROA
2 stops36h 58m
United Airlines
Deal found 1/29$900
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:50 pm
ROA
-
SCL
2 stops59h 00m
United Airlines
Fri 3/279:45 pm
SCL
-
ROA
2 stops22h 17m
United Airlines
Deal found 1/29$917
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/207:50 pm
ROA
-
SCL
2 stops35h 00m
United Airlines
Fri 3/279:45 pm
SCL
-
ROA
2 stops22h 17m
United Airlines
Deal found 1/29$925
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/167:50 pm
ROA
-
GIG
2 stops36h 45m
United Airlines
Mon 3/238:55 pm
GIG
-
ROA
2 stops37h 48m
United Airlines
Deal found 1/29$1,084
This LATAM Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1911:20 am
ROA
-
SCL
3 stops21h 44m
LATAM Airlines
Wed 9/235:40 am
SCL
-
ROA
2 stops19h 10m
LATAM Airlines
Deal found 1/27$1,135
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:20 am
ROA
-
GYE
2 stops15h 32m
United Airlines
Wed 10/282:35 pm
GYE
-
ROA
2 stops18h 57m
United Airlines
Deal found 1/29$1,140
This United Airlines deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:20 am
ROA
-
GIG
2 stops24h 55m
United Airlines
Wed 8/199:05 pm
GIG
-
ROA
2 stops51h 18m
United Airlines
Deal found 1/29$1,206

Find flight deals from Roanoke to South America

Keep the following information in mind while searching for Roanoke to South America flight deals. Data was last updated January 30, 2026.

Round-trip from

$637
(American Airlines)

One-way from

$520
(LATAM Airlines)
From Roanoke to South America
Search Deals
One-way flight from Roanoke to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
Use the filters below to find and compare flights from Roanoke to South America that are best for you.

Fly from

Roanoke

Fly to

South America

Route

Depart

Return

Price

RoanokeGuayaquil

ROA - GYE

ROAGYE

Roanoke

Fri 2/13

6:04 pm-2:30 pm

2 stops20h 26m

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

3:30 pm-11:34 am

2 stops20h 04m

$637

RoanokeGuayaquil

ROA - GYE

ROAGYE

Roanoke

Fri 2/13

8:00 pm-2:30 pm

2 stops18h 30m

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

3:30 pm-10:37 am

2 stops19h 07m

$652

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 5/5

10:34 am-11:25 pm

2 stops13h 51m

Quito Mariscal Sucr

Thu 5/7

12:35 am-11:44 pm

2 stops22h 09m

$726

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Tue 5/5

11:08 am-4:43 am

2 stops18h 35m

Quito Mariscal Sucr

Thu 5/7

12:59 am-2:42 pm

1 stop12h 43m

$758

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 3/21

7:50 pm-7:50 am

2 stops59h 00m

Santiago Arturo Merino Benitez

Thu 3/26

9:45 pm-9:43 am

2 stops36h 58m

$877

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Fri 3/20

7:50 pm-7:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Thu 3/26

9:45 pm-9:43 am

2 stops36h 58m

$900

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 3/21

7:50 pm-7:50 am

2 stops59h 00m

Santiago Arturo Merino Benitez

Fri 3/27

9:45 pm-7:02 pm

2 stops22h 17m

$917

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Fri 3/20

7:50 pm-7:50 am

2 stops35h 00m

Santiago Arturo Merino Benitez

Fri 3/27

9:45 pm-7:02 pm

2 stops22h 17m

$925

RoanokeRio de Janeiro

ROA - GIG

ROAGIG

Roanoke

Mon 3/16

7:50 pm-9:35 am

2 stops36h 45m

Rio de Janeiro–Galeão Intl

Mon 3/23

8:55 pm-9:43 am

2 stops37h 48m

$1,084

RoanokeRio de Janeiro

ROA - SDU

ROASDU

Roanoke

Mon 3/16

2:55 pm-4:45 pm

2 stops24h 50m

Rio de Janeiro Santos Dumont

Mon 3/23

1:50 pm-2:09 pm

2 stops25h 19m

$1,209

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 26 results
1
2
3

Best time to book a flight from Roanoke to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South America

What is the cheapest month to book a flight from Roanoke to South America?

Currently, April is the cheapest month in which you can book a flight from Roanoke to South America (average of $301). Flying from Roanoke to South America in December is currently the most expensive (average of $628). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 30, 2026.
Read reviews from past customers who have flown Delta, LATAM Airlines, and American Airlines from Roanoke to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,126 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,126 reviews
Delta
7.9
Good
8,126 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,917 reviews
Delta
7.9
Good
8,126 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,207 reviews
Delta
7.9
Good
8,126 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Boarding

8.1

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South America?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to South America. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • How long is the flight from Roanoke to South America?

    American Airlines, United Airlines, and LATAM Airlines can get you from Roanoke to South America in just under 13h 51m. Your travel time can differ by up to 6h 35m. There are 2587 mi between Roanoke and South America. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South America?

    The most popular route from Roanoke to South America is Roanoke - Rio de Janeiro Santos Dumont. You may also consider Roanoke - Rio de Janeiro–Galeão Intl or Roanoke - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from Roanoke to South America that include hotel bookings?

    Yes. In addition to deals on Roanoke to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South America.

  • Can I find deals for business class flights from Roanoke to South America?

    Yes. Cheapflights offers flight deals from Roanoke to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South America?

    Currently, April is the cheapest month in which you can book a flight from Roanoke to South America (average of $301). Flying from Roanoke to South America in December is currently the most expensive (average of $628). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Roanoke to South America

See prices for flight routes from nearby airports that may be better suited for you.
Dulles Intl to Miami flights
Reagan-National to Miami flights
Dulles Intl to Cancún flights
Dulles Intl to Orlando flights
Dulles Intl to Las Vegas flights
Dulles Intl to Fort Lauderdale flights
Dulles Intl to Dallas/Fort Worth flights
Reagan-National to Orlando flights
Reagan-National to Fort Lauderdale flights
Reagan-National to Las Vegas flights
Reagan-National to Los Angeles flights
Reagan-National to Seattle flights
Dulles Intl to Los Angeles flights
Dulles Intl to Tampa flights
Dulles Intl to Luis Munoz Marin Intl flights
Reagan-National to Hobby flights
Dulles Intl to Seattle flights
Reagan-National to San Francisco flights
Dulles Intl to Sky Harbor Intl flights
Dulles Intl to Atlanta flights
Reagan-National to Luis Munoz Marin Intl flights
Dulles Intl to San Francisco flights
Reagan-National to Dallas/Fort Worth flights
Reagan-National to Cancún flights
Raleigh to Miami flights
Dulles Intl to Hobby flights
Dulles Intl to Heathrow flights
Reagan-National to O'Hare Intl flights
Reagan-National to Tampa flights
Reagan-National to Atlanta flights
Dulles Intl to Denver flights
Dulles Intl to O'Hare Intl flights
Dulles Intl to New Orleans flights
Raleigh to Las Vegas flights
Reagan-National to George Bush Intcntl flights
Raleigh to John F Kennedy Intl flights
Dulles Intl to Mexico City flights
Dulles Intl to Charles de Gaulle flights
Dulles Intl to Salt Lake City flights
Reagan-National to New Orleans flights
Raleigh to Fort Lauderdale flights
Reagan-National to Boston flights
Dulles Intl to George Bush Intcntl flights
Dulles Intl to Haneda flights
Dulles Intl to Austin flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Reagan-National to West Palm Beach flights
Raleigh to Orlando flights
Reagan-National to Sky Harbor Intl flights
Raleigh to Newark flights

Top 2 airlines flying from Roanoke to South America

Discover the top 2 airlines that operate flights from Roanoke to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 30, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$746Average$829FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$857Average$973FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights