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South America

$728+ Cheap flights from Roanoke (ROA) to South America

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
ROA — BOG
Dec 20 — Dec 271
Sat 12/20
Sat 12/27
1 adult, Economy
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Cheap flight deals from Roanoke to South America

Keep the following information in mind while searching for Roanoke to South America flight deals. Data was last updated November 20, 2025.

Round-trip from

$637
(American Airlines)
From Roanoke to South America
Search Deals

Find flight deals from Roanoke to South America

Cheapest flights from Roanoke to South America
Explore the most affordable flight options available from Roanoke to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 20, 2025.

This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:03 pmROA - GYE
2 stops30h 03mAmerican Airlines
Fri 12/126:10 amGYE - ROA
2 stops26h 24mAmerican Airlines
Deal found 11/18$728
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:50 amROA - UIO
2 stops19h 20mUnited Airlines
Thu 12/251:35 amUIO - ROA
2 stops45h 55mUnited Airlines
Deal found 11/18$766
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:00 amROA - UIO
2 stops23h 17mDelta
Fri 12/2611:45 pmUIO - ROA
1 stop14h 05mDelta
Deal found 11/18$909
This KAYAK deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:50 pmROA - UIO
2 stops13h 27mLATAM Airlines
Fri 12/2611:45 pmUIO - ROA
1 stop10h 52mLATAM Airlines
Deal found 11/18$969
This Mytrip deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:20 amROA - UIO
2 stops16h 30mMultiple Airlines
Fri 12/265:05 amUIO - ROA
3 stops18h 25mMultiple Airlines
Deal found 11/18$1,850
This Mytrip deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:20 amROA - UIO
3 stops22h 30mAir Canada
Fri 12/265:05 amUIO - ROA
3 stops18h 25mAir Canada
Deal found 11/18$2,026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Roanoke to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
Use the filters below to find and compare flights from Roanoke to South America that are best for you.

Fly from

Roanoke

Fly to

South America

Route

Depart

Return

Price

RoanokeGuayaquil

ROA - GYE

ROAGYE

Roanoke

Mon 12/8

5:03 pm-11:06 pm

2 stops30h 03m

Guayaquil Jose Joaquin de Olmedo

Fri 12/12

6:10 am-8:34 am

2 stops26h 24m

$728

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Fri 12/5

10:50 am-6:10 am

2 stops19h 20m

Quito Mariscal Sucr

Thu 12/25

1:35 am-11:30 pm

2 stops45h 55m

$766

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Fri 12/5

6:00 am-5:17 am

2 stops23h 17m

Quito Mariscal Sucr

Fri 12/26

11:45 pm-1:50 pm

1 stop14h 05m

$909

RoanokeQuito

ROA - UIO

ROAUIO

Roanoke

Fri 12/5

3:50 pm-5:17 am

2 stops13h 27m

Quito Mariscal Sucr

Fri 12/26

11:45 pm-10:37 am

1 stop10h 52m

$969

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 2/28

7:33 am-7:50 am

2 stops22h 17m

Santiago Arturo Merino Benitez

Wed 3/4

10:15 pm-5:36 pm

2 stops21h 21m

$969

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 2/28

3:55 pm-3:30 pm

2 stops21h 35m

Santiago Arturo Merino Benitez

Wed 3/4

11:15 pm-10:41 am

1 stop13h 26m

$1,114

RoanokeSantiago

ROA - SCL

ROASCL

Roanoke

Sat 2/28

3:55 pm-3:30 pm

2 stops21h 35m

Santiago Arturo Merino Benitez

Tue 3/3

12:20 am-7:18 pm

2 stops20h 58m

$1,114

RoanokeRio de Janeiro

ROA - GIG

ROAGIG

Roanoke

Mon 3/23

3:25 pm-7:20 am

1 stop14h 55m

Rio de Janeiro–Galeão Intl

Wed 3/25

9:30 pm-10:33 am

1 stop14h 03m

$1,141

RoanokeRio de Janeiro

ROA - GIG

ROAGIG

Roanoke

Mon 3/23

11:20 am-7:20 am

1 stop19h 00m

Rio de Janeiro–Galeão Intl

Wed 3/25

7:15 am-2:39 pm

2 stops32h 24m

$1,141

RoanokeRio de Janeiro

ROA - GIG

ROAGIG

Roanoke

Mon 3/23

2:55 pm-9:35 am

2 stops17h 40m

Rio de Janeiro–Galeão Intl

Wed 3/25

8:55 pm-2:09 pm

2 stops18h 14m

$1,145

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/18

Showing 1-10 of 14 results
1
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Best time to book a flight from Roanoke to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Roanoke with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Roanoke to South America

What is the cheapest month to book a flight from Roanoke to South America?

Currently, April is the cheapest month in which you can book a flight from Roanoke to South America (average of $302). Flying from Roanoke to South America in October is currently the most expensive (average of $662). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ROA to SA?

Find hourly flight availability from Roanoke to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Roanoke to South America in the morning. If you’re flexible enough to do this you can expect to save up to 43% on your trip compared to booking a flight at noon.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 20, 2025.
Read reviews from past customers who have flown Delta and American Airlines from Roanoke to South America. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,002 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,002 reviews

Comfort

7.9

Entertainment

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Roanoke to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Roanoke to South America?

    Most people fly from Roanoke (ROA) if they book a flight from Roanoke to South America. Roanoke is conveniently located just 4.2 mi from Roanoke’s city center.

  • How long is the flight from Roanoke to South America?

    American Airlines, United Airlines, and Delta can get you from Roanoke to South America in just under 19h 20m. Your travel time can differ by up to 10h 43m. There are 2587 mi between Roanoke and South America. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Roanoke to South America?

    The most popular route from Roanoke to South America is Roanoke - Santiago Arturo Merino Benitez. You may also consider Roanoke - Rio de Janeiro–Galeão Intl or Roanoke - Guayaquil Jose Joaquin de Olmedo.

  • Can I find deals for flights from Roanoke to South America that include hotel bookings?

    Yes. In addition to deals on Roanoke to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Roanoke to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Roanoke to South America.

  • Can I find deals for business class flights from Roanoke to South America?

    Yes. Cheapflights offers flight deals from Roanoke to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Roanoke to South America?

    Currently, April is the cheapest month in which you can book a flight from Roanoke to South America (average of $302). Flying from Roanoke to South America in October is currently the most expensive (average of $662). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Roanoke to South America

Discover the top 2 airlines that operate flights from Roanoke to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$484FlexibilityNo cancel feeOn-time71%
DeltaCheapest$501Average$769FlexibilityNo cancel feeOn-timeN/A

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